• KOL
    • Static Encephalopathy
    • Mri, Mr Spectroscopy, And...
    • MRI, MR spectroscopy, and diffusion tensor imaging findings in patient with static encephalopathy of childhood with neurodegeneration in adulthood (SENDA): Influence Statistics

      Expert Impact

      Concepts for whichthey havehas direct influence:Static encephalopathy,Diffusion tensor imaging,Diffusion tensor,Tensor imaging,Childhood neurodegeneration,Imaging findings,Neurodegeneration adulthood,Adulthood senda.

      Key People For Static Encephalopathy

      Top KOLs in the world
      #1
      Nathalie Boddaert
      magnetic resonance social perception brain mri
      #2
      Khailash P Bhatia
      movement disorders cervical dystonia parkinson disease
      #3
      Michael C Kruer
      cerebral palsy intellectual disability brain iron accumulation
      #4
      John Anthony Hardy
      alzheimer disease frontotemporal dementia lewy bodies
      #5
      Susan J Hayflick
      brain iron accumulation pantothenate kinase alcohol acceptor
      #6
      Penelope Hogarth
      brain iron accumulation parkinson disease medical therapy

      MRI, MR spectroscopy, and diffusion tensor imaging findings in patient with static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)

      Abstract

      Static encephalopathy of childhood with neurodegeneration in adulthood (SENDA) is a recently established disorder that is a subtype of neurodegeneration with brain iron accumulation (NBIA). We presented the first case report of SENDA of a 39-year-old female. She had psychomotor retardation from childhood and remained static for two decades. Then, at the age of 30, she developed severe dystonia and parkinsonism. Brain MRI revealed T2-weighted hypointensity signal in the globus pallidus and substantia nigra, and T1-weighted hyperintensity signal in the substantia nigra with a central hypointensity area. These clinical and imaging findings are characteristic of SENDA. Advanced MRI, including (1)H-MR spectroscopy (MRS) and diffusion tensor imaging (DTI), demonstrated similar findings of pantothenate kinase-associated neurodegeneration (PKAN), which is a major syndrome of SENDA. MRI plays a crucial role in the diagnosis of NBIA, especially SENDA.

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