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  • Joanna Marguerite Wardlaw
Joanna Marguerite Wardlaw

Joanna Marguerite Wardlaw

Centre For Clinical Brain Sciences, University Of Edinburgh, Edinburgh Eh16 4sb, Uk;, M.j.thrippleton@ed.ac.uk, (M.j.t.);, Gordon.blair@ed.ac.uk, (G.w.b.);, ...

Direct Impact

Concepts for which Joanna Marguerite Wardlaw has direct influence:

small vessel
lacunar stroke
white matter
lothian birth
perivascular spaces
blood pressure
cognitive ability

External impact

Concepts related to the work of other authors for which Joanna Marguerite Wardlaw has influence:

antiplatelet therapy
intracerebral haemorrhage
occlusive vascular
white matter
cognitive impairment
cerebral small vessel
acute stroke

Prominent publications by Joanna Marguerite Wardlaw

KOL-Index: 437 BACKGROUND: Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used ...
Known for
Intracranial Haemorrhage | Iqr | Vascular Antiplatelet | Allocated
KOL-Index: 425 BACKGROUND AND PURPOSE: Hyperdense middle cerebral artery sign (HMCAS) on CT is a well known indication of thromboembolic arterial occlusion. Its disappearance after thrombolytic therapy is poorly described. Taking the rate of HMCAS disappearance as a surrogate for MCA recanalisation, its prognostic value after intravenous thrombolysis was examined. METHODS: 1905 stroke patients with HMCAS ...
Known for
Mca Recanalisation | 831 | Safe Implementation | 1905 Stroke
KOL-Index: 419 BACKGROUND: Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral ...
Known for
Recurrent Intracerebral Haemorrhage | Primary Subgroup | Cerebral Small | Allocation
KOL-Index: 286 BACKGROUND: High blood pressure is common in acute stroke and associated with a worse functional outcome. Glyceryl trinitrate, a nitric oxide donor, lowers blood pressure in acute stroke and may improve outcome. AIMS: Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) tested the feasibility of performing a UK multicenter ambulance-based stroke trial, and the ...
Known for
Sham Ultra | Recruited Intervention | 2018 1149 | Trinitrate Hypertensive
KOL-Index: 238 OBJECTIVE: To investigate the relationship between baseline white matter hyperintensities (WMH) in patients with ischemic stroke and long-term risk of dementia, functional impairment, recurrent stroke, and mortality. METHODS: Following the Meta-analysis of Observational Studies in Epidemiology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO ...
Known for
Newcastle-Ottawa | Baseline Dementia | Poststroke | Ct-Assessed Wmh
KOL-Index: 189 Cerebrovascular reactivity (CVR) magnetic resonance imaging (MRI) probes cerebral haemodynamic changes in response to a vasodilatory stimulus. CVR closely relates to the health of the vasculature and is therefore a key parameter for studying cerebrovascular diseases such as stroke, small vessel disease and dementias. MRI allows in vivo measurement of CVR but several different methods have ...
Known for
Cvr Methods | Blood Oxygen Level Dependent | Image Processing Technique | Pulse Sequence
KOL-Index: 184 Abstract Birth weight, an indicator of fetal growth, is associated with cognitive outcomes in early life and risk of metabolic and cardiovascular disease across the life course. Cognitive ability in early life is predictive of cognitive ability in later life. Brain health in older age, defined by MRI features, is associated with cognitive performance. However, little is known about how ...
Known for
Weight Brain | Cognitive Ability | Cortical Surface Area | Tissue Atrophy
KOL-Index: 167 BACKGROUND: Most strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage has occurred and improve recovery after stroke in some people. Thrombolytic drugs, however, can also cause serious bleeding in the brain, which can be fatal. One drug, recombinant tissue plasminogen activator ...
Known for
Haemorrhage Hours | Aged Trials | People Thrombolytic
KOL-Index: 165 Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for ...
Known for
Genome | Associations | Age Cognitive Function | Heart

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK;, m.j.thrippleton@ed.ac.uk, (M.J.T.);, gordon.blair@ed.ac.uk, (G.W.B.);, M.Valdes-Hernan@ed.ac.uk, (M.C.V.-H.);, andi@mingsze.com, (A.G.);, fergus.doubal@ed.ac.uk, (F

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