Prominent publications by Jean Michel Coindre

KOL Index score: 15367

BACKGROUND: Activating enhancer of zeste homolog 2 (EZH2) mutations or aberrations of the switch/sucrose non-fermentable (SWI/SNF) complex (eg, mutations or deletions of the subunits INI1 or SMARCA4) can lead to aberrant histone methylation, oncogenic transformation, and a proliferative dependency on EZH2 activity. In this first-in-human study, we aimed to investigate the safety, clinical activity, pharmacokinetics, and pharmacodynamics of tazemetostat, a first-in-class selective ...

Also Ranks for: Solid Tumours |  ezh2 inhibitor |  phase 1 |  zeste homolog |  lymphoma cell
KOL Index score: 14912

Subsets of primitive round-cell sarcomas remain difficult to diagnose and classify. Among these is a rare round-cell sarcoma that harbors a CIC gene rearrangement known as CIC-rearranged undifferentiated round-cell sarcoma, which is most commonly fused to the DUX4 gene. Owing to its aggressive clinical behavior and potential therapeutic implications, accurate identification of this novel soft tissue sarcoma is necessary. Definitive diagnosis requires molecular confirmation, but only a ...

Also Ranks for: Cell Sarcomas |  ewing sarcoma |  undifferentiated round |  cic rearranged |  tumor child diagnosis
KOL Index score: 14278

Epithelioid sarcomas (ES) are mesenchymal neoplasms subclassified into distal and proximal subtypes based on their distinct clinical presentations and histologic features. Consistent loss of SMARCB1 nuclear expression has been considered as the hallmark abnormality for both subtypes, a feature shared with atypical teratoid/rhabdoid tumor of infancy (ATRT). While virtually all ATRTs harbor underlying SMARCB1 somatic or germline alterations, mechanisms of SMARCB1 inactivation in ES are ...

Also Ranks for: Epithelioid Sarcoma |  smarcb1 inactivation |  myoepithelial carcinomas |  situ hybridization |  chromosomal proteins
KOL Index score: 13968

HMGA2, CDK4, and JUN genes have been described as frequently coamplified with MDM2 in atypical lipomatous tumor, well-differentiated liposarcoma, and dedifferentiated liposarcoma. We studied the frequency of amplification of these genes in a series of 48 dedifferentiated liposarcomas and 68 atypical lipomatous tumors/well-differentiated liposarcomas. We correlated their amplification status with clinicopathological features and outcomes. Histologically, both CDK4 (P=0.007) and JUN ...

Also Ranks for: Dedifferentiated Liposarcoma |  distant metastasis |  situ hybridization |  cdk4 amplification |  lipomatous tumor
KOL Index score: 13963

Low-grade osteosarcoma is a rare malignancy that may be subdivided into two main subgroups on the basis of location in relation to the bone cortex, that is, parosteal osteosarcoma and low-grade central osteosarcoma. Their histological appearance is quite similar and characterized by spindle cell stroma with low-to-moderate cellularity and well-differentiated anastomosing bone trabeculae. Low-grade osteosarcomas have a simple genetic profile with supernumerary ring chromosomes comprising ...

Also Ranks for: Grade Osteosarcoma |  osseous lesions |  mdm2 cdk4 |  situ hybridization |  fibrous dysplasia
KOL Index score: 13718

PURPOSE: To assess the prognostic value of SYT-SSX fusion type, in comparison with other factors, in a population of 165 patients with synovial sarcoma (SS).

PATIENTS AND METHODS: Data on 165 patients with SS (141 with localized disease at diagnosis) were studied retrospectively. The following parameters were examined for their potential prognostic value: age at diagnosis, sex, tumor site (extremities v proximal/truncal), size, histology, mitotic count, necrosis, histologic grade ...

Also Ranks for: Histologic Grade |  fusion type |  synovial sarcoma |  dss mfs |  localized disease
KOL Index score: 13585

Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor that is often mistaken for either more benign or more malignant tumor types. Cytogenetic analyses have identified a recurrent balanced translocation t(7;16) (q32–34;p11), later shown by molecular genetic approaches to result in a FUS/CREB3L2 fusion gene. Whereas preliminary studies suggest that this gene rearrangement is specific for LGFMS, its incidence in this tumor type and the ...

Also Ranks for: Fusion Gene |  human pair |  fibromyxoid sarcoma |  transcription factors |  tissue tumor
KOL Index score: 13503

BACKGROUND: The objective of this study was to determine whether specific single nucleotide polymorphisms (SNPs) from nucleotide excision repair (NER) and homologous recombination (HR) DNA repair pathways are associated with sensitivity to trabectedin in patients with soft tissue sarcoma (STS).

METHODS: The authors analyzed excision repair cross-complementation group 5/xeroderma pigmentosum group G (ERCC5/XPG) (NER), excision repair cross-complementation group 1 (ERCC1) (NER), and breast ...

Also Ranks for: Soft Tissue Sarcoma |  clinical benefit |  expression ercc1 |  ercc5 xpg |  dna repair
KOL Index score: 13301

Data concerning the fine structure of the 12q13-15 amplicon which contains MDM2 and CDK4 in well-differentiated and dedifferentiated liposarcomas (WDLPS/DDLPS) are scarce. We investigated a series of 38 WDLPS/DDLPS using fluorescence in situ hybridization analysis with 17 probes encompassing the 12q13-15 region. In addition, using quantitative RT-PCR we studied the expression of MDM2, CDK4, DDIT3 (CHOP/GADD153), DYRK2, HMGA2, TSPAN31 and YEATS4 (GAS41) in 11 cases. We showed that CDK4 ...

Also Ranks for: Mdm2 Cdk4 |  wdlps ddlps |  situ hybridization |  cyclindependent kinase |  cell differentiation chromosomes
KOL Index score: 13132

Low-grade fibromyxoid sarcomas (LGFMS) bear either the t(7,16) (q32-34;p11) or t(11,16) (p11;p11) translocations, resulting in FUS-CREB3L2 or FUS-CREB3L1 fusions, respectively. Heretofore, fusion transcripts were mainly detected in frozen tissues, using reverse transcription-polymerase chain reaction. In this study, we aimed to develop a reliable method to detect these in paraffin-embedded tissues, and to examine the clinicopathologic characteristics of a series of translocation-positive ...

Also Ranks for: Epithelioid Fibrosarcoma |  fibromyxoid sarcoma |  morphologic spectrum |  fusion transcripts |  situ hybridization
KOL Index score: 13013

Synovial sarcoma (SS) is a relatively rare sarcoma, which may be confused with several other mesenchymal and nonmesenchymal lesions. It bears the t(X;18) (SYT;SSX) translocation, which seems to be specific for this tumor type and can be detected in paraffin-embedded tissue, using reverse transcriptase-polymerase chain reaction (RT-PCR). However, the specificity and sensitivity of this detection method have rarely been examined in a large series. Using RT-PCR, we examined 250 mesenchymal ...

Also Ranks for: Molecular Analysis |  synovial sarcoma |  chain reaction |  reverse transcriptase |  embedded tissue
KOL Index score: 12930

Dedifferentiated liposarcoma (DDLPS) has been defined as a tumor composed of well-differentiated liposarcoma associated with a nonlipogenic undifferentiated sarcoma and is genetically characterized by a 12q13-15 amplicon with MDM2 amplification. Some peripheral (extremities, trunk wall, head/neck) undifferentiated pleomorphic sarcomas (UPS) without areas of well-differentiated liposarcoma present an MDM2 amplification. We addressed whether they are true DDLPS or not. We compared the ...

Also Ranks for: Mdm2 Amplification |  differentiated liposarcoma |  situ hybridization |  pleomorphic sarcomas |  fish analysis
KOL Index score: 12708

Atypical lipomatous tumor/well-differentiated liposarcomas and dedifferentiated liposarcomas are characterized by the amplification of MDM2 and CDK4 genes. To evaluate the accuracy of fluorescence in situ hybridization (FISH) analysis in the differential diagnosis of adipose tissue tumors, we investigated MDM2-CDK4 status by FISH, real-time polymerase chain reaction (PCR) [quantitative PCR (Q-PCR)] and immunohistochemistry (IHC) in a series of 200 adipose tumors. First, we evaluated ...

Also Ranks for: Situ Hybridization |  cdk4 amplification |  tissue tumors |  dedifferentiated liposarcomas |  fish pcr
KOL Index score: 12310

Ovarian small cell carcinoma of the hypercalcemic type (SCCOHT)/ovarian rhabdoid tumor is a rare and highly malignant tumor that typically occurs in young women. Up until now the diagnosis has been made on the basis of morphology without any specific immunohistochemical (IHC) markers. However, several authors have shown recently that SCCOHTs are characterized by inactivation of the SMARCA4 gene (encoding the BRG1 protein) resulting in a loss of BRG1 protein expression in IHC. We ...

Also Ranks for: Hypercalcemic Type |  cell carcinoma |  ovarian small |  tumors brg1 |  soft tissue

Key People For Soft Tissue

Top KOLs in the world
Christopher * * *********
soft tissue situ hybridization fibrous histiocytoma
Murray, * *******
gastric cancer soft tissue pancreatic adenocarcinoma
Jean ****** *******
soft tissue french sarcoma situ hybridization
Cyril *******
soft tissue synovial sarcoma situ hybridization
Cristina * *********
situ hybridization soft tissue gastrointestinal stromal
James * ********
synovial sarcoma soft tissue 5 years

Jean Michel Coindre:Expert Impact

Concepts for whichJean Michel Coindrehas direct influence:Soft tissue,  French sarcoma,  Situ hybridization,  Soft tissue sarcomas,  Soft tissue sarcoma,  Desmoid tumors,  Cdk4 amplification,  Synovial sarcoma.

Jean Michel Coindre:KOL impact

Concepts related to the work of other authors for whichfor which Jean Michel Coindre has influence:Soft tissue,  Breast cancer,  Synovial sarcoma,  Situ hybridization,  Tumor cells,  Differential diagnosis,  Radiation therapy.



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Department of Biopathology, Institut Bergonié, Comprehensive Cancer Center, F-33000, Bordeaux, France | University of Bordeaux, Talence, France | Department of Biopathology, Bergonie Institute, Comprehensive Cancer Center, Bordeaux, France | Departme