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    • Spinal Cord
    • Clifford J Woolf
    • Clifford J Woolf: Influence Statistics

      Clifford J Woolf

      Clifford J Woolf

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      F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA 02115, USA | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA | FM Kirby ...

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      Clifford J Woolf:Expert Impact

      Concepts for whichClifford J Woolfhas direct influence:Spinal cord,Dorsal horn,Neuropathic pain,Central sensitization,Sensory neurons,Nerve injury,Chronic pain,Pain hypersensitivity.

      Clifford J Woolf:KOL impact

      Concepts related to the work of other authors for whichfor which Clifford J Woolf has influence:Neuropathic pain,Spinal cord,Nerve injury,Dorsal horn,Central sensitization,Sensory neurons,Mechanical allodynia.

      KOL Resume for Clifford J Woolf

      Year
      2022

      F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA 02115, USA

      Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, US.

      2021

      Department of Neurobiology, Harvard Medical School, Boston, MA 02115

      Boston Children’s Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA

      Lead contact

      2020

      F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA

      Department of Neurobiology, Harvard Medical School, Boston, USA

      2019

      FM Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

      Department of Neurobiology, Harvard Medical School, Boston, MA, United States

      F.M. Kirby Neurobiology Center, Boston Children’s Hospital, 3 Blackfan Cir. Boston, MA 02115

      Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts

      2018

      F.M. Kirby Neurobiology Center, Boston Children’s Hospital, 02155, Boston, MA, USA

      FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, United States of America

      2017

      Department of Neurobiology, Harvard Medical School, Boston Children's Hospital, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA

      FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States

      2016

      F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA,

      Boston Children's Hospital, Boston, Massachusetts.

      2015

      F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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      Sample of concepts for which Clifford J Woolf is among the top experts in the world.
      Concept World rank
      activitydependent proteins #1
      expressed nociceptors #1
      trigeminal pain signals #1
      sensory immunohistochemistry messenger #1
      slow wave time #1
      pyrogen norepinephrine prostaglandins #1
      2fold cut #1
      naïve axotomy comparison #1
      pain tight ligation #1
      kclcotransporter #1
      central cox2 #1
      snt cci #1
      automated preclinical #1
      vrl2 sequence homology #1
      atf3 nerve regeneration #1
      hsp27 mrna protein #1
      peripheral axonal injury #1
      deepethogram #1
      deepethogram videos #1
      implications major #1
      bnac isoforms #1
      serpina3n drg neurons #1
      lymph nodes klh #1
      0120 microm #1
      morphology somatotopic organization #1
      sensory neuron sns2 #1
      controls brain responses #1
      caudal l5 #1
      moderate intensities response #1
      lidocaine capsaicin #1
      distinct peripheral #1
      trpv1 external solutions #1
      e17 nav19 #1
      ventral root vrp #1
      80 valdecoxib #1
      axons optogenetics #1
      placebo zd6416 #1
      nociceptors sensory neurons #1
      afibres l5 segment #1
      vm cumulative depolarization #1
      sciatic cut crush #1
      conditioning inputs #1
      expression ttxresistant vgscs #1
      elevation beta #1
      birth central terminals #1
      deepethogram behaviors #1
      sepiapterin levels #1
      pkc central sensitization #1
      modeling pain #1
      injured neurons increase #1
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      Prominent publications by Clifford J Woolf

      KOL-Index: 21221

      Molecular mechanisms underlying C-fiber stimulation-induced ERK (extracellular signal-regulated kinase) activation in dorsal horn neurons and its contribution to central sensitization have been investigated. In adult rat spinal slice preparations, activation of C-fiber primary afferents by a brief exposure of capsaicin produces an eightfold to 10-fold increase in ERK phosphorylation (pERK) in superficial dorsal horn neurons. The pERK induction is reduced by blockade of NMDA, ...

      Known for Protein Kinase | Erk Activation | Dorsal Horn Neurons | Response Element | Spraguedawley Receptors
      KOL-Index: 20741

      1. Peripheral inflammation is associated with the local production of neuroactive inflammatory cytokines and growth factors. These may contribute to inflammatory pain and hyperalgesia by directly or indirectly altering the function or chemical phenotype of responsive primary sensory neurones. 2. To investigate this, inflammation was produced by the intraplantar injection of complete Freund's adjuvant (CFA) in adult rats. This resulted in a significant elevation in interleukin-1 beta ...

      Known for Inflammatory Hyperalgesia | Ngf Levels | Nonsteroidal Behavior | Inflamed Tissue | Cfa Inflammation
      KOL-Index: 18656

      The possible involvement of p38 mitogen-activated protein kinase activation in spinal cord and dorsal root ganglion (DRG) cells in the development of peripheral neuropathic pain has been explored. Ligation of the L5 spinal nerve (SNL) on one side in adult rats produces an early onset and long-lasting mechanical allodynia. This lesion results in activation of p38 in the L5 segment of the spinal cord, most prominently in the ipsilateral dorsal horn, starting soon after the lesion (<1 d) ...

      Known for Neuropathic Pain | Spinal Cord | P38 Mitogen | Activated Protein | Dorsal Root Ganglion
      KOL-Index: 16377

      1. Pain hypersensitivity is characterized by an increase in the response to noxious stimuli (hyperalgesia) and a reduction in threshold such that innocuous stimuli begin to elicit pain (allodynia). These sensitivity changes can be produced by an increase in excitability of dorsal horn neurons; the phenomenon of central sensitization. We have now examined whether a reduction in local segmental inhibitory mechanisms produces similar changes. The model system used for studying touch-evoked ...

      Known for Central Sensitization | Glycine Receptors | Spinal Cord | Evoked Allodynia | Sural Nerve
      KOL-Index: 16369

      Activation of ERK (extracellular signal-regulated kinase) MAP (mitogen-activated protein) kinase in dorsal horn neurons of the spinal cord by peripheral noxious stimulation contributes to short-term pain hypersensitivity. We investigated ERK activation by peripheral inflammation and its involvement in regulating gene expression in the spinal cord and in contributing to inflammatory pain hypersensitivity. Injection of complete Freund's adjuvant (CFA) into a hindpaw produced a persistent ...

      Known for Kinase Activation | Spinal Cord | Pain Hypersensitivity | Erk Map | Persistent Inflammatory
      KOL-Index: 16178

      Transganglionic transport of wheatgerm agglutinin conjugated horse-radish peroxidase (WGA-HRP) was used to reveal the central distribution of terminals of primary afferent fibers from peripheral nerves innervating the hind leg of the rat. In separate experiments the sizes and locations of cutaneous peripheral receptive fields were determined by electrophysiological recording techniques for each of the nerves that had been labeled with WGA-HRP. By using digital image analysis, the sizes ...

      Known for Dorsal Horn | Afferent Terminals | Somatotopic Organization | Rat Spinal Cord | Peroneal Nerve
      KOL-Index: 15780

      Here we studied the role of signaling through ErbB-family receptors in interactions between unmyelinated axons and non-myelinating Schwann cells in adult nerves. We generated transgenic mice that postnatally express a dominant-negative ErbB receptor in non-myelinating but not in myelinating Schwann cells. These mutant mice present a progressive peripheral neuropathy characterized by extensive Schwann cell proliferation and death, loss of unmyelinated axons and marked heat and cold pain ...

      Known for Schwann Cell | Erbb Receptor | Unmyelinated Axons | Transgenic Microscopy | Oncogene Proteins
      KOL-Index: 15592

      Excitatory amino acids (EAA) acting on N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate receptors play an important role in synaptic transmission in the spinal cord. Quantitative autoradiography and physiological experiments suggest that NMDA receptors are localized mainly in lamina II while kainate and AMPA receptors are found on both dorsal and ventral horn neurons. However the cell types expressing EAA receptors and their ...

      Known for Spinal Cord | Amino Acid | Ampa Receptors | Neurons Expressing | Cobalt Uptake
      KOL-Index: 14960

      Peripheral neuropathic pain is produced by multiple etiological factors that initiate a number of diverse mechanisms operating at different sites and at different times and expressed both within, and across different disease states. Unraveling the mechanisms involved requires laboratory animal models that replicate as far as possible, the different pathophysiological changes present in patients. It is unlikely that a single animal model will include the full range of neuropathic pain ...

      Known for Animal Model | Peripheral Neuropathic Pain | Nerve Injury | Tight Ligation | Partial Denervation
      KOL-Index: 14939

      To clarify whether inhibitory transmission in the superficial dorsal horn of the spinal cord is reduced after peripheral nerve injury, we have studied synaptic transmission in lamina II neurons of an isolated adult rat spinal cord slice preparation after complete sciatic nerve transection (SNT), chronic constriction injury (CCI), or spared nerve injury (SNI). Fast excitatory transmission remains intact after all three types of nerve injury. In contrast, primary afferent-evoked IPSCs are ...

      Known for Superficial Dorsal Horn | Nerve Injury | Spinal Cord | Selective Loss | Spraguedawley Receptors
      KOL-Index: 14865

      The somatotopic organization of A- and C-afferent fibre terminals in the dorsal horn of the rat lumbar spinal cord was compared with the spatial location of second-order dorsal horn neuronal mechanoreceptive fields. The central terminal fields of the sural, saphenous, and tibial nerve were mapped by labelling the nerves with horseradish peroxidase (HRP). A previous study used the transganglionic transport of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) to produce ...

      Known for Somatotopic Organization | Receptive Fields | Dorsal Horn | Spinal Cord | Afferent Terminals
      KOL-Index: 14609

      BACKGROUND: Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314 into nociceptors when coadministered with capsaicin, a transient receptor potential vanilloid 1 (TRPV1) channel agonist. However, the pain evoked by capsaicin before establishment of the QX-314-mediated block would limit clinical utility. Because TRPV1 channels are also activated by lidocaine, the authors tested whether lidocaine can substitute for capsaicin to ...

      Known for Lidocaine Qx314 | Nociceptive Blockade | Sodium Channel | Nociceptors Capsaicin | Permanently Charged
      KOL-Index: 14309

      1. Peripheral inflammation is characterized by heightened pain sensitivity. This hyperalgesia is the consequence of the release of inflammatory mediators, cytokines and growth factors. A key participant is the induction of the neurotrophin nerve growth factor (NGF) by interleukin-1 beta (IL-1 beta). 2. Tumour necrosis factor alpha (TNF alpha) has been shown both to produce hyperalgesia and to upregulate IL-1 beta. We have now examined whether the induction of TNF alpha in inflammatory ...

      Known for Inflammatory Hyperalgesia | Tnf Alpha | Growth Factor | Tumour Necrosis | Intraplantar Injection
      KOL-Index: 14282

      When adult dorsal root ganglion cells are dissociated and maintained in vitro, both the small dark and the large light neurons show increases in the growth-associated protein GAP-43, a membrane phosphoprotein associated with neuronal development and plasticity. Immunoreactivity for GAP-43 appears in the cytoplasm of the cell bodies as early as 3.5 h post axotomy and is present in neurites and growth cones as soon as they develop. At early stages of culture (4 h to eight days) ...

      Known for Dorsal Horn | Nerve Injury | Ganglion Cells | Gap43 Immunoreactivity | Rat Spinal Cord
      KOL-Index: 14277

      Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means. We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if this contributes to the neuropathic pain-like behavior generated in this model. An L5 SNL induces an immediate (<10 min) but transient (<6 h) induction of phosphoERK (pERK) ...

      Known for Microglia Astrocytes | Mechanical Allodynia | Pain Rats | Perk Neurons | Nerve Ligation

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      F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA 02115, USA | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA | FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, US. | Bos

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