• Spinal Cord
    • Tony L Yaksh
    • Tony L Yaksh: Influence Statistics

      Tony L Yaksh

      Tony L Yaksh

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      Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States | Anesthesiology, University of California San Diego, La Jolla, CA, USA | ...

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      Tony L Yaksh:Expert Impact

      Concepts for whichTony L Yakshhas direct influence:Spinal cord,Intrathecal morphine,Spraguedawley receptors,Formalin test,Thermal hyperalgesia.

      Tony L Yaksh:KOL impact

      Concepts related to the work of other authors for whichfor which Tony L Yaksh has influence:Neuropathic pain,Spinal cord,Dorsal horn,Nerve injury,Mechanical allodynia,Rat model,Opioid receptors.

      KOL Resume for Tony L Yaksh


      Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States


      Department of Anesthesiology and Pharmacology, University of California San Diego, San Diego, CA 92093, USA;, (S.M.);, (T.Y.)

      Pharmacology, University of California San Diego, La Jolla, CA, United States.


      Department of Anesthesiology, UCSD, San Diego, CA, USA


      Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.


      Departments of Anesthesiology, University of California, San Diego, CA, USA

      Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States.


      Department of Anesthesiology, University of California, San Diego, La Jolla, California


      Department of Anesthesiology, University of California, San Diego, La Jolla, California.

      University of California San Diego, La Jolla CA USA


      Columbus, Ohio

      Anesthesiology Research, Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

      President and Medical Director, Animal Emergency Care Centers, Peak Performance Veterinary Group, HemoSolutions, Breckenridge and Colorado Springs, Colorado


      University of California, San Diego Anesthesiology Research Department of Anesthesiology La Jolla CA USA


      Tony Yaksh is in the Department of Anesthesiology, School of Medicine, University of California, San Diego.

      Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, San Diego, La Jolla, CA 92093-0818, USA

      Professor of Anesthesiology and Pharmacology.


      University of California Anesthesiology Research Department of Anesthesiology San Diego CA USA

      Department of Anesthesiology and


      Institute of Neurobiology, Slovak Academy of Sciences, Soltesovej 4, 04001 Kosice, Slovakia

      Anesthesiology Research Laboratory, University of California, San Diego 9500 Gilman Drive, La Jolla, California 92093-0695

      Pharmacology, University of California, San Diego, La Jolla, California 92093

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      Sample of concepts for which Tony L Yaksh is among the top experts in the world.
      Concept World rank
      small afferent #1
      agonist st91 #1
      allopregnanolone 30 μg #1
      morphine sites #1
      point manipulation #1
      intrathecal levobupivaciane #1
      drug imidazoles injections #1
      potassium capsaicin #1
      interaction intrathecal morphine #1
      antibody‐induced inflammation #1
      pag leucine enkephalin #1
      pain behavior hemodynamics #1
      unanaesthetized rat #1
      tiz sra #1
      epidural fadolmidine #1
      animal formaldehyde injections #1
      delayed allodynia #1
      peripheral inflammatory disease #1
      implanted enkephalin #1
      cap vn #1
      narcotic analgetics #1
      ketorolac cisplatin animals #1
      spinal release tnf #1
      ct2000 rats #1
      hxs alox12 #1
      carbachol spinal cord #1
      hyperesthetic paw #1
      opioids injury #1
      snx239 #1
      paramedial medulla #1
      tail flick response #1
      drg cisplatintreated mice #1
      prepared chronic #1
      pain state magnitude #1
      analgesia eeg activity #1
      intradural granulomas #1
      tlr4 allodynia tirap #1
      encapsulated morphine dogs #1
      153186 #1
      magnitude pain state #1
      release vipli #1
      touchevoked agitation #1
      naltrindole rat #1
      bontb spinal nerve #1
      endorphins review #1
      cats cholecystokinin #1
      fentanyl alfentanil sufentanil #1
      rigidity animals #1
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      Prominent publications by Tony L Yaksh

      KOL-Index: 16201

      In rats stereotaxically implanted with microinjection cannula in either the periaqueductal gray matter (PAG) or the medial/paramedial medullary reticular formation (MRF), microinjection of morphine, sufentanil, D-Ala2-D-Leu5-enkephalin (DADL) or D-Ser2-Thr6-leucine enkephalin (DSTLE) produced dose-dependent elevations in the response latency on tail-flick and hot plate tests. These effects were reversed by naloxone administered by microinjection into the same intracerebral site. Both mu ...

      Known for Delta Opioid | Antinociceptive Action | Leucine Enkephalin | Pag Mrf | Microinjection Morphine
      KOL-Index: 15316

      Activation of p38 mitogen-activated protein kinase (p38) in spinal microglia is implicated in spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective inhibition of microglial activation, a function that is distinct from its antibiotic activity. In the present study we examined antinociceptive effects of intrathecal (IT) administration of minocycline in experimental models of inflammation-evoked hyperalgesia in addition to the effect of minocycline on ...

      Known for Spinal Microglia | Intrathecal Minocycline | P38 Mapk | Western Cells | Induced Hyperalgesia
      KOL-Index: 15137

      Tumor necrosis factor-alpha (TNF) is upregulated after nerve injury, causes pain on injection, and its blockade reduces pain behavior resulting from nerve injury; thus it is strongly implicated in neuropathic pain. We investigated responses of intact and nerve-injured dorsal root ganglia (DRG) neurons to locally applied TNF using parallel in vivo and in vitro paradigms. In vivo, TNF (0.1-10 pg/ml) or vehicle was injected into L5 DRG in naive rats and in rats that had received L5 and L6 ...

      Known for Spinal Nerve Ligation | Tumor Necrosis | Naive Rats | Adjacent Uninjured | Increased Sensitivity
      KOL-Index: 14981

      High pressure liquid chromatography with electrochemical detection was used to quantify the efflux, in the same sample, of endogenous 5-hydroxytryptamine (5-HT), noradrenaline (NA), and 5-hydroxyindoleacetic acid (5-HIAA) into superfusates of the rat spinal cord in vivo. The efflux of these three agents was measured prior to, and during, electrical stimulation of the nucleus raphe magnus (n.r.m.) and nucleus reticularis paragigantocellularis (n.r.p.g.), two medullary nuclei implicated in ...

      Known for Spinal Cord | 5 Ht | Stimulation Nrm | Basal Efflux | Raphe Nuclei
      KOL-Index: 14904

      Western blots show the constitutive expression of COX-1 and COX-2 in the rat spinal dorsal and ventral horns and in the dorsal root ganglia. Using selective inhibitors of cyclooxygenase (COX) isozymes, we show that in rats with chronic indwelling intrathecal catheters the acute thermal hyperalgesia evoked by the spinal delivery of substance P (SP; 20 nmol) or NMDA (2 nmol) and the thermal hyperalgesia induced by the injection of carrageenan into the paw are suppressed by intrathecal and ...

      Known for Spinal Prostaglandin | Cox1 Cox2 | Cyclooxygenase Inhibitors | Intraperitoneal Injections | Thermal Hyperalgesia
      KOL-Index: 14750

      Transient spinal cord ischemia may lead to a progressive degeneration of spinal interneurons and subsequently to increased hind limb motor tone. In the present work we sought to characterize the rigidity and spasticity components of this altered motor function by: i) tonic electromyographic activity measured in gastrocnemius muscle before and after ischemia, ii) measurement of muscle resistance during the period of ankle flexion and corresponding changes in electromyographic activity, ...

      Known for Spinal Cord | Spasticity Rigidity | Muscle Resistance | Motor Evoked | Gaba Uptake Inhibitor
      KOL-Index: 14657

      Both mu opioid agonists and N-methyl-D-aspartate (NMDA) receptor antagonists are implicated in the regulation of neuropathic pain in post-nerve injury preclinical pain models. This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on human neuropathic pain states, characterized by allodynia and hyperalgesia. Using diphenhydramine as the placebo, alfentanil and ketamine infusions were given in a ...

      Known for Intravenous Alfentanil | Allodynia Hyperalgesia | Pain Scores | Nmda Receptor | Ketamine Infusion
      KOL-Index: 14559

      We studied the effect of thoracic aortic occlusion and cerebrospinal fluid (CSF) drainage on regional spinal cord blood flow and its correlation with neurologic outcome. Using isotope-tagged microspheres, we determined blood flow to the gray and white matter of five regions of the spinal cord in dogs: group I (control), group II (cross-clamp only), group III (cross-clamp plus CSF drainage). At 60 minutes after thoracic aortic occlusion in group II, median gray matter blood flow (GMBF) in ...

      Known for Neurologic Outcome | Thoracic Aortic Occlusion | Blood Flow | Cerebrospinal Fluid | Spinal Cord
      KOL-Index: 13934

      Injection of formalin into the hind paw evokes a biphasic flinching of the injured paw. Pharmacological characterization of this behavior has implicated the spinal release of excitatory amino acids (EAAs) and cyclooxygenase (COX) products. To address this hypothesis, we examined the effect of paw formalin injection on release of EAAs and prostaglandin E2-like immunoreactivity (PGE2-LI) from the spinal cord in unanesthetized rats using a dialysis probe placed in the lumbar subarachnoid ...

      Known for Spinal Release | Paw Formalin Injection | Microdialysis Study | Unanesthetized Rats | Amino Acids
      KOL-Index: 13902

      Intrathecally administered mu-opioid (morphine; DAMGO ([D-Ala2,N-MePhe4,Gly5-ol]enkephalin)) and delta-opioid (DPDPE ([D-Pen2,D-Pen5] enkephalin); DADLE ([D-Ala2,D-Leu5]enkephalin)) receptor preferring agonists were systematically challenged with the competitive opiate antagonists naloxone or naltrindole in the rat. Naloxone produced a dose-dependent reduction in agonist effect with the intrathecal IC50 being similar for all agonists (2.1-5.4 micrograms). In contrast, the naltrindole ...

      Known for Spinal Opioid | Spraguedawley Receptors | Receptor Agonists | Drug Enkephalin | Dependent Antagonism
      KOL-Index: 13618

      1. In the present study, the object was to examine the effects of morphine on spinal release in vivo of excitatory amino acids (EAA), prostaglandin E2 (PGE2), and a marker for nitric oxide (NO) synthesis, citrulline (Cit), evoked by a protracted noxious stimulus produced by the injection of formalin into the paw. Spinal release was monitored in conscious rats using a microdialysis probe implanted into the subarachnoid space with the active site placed at the level of the lumbar ...

      Known for Spinal Release | Amino Acids | Glu Asp | Conscious Rats | Formalin Evoked
      KOL-Index: 13474

      BACKGROUND: Noxious cutaneous stimuli enhance spinal excitability. The behavioral correlate to this response is found in the rat formalin test, in which formalin injection into the hindpaw evokes signs of nociception (flinching and licking of the injected paw) with acute (phase 1) and delayed-hyperalgesic (phase 2) components.

      METHODS: The effect of intrathecal morphine (a mu agonist), U50488H (a kappa agonist), ST-91 (an alpha 2 agonist), L-PIA (an adenosine A1 agonist), and ketorolac ...

      Known for Formalin Test | Isobolographic Analysis | Spinal Action | Ketorolac Morphine | Phase 2

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      Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States | Anesthesiology, University of California San Diego, La Jolla, CA, USA | Departments of Anesthesiology and Pharmacology, University of California, San Die

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