Bert Jan Vermeer
Department of Dermatology, University Hospital Leiden, P.O. Box 9600, 2300 RC Leiden, The Netherlands | Department of Dermatology | Departments of Dermatology University ...
Is this your profile? Claim your profile Copy URL Embed Link to your profile
Bert Jan Vermeer:Expert Impact
Concepts for whichBert Jan Vermeerhas direct influence:Skin cancer,Plasma membrane,Renal transplant recipients,Keratotic skin lesions,Solar lentigines,Hla antigens,Cholesterol synthesis,Dna damage.
Bert Jan Vermeer:KOL impact
Concepts related to the work of other authors for whichfor which Bert Jan Vermeer has influence:Skin cancer,Basal cell carcinoma,Human papillomavirus,Squamous cell,Transplant recipients,Illness perceptions,Epidermodysplasia verruciformis.
KOL Resume for Bert Jan Vermeer
Department of Dermatology, University Hospital Leiden, P.O. Box 9600, 2300 RC Leiden, The Netherlands
Department of Dermatology
Departments of Dermatology University Medical Centre, Leiden, The Netherlands
Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Department of Dermatology and Clinical Epidemiology, Leiden University Medical Center, The Netherlands
Department of Dermatology, Leiden, The Netherlands
Department of Dermatology, University Medical Center, Leiden, The Netherlands
Department of Dermatology, University Hospital Leiden, The Netherlands
Academisch Ziekenhuis, afd. Huidziekten, Leiden.
Department of Dermatology, University Hospital Leiden, PO Box 9600, 2300 RC Leiden, the Netherlands
ICRF Skin Tumour Laboratory, Royal London Hospital, London, United Kingdon
From the Department of Dermatology, University Hospital Leiden, Leiden, The Netherlands, and the Department of Dermatology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
Dept Dermatology, University Medical Center, 2333 AA Leiden Netherlands
Department of Dermatology, University Hospital Leiden, P.O. Box 9600, 2300 RC Leiden
Department of Dermatology, Academic Hospital Leiden, The Netherlands
Department of Dermatology, University Medical Centre, Leiden, The Netherlands
Department of Dermatology, University Hospital, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands
Department of Dermatology.
Department of Dermatology, State University Hospital, Leiden, The Netherlands
Nephrology, Rheumatology, Dermatology, Pathology, and Virology Departments, University Hospital, 2300 RC Leiden, The Netherlands
Department of Dermatology Service, Veterans Administration Medical Center (SG, BJV), San Francisco, California, U.S.A.
Departments of Dermatology and Electron Microscopy, University Medical Centre, Leiden, The Netherlands
Departments of Dermatology, University Medical Centre Leiden, The Netherlands
aDepartments of Nephrology, University Hospital, Leiden; TNO, Rijswijk, The Netherlands bDepartments of Dermatology, University Hospital, Leiden; TNO, Rijswijk, The Netherlands cDepartments of Pathology, University Hospital, Leiden; TNO, Rijswijk, The Netherlands dDepartments of Institute for Experimental Gerontology, University Hospital, Leiden; TNO, Rijswijk, The Netherlands
Consultant Dermatologist, Guy's Hospital, London, UK
Department of Dermatology, University Medical Center
Department of Dermatology and Electron Microscopy, University Hospital, 2333 AA Leiden, The Netherlands
Department of Dermatology and Electronmicroscopy, University Medical Centre, Leiden, The Netherlands
Departments of Dermatology and Immunohaematology, University Medical Centre Leiden, 2333 AA Leiden, Netherlands
Gaubius Institute, Health Research Organization TNO, Herenstraat 5d, 2313 AD LeidenThe Netherlands
Department of Dermatology, University Medical Centre, Rijnsburgerweg 10, Leiden, The Netherlands
Department of Dermatology, Leiden University Medical Centre, Rijnsburgerweg 10, Leiden, The Netherlands
Department of Dermatology, University Hospital, Rijnsburgerweg 10, Leiden, The Netherlands
Department of Dermatology, University Medical Centre, Rijnsburgerweg 10, LeidenThe Netherlands
Departments of Dermatology (Head: Prof. M.K. Polano) and Pediatrics (Head: Prof. G.M.H. Veeneklaas), Leiden University Hospital, Leiden
|angina pectoris claudication||#1|
|types melanocytic cells||#1|
|xanthomas fatty acids||#1|
|g418 resistance plasmid||#1|
|65 higher induction||#1|
|aqueous phase digitonin||#1|
|ldl male microscopy||#1|
|ultrastructural findings lipoproteinsin||#1|
|normal suprabasal cells||#1|
|disease ligandreceptor interactions||#1|
|permitted demonstration presence||#1|
|usual melanosome ontogenesis||#1|
|free cholesterol cholesterolesters||#1|
|endocytosis gamma endorphin||#1|
|erythema uv meter||#1|
|expression alpha beta||#1|
|melanogenesis transfected fibroblasts||#1|
|17 xanthomatous lesions||#1|
|ldl electron receptors||#1|
|atypical naevus cells||#1|
|risk estimates melanocytes||#1|
|normal melanosome biogenesis||#1|
|Sign-in to see all concepts, it's free!|
Prominent publications by Bert Jan Vermeer
BACKGROUND: Recipients of renal allografts are at an increased risk for skin cancer. It is also known that recipients who are homozygous for HLA antigens are at an increased risk for certain cancers, as are those who are mismatched with their donors for these antigens. In a case-control study we assessed the relation between skin cancer in renal-transplant recipients and HLA homozygosity and mismatching.
METHODS: Of 764 patients who received renal transplants between 1966 and 1988, 66 ...
|Known for Hla Antigens | Skin Cancer | Transplant Recipients | Basal Cell Carcinoma | Exposure Sunlight|
Melanocortin-1 Receptor Gene Variants Determine the Risk of Nonmelanoma Skin Cancer Independently of Fair Skin and Red Hair
[ PUBLICATION ]
Melanocortin-1 receptor (MC1R) gene variants are associated with fair skin and red hair and, independently of these, with cutaneous malignant melanoma. The association of MC1R gene variants with nonmelanoma skin cancer is largely unknown. A total of 838 subjects were included in the present study: 453 patients with nonmelanoma skin cancer and 385 subjects with no skin cancer. The coding sequence of the human MC1R gene was tested using single-stranded conformation polymorphism analysis ...
|Known for Fair Skin | Gene Variants | Corticotropin Receptors | Variant Alleles | Risk Carriers|
Cultured Human Skin Fibroblasts and Keratinocytes: Differences in the Regulation of Cholesterol Synthesis
[ PUBLICATION ]
The regulation of cholesterol synthesis in cultured human skin fibroblasts and keratinocytes was compared, the incorporation of [14C]-acetate or [14C]-octanoate into [14C]-cholesterol being taken as a measure of de novo cholesterol synthesis. The two types of cultured cells differed in the following features of the regulation of cholesterol synthesis: (1) Keratinocytes synthesized 10-fold more cholesterol/mg cell protein. (2) Keratinocytes retained a greater amount of the de novo ...
|Known for Cholesterol Synthesis | Skin Fibroblasts | Ldl Keratinocytes | Cultured Human | Culture Medium|
THE PREVALENCE OF HUMAN PAPILLOMAVIRUS DNA IN BENIGN KERATOTIC SKIN LESIONS OF RENAL TRANSPLANT RECIPIENTS WITH AND WITHOUT A HISTORY OF SKIN CANCER IS EQUALLY HIGH: A CLINICAL STUDY TO ASSESS RISK FA
[ PUBLICATION ]
DNA of the epidermodysplasia-verruciformis associated subgroup of HPV (EV-HPV) is frequently detected in biopsies of premalignant lesions and nonmelanoma skin cancers of renal transplant recipients. The prevalence of EV-HPVs, however, has never been systematically studied in benign keratotic skin lesions of patients with or without a history of skin cancer. This study included 42 renal transplant recipients with and 36 without a history of skin cancer. A total of 176 skin biopsies were ...
|Known for Skin Cancer | Renal Transplant | Human Papillomavirus Dna | Premalignant Lesions | Epidermodysplasia Verruciformis|
[ PUBLICATION ]
The association between human papillomavirus (HPV)-associated cervical cancer and cutaneous squamous cell carcinoma and codon 72 polymorphism in the p53 gene is not unequivocal. Especially, it is not known whether carriers of the arginine form have an increased risk of cancer that necessitates screening. The alternative is that the polymorphism is a tumor marker instead of a risk factor. We set out a case-control study to determine the risk of squamous cell carcinoma of the skin in ...
|Known for Cell Carcinoma | P53 Codon | 72 Polymorphism | Cutaneous Squamous | Human Papillomavirus|
In a retrospective follow-up study, 36 renal transplant recipients with, and 101 without, skin cancer, who had received their first transplant before January 1981 and who were still alive with a functioning graft on 1 August 1989, were assessed to determine the risk of non-melanoma skin cancer in relation to exposure to sunlight during childhood and adolescence. The contribution of the number of keratotic skin lesions to the skin cancer risk was also assessed. The estimated relative ...
|Known for Skin Cancer | Exposure Sunlight | Renal Transplant | Basal Cell Carcinoma | Odds Ratios|
HLA class II expression on human epidermal langerhans cells in situ: Upregulation during the elicitation of allergic contact dermatitis
[ PUBLICATION ]
An immunoelectron-microscopic technique was applied to investigate the localization of molecules that are involved in the elicitation of allergic contact dermatitis in human epidermal cells in situ. Langerhans cells in the epidermis of lesions showed a strongly increased cell surface expression of HLA class II molecules as compared with normal skin. In addition, a high number of intracellularly located HLA class II molecules were present in Langerhans cells of lesional epidermis, ...
|Known for Langerhans Cells | Hla Class | Allergic Contact Dermatitis | Birbeck Granules | Human Epidermal|
Solar lentigines and ephelides are different types of pigmented skin lesions predominantly present on sun-exposed skin. Both lesions are risk indicators for melanoma and non-melanoma skin cancer. Solar lentigines are considered as a sign of photodamage although well-conducted epidemiological studies are lacking on this subject. Ephelides are associated with fair skin type and red hair. The aim of the present study was to investigate the relation of sun-exposure estimates with solar ...
|Known for Solar Lentigines | Sun Exposure | Skin Type | Contrast Ephelides | Lentigo Male|
THE ACTION SPECTRA FOR UV‐INDUCED SUPPRESSION OF MLR and MECLR SHOW THAT IMMUNOSUPPRESSION IS MEDIATED BY DNA DAMAGE
[ PUBLICATION ]
Ultraviolet-B (UVB, 280-320 nm) radiation can promote the induction of skin cancer by two mechanisms: damage of epidermal DNA and suppression of the immune system, allowing the developing tumor to escape immune surveillance. The mixed lymphocyte reaction (MLR) and the mixed epidermal cell lymphocyte reaction (MECLR) are commonly used methods to study the immunosuppressive effects of UVB radiation. To obtain a better understanding of the mechanism by which UVB radiation decreases the ...
|Known for Action Spectra | Dna Damage | Mlr Meclr | 254 Nm | Epidermal Cells|
Calcium‐mediated regulation of the low density lipoprotein receptor and intracellular cholesterol synthesis in human epidermal keratinocytes
[ PUBLICATION ]
Unlike cells cultured under physiological Ca2+ concentrations (1-2 mM), keratinocytes cultured in media containing Ca2+ in low concentrations (less than 0.1 mM) do not stratify. The latter cells also differ with respect to several features of the regulation of cholesterol synthesis. In keratinocytes cultured in medium containing high Ca2+ concentrations (1.6 mM) and fetal calf serum, the rate of cholesterol synthesis was 20-30 times higher than in keratinocytes exposed to a low Ca2+ ...
|Known for Cholesterol Synthesis | Human Epidermal Keratinocytes | Low Density Lipoprotein | Electron Receptors | Epidermal Cells|
Effect of Topical Sunscreens on the UV-Radiation–Induced Suppression of the Alloactivating Capacity in Human Skin In Vivo
[ PUBLICATION ]
Exposure of mice or humans to solar or artificial ultraviolet radiation (UV) has been shown to induce a number of changes in the immune system that may influence their susceptibility to skin tumors. The protective effect of sunscreens on these changes is not clear. Thirty-two patients with a variety of dermatoses routinely undergoing treatment with standard UVB (n = 19) or PUVA (n = 13) therapy were studied. One of the two tested sunscreens or its vehicle was applied to the right flexor ...
|Known for Alloactivating Capacity | Human Skin | Induced Suppression | Sunscreens Uv | 4 Weeks|
High Frequency of Detection of Epidermodysplasia Verruciformis–Associated Human Papillomavirus DNA in Biopsies from Malignant and Premalignant Skin Lesions from Renal Transplant Recipients
[ PUBLICATION ]
Based on immunologic and epidemiologic data, it is plausible that skin cancer in renal transplant recipients is associated with human papillomaviruses (HPV). At present, conflicting evidence exists concerning the presence of HPV DNA in these cancers. We recently described a nested polymerase chain reaction method that enables the detection of all previously isolated epidermodysplasia verruciformis (EV)-associated HPVs. We now describe the detection of EV-associated HPV DNA in 49 (80%) of ...
|Known for Epidermodysplasia Verruciformis | Renal Transplant Recipients | Hpv Dna | Premalignant Skin | Human Papillomaviruses|
Differential effects of interleukin 1-alpha (IL-1 alpha) or tumor necrosis factor-alpha (TNF-alpha) on motility of human melanoma cell lines on fibronectin.
[ PUBLICATION ]
Interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF-alpha) induce a motogenic response in a number of benign and malignant cells. We examined the chemokinetic effects of these cytokines on the cell migration of four melanoma cell lines on fibronectin using modified Boyden chambers and video-time lapse analysis. Flow cytometry analysis of IL-1 receptors, TNF receptors, and shifts in beta 1 integrin expression were correlated with the effects of these cytokines on cell ...
|Known for Melanoma Cell | Tumor Necrosis | Tnf Alpha | Integrin Expression | Migration Fibronectin|