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    • Salivary Gland
    • Robert P Coppes
    • Robert P Coppes: Influence Statistics

      Robert P Coppes

      Robert P Coppes

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      Department of Biomedical Sciences of Cells & Systems, Section Molecular Cell Biology and Radiation Oncology, University Medical Center Groningen, University of Groningen, 9700 ...

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      Robert P Coppes:Expert Impact

      Concepts for whichRobert P Coppeshas direct influence:Salivary gland,Parotid gland,Portal vein,Salivary glands,Spinal cord,Stem cell,Stem cells,Gland function.

      Robert P Coppes:KOL impact

      Concepts related to the work of other authors for whichfor which Robert P Coppes has influence:Salivary glands,Stem cells,Radiation therapy,Parotid gland,Neck cancer,Spinal cord,Autophagic flux.

      KOL Resume for Robert P Coppes

      Year
      2022

      Department of Biomedical Sciences of Cells & Systems, Section Molecular Cell Biology and Radiation Oncology, University Medical Center Groningen, University of Groningen, 9700 AD Groningen, The Netherlands;, (L.D.);, (R.P.C.)

      2021

      University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

      2020

      Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

      2019

      Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands

      2018

      Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

      2017

      Departments of Cell Biology and Radiation Oncology, University Medical Centrum Groningen, University of Groningen, The Netherlands

      2016

      Department of Cell Biology University of Groningen, University Medical Centrum Groningen Groningen The Netherlands

      2015

      Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, Netherlands. Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713AV Groningen, Netherlands.

      2014

      Department of Radiation Oncology and Cell Biology, University Medical Center Groningen, Internal Zipcode DA30, 30001, 9700 RB, Groningen, The Netherlands

      2013

      Department of Cell Biology, University Medical Centre Groningen, University of Groningen, The Netherlands

      2012

      Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

      2011

      1, Department of Cell Biology, University Medical Center Groningen, University of Groningen

      2010

      Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, A. Deusinglaan 1, 9713AV Groningen, The Netherlands

      2009

      Department of Cell Biology, Section Radiation & Stress Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands

      2008

      Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands

      2007

      Department of Radiation Oncology, University of Groningen, The Netherlands

      2006

      Department of Radiation and Stress Cell Biology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands

      2005

      Department of Radiation Oncology, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands

      2004

      Department of Radiotherapy, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands

      2003

      Department of Radiation and Stress Cell Biology, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, the Netherlands

      2002

      Department of Radiation and Stress Cell Biology, University of Groningen, 9713 AV Groningen, The Netherlands

      2001

      Department of Radiotherapy, University Hospital, P.O. Box 30.0019700 RB, Groningen, The Netherlands

      2000

      Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands

      1999

      Department of Radiotherapy, University of Utrecht, Utrecht, The Netherlands

      1998

      Department of Radiobiology, University of Groningen, Bloemsingel 1, 9713 BZ Groningen, The Netherlan ds.

      1997

      Department of Radiobiology, University of Groningen, The Netherlands.

      1994

      Department of Clinical Pharmacology, Sahlgren's Hospital, University of Gothenburg, S-413 45, Gothenburg, Sweden

      1993

      Department of Pharmacology and Therapeutics, University of Groningen, Ant. Deusinglaan 2, 9713 AW Groningen, Netherlands

      1992

      Department of Pharmacology and Therapeutics, University of Groningen, Antonius Deusinglaan 2, 9713 AW Groningen, The Netherlands

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      Sample of concepts for which Robert P Coppes is among the top experts in the world.
      Concept World rank
      late effects cranial #1
      msgsc gdnfwt #1
      stem progenitor proliferation #1
      postir sphere #1
      cell gdnfwt #1
      50 caudal #1
      primary salispheres #1
      irradiated gland pilocarpine #1
      equal absorbed doses #1
      salisphere cells potential #1
      tissue function patients #1
      irradiated gland #1
      msgsc response #1
      pain dental caries #1
      organoids radiobiology #1
      gdnfwt wt #1
      pretreatment phenylephrine #1
      pilocarpine irradiation #1
      vivo msgsc transplantation #1
      absorbed entrance dose #1
      damage parotid #1
      radiationinduced hyposalivation #1
      pilocarpine irradiated gland #1
      collimators conformal #1
      caudal partial #1
      study lombaert #1
      gland stem #1
      classical lab models #1
      agonists parotid #1
      computerassisted rats rats #1
      pilocarpine flow rate #1
      mucinexpressing acinarlike cells #1
      pertinent volume #1
      salivary glands isolation #1
      salivary glands knowledge #1
      3000 ckit cells #1
      glands apoptotic appearance #1
      observed gland #1
      longterm regenerative capacity #1
      secondary spheres #1
      early radiation damage #1
      hampered speech #1
      purpose gdnf #1
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      Prominent publications by Robert P Coppes

      KOL-Index: 12625

      PURPOSE: The effects of dose distribution on dose-effect relationships have been evaluated and, from this, iso-effective doses (ED(50)) established.

      METHODS AND MATERIALS: Wistar rats were irradiated on the cervical spinal cord with single doses of unmodulated protons (150 MeV) to obtain sharp lateral penumbras, using the shoot-through technique, which employs the plateau of the depth-dose profile rather than the Bragg peak. Two types of inhomogeneous dose distributions have been ...

      Known for Dose Distribution | Spinal Cord | Rat Cervical | 4 Mm | Small Volume
      KOL-Index: 11139

      Each year, 500,000 patients are treated with radiotherapy for head and neck cancer, resulting in relatively high survival rates. However, in 40% of patients, quality of life is severely compromised because of radiation-induced impairment of salivary gland function and consequent xerostomia (dry mouth). New radiation treatment technologies enable sparing of parts of the salivary glands. We have determined the parts of the major salivary gland, the parotid gland, that need to be spared to ...

      Known for Salivary Gland | Stem Cells | Neck Cancer | Saliva Production | Radiotherapy Head
      KOL-Index: 11065

      BACKGROUND: Recently, we showed that transplantation of 100-300 c-Kit(+) stem cells isolated from cultured salispheres ameliorates radiation-damage in murine salivary glands. The aim of this study is to optimize and translate these findings from mice to man.

      METHODS: Mouse and human non-malignant parotid and submandibular salivary gland tissue was collected and enzymatically digested. The remaining cell suspension was cultured according to our salisphere culture method optimized for ...

      Known for Stem Cell | Human Salivary | Reduce Radiation | Induced Hyposalivation | Ductal Structures
      KOL-Index: 10659

      Head and neck cancer is the fifth most common malignancy and accounts for 3% of all new cancer cases each year. Despite relatively high survival rates, the quality of life of these patients is severely compromised because of radiation-induced impairment of salivary gland function and consequential xerostomia (dry mouth syndrome). In this study, a clinically applicable method for the restoration of radiation-impaired salivary gland function using salivary gland stem cell transplantation ...

      Known for Cell Transplantation | Salivary Gland Function | Irradiated Glands | Gland Stem | Radiation Damage
      KOL-Index: 10369

      Irradiation of salivary glands during radiotherapy treatment of patients with head and neck cancer evokes persistent hyposalivation. This results from depletion of stem cells, which renders the gland incapable of replenishing saliva to produce acinar cells. The aim of this study was to investigate whether it is possible to expand the salivary gland stem/progenitor cell population, thereby preventing acinar cell depletion and subsequent gland dysfunction after irradiation. To induce cell ...

      Known for Salivary Glands | Stem Cells | Growth Factor | Progenitor Cell | Irradiation Treatment
      KOL-Index: 10046

      PURPOSE: To investigate the effect of concomitant administration of pilocarpine during radiotherapy for head-and-neck squamous cell carcinoma (HNSCC) on postradiotherapy xerostomia.

      METHODS AND MATERIALS: A prospective, double blind, placebo-controlled randomized trial including 170 patients with HNSCC was executed to study the protective effect of pilocarpine on radiotherapy-induced parotid gland dysfunction. The primary objective endpoint was parotid flow rate complication probability ...

      Known for Salivary Function | Pilocarpine Patients | Concomitant Administration | Parotid Glands | Lent Soma
      KOL-Index: 9972

      PURPOSE: To study the ability of a prophylactic pilocarpine administration to preserve the rat parotid gland function after unilateral irradiation with graded doses of X-rays.

      METHODS: The right parotid gland of male albino Wistar rats was irradiated with single doses of X-rays (10-30 Gy, at 1.5 Gy min(-1)). Pilocarpine (4 mg/kg) was administered intraperitoneally, 1 hour prior to irradiation. Saliva samples of both left and right parotid gland were collected by means of miniaturized ...

      Known for Parotid Gland | Pilocarpine Treatment | Compensatory Mechanisms | Radiation Dose | Experimental Rats Rats
      KOL-Index: 9968

      Damage to salivary glands after radiotherapeutic treatment of head and neck tumours can severely impair the quality of life of the patients. In the current study we have investigated the early-to-late pathogenesis of the parotid gland after radiation. Also the ability to ameliorate the damage using pretreatment with adrenergic or muscarinic receptor agonists is studied. Rats were locally irradiated with or without i.p. pretreatment with phenylephrine (alpha-adrenoceptor agonist, 5 mg ...

      Known for Parotid Gland | Radiation Damage | Amylase Secretion | Muscarinic Receptor | Acinar Cell
      KOL-Index: 9775

      BACKGROUND: Stem cell therapy could be a potential way for reducing radiation-induced hyposalivation and improving the patient's quality of life. However, the identification and purification of salivary gland stem cells have not been accomplished. This study aims to better characterize the stem/progenitor cell population with regenerative potential residing in the mouse salivary gland.

      METHODS: Mouse submandibular gland tissue, isolated cells and cultured 3 day old salispheres were ...

      Known for Stem Cell | Irradiated Salivary Glands | Mouse Salivary | Regenerative Potential | Intraglandular Transplantation
      KOL-Index: 9481

      The effect of adrenaline on the electrically evoked noradrenaline overflow in the portal vein of adrenal demedullated freely moving rats was studied. Adrenaline (100 ng/min) was infused for 2 h into the portal vein. After a 1-h interval when plasma adrenaline had returned to pre-infusion undetectable levels, the portal vein nervus plexus was electrically stimulated. During stimulation (2 Hz, 3 ms, 5 mA) adrenaline and noradrenaline were released. The stimulus-evoked noradrenaline ...

      Known for Wistar Receptors | Portal Vein | Noradrenaline Adrenaline | Evoked Overflow | Freely Moving
      KOL-Index: 9462

      PURPOSE: The dose-response relationship for a relatively short length (4 mm) of rat spinal cord has been shown to be significantly modified by adjacent low-dose fields. In an additional series of experiments, we have now established the dose-volume dependence of this effect.

      METHODS AND MATERIALS: Wistar rats were irradiated on the cervical spinal cord with single doses of unmodulated protons (150 MeV) to obtain sharp lateral penumbras, by use of the shoot-through technique, which ...

      Known for Spinal Cord | Bath Dose | 2 Mm | Wistar Rats | Bragg Peak
      KOL-Index: 9252

      BACKGROUND AND PURPOSE: It has been proposed that radiation induced stimulation of ATM and downstream components involves activation of TGFbeta-1 and that this may be due to TGFbeta-1-receptor I-Smad signalling. Therefore, the aim of this study was to clarify the distinct role of TGFbeta-1-receptor I-Smad signalling in mediating ATM activity following radiation exposure.

      MATERIALS AND METHODS: A549 cells were stably transfected with a conditionally regulatable TGFbeta-1 antisense ...

      Known for Ionizing Radiation | Transforming Growth Factor | Proteins Cell | Phosphorylation Atm | Smad Signalling
      KOL-Index: 9226

      Hyposalivation underlying xerostomia after radiotherapy is still a major problem in the treatment of head and neck cancer. Stem cell therapy may provide a means to reduce radiation-induced hyposalivation and improve the quality of life of patients. This review discusses the current status in salivary gland stem cell research with respect to their potential to attenuate salivary gland dysfunction. Knowledge on the embryonic development, homeostasis and regeneration after atrophy of the ...

      Known for Stem Cell | Salivary Gland | Proliferation Differentiation | Radiation Induced | Embryonic Development
      KOL-Index: 9014

      Complaints of a dry mouth (xerostomia) and sialoadenitis are frequent side effects of radioiodine treatment in differentiated thyroid cancer (DTC) patients. However, detailed prospective data on alterations in salivary gland functioning after radioiodine treatment (131I) are scarce. Therefore, the primary aim of this study was to prospectively assess the effect of high-activity radioiodine treatment on stimulated whole saliva flow rate. Secondary aims were to study unstimulated whole and ...

      Known for Radioiodine Treatment | Salivary Gland | Dtc Patients | Differentiated Thyroid Carcinoma | Dry Mouth

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      Department of Biomedical Sciences of Cells & Systems, Section Molecular Cell Biology and Radiation Oncology, University Medical Center Groningen, University of Groningen, 9700 AD Groningen, The Netherlands;, l.du@umcg.nl, (L.D.);, r.p.coppes@umcg.nl,

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