• Disease
  • Mycosis
  • Mycosis Fungoides
  • Lorenzo Cerroni

    Prominent publications by Lorenzo Cerroni

    KOL Index score: 19422

    T(11;18)(q21;q21) is the most common structural abnormality in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) leading to the fusion of the apoptosis inhibitor-2 (API2) gene and the MALT lymphoma-associated translocation (MALT1) gene. In 2 patients with MALT lymphoma of the liver and skin, respectively, t(14;18)(q32;q21) was observed by cytogenetic analysis. Subsequent fluorescence in situ hybridization (FISH) studies disclosed that the ...

    Also Ranks for: Malt Lymphoma |  human pair |  t1418q32q21 igh |  situ hybridization |  neoplasms translocation
    KOL Index score: 16977

    The interchromosomal 14;18 translocation occurs in approximately 70-80% of follicular lymphomas and in a lower proportion of high-grade non-Hodgkin lymphomas of the lymph nodes. This translocation results in the fusion of the bcl-2 oncogene on chromosome 18 with immunoglobulin heavy chain genes on chromosome 14, and in the expression of higher amounts of normal bcl-2 protein. We studied bcl-2 expression in biopsies of 108 patients with benign and malignant cutaneous lymphoproliferative ...

    Also Ranks for: Protein Expression |  cutaneous lymphomas |  bcell lymphoma |  human pair |  chain reaction
    KOL Index score: 14965

    Spitz tumors represent a group of melanocytic neoplasms that typically affect young individuals. Microscopically, the lesions are composed of cytologically distinct spindle and epithelioid melanocytes, with a range in the architectural display or the cells, their nuclear features, and secondary epidermal or stromal changes. Recently, kinase fusions have been documented in a subset of Spitz tumors, but there is limited information on the clinical and pathologic features associated with ...

    Also Ranks for: Spitz Tumors |  alk fusions |  situ hybridization |  melanocytic neoplasms |  2 years
    KOL Index score: 14570

    BACKGROUND: Few recent studies have analyzed the clinicopathologic features of specific cutaneous manifestations of myelogenous leukemia in a large number of patients.

    OBJECTIVE: We characterize the clinical and histopathologic spectrum of specific cutaneous manifestations in acute (AML) and chronic (CML) myelogenous leukemia, ascertain further diagnostic criteria, and examine current prognosis.

    METHODS: Thirty-six lesions of specific cutaneous infiltrates from 26 patients with ...

    Also Ranks for: Myelogenous Leukemia |  aml cml |  cutaneous infiltrates |  neoplastic cells |  onset skin lesions
    KOL Index score: 14369

    In past years, association of primary cutaneous B-cell lymphoma (CBCL) with infection by Borrelia burgdorferi has been reported in a few patients. The evidence for a pathogenetic role was based on clinical grounds or raised titre of antibodies in serum. Both methods, however, do not prove the association between the micro-organism and the CBCL, especially in countries where infection by Borrelia burgdorferi is endemic. Moreover, the exact percentage of Borrelia burgdorferi-positive CBCL ...

    Also Ranks for: Borrelia Burgdorferi |  cell lymphoma |  patients cbcl |  pcr analysis |  50 cases
    KOL Index score: 14348

    We recently reported that germline mutations in BAP1 cause a familial tumor syndrome characterized by high penetrance for melanocytic tumors with distinct clinical and histologic features. Melanocytic neoplasms in affected individuals harbored BRAF mutations, showed loss of BAP1 expression, and histologically resembled so-called "atypical Spitz tumors" (ASTs). ASTs are an ill-defined and probably heterogenous group of melanocytic tumors that display histologic features seen in both Spitz ...

    Also Ranks for: Bap1 Expression |  braf mutation |  distinct subset |  spitz tumors |  melanocytic neoplasms
    KOL Index score: 14061

    BACKGROUND: Cutaneous lymphoid infiltrates at sites of herpes zoster scars in patients with B-cell chronic lymphocytic leukemia (B-CLL) often are diagnosed as benign lymphoid hyperplasia ("pseudolymphomas"). The histologic and immunophenotypic features of these lesions are not well characterized. Appearance of skin lesions in B-CLL patients is considered a poor prognostic sign.

    METHOD: Eight punch biopsies from five patients (three males, two females; mean age, 66.7 years) affected by ...

    Also Ranks for: Specific Cutaneous Infiltrates |  herpes zoster |  chronic lymphocytic |  patients bcll |  simplex scars
    KOL Index score: 13999

    Histopathological evaluation of melanocytic tumours usually allows reliable distinction of benign melanocytic naevi from melanoma. More difficult is the histopathological classification of Spitz tumours, a heterogeneous group of tumours composed of large epithelioid or spindle-shaped melanocytes. Spitz tumours are biologically distinct from conventional melanocytic naevi and melanoma, as exemplified by their distinct patterns of genetic aberrations. Whereas common acquired naevi and ...

    Also Ranks for: Genomic Aberrations |  spitz tumours |  braf mutations |  prognosis therapy |  spindle cell nevus
    KOL Index score: 13022

    BACKGROUND: Cutaneous lymphomas expressing a cytotoxic or natural killer (NK) cell phenotype represent a group of lymphoproliferative disorders for which there is currently much confusion and little consensus regarding the best nomenclature and classification.

    METHODS: This study analyzes 48 cases of primary cutaneous lymphoma expressing cytotoxic proteins and/or the NK cell marker, CD56. These cases were collected for a workshop of the European Organization for Research and Treatment of ...

    Also Ranks for: Cutaneous Lymphoma |  natural killer |  cytotoxic proteins |  nk cell |  nasal type
    KOL Index score: 12854

    A new group of subcutaneous, natural killer (NK), NK/T-cell, and other cytotoxic T-cell lymphomas of the skin has been recently described, and some have been included as distinct clinicopathologic entities in the classification of hematologic malignancies recently proposed by the World Health Organization. In the European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas, they would be classified either as CD30- large T-cell lymphoma, small/medium ...

    Also Ranks for: Natural Killer |  lymphoma cell |  8 cases |  5 year |  cancer classification
    KOL Index score: 12327

    Primary cutaneous B-cell lymphomas (CBCL) represent approximately 20% to 25% of all primary cutaneous lymphomas. With the advent of the World Health Organization-European Organization for Research and Treatment of Cancer (EORTC) Consensus Classification for Cutaneous Lymphomas in 2005, uniform terminology and classification for this rare group of neoplasms were introduced. However, staging procedures and treatment strategies still vary between different cutaneous lymphoma centers, which ...

    Also Ranks for: Cutaneous Lymphoma |  european organization |  monoclonal antibodies |  large bcell |  treatment cancer
    KOL Index score: 12096

    Individuals suffering from psoriasis are treated with a combination of psoralen and UVA radiation, commonly referred to as "PUVA" therapy. Epidemiologic studies have shown that PUVA therapy is a risk factor for skin cancer in psoriasis patients. Although PUVA treatment induces skin cancer in laboratory animals, it is unknown whether the increased incidence of skin cancer reported in PUVA-treated psoriasis patients is due to the carcinogenic effects of PUVA or due to other factors such as ...

    Also Ranks for: Psoriasis Patients |  p53 mutation |  puva therapy |  skin cancer |  squamous cell
    KOL Index score: 12082

    Recently a new classification of primary cutaneous B-cell lymphomas (PCBCLs) has been proposed by the European Organization for Research and Treatment of Cancer (EORTC)--Cutaneous Lymphoma Project Group. The marginal zone B-cell lymphomas (MZLs) were not included as a distinct entity because of insufficient experience and controversial opinions. We have studied 32 patients (M:F ratio 1.5:1; age range 25-93 years; mean age 49.6 years; median age 50 years) to determine the diagnostic ...

    Also Ranks for: Marginal Zone |  primary cutaneous |  cell lymphoma |  lymphocytic chronic |  tumor diagnosis
    KOL Index score: 11894

    Pigmented actinic keratosis is one of the simulators of early melanoma in situ from severely sun-damaged skin. Close scrutiny of the hematoxylin and eosin stained section does not always allow an unequivocal diagnosis, because it is sometimes difficult to distinguish pigmented keratinocytes from melanocytes. Immunohistochemical stains, such as S-100 and HMB-45, are used routinely to address this problem. Melan-A, also known as MART-1, is an additional melanocytic marker and has proved to ...

    Also Ranks for: Actinic Keratosis |  neoplasm biomarkers |  damaged skin |  tumor carcinoma |  early melanoma
    KOL Index score: 11874

    Cutaneous lymphomas are rare in young patients and are mostly represented by mycosis fungoides and its variants and CD30+ lymphoproliferative disorders (lymphomatoid papulosis [LYP] and anaplastic large T-cell lymphoma). We report our observations in a series of 69 patients less than 20 years of age who presented either with primary cutaneous lymphoma (n = 62) or with secondary manifestations of extracutaneous disease (n = 7). Clinicopathologic features permitted classification of the ...

    Also Ranks for: Cutaneous Lymphomas |  20 years |  cell lymphoma |  clinicopathologic features |  mycosis fungoides


    Lorenzo Cerroni: Influence Statistics

    Sample of concepts for which Lorenzo Cerroni is among the top experts in the world.
    Concept World rank
    primary ctcl expression #1
    uncommon histological variants #1
    pilomatricoma melanocytic #1
    specificity histopathological review #1
    vascular coagulopathies #1
    leg type dlbcls #1
    cutaneous fcl #1
    miliary papules #1
    cycle denileukin diftitox #1
    pseudolymphomatous #1
    patients sptcl #1
    differential diagnostic errors #1
    sptcl patients #1
    aberrant experession cytokeratins #1
    immunohistochemistry immunophenotyping interferon #1
    pilomatrixoma predictive #1
    knowledge accurate diagnosis #1
    new horizons advances #1
    mucocutaneous lesions syphilis #1
    pcr united states #1
    conventional mf imf #1
    infiltrate eosinophils #1
    ffm pallidum #1
    sites typical #1
    histopathologic mimicker #1
    vexing problems dermatology #1
    pcfcls #1
    syringotropic #1
    tumor cells losses #1
    mswat score patients #1
    disorders cutaneous #1
    age sex location #1
    skinrestricted pcfcl scfl #1
    melanoma broad constellation #1
    histopathologic diagnosis d1 #1
    new criteria differentiation #1
    iptclb #1
    amyloidoma skin #1
    ontak bexarotene #1
    mf cutaneous #1
    iptclbs #1
    conditions ctcl #1
    interstitial mf case #1
    ambiguous tumors #1
    cases chromosomal aberrations #1
    1 dermatopathologists #1
    syringotropic lp #1
    sptcl differential diagnosis #1
    onset skin lesions #1
    lymphocytic infiltrate cd8 #1

    Key People For Mycosis Fungoides

    Top KOLs in the world
    Rein Willemze
    mycosis fungoides cell lymphoma sézary syndrome
    Eric C Vonderheid
    mycosis fungoides sézary syndrome cell lymphoma
    Sean J Whittaker
    mycosis fungoides sézary syndrome cell lymphoma
    Lorenzo Cerroni
    mycosis fungoides cell lymphoma skin neoplasms
    Günter Burg
    cutaneous lymphomas mycosis fungoides cell lymphoma
    Robert Martin Knobler
    extracorporeal photopheresis host disease mycosis fungoides

    Lorenzo Cerroni:Expert Impact

    Concepts for whichLorenzo Cerronihas direct influence:Mycosis fungoides,  Cell lymphoma,  Cutaneous lymphomas,  Cutaneous lymphoma,  Skin neoplasms,  Histopathologic features,  Primary cutaneous,  Histopathologic diagnosis.

    Lorenzo Cerroni:KOL impact

    Concepts related to the work of other authors for whichfor which Lorenzo Cerroni has influence:Mycosis fungoides,  Cell lymphoma,  Sézary syndrome,  Skin neoplasms,  Primary cutaneous,  Situ hybridization,  Marginal zone.



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    Medical University of Graz, Graz, Austria. | Department of Dermatology, Medical University of Graz, Austria | Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria. | Die Dermatopathologie der Universitä