George Lee Irvin

George Lee Irvin

Department Of Surgery, University Of Miami School Of Medicine, Miami, Fl. Usa Veterans Affairs Medical Center, Research Service, Miami, Fl. Usa

Direct Impact

Concepts for which George Lee Irvin has direct influence:

sporadic primary hyperparathyroidism
successful parathyroidectomy
parathyroid cancer
flow cytometry
normal range
nuclear protein
hypercalcemic crisis

External impact

Concepts related to the work of other authors for which George Lee Irvin has influence:

primary hyperparathyroidism
parathyroid hormone
serum calcium
flow cytometric
lateral approach
endocrine neoplasia
dna content

Prominent publications by George Lee Irvin

KOL-Index: 22 We developed a rapid technique for preservation of Hoechst 33342/propidium iodide-stained cells, using ethanol as a fixative. Combined staining with these dyes makes possible analysis of cell-cycle phase-specific cell death. The technique relies on exclusion of propidium iodide from the viable cells, whereas Hoechst stains all of the cells. The bivariate histograms resulting from the flow ...
Known for
Cytostatic Cytotoxic Agents | Technique Preservation | Cell-Cycle Phase-Specific Effects | 25 Ethanol
KOL-Index: 21 Phytohemagglutinin-stimulated human peripheral blood lymphocytes incorporating high concentrations of 3H-thymidine accumulate in G2 and show a consequent reduction in the number of cells entering M (division delay). The simultaneous flow cytometric analysis of DNA content (propidium iodide fluorescence) and nuclear protein content (fluorescein isothiocyanate fluorescence) allows for the ...
Known for
Simultaneous Flow Cytometric | G2a G2b | Propidium Iodide Fluorescence | Dna Nuclear
KOL-Index: 20 BACKGROUND: The quick parathyroid hormone assay (QPTH) reliably measures intact parathyroid hormone (iPTH) levels intraoperatively. The accuracy in predicting postoperative calcemia is related to blood sample timing and the criteria applied. To improve specificity or to decrease the cost of QPTH, several criteria have been used to predict complete excision. This study compares the Miami ...
Known for
Published Qpth Criteria | Quick Parathyroid Hormone | 3 Rate | Predict Excision
KOL-Index: 17 The technique of flow cytometric DNA histogram analysis (FCM) shows there to be two distinct cell populations (diploid vs aneuploid) in the poorly differentiated R3327-G rat prostatic adenocarcinoma. The following study compares tumor weight measurements with several FCM computer-based methods designed to determine rapidly the proliferative status of tumors. Hypophysectomy, bilateral ...
Known for
Orchiectomy Diethylstilbestrol | Prostatic Carcinoma Response | Flow Cytometric Dna Histogram | Fcm Computer-Based Methods
KOL-Index: 15 BACKGROUND: Controversy continues between bilateral neck exploration and limited parathyroidectomy. One approach depends on gland size and histopathologic factors; the other approach limits excision to only hypersecreting glands. Both have excellent early operative success, but late recurrence rates with limited exploration are unknown. METHODS: Three hundred twenty consecutive patients with ...
Known for
Excellent Early Operative | Recurrent Hyperfunctioning Glands | Late Recurrence Rates | Approach Limits Excision
KOL-Index: 14 The synthetic gonadotropin releasing hormone agonist [D-leu6, desgly-NH2(10), proethylamide9]-GnRH (leuprolide) was tested for its ability to inhibit androgen-sensitive R3327-G rat prostatic tumor growth in Copenhagen X Fischer F1 male rats. The chronic administration of leuprolide at 50 micrograms per kg. body weight or 1000 micrograms per kg. body weight significantly reduced serum ...
Known for
Orchiectomy | Chronic Leuprolide | Kinetic Responses | Testis Weights


KOL-Index: 14 The possibility of bilateral, extra-adrenal, and malignant tumors has dictated a thorough abdominal exploration through an anterior incision in the management of patients with pheochromocytomas. Careful visualization or palpation of the sites known to harbor secondary tumors is still recommended by many surgeons. The present study contrasts the results and morbidity of the retroperitoneal ...
Known for
Pheochromocytoma Morbidity | 20 Underwent Resection | Intraperitoneal Operative Approach | Minor Postoperative Complications
KOL-Index: 14 A cooperative Veterans Administration study of the septic complication rate during large-bowel surgery was undertaken in two groups of patients. The first group received oral neomycin and erythromycin base plus parenteral placebo; the second, the oral antibiotics plus parenteral cephalothin sodium. During a five-year period, 1,128 patients were studied. The overall septic complication rate ...
Known for
Receiving Oral | Five-Year Period | Elective Colon Surgery | Unknown Origin
KOL-Index: 13 BACKGROUND: With a secure diagnosis of hyperparathyroidism, preoperative localization of abnormal glands is the initial step toward limited parathyroidectomy. Nuclear scanning and ultrasonography done by third parties are costly. We investigated whether ultrasonography performed by the operating surgeon (SUS) could be the initial and only preoperative localization study in patients with ...
Known for
Localization Sporadic | Preoperative Sestamibi | Hormone Surgeon | Ultrasonography Initial
KOL-Index: 13 INTRODUCTION: In the new era of resident work hour restrictions and an emphasis on minimally invasive surgery, experience in performing open biliary surgery is diminishing. We sought to review our resident operative experience to determine if it appears adequate for a well-trained general surgeon. METHODS: The case logs of the General Surgery, Oncology, and Trauma/Emergency General Surgery ...
Known for
Conversions | Pancreatico-Duodenectomy | Open Biliary Surgery | Bile Duct Explorations

Department of Surgery, University of Miami School of Medicine, Miami, FL. USA Veterans Affairs Medical Center, Research Service, Miami, FL. USA

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