Prominent publications by Thiravat HEMACHUDHA

KOL Index score: 9293

Encephalitis and polyneuritis occurring after rabies vaccination are believed to be immunologically mediated. We studied antibody responses to neural antigens in 36 patients with major neurologic complications, 25 with minor complications, and 39 with no complications after immunization with a brain-derived, Semple rabies vaccine. Patients with major complications had significantly elevated levels of antibody to brain white matter as compared with the other groups (P less than 0.001). ...

Known for Myelin Basic Protein |  Rabies Vaccination |  Cerebrospinal Fluid |  Antibody Responses |  Autoimmune Diseases
KOL Index score: 8847

Hepatitis C virus (HCV) is among the most relevant causes of liver cirrhosis and hepatocellular carcinoma. Research is complicated by a lack of accessible small animal models. The systematic investigation of viruses of small mammals could guide efforts to establish such models, while providing insight into viral evolutionary biology. We have assembled the so-far largest collection of small-mammal samples from around the world, qualified to be screened for bloodborne viruses, including ...

Known for Molecular Genome |  Hepatitis Virus Hcv |  Rna Viral |  Virus Detection |  Small Mammals
KOL Index score: 8728

After 12 serial Nipah virus outbreaks in humans since 1998, it has been noted that all except the initial event in Malaysia occurred during the first 5 months of the year. Increasingly higher morbidity and mortality have been observed in subsequent outbreaks in India and Bangladesh. This may have been related to different virus strains and transmission capability from bat to human without the need for an amplifying host and direct human-to-human transmission. A survey of virus strains in ...

Known for Nipah Virus |  Pteropus Lylei |  Disease Transmission |  Bangladesh Strain |  Animals Chiroptera
KOL Index score: 8551

Noninvasive molecular tests of urine cells have been developed to monitor the activity of kidney diseases. We evaluate whether measurement of urinary messenger RNA (mRNA) levels of chemokine and growth factor genes could distinguish between diffuse proliferative lupus nephritis (class IV LN) and others and whether it is able to predict the response to therapy. Prebiopsy urine samples were collected from 26 LN patients. Urine specimens were serially collected over a period of 6 months ...

Known for Growth Factor |  Lupus Nephritis |  Urinary Chemokine |  Messenger Rna |  Cxcr3 Receptors
KOL Index score: 8348

BACKGROUND: Nipah virus (NiV) first emerged in Malaysia in 1998, with two bat species (Pteropus hypomelanus and P. vampyrus) as the putative natural reservoirs. In 2002, NiV IgG antibodies were detected in these species from Thailand, but viral RNA could not be detected for strain characterization. Two strains of NiV (Malaysia and Bangladesh) have been found in P. lylei in central Thailand, although Bangladesh strain, the causative strain for the outbreak in Bangladesh since 2001, was ...

Known for Nipah Virus |  Niv Thailand |  Genetic Variation |  Pteropus Bats |  Rna Detected
KOL Index score: 8279

BACKGROUND: In Thailand, rabies remains a neglected disease with authorities continuing to rely on human death statistics while ignoring the financial burden resulting from an enormous increase in post-exposure prophylaxis. Past attempts to conduct a mass dog vaccination and sterilization program have been limited to Bangkok city and have not been successful. We have used molecular epidemiology to define geographic localization of rabies virus phylogroups and their pattern of spread in ...

Known for Rabies Virus |  Transmission Dynamics |  Dogs Humans |  Disease Control |  Molecular Epidemiology
KOL Index score: 7967

Among the many questions unanswered for the COVID-19 pandemic are the origin of SARS-CoV-2 and the potential role of intermediate animal host(s) in the early animal-to-human transmission. The discovery of RaTG13 bat coronavirus in China suggested a high probability of a bat origin. Here we report molecular and serological evidence of SARS-CoV-2 related coronaviruses (SC2r-CoVs) actively circulating in bats in Southeast Asia. Whole genome sequences were obtained from five independent bats ...

Known for Southeast Asia |  Origin Sarscov2 |  Genome Sequences |  Rhinolophus Acuminatus |  Neutralizing Antibodies
KOL Index score: 7960

BACKGROUND: Bats are reservoirs for a diverse range of coronaviruses (CoVs), including those closely related to human pathogens such as Severe Acute Respiratory Syndrome (SARS) CoV and Middle East Respiratory Syndrome CoV. There are approximately 139 bat species reported to date in Thailand, of which two are endemic species. Due to the zoonotic potential of CoVs, standardized surveillance efforts to characterize viral diversity in wildlife are imperative.

FINDINGS: A total of 626 bats ...

Known for Covs Bats |  Bat Species |  Sars Cov |  Viral Diversity |  Rectal Swabs
KOL Index score: 7685

BACKGROUND: Herpes simplex virus (HSV) is the most common cause of sporadic encephalitis worldwide. The high mortality rate (70-80 %) of herpes simplex encephalitis (HSE) can be reduced to 20-30 % by antiviral therapy. However, normocellular CSF can lure physicians to look for non-infectious causes, resulting in delayed treatment. This study aimed to investigate, characterize and differentiate HSE patients, with normocellular and pleocytosis CSF, according to neuroimaging patterns, ...

Known for Herpes Simplex |  Normocellular Csf |  Patients Encephalitis |  Mortality Rate |  Viral Infections
KOL Index score: 7531

To determine the burden of rabies in developing countries, a reliable and accurate diagnostic test for the examination of the brains of animals is needed. Recently, the number of samples and carcasses submitted to rabies diagnostic units has been declining. Methods for obtaining tissues from different regions of the brain are even more difficult, and direct florescent antibody examination may fail if the samples decomposed. The spread of rabies virus to peripheral non-nervous tissues ...

Known for Rabies Virus |  Viral Rna |  Polymerase Chain |  Developing Countries |  Antemortem Diagnosis
KOL Index score: 7190

In the age of a pandemic, such as the ongoing one caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the world faces a limited supply of tests, personal protective equipment, and factories and supply chains are struggling to meet the growing demands. This study aimed to evaluate the efficacy of specimen pooling for testing of SARS-CoV-2 virus, to determine whether costs and resource savings could be achieved without impacting the sensitivity of the testing. Ten ...

Known for Specimen Pooling |  Low Prevalence |  Testing Sars |  Resource Burden |  Viral Load
KOL Index score: 7164

Background: Nipah virus (NiV) is an emerging zoonosis of paramyxovirus that causes febrile encephalitis with high death rates in humans. It has been successfully isolated and genetically characterized in three species of fruit bats including Pteropus hypomelanus, P. vampyrus in Malaysia, and P. lylei (Lyle’s fruit bat) in Cambodia. Little is still known about NiV genetic information in Lyle’s fruit bats in Thailand. Objective: Partial NiV sequences obtained from 61 isolates from nine bat ...

Known for Nipah Virus |  Fruit Bats |  Pteropus Lylei |  Thailand Malaysia |  Serum Specimens
KOL Index score: 7037

Five methods for the RNA detection of rabies virus were directly compared in this study. These included conventional nucleic acid sequence-based amplification with electrochemiluminescence (NASBA-ECL) assay, reverse transcription (RT)-heminested (hn) polymerase chain reaction (PCR) and TaqMan real-time RT-PCR using protocols as described previously. The first two methods have been routinely utilised for ante-mortem diagnosis of human rabies in Thailand and other rabies-endemic Asian and ...

Known for Time Pcr |  Comparative Detection |  Rabies Virus |  Reverse Transcription |  Polymerase Chain
KOL Index score: 6467

Pre- as well as post-exposure prophylaxis plays an important role in controlling the number of deaths associated with human rabies. Rabies vaccines, classically injected intramuscularly, are now also administered by intradermal (ID) route. Vaccines to be administered by the ID route should meet the same quality, safety and efficacy specifications as vaccines for intramuscular (IM) use. The aim of this paper is to provide information based on publicly available data regarding the ID use ...

Known for Intradermal Route |  Rabies Vaccines |  Exposure Prophylaxis |  Antibodies Viral |  Immunogenicity Effectiveness


Thiravat HEMACHUDHA: Influence Statistics

Sample of concepts for which Thiravat HEMACHUDHA is among the top experts in the world.
Concept World rank
cannabinoid impaired homeostasis #1
process automated extraction #1
hypomelanus southern thailand #1
heminested pcr products #1
specificity specimen types #1
cerebrospinal fluid presentation #1
viral histoplasma humans #1
4 guillainbarré syndromegbs #1
nucleocapsid glycoprotein genes #1
patients furious rabies #1
thai dogs serum #1
rantes levels groups #1
case malaysian strain #1
travel histories lineages #1
delayed diagnosis nucleocapsid #1
thai bats #1
detection rabies diagnosis #1
confirmation familywide pcr #1
biting risk assessment #1
intracellular 16 #1
rabies virus phylogroups #1
small north community #1
39 116 #1
serum 180 360 #1
immunoglobulin optimal strategy #1
details obstacles #1
paralytic spinal #1
preexposure rabies vaccine #1
11 rabies patients #1
stage rabies #1
180 360 vaccination #1
301bp #1
intensive canine vaccination #1
rabies provocation #1
semple rabies vaccination #1
furious rabies patient #1
encephalitic furious #1
amplification targets design #1
quarter early january #1
nuclisens easyq analyser #1
responsible weakness #1
furious form #1
encephalitic #1
brainstem human rabies #1

Key People For Rabies Virus

Top KOLs in the world
Hilary Koprowski
rabies virus monoclonal antibodies multiple sclerosis
Charles , E Rupprecht
united states rabies virus procyon lotor
Bernhard Dietzschold
rabies virus monoclonal antibodies borna disease
Tadeusz J Wiktor
rabies virus monoclonal antibodies antigenic variants
Noël Tordo
rabies virus middle east hemorrhagic fever
William H Wunner
rabies virus monoclonal antibodies core glycosylation

Thiravat HEMACHUDHA:Expert Impact

Concepts for whichThiravat HEMACHUDHAhas direct influence:Rabies virus,  Human rabies,  Paralytic rabies,  Spinal cord,  Nipah virus,  Myelin basic protein,  Pteropus lylei,  Genetic diversity.

Thiravat HEMACHUDHA:KOL impact

Concepts related to the work of other authors for whichfor which Thiravat HEMACHUDHA has influence:Rabies virus,  Lupus nephritis,  Central nervous,  Neutralizing antibodies,  Infectious diseases,  Sri lanka,  Multiple sclerosis.



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King Chulalongkorn Memorial Hospital Faculty of Medicine, Thai Red Cross Emerging Infectious Diseases - Health Science Centre, World Health Organization Collaborating Centre for Research and Training on Viral Zoonoses, Chulalongkorn University, 10330

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