Laura McCracken

Laura McCracken

Department Of Oncology, University Of Cambridge, Hutchison/mrc Research Centre, Hills Road, Cambridge Cb2 0xz, Uk Wellcome Trust-Medical Research Council Cambridge Stem Cell ...

Direct Impact

Concepts for which Laura McCracken has direct influence:

spinal cord
bowel function
stimulation bladder
tcscs sexual
invasive neuromodulation

External impact

Concepts related to the work of other authors for which Laura McCracken has influence:

spinal cord injury
neuroprosthetic baroreflex
epidural electrical stimulation
sympathetic circuits
haemodynamic instability
motor responses
ees protocols

Prominent publications by Laura McCracken

KOL-Index: 90 Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal column of the spinal cord. Here, we hypothesized that an arrangement of electrodes targeting the ensemble of dorsal roots involved in leg ...
Known for
Configuration | Trunk Leg Motor Functions | Activity Stimulation | Superior
KOL-Index: 20 The proneural transcription factor Neurogenin3 (Ngn3) plays a critical role in pancreatic endocrine cell differentiation, although regulation of Ngn3 protein is largely unexplored. Here we demonstrate that Ngn3 protein undergoes cyclin-dependent kinase (Cdk)-mediated phosphorylation on multiple serine-proline sites. Replacing wild-type protein with a phosphomutant form of Ngn3 increases α ...
Known for
-Myc | Α Generation | Phosphorylation Pancreatic | Serine-Proline Sites
KOL-Index: 2 Recent findings have demonstrated that electrical stimulation to the spinal cord (i.e. implanted electrodes) can significantly recover bladder, bowel, and sexual function after injury. While promising, a major drawback is that individuals must undergo a highly invasive and expensive surgical procedure to implant the stimulator on top of the spinal cord. Moreover, the inability to re-position ...
Known for
Participant Bowel | Sci Electrical | Cord Implanted | Procedure Tcscs

Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK

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