Prominent publications by Mark Douglas Murphey

KOL Index score: 11438

PURPOSE: To determine the diagnostic accuracy of image-guided percutaneous biopsy in 110 primary bone tumors of varying internal compositions.

MATERIALS AND METHODS: One hundred ten consecutive patients with primary bone tumors underwent biopsy with computed tomography (CT) or fluoroscopy. Ninety-one patients underwent surgical follow-up and 19 received medical treatment and underwent subsequent imaging studies. Final analysis of bone biopsy results included tumor type, malignancy, final ...

Also Ranks for: Percutaneous Biopsy |  bone tumors |  diagnosis malignancy |  computed tomography |  image guided
KOL Index score: 10619

A new case of familial tumoral calcinosis (FTC)/hyperostosis–hyperphosphatemia syndrome (HHS) due to a novel compound heterozygous mutation in N-acetylgalactosaminyltransferase 3 (GALNT3) and with new phenotypic findings is presented. The response in serum phosphate and fibroblast growth factor 23 (FGF23) to medical treatment is detailed. This case expands the genotype and phenotype of FTC/HHS and gives insight into its treatment and pathophysiology.IntroductionFTC and HHS are caused by ...

Also Ranks for: Familial Tumoral Calcinosis |  fgf23 galnt3 |  ftc hhs |  serum phosphate |  medical treatment
KOL Index score: 10200

Benign lipomatous lesions involving soft tissue are common musculoskeletal masses that are classified into nine distinct diagnoses: lipoma, lipomatosis, lipomatosis of nerve, lipoblastoma or lipoblastomatosis, angiolipoma, myolipoma of soft tissue, chondroid lipoma, spindle cell lipoma and pleomorphic lipoma, and hibernoma. Soft-tissue lipoma accounts for almost 50% of all soft-tissue tumors. Radiologic evaluation is diagnostic in up to 71% of cases. These lesions are identical to ...

Also Ranks for: Soft Tissue |  lipomatous lesions |  lipoma arborescens |  myxofibrous tumor |  spindle cell
KOL Index score: 9846

The radiologic features of giant cell tumor (GCT) and giant cell reparative granuloma (GCRG) of bone often strongly suggest the diagnosis and reflect their pathologic appearance. At radiography, GCT often demonstrates a metaepiphyseal location with extension to subchondral bone. GCRG has a similar appearance but most commonly affects the mandible, maxilla, hands, or feet. Computed tomography and magnetic resonance (MR) imaging are helpful in staging lesions, particularly in delineating ...

Also Ranks for: Giant Cell |  bone granuloma |  magnetic resonance |  computed tomography |  tumor gct
KOL Index score: 9314

BACKGROUND: Alkaptonuria, caused by mutations in the HGO gene and a deficiency of homogentisate 1,2-dioxygenase, results in an accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue. There is no effective therapy for this disorder, although nitisinone inhibits the enzyme that produces HGA. We performed a study to delineate the natural history of alkaptonuria.

METHODS: We evaluated 58 patients with alkaptonuria (age range, 4 to 80 years), using clinical, ...

Also Ranks for: Natural Alkaptonuria |  treatment nitisinone |  connective tissue |  effective therapy |  12 dioxygenase
KOL Index score: 9257

BACKGROUND: Enchondroma is the most common benign tumor of the bones of the foot. Chondrosarcoma in this area is relatively rare with malignant transformation from enchondroma occurring rarely. In contrast to similar tumors in the appendicular skeleton, it is difficult to distinguish between these two tumors when they occur in the foot.

METHODS: We reviewed the medical records and radiographs of all patients with enchondroma and chondrosarcoma arising from enchondroma (secondary ...

Also Ranks for: Secondary Chondrosarcoma |  radiographic features |  tumors foot |  patients enchondroma |  malignant transformation
KOL Index score: 8926

Osteochondroma represents the most common bone tumor and is a developmental lesion rather than a true neoplasm. It constitutes 20%-50% of all benign bone tumors and 10%-15% of all bone tumors. Its radiologic features are often pathognomonic and identically reflect its pathologic appearance. Osteochondromas are composed of cortical and medullary bone with an overlying hyaline cartilage cap and must demonstrate continuity with the underlying parent bone cortex and medullary canal. ...

Also Ranks for: Malignant Transformation |  complications osteochondromas |  bone tumors |  subungual exostosis |  skeletal maturity
KOL Index score: 8780

From 1986 to 1990, 42 feet in 30 patients had a combined chevron osteotomy and lateral release to correct their painful bunion deformity. Seventeen patients, 23 feet, were available for follow-up. The purpose of this study was to evaluate the outcome of this procedure and to determine the incidence of avascular necrosis. The patients were examined by an independent examiner, radiographs obtained, and questionnaires filled out. Avascular necrosis was determined using plain films read by a ...

Also Ranks for: Lateral Release |  distal chevron osteotomy |  avascular necrosis |  hallux valgus |  intermetatarsal angle
KOL Index score: 8706

PURPOSE: To validate a technique for reproducible measurement of the osteochondroma cartilage cap with computed tomography (CT) and magnetic resonance (MR) imaging and to reevaluate the correlation of the thickness of the cartilage cap with pathologic findings to improve noninvasive differentiation of benign osteochondromas from secondary chondrosarcomas.

MATERIALS AND METHODS: The institutional review board approved the study and waived the need for informed consent. HIPAA compliance ...

Also Ranks for: Cartilage Cap |  secondary chondrosarcomas |  magnetic resonance imaging |  multiple hereditary |  computed tomography
KOL Index score: 8371

Benign fibrous (fibroblastic or myofibroblastic) soft-tissue tumors are a heterogeneous group of fibrous lesions with widely varied anatomic locations, biologic behavior, and pathologic features. The four broad categories of fibrous proliferation are benign fibrous proliferations, fibromatoses, fibrosarcomas, and fibrous proliferations of infancy and childhood. The first two categories include nonaggressive fibroblastic lesions such as nodular fasciitis, as well as fibromatoses that ...

Also Ranks for: Imaging Features |  tissue tumors |  fibrous soft |  differential humans |  t2weighted images
KOL Index score: 8105

Numerous neurogenic tumors can affect the musculoskeletal system, including traumatic neuroma, Morton neuroma, neural fibrolipoma, nerve sheath ganglion, neurilemoma, neurofibroma, and malignant peripheral nerve sheath tumors (PNSTs). The diagnosis of neurogenic tumors can be suggested from their imaging appearances, including lesion shape and intrinsic imaging characteristics. It is also important to establish lesion location along a typical nerve distribution (eg, plantar digital nerve ...

Also Ranks for: Neurogenic Tumors |  morton neuroma |  neurilemoma neurofibroma |  computed tomography |  nerve sheath
KOL Index score: 8003

A thrombotic etiology has been suggested as the cause of idiopathic avascular necrosis of the hip, although the underlying pathophysiological mechanisms are unknown. Transient osteoporosis of the hip has also been suggested to represent bone marrow edema that may be related to ischemia. We evaluated four patients with idiopathic avascular necrosis and one patient with transient osteoporosis of the hip for thrombotic potential placing a special emphasis on the fibrinolytic system. All ...

Also Ranks for: Transient Osteoporosis |  hip patients |  avascular necrosis |  plasminogen activator |  elevated levels

Key People For Soft Tissue

Top KOLs in the world
Christopher * * *********
soft tissue situ hybridization fibrous histiocytoma
Murray, * *******
gastric cancer soft tissue pancreatic adenocarcinoma
Jean ****** *******
soft tissue french sarcoma situ hybridization
Cyril *******
soft tissue synovial sarcoma situ hybridization
Cristina * *********
situ hybridization soft tissue gastrointestinal stromal
James * ********
synovial sarcoma soft tissue 5 years

Mark Douglas Murphey:Expert Impact

Concepts for whichMark Douglas Murpheyhas direct influence:Soft tissue,  Magnetic resonance,  Axial gout,  Soft tissue tumors,  Pathologic fracture,  Imaging characteristics,  Magnetic resonance imaging,  Primary tumors.

Mark Douglas Murphey:KOL impact

Concepts related to the work of other authors for whichfor which Mark Douglas Murphey has influence:Magnetic resonance,  Soft tissue,  Giant cell tumor,  Differential diagnosis,  Computed tomography,  Imaging features,  Synovial chondromatosis.



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From the Departments of Radiology (J.A.J.), Pathology (D.R.L.), and Orthopaedic Surgery (G.W.S.), University of Michigan Medical Center, Ann Arbor, MI; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (W.D.M