Frank LeeShow email address
University of Sussex, Brighton, BN1 9RH, UK. email@example.com. | Department of Physics and Astronomy, University of Sussex, Brighton, BN1 9RH, United Kingdom | Addiction ...
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Frank Lee:Expert Impact
Concepts for whichFrank Leehas direct influence:Mucinous neoplasms,Bier block,Sodium arsenite,Tumor cells,Functional networks,Reverse logistics,Fluorescent whitening agents,Cytokine traps.
Frank Lee:KOL impact
Concepts related to the work of other authors for whichfor which Frank Lee has influence:Human herpesvirus,Kaposi sarcoma,Endothelial cells,Primary effusion lymphoma,Kshv infection,Lytic replication,Gene expression.
KOL Resume for Frank Lee
University of Sussex, Brighton, BN1 9RH, UK.
Department of Physics and Astronomy, University of Sussex, Brighton, BN1 9RH, United Kingdom
Addiction Medicine Recovery Program, Santa Clara Medical Center, CA.
London Spinal Cord Injury Centre, Royal National Orthopaedic Hospital, Stanmore, UK
Taiwan Semiconductor Manufacturing Company, Nanjing, 211806, China
Taiwan Semiconductor Manufacturing Company
GenapSys, Inc., 200 Cardinal Way, 3, Floor. Redwood City, CA 94063
Morphotek, Inc., Exton, PA, USA.
The Princess Grace Hospital, London, UK
BRIM Biotechnology, Inc , Taipei, Taiwan.
IBM Corp., St. Louis, MO, USA
Department of Urology, St George's Hospital, Blackshaw Road, Tooting, London SW17 0QT, UK
TSMC Design and Technology Platform
Department of Logistics Management, National Kaohsiung First University of Science and Technology, 2, Juoyue Road, Nantz District, Kaohsiung, 811 Taiwan, ROC
Ciba‐Geigy AG, Basle, Switzerland
Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California
Department of Physics and Astronomy, University of California, Los Angeles, California 90095, USA
From the Department of Otolaryngology–Head and Neck Surgery, University of California, Irvine, California, U.S.A.
Contribution from the Department of Chemical Engineering, Texas Materials Institute, Center for Nano- and Molecular Science and Technology, The University of Texas at Austin, Austin, Texas 78712-1062
From the Department of Otolaryngology–Head & Neck Surgery (f.lee), University of California, Irvine Medical Center, Orange, California; and the House Ear Institute, Section on Histopathology (f.linthicum, g.h.), Los Angeles, California, U.S.A.
Department of Preclinical Manufacturing and Process Development, Regeneron Pharmaceuticals, Inc., TarrytownNew York, USA
Sections of Cardiology,
DNAX Research Institute, Department of Molecular Biology, Palo Alto, CA 94304-1104, USA.
Director of Libraries, Latham & Watkins
DNAX Research Institute of Molecular and Cellular Biology Palo Alto, California 94304 USA
Department of Chemistry, University of California, Los Angeles, CA 90024 U.S.A.
Florida State University
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|extra appendiceal mucin||#2|
|archival paraffinembedded blocks||#5|
|acth secretory granules||#8|
|sv40pbr322 recombinant vector||#8|
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Prominent publications by Frank Lee
Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation
[ PUBLICATION ]
The AtT-20 cell line, derived from the mouse anterior pituitary, synthesizes an adrenocorticotropic hormone (ACTH) precursor, proteolytically processes it to mature ACTH, stores it in secretory granules, and releases mature ACTH on stimulation with a secretagogue. A cDNA for human proinsulin inserted downstream from the SV40 early promoter in an SV40-pBR322 recombinant vector was introduced into AtT-20 cells. The stably transformed cell line, AtT-20ins4b/1, stores immunoreactive insulin, ...
|Known for Human Proinsulin | Proteolytic Processing | Intracellular Storage | Anterior Pituitary | Att20 Cells|
Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus ...
|Known for Dna Sequences | Saimiriine Herpesvirus | Amino Acid | Southern Cloning | Kaposi Sequence Homology|
[ PUBLICATION ]
Mucinous neoplasms of the appendix are a heterogeneous group of neoplasms ranging from simple mucoceles to complex pseudomyxoma peritonei. Considerable controversy exists on their pathologic classification and nomenclature. Clear understanding of the histopathologic diversity of these neoplasms helps in establishing proper communication between the radiologist, the pathologist and the surgeon. In this article, we present a brief discussion of the current taxonomy and nomenclature of ...
|Known for Mucinous Neoplasms | Differential Humans | Pseudomyxoma Peritonei | New Classification | Imaging Features|
Cu(2)S nanocrystals with disklike morphologies were synthesized by the solventless thermolysis of a copper alkylthiolate molecular precursor. The nanodisks ranged from circular to hexagonal prisms from 3 to 150 nm in diameter and 3 to 12 nm in thickness depending on the growth conditions. High resolution transmission electron microscopy (HRTEM) revealed the high chalcocite (hexagonal) crystal structure oriented with the c-axis ( direction) orthogonal to the favored growth direction. ...
|Known for Monodisperse Cu2s | Solventless Synthesis | 001 Direction | Growth Conditions | Disk Morphology|
Cytokines can initiate and perpetuate human diseases, and are among the best-validated of therapeutic targets. Cytokines can be blocked by the use of soluble receptors; however, the use of this approach for cytokines such as interleukin (IL)-1, IL-4, IL-6 and IL-13 that use multi-component receptor systems is limited because monomeric soluble receptors generally exhibit low affinity or function as agonists. We describe here a generally applicable method to create very high-affinity ...
|Known for Cytokine Traps | Soluble Receptors | Interleukin Il1 | Extracellular Domains | Constant Region|
[ PUBLICATION ]
BACKGROUND: Menin is the tumor suppressor protein product of the gene identified in MEN1 syndrome. Evidence suggests menin binds DNA and interacts with proteins implicated in DNA damage pathways. The canonical cellular response to UV-induced DNA damage involves activation of the ataxia-telangiectasia-mutated and Rad3-related (ATR) kinase pathway.
MATERIALS AND METHODS: HEK293 cells were irradiated in a UV chamber. Menin's cellular location before and after UV irradiation was investigated ...
|Known for Dna Damage | Men1 Syndrome | Nuclear Matrix | Proteins Cell | Protein Kinases|
Outsourcing reverse logistics of high-tech manufacturing firms by using a systematic decision-making approach: TFT-LCD sector in Taiwan
[ PUBLICATION ]
Reverse logistics are increasingly crucial for the supply chain strategy of global high-tech manufacturing firms. As reverse logistics operations are significantly more complex than traditional manufacturing supply chains, many high-tech manufacturers are examining the feasibility of outsourcing reverse logistics activities to third party logistics providers (3PLs) from a strategic planning perspective. Internal resources and capabilities are thus examined from a resource-based ...
|Known for Reverse Logistics | Making Approach | Internal Resources | Tft Lcd | Based Perspective|
[ PUBLICATION ]
We tested the hypothesis that a reduction in sympathetic tone to exercising forearm muscle would increase blood flow, reduce muscle acidosis, and attenuate reflex responses. Subjects performed a progressive, four-stage rhythmic handgrip protocol before and after forearm bier block with bretylium as forearm blood flow (Doppler) and metabolic (venous effluent metabolite concentration and (31)P-NMR indexes) and autonomic reflex responses (heart rate, blood pressure, and sympathetic nerve ...
|Known for Bier Block | Blood Flow | Heart Rate | Hand Strength | Muscle Skeletal|
Official data from statistical agencies are not always ideal for cross-country comparisons because of differences in data sources and methodology. Analysts who engage in cross-country comparisons need to carefully choose among alternatives and sometimes adapt data especially for their purposes. This paper develops comparable capital stock estimates to examine the relative capital intensity of Canada and the United States. To do so, the paper applies common depreciation rates to Canadian ...
|Known for United States|
Symptom prevalence, bother, and treatment satisfaction in men with lower urinary tract symptoms in Southeast Asia: a multinational, cross-sectional survey
[ PUBLICATION ]
PurposeThe overall objective of the survey was to systematically examine patients’ perspectives on lower urinary tract symptoms (LUTS) and their treatment in Southeast Asia.MethodsA multinational cross-sectional survey involving adult men seeking consultation at urology outpatient clinics because of LUTS in Southeast Asia was conducted using convenience sampling. Self-reported prevalence, bother, treatment and treatment satisfaction of selected LUTS including urgency, nocturia, slow ...
|Known for Urinary Tract | Prevalence Nocturia | Symptoms Luts|
Large-scale machine learning based on functional networks for biomedical big data with high performance computing platforms
[ PUBLICATION ]
Currently, the exponential growth of biomedical data along with the complexities of managing high dimensionality, imbalanced distribution, sparse attributes instigates a difficult challenge of effectively applying functional networks as a new large-scale predictive modeling in healthcare and biomedicine. This article proposes functional networks based on propensity score and Newton Raphson-maximum-likelihood optimizations as a new large-scale machine learning classifier to enhance its ...
|Known for Functional Networks | Machine Learning | Biomedical Data | Performance Computing | Simulation Studies|
OBJECTIVE: To determine our single centre experience of long term renal function and mortality rates of our cohort of spina bifida patients born since 1970.
MATERIALS AND METHODS: We collected a prospective database and included all patients born with spina bifida between 1970 and 2011 managed by our centre. Data we collected included the glomerular filtration rates, results of renal tract imaging, management strategies and mortalities.
RESULTS: Of 160 patients identified, 120 were ...
|Known for Spina Bifida | Renal Failure | Glomerular Filtration | Mortality Rates | Rate Humans|
The properties of the luminescence pulse from collapsing laser-created bubbles in pressurized water are studied for pressures between 0.25 and 15 bars. The duration of the light pulse is found to be linear in the maximum bubble size, but for a given bubble size it increases with the applied pressure p as p0.38. The number of photons emitted increases quadratically with the bubble size, and increases approximately linearly with pressure. The spectrum of the luminescence is blackbody in ...
|Known for Bubble Size | Collapse Point | Light Pulse | Luminescence Laser | Temperature Pressure|
Proliferation Potential in Recurrent Acoustic Schwannoma Following Gamma Knife Radiosurgery versus Microsurgery
[ PUBLICATION ]
OBJECTIVE: To evaluate the proliferation potential of recurrent acoustic schwannoma following gamma knife radiosurgery (GKR) versus microsurgery.
STUDY DESIGN: Retrospective study.
METHODS: A review of surgical records of the House Ear Clinic revealed 8 patients who had undergone GKR and 15 patients who had undergone microsurgery who had unilateral acoustic schwannoma recurrences. Immunohistochemical studies were performed to evaluate the expression of proliferating cell nuclear antigen ...
|Known for Local Neuroma | Gamma Knife | Cell Proliferation | 15 Patients | Retrospective Studies|