Gerbert Rebell

Natamycin (pimaricin) as a 5% suspension, was used sucessfully in 16 of 18 consecutive Fusarium solani corneal ulcers between February 1969 and January 1971. Thirteen of these patients obtained a visual result of 20/40 or better. These results compare favorably with a series of 20 Fusarium ulcers treated with amphotericin B prior to February 1969. Amphotericin B was effective in eliminating the fungus in only seven patients, five of whom retained a visual acuity of 20/40 or better. These ...

BACTERIA of the Mima-Herellea group were not recognized as distinct and remained undescribed until 1942, when De Bord1 suggested the name Mimeae for a new tribe of gram-negative, nonmotile organisms which resembled Neisseria morphologically, but differed in biochemical characteristics. He named the two new organisms Mima polymorpha and Herellea vaginicola.During subsequent years, other authors reported similar organisms but gave them different names so that the situation became extremely ...

The limulus lysate assay is an inexpensive, reliable, and rapid means of detecting and presence of Gram-negative endotoxin. In all ten cases of experimentally induced Proteus endophthalmitis in rabbits, the assay was positive, and the assay was appropriately negative in all ten cases of Staphylococcal endophthalmitis, ten cases of Candida endophthalmitis, and ten cases of sterile endophthalmitis in rabbits. In a clinical assessment of keratitis, the assay of corneal scrapings was ...

Because of the frequency of fungal keratitis due to Fusarium solani, we needed a sustained, progressive infection in an animal model to determine the mechanisms of pathogenicity and to evaluate the new antifungal agents. Pigmented rabbits interlamellarly injected with actively germinating conidia from lyophilized temperature-tolerant strains of F. solani produced sustained culture-positive ulcers in high percentage of eyes at two and three weeks, pretreatment with subconjunctival ...

A new culture medium (DTM) has been devised for the simplified diagnosis of dermatophytosis. Results can be evaluated by a color change in the medium without detailed knowledge of colony morphology. Although microscopic features are required for positive botanical identification, the nonmycologist can now recognize a griseofulvin-sensitive infection quite well by noting the change of the color of the agar from yellow to red.The medium is superior to currently available commercial ...

A 68-year-old woman had a marked decrease in visual acuity, increased intraocular pressure, and acute iridocyclitis. She developed a pigmented hypopyon simulating an occult intraocular melanoma. Two anterior chamber paracenteses showed growth of Listeria monocytogenes. The patient received systemic intravenous penicillin, topical fortified gentamicin sulfate drops, and intraocular injections of cephaloridine. On discharge from the hospital after a two-week stay, visual acuity had ...

Medical management of 61 cases of mycotic keratitis, including the use of natamycin (pimaricine) in 53 cases, resulted in successful healing in 46 cases. A final visual acuity of 20/40 or better was achieved in 25 cases by medical therapy alone. Thirteen cases were considered medical treatment failures, and 11 necessitated therapeutic surgery. A final visual acuity of 20/70 or better was achieved in six of these cases, including five of nine therapeutic penetrating keratoplasties. In ...

Causative isolates, clinical features, and laboratory studies are reported for sixty-one cases of culture-proved mycotic keratitis. Isolates are categorized into four groups, including 36 Fusarium solani, 11 other Moniliaceae species, seven Dematiaceae, and seven yeasts. Of the 61 patients, 42 were men. Mild outdoor trauma was sustained in 14 of 24 cases. Patients were often referred with a clinical diagnosis of presumed fungal keratitis, within one week of symptom development, and ...

Pitted keratolysis is a superficial infection of the skin confined to the stratum corneum. The causative organism has not been identified. The clinical syndrome is distinct and is characterized by pits and superficial erosions in the pressure areas of the soles and in the lateral surfaces of the toes. The histopathology of the lesions is presented and world literature is reviewed. It is concluded that this disease is not limited to the tropical climates, although cases tend to be more ...

An epidemic of disease in recently hatched green turtles (Chelonia mydas) was found to be associated with a new coccidial intestinal parasite. The disease and associated mortality appeared in young turtles approximately 30 days after hatching, and ran a 60 day course through the stock hatchlings at the farm. Symptoms of the disease were emaciation and lethargy. Tube-like casts of intestinal mucosa and impaction of the gut with caseous masses of oocysts occured late in the disease. Active ...

A shortened version of Grocott's methenamine-silver technique for use in staining corneal scrapings was superior to current methods for the diagnosis of mycotic keratitis.

Since the publication of the paper of Lamb, Jones, and Maxwell1 on solar dermatitis there have been inquiries in regard to the case reported whose colored photographs showed severe erythema perstans from fluorescent lighting and to the possibility that blue-light sensitivity might account for some of those cases of polymorphic light eruptions which do not seem to improve with use of the antimalarials.McNairy2 queried how to proceed with an erythematous type of polymorphic lightsensitive ...