Prominent publications by Karl‐Erik Andersson

KOL Index score: 17186

The possible existence of a beta3-adrenergic receptor (beta3-AR) in the human detrusor muscle was investigated by in vitro functional studies and analysis of mRNA expression. Isoprenaline, noradrenaline and adrenaline each produced a concentration-dependent relaxation of the human detrusor. The rank order for their relaxing potencies was isoprenaline (pD2 6.37+/-0.07) > or = noradrenaline (pD2 6.07+/-0.12) > or = adrenaline (pD2 5.88< or =0.11). Neither dobutamine (beta1- and beta2-AR ...

Also Ranks for: Human Detrusor |  messenger receptors |  receptor agonists |  adrenergic beta3 |  muscle relaxation
KOL Index score: 16369

1. We studied the non-adrenergic, non-cholinergic (NANC) nerve-mediated relaxation induced by electrical stimulation in pig isolated lower urinary tract smooth muscle, and the possible involvement of the L-arginine (L-ARG)/nitric oxide (NO) pathway in this response. 2. Trigonal strips, precontracted by noradrenaline (NA), carbachol or endothelin-1 (ET-1), relaxed frequency-dependently in response to electrical stimulation. Maximum relaxation was obtained at 6-8 Hz, and amounted to 56 +/- ...

Also Ranks for: Urinary Tract |  electrical stimulation |  nitric oxide |  pig lower |  muscle relaxation
KOL Index score: 15483

Tissue specimens from various parts of the uteroplacental unit were obtained from women undergoing caesarean section, and placental tissue from women with normal deliveries. Strips of myometrial tissue, and segments of intramyometrial arteries were dissected together with segments of chorionic plate arteries and veins, and stem villous arteries. The preparations were mounted in organ baths, isometric tension recorded, and the responses to angiotensin II, vasopressin, and oxytocin were ...

Also Ranks for: Smooth Muscle |  vasopressin oxytocin |  uteroplacental unit |  villous arteries |  responses angiotensin
KOL Index score: 15063

1. The effects of omega-conotoxin GVIA (an inhibitor of N-type voltage-operated calcium channels; VOCCs) were compared on adrenergic, cholinergic and non-adrenergic, non-cholinergic (NANC) responses induced by electrical field stimulation (EFS) in the rabbit urethra and detrusor. 2. EFS induced a relaxation in urethral smooth muscle and lamina propria precontracted by arginine vasopressin (AVP). The relaxation was abolished by tetrodotoxin (TTX) or the nitric oxide (NO) synthase ...

Also Ranks for: Rabbit Urethra |  nanc neurotransmission |  omega conotoxin |  adrenergic contraction |  lamina propria
KOL Index score: 15014

In isolated bladder smooth muscle from both rabbit and man, carbachol-induced contractions were reduced by the calcium channel blocker nifedipine, whereas the calcium channel promotor Bay K 8644 had no effect. In nominally calcium-free medium containing 10(-4) M EGTA, carbachol-induced contractions were reduced by 69% (rabbit) and 87% (man). These contractions were abolished by nifedipine, whereas Bay K 8644 significantly increased their amplitude, in rabbit preparations almost to ...

Also Ranks for: Calcium Channel |  muscarinic receptor stimulation |  bladder muscle |  bay 8644 |  induced contractions
KOL Index score: 14988

OBJECTIVES: ClockΔ19/Δ19 mice is an experimental model mouse for nocturia (NOC). Using the bladder mucosa obtained from ClockΔ19/Δ19 mice, we investigated the gene expression rhythms of mechanosensory cation channels such as transient receptor potential cation channel subfamily V member 4 (TRPV4) and Piezo1, and main ATP release pathways including vesicular nucleotide transporter (VNUT) and Connexin26(Cx26), in addition to clock genes.

MATERIALS AND METHODS: Eight- to twelve-week-old ...

Also Ranks for: Clock Genes |  circadian expression |  bladder mucosa |  cx26 vnut |  piezo1 trpv4
KOL Index score: 14974

1. The distribution and colocalization of nitric oxide synthase (NOS)-like immunoreactivity and NADPH diaphorase activity in the pig lower urinary tract were investigated by immunohistochemical and histochemical staining techniques. Functional in vitro studies were performed to correlate the presence of NOS-immunoreactivity/NADPH diaphorase staining with smooth muscle responses involving the L-arginine/nitric oxide (NO) pathway. 2. NOS-immunoreactivity and NADPH diaphorase activity were ...

Also Ranks for: Smooth Muscle |  oxide synthase |  urinary tract |  functional effects |  nerve fibres
KOL Index score: 14972

Ring preparations of human mesenteric arteries and veins were contracted by noradrenaline (1.8 x 10(-5)M) or potassium (127mM). Isometric tension was recorded. In the arterial preparations, the maximum response to noradrenaline was 97 +/- 8% (mean +/- S.E.M.) of that to potassium. In the veins, the corresponding figure was 38 +/- 4%. The calcium antagonists verapamil (2.2 x 10(-7)-2.2 x 10(-5)M) and nifedipine (2.9 x 10(-8)-2.9 x 10(-6)M) relaxed both arteries and veins contracted by ...

Also Ranks for: Mesenteric Arteries |  verapamil nifedipine |  noradrenaline potassium |  calcium antagonists |  contractions induced
KOL Index score: 14872

1. The present study was performed to investigate how blockade of the L-arginine/nitric oxide (NO) pathway influences the function of the lower urinary tract in vivo, as studied by cystometry in conscious rats and in vitro, in isolated muscle preparations from the rat detrusor and urethra. 2. L-NG-nitro arginine methyl ester (L-NAME), 10 and 20 mg kg-1, administered intra-arterially, decreased micturition volume and bladder capacity, and increased spontaneous bladder contractions. D-NAME ...

Also Ranks for: Urinary Tract |  detrusor muscle |  snp lname |  oxide pathway |  electrical stimulation
KOL Index score: 14727

PURPOSE: We investigated the distribution of cannabinoid receptor subtypes 1 and 2 in the detrusor of different species and studied the effects of cannabinoid receptor 1 and 2 agonists on bladder function.

MATERIALS AND METHODS: Cannabinoid receptor 1 and 2 expression was studied with Western blot and immunohistochemistry in rat, monkey and human detrusors. Co-staining was done for markers of sensory nerves using calcitonin gene-related peptide (Euro-Diagnostica, Malmö, Sweden) and ...

Also Ranks for: Cannabinoid Receptor |  human bladder |  threshold pressure |  micturition interval |  effects cp55940
KOL Index score: 14676

The inhibitors of the cGMP-inhibited, low-Km cAMP phosphodiesterase--milrinone and OPC 3911--and an inhibitor of a non-cGMP-inhibited low-Km cAMP phosphodiesterase--rolipram--were used to evaluate the functional importance of the two cAMP phosphodiesterase activities in vascular smooth muscle and in platelets. Vinpocetine, an inhibitor of a calcium-calmodulin-dependent phosphodiesterase was also studied. OPC 3911 and milrinone relaxed the contracted rat aorta, inhibited ADP-induced ...

Also Ranks for: Smooth Muscle |  platelet aggregation |  rat aorta |  phosphodiesterase inhibitors |  camp levels
KOL Index score: 14454

OBJECTIVES: To investigate the distribution of the transient receptor potential (TRP) A1 ion channel in the rat urinary bladder, and to study the effects of hydrogen sulfide (H(2)S) and known TRPA1 activators on micturition in conscious rats and on heterologously expressed ion channels.

METHODS: The expression of TRPA1 in urinary bladder was studied with fluorescence immunohistochemistry and real-time PCR in female Sprague-Dawley rats. Cystometric investigations were performed in ...

Also Ranks for: Urinary Bladder |  hydrogen sulfide |  ion channel |  unmyelinated neurons |  trpa1 nahs
KOL Index score: 14033

The cholinergic and purinergic neurotransmission involved in micturition contraction and premicturition contractile activity (bladder hyperactivity) were investigated by continuous cystometry in unanesthetized rats with outlet obstruction. Adenosine triphosphate (ATP), administered intra-arterially close to the bladder, produced rapid, phasic dose-dependent increases in bladder pressure and micturition immediately after the injections. The percentage volume expelled was 74 +/- 9% after 5 ...

Also Ranks for: Premicturition Contractions |  outlet obstruction |  bladder pressure |  micturition volume |  betamethylene atp
KOL Index score: 13688

Inhibition of prostate smooth muscle contraction is an important strategy for medical treatment of lower urinary tract symptoms (LUTS). Besides α1-adrenoceptors, prostate smooth muscle contraction is induced by activation of thromboxane (TXA2) receptors (TXA2-R). Here, we examined the effects of the TXA2-R antagonist picotamide on contraction of human prostate tissue. Prostate tissues were obtained from radical prostatectomy. The effects of picotamide (300 μM), L-665,240 (3 μM), and ...

Also Ranks for: Smooth Muscle |  human prostate |  receptors thromboxane |  antagonist picotamide |  induced contraction
KOL Index score: 13613

Nitric oxide (NO)/cyclic GMP (cGMP)-mediated mechanisms have a pivotal function in reducing the tone of the penile smooth musculature during normal erectile responses. The cyclic AMP (cAMP) signaling pathway is also involved in the adjustment of smooth muscle contractility, and suggestions for interactions between cGMP- and cAMP-mediated mechanisms have been presented. Using activators of the cGMP- or the cAMP-pathway, as well as inhibitors of protein kinase A (PKA; cAMP-dependent ...

Also Ranks for: Smooth Muscle |  cgmp camp |  protein kinase |  cyclic gmp |  pde3 pde4

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Karl‐Erik Andersson:Expert Impact

Concepts for whichKarl‐Erik Anderssonhas direct influence:Smooth muscle,  Urinary bladder,  Nitric oxide,  Overactive bladder,  Detrusor overactivity,  Bladder function,  Urinary tract,  Erectile dysfunction.

Karl‐Erik Andersson:KOL impact

Concepts related to the work of other authors for whichfor which Karl‐Erik Andersson has influence:Erectile dysfunction,  Overactive bladder,  Nitric oxide,  Smooth muscle,  Urinary incontinence,  Benign prostatic hyperplasia,  Detrusor overactivity.



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Institute of Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA;,, (J.K.W.);,, (K.-E.A.) | Institute for Regenerative Medicine, Wake Forest School of Me