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Luigi Atzori: Influence Statistics

To date, we have little knowledge on the overall metabolic status of neonates with intrauterine growth retardation (IUGR). In the last few years, the analysis of metabolomics has assumed an important clinical role in identifying "disorders" in the metabolic profile of patients. The aim of this work has been to analyze the urine metabolic profiles of neonates with IUGR and compare them with controls to define the metabolic patterns associated with this pathology. To our knowledge, this is ...

OBJECTIVE: Bronchopulmonary dysplasia (BPD) or chronic lung disease is one of the principal causes of mortality and morbidity in preterm infants. Early identification of infants at the greater risk of developing BPD may allow a targeted approach for reducing disease severity and complications. The trigger cause of the disease comprehends the impairment of the alveolar development and the increased angiogenesis. Nevertheless, the molecular pathways characterizing the disease are still ...

PURPOSE: MET, the tyrosine kinase receptor for hepatocyte growth factor, is frequently overexpressed in colon cancers with high metastatic tendency. We aimed to evaluate the role of its negative regulators, miR-1 and miR-199a*, and its transcriptional activator, the metastasis-associated in colon cancer 1 (MACC1), in controlling MET expression in human colon cancer samples.

EXPERIMENTAL DESIGN: The expression of MET, miR-1, miR-199a*, and MACC1 was evaluated by real-time PCR in 52 ...

Internet of Things (IoT) systems cannot successfully realize the notion of ubiquitous connectivity of everything if they are not capable to truly include ‘multimedia things’. However, the current research and development activities in the field do not mandate the features of multimedia objects, thus leaving a gap to benefit from multimedia content based services and applications. In this paper, we analyze this issue by contemplating the concept of IoT and drawing an inspiration towards ...

BACKGROUND: Clinical metabolomics is a recent "omic" technology which is defined as a global holistic overview of the personal metabolic status (fingerprinting). This technique allows to prove metabolic differences in different groups of people with the opportunity to explore interactions such as genotype-phenotype and genotype-environment type, whether normal or pathological.

AIM: To study chronic kidney injury 1) using urine metabolomic profiles of young adults born extremely low-birth ...

BACKGROUND: Colon cancer predisposition is associated with mutations in BRCA1. BRCA1 protein stability depends on binding to BARD1. In different cancers, expression of differentially spliced BARD1 isoforms is correlated with poor prognosis and decreased patient survival. We therefore suspected a role of BARD1 isoforms in colon cancer.

METHODS: We performed immunohistochemistry in 168 colorectal cancers, using four antibodies directed against differentially expressed regions of BARD1. We ...

The highly demanding Over-The-Top (OTT) multimedia applications pose increased challenges to Internet Service Providers (ISPs) for assuring a reasonable Quality of Experience (QoE) to their customers due to lack of flexibility, agility and scalability in traditional networks. The future networks are shifting towards the cloudification of the network resources via Software Defined Networks (SDN) and Network Function Virtualization (NFV). This will equip ISPs with cutting-edge technologies ...

BRCA1 mRNA overexpression is correlated with poor survival in NSCLC. However, BRCA1 functions depend on the interaction with BARD1 for its stability, nuclear localization and ubiquitin ligase activity. Expression of alternatively spliced BARD1 isoforms that lack the BRCA1-interaction domain was found upregulated and correlated with poor prognosis in breast and ovarian cancer. These BARD1 isoforms are essential for proliferation of cancer cells in vitro. We investigated whether BARD1 ...

The Internet of Things (IoT) is expected to be overpopulated by a very large number of objects, with intensive interactions, heterogeneous communications, and millions of services. Consequently, scalability issues will arise from the search of the right object that can provide the desired service. A new paradigm known as Social Internet of Things (SIoT) has been introduced and proposes the integration of social networking concepts into the Internet of Things. The underneath idea is that ...

Sardinia is a major Island in the Mediterranean with a high incidence of multiple sclerosis, a chronic autoimmune inflammatory disease of the central nervous system. Disease susceptibility in Sardinian population has been associated with five alleles of major histocompatibility complex (MHC) class II DRB1 gene. We performed 120 ns of molecular dynamics simulation on one predisposing and one protective alleles, unbound and in complex with the two relevant peptides: Myelin Basic Protein ...

The Internet of Things is expected to be overpopulated by a very large number of objects, with intensive interactions, heterogeneous communications and millions of services. Consequently, scalability issues will arise from the search of the right object that can provide the desired service. A new paradigm known as Social Internet of Things has been introduced and proposes the integration of social networking concepts into the Internet of Things. The underneath idea is that every object ...

The Internet of Vehicles (IoV) represents the emerging paradigm where vehicles are (almost) always connected to the Internet to deliver and receive information to/from other services so as to augment the knowledge and services the users can benefit from when moving in urban and rural areas by their vehicles, but not only. Furthermore, the exploitation of social networking notions into the IoV has brought to the definition of the Social IoV (SIoV) paradigm, i.e., a social network where ...

OBJECTIVE: The aim of the present study was to investigate the metabolic profile of preterm human breast milk (HBM) by using a metabolomic approach.

METHODS: NMR spectroscopy and GC/MS were used to analyze the water-soluble and lipid fractions extracted from milk samples obtained from mothers giving birth at 26-36 weeks of gestation. For the sake of comparison, preterm formula milk was also studied.

RESULTS: The multivariate statistical analysis of the data evidenced biochemical ...