• Disease
  • Slit
  • Slit Ventricle
  • Slit Ventricle Syndrome
  • Philip H Cogen

    Prominent publications by Philip H Cogen

    KOL Index score: 12516

    Inactivation of the PTCH tumor suppressor gene occurs in a subset of sporadic medulloblastomas, suggesting that alterations in the PTCH pathway may be important in the development of this tumor. In order to address the frequency of genetic alterations affecting genes in this pathway, we used a combination of loss of heterozygosity (LOH) analysis, single-stranded conformational polymorphism (SSCP) analysis, and direct sequencing of DNA samples from sporadic primitive neuroectodermal ...

    Also Ranks for: Shh Pathway |  ptch gene |  cell surface receptors |  human pair |  sporadic medulloblastomas
    KOL Index score: 11684

    The best operative intervention for children with arachnoid cysts remains the subject of controversy. Recent reports stress that craniotomy for cyst fenestration is associated with a low incidence of morbidity and mortality and may leave the child shunt-independent. The cases of 40 pediatric patients with arachnoid cysts treated between 1978 and 1989 are reported. Five children with mild symptoms and small cysts that remained stable on follow-up studies have not required surgical ...

    Also Ranks for: Arachnoid Cysts |  cyst fenestration |  20 patients |  infant magnetic resonance |  surgical intervention
    KOL Index score: 10551

    DNA methylation and epigenetic inactivation of the O6-methylguanine methyltransferase (MGMT) gene induces MGMT deficiency, reducing the tumor cell's DNA repair capacity and increasing its susceptibility to alkylating chemotherapeutic agents. Consequently, adult patients whose tumors are deficient in MGMT have better outcomes with alkylator chemotherapy, and MGMT methylation has been proposed as a screening marker of deficient tumors. In order to test the feasibility of this approach for ...

    Also Ranks for: Mgmt Methylation |  dna repair |  mrna expression |  chemotherapeutic agents |  chain reaction
    KOL Index score: 10096

    Ependymomas are glial tumors of the brain and spinal cord occurring both sporadically and in a familial syndrome, neurofibromatosis type 2 (NF2). Previous analyses performed on specimens obtained predominantly from adult patients have shown loss of DNA sequences from chromosome arm 22q, which is the location of the NF2 gene. Previously, we documented the consistent loss of chromosome arm 17p DNA in medulloblastoma and astrocytoma, which are the most common brain tumors in children. ...

    Also Ranks for: Chromosome Arm |  pediatric ependymomas |  human pair |  nf2 gene |  loss 22q
    KOL Index score: 9691

    Little is known about the genetic regulation of medulloblastoma dissemination, but metastatic medulloblastoma is highly associated with poor outcome. We obtained expression profiles of 23 primary medulloblastomas clinically designated as either metastatic (M+) or non-metastatic (M0) and identified 85 genes whose expression differed significantly between classes. Using a class prediction algorithm based on these genes and a leave-one-out approach, we assigned sample class to these tumors ...

    Also Ranks for: Metastatic Disease |  mapk pathway |  pdgfra tumors |  medulloblastoma metastasis |  genetic regulation
    KOL Index score: 8867

    Loss of heterozygosity for sequences located on chromosome 17p in several tumor types is often associated with mutations in the tumor suppressor gene p53. We previously showed consistent deletion of chromosome 17p12-13.1 in medulloblastoma, a common childhood brain tumor. Using denaturing gradient gel electrophoresis and direct sequencing, we have detected p53 mutations in only two of 20 medulloblastoma specimens. Moreover, additional RFLP studies of these 20 specimens showed loss of ...

    Also Ranks for: Chromosome 17p |  p53 mutations |  medulloblastoma tumorigenesis |  human pair |  loss heterozygosity
    KOL Index score: 8576

    Medulloblastoma is the most common childhood primary CNS tumor, and treatment approaches have evolved over the past three decades. The biologic underpinnings of medulloblastoma are not fully characterized, but recent work has identified new, important directions for research. Stratification of patients with medulloblastoma into risk groups is the backbone of most ongoing therapeutic studies. Patients are usually characterized as being either average risk or poor risk, although an ...

    Also Ranks for: Medulloblastoma Children |  radiation chemotherapy |  adjuvant child child |  local neuroectodermal tumors |  average risk
    KOL Index score: 7994

    PURPOSE: To report the early results of hyperfractionated craniospinal radiation therapy with and without adjuvant chemotherapy for primitive neuroectodermal brain tumors (PNETs).

    METHODS AND MATERIALS: Thirty-nine patients with PNETs were classified as good-risk (23) or poor-risk (16), based on postoperative magnetic resonance imaging and a cytological examination of cerebrospinal fluid. All patients received hyperfractionated craniospinal radiation therapy; poor-risk patients ...

    Also Ranks for: Adjuvant Chemotherapy |  radiation therapy |  primitive neuroectodermal |  hyperfractionated craniospinal |  patients risk
    KOL Index score: 7933

    In adults, loss of heterozygosity for DNA on 17p has been shown in high-grade anaplastic astrocytomas (AAs) and glioblastomas multiforme (GMs), and mutation of the TP53 tumor suppressor gene has been reported in all grades of astrocytomas. Little is known, however, about 17p deletion and TP53 mutation in juvenile pilocytic astrocytomas (JPAs), the most common low-grade tumors seen in children. To elucidate the genetic characteristics of pediatric high-grade astrocytomas and JPAs, we ...

    Also Ranks for: Pilocytic Astrocytomas |  chromosome arm |  tp53 gene |  17p dna |  human pair
    KOL Index score: 7770

    Embryonal central nervous system (CNS) tumors are the most common group of malignant brain tumors in children. The diagnosis and classification of tumors belonging to this family have been controversial; however, utilization of molecular genetics is helping to refine traditional histopathologic and clinical classification schemes. Currently, this group of tumors includes medulloblastomas, supratentorial primitive neuroectodermal tumors, atypical teratoid/rhabdoid tumors, ...

    Also Ranks for: Molecular Genetics |  cns tumors |  germ cell |  advances diagnosis |  neoplasms child
    KOL Index score: 7741

    Little is known about the risk of developing multicentric disease in patients with juvenile pilocytic astrocytoma (JPA), and even less about its prognosis. Only five cases have been reported. Between 1986 and 1992, the authors treated 90 patients with either primary or recurrent JPA, 11 of whom developed multicentric spread. Ten patients had primary tumors in the hypothalamic region, eight were under 4 years of age at initial diagnosis, all had initially undergone a subtotal resection or ...

    Also Ranks for: Multicentric Disease |  adjuvant child child |  hypothalamic region |  juvenile pilocytic |  initial diagnosis
    KOL Index score: 6925

    Although primary intracranial neoplasms are the most common type of solid cancer in children, little is known about their etiology at the molecular genetic level. Recently, studies have shown that a class of genes known as tumor suppressors play an important role in the origin of several different types of human tumors, including those located in the central nervous system (CNS). Using a variety of techniques, selective loss of DNA sequences has been identified in tissue specimens from ...

    Also Ranks for: Tumor Suppressor |  retinoblastoma genes |  children medulloblastoma |  dna sequences |  central nervous


    Philip H Cogen: Influence Statistics

    Sample of concepts for which Philip H Cogen is among the top experts in the world.
    Concept World rank
    ganglioglioma subarachnoid space #1
    arm 17p #1
    nf2 locus chromosome #1
    loss dna sequences #1
    p53 gene medulloblastoma #1
    prognosis childhood tumors #1
    located 17p #1
    contrast 18 specimens #1
    medulloblastoma locus #1
    mapping medulloblastoma #1
    sporadic pediatric ependymomas #1
    arm 22q #1
    17p dna #1
    17p markers contrast #1
    17p involved #1
    children rflp #1
    oncogenesis human meningioma #1
    2 spinal loss #1
    subarachnoid tumor #1
    p53 located #1
    infratentorial pnets #1
    infratentorial neoplasms medulloblastomas #1
    8 hemispheric pnets #1
    loss 22q dna #1
    ganglioglioma child #1
    2 genes human #1
    chromosome 17p etiology #1
    ependymoma female genes #1
    markers d22s1 #1
    chromosome 17p sequences #1
    report 20monthold #1
    medulloblastoma loh #1
    heterogeneity supratentorial #1
    contrast ependymomas #1
    leptomeningeal involvement ganglioglioma #1
    chromosomal region loss #1
    22q sequences #1
    heterozygosity medulloblastoma #1
    medulloblastomas 17p #1
    etiology medulloblastoma #1
    loss chromosome arm #1
    tumors hic1 #1
    22q dna #1
    cases documented neurofibromatosis #1
    rflp investigation #1
    diffuse leptomeningeal involvement #1
    17p sequences #1

    Key People For Slit Ventricle Syndrome

    Top KOLs in the world
    Harold L Rekate
    hypothalamic hamartoma intracranial pressure cerebrospinal fluid
    Frank E Nulsen
    spinal cord intracranial pressure carotid ligation
    Fred J Epstein
    spinal cord brain stem surgical management
    M Deborah HydeRowan
    collapsed ventricles oral contraception transsphenoidal tumor removal
    Satoshi Matsumoto
    fetal hydrocephalus moyamoya disease spina bifida
    Shizuo OI
    congenital hydrocephalus spina bifida neuroendoscopic surgery

    Philip H Cogen:Expert Impact

    Concepts for whichPhilip H Cogenhas direct influence:Slit ventricle syndrome,  Tumor suppressor genes,  Chromosome 17p,  Chromosome arm,  Molecular genetics,  Spinal cord,  P53 gene,  Sporadic pediatric ependymomas.

    Philip H Cogen:KOL impact

    Concepts related to the work of other authors for whichfor which Philip H Cogen has influence:Brain tumors,  Arachnoid cysts,  Central nervous,  Neurofibromatosis type,  Pilocytic astrocytoma,  Gene therapy,  Medulloblastoma cells.



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    Departments of Infectious Diseases (OB, BAJ) Laboratory Medicine (JMC) and Neurosurgery (PHC) Children’s National Medical Center The George Washington University School of Medicine and Health Sciences Washington, DC | Neurosurgery, and | Division of