• Stem Cells
    • Fred H Gage
    • Fred H Gage: Influence Statistics

      Fred H Gage

      Fred H Gage

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      Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA | Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA | ...

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      Fred H Gage:Expert Impact

      Concepts for whichFred H Gagehas direct influence:Stem cells,Dentate gyrus,Adult neurogenesis,Nerve growth factor,Stem cell,Central nervous,Spinal cord,Gene transfer.

      Fred H Gage:KOL impact

      Concepts related to the work of other authors for whichfor which Fred H Gage has influence:Stem cells,Spinal cord,Dentate gyrus,Gene expression,Cell proliferation,Central nervous,Growth factor.

      KOL Resume for Fred H Gage


      Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA

      The Salk Institute for Biological Studies


      Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 USA


      Laboratory of Genetics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

      Salk Institute for Biological Studies, La Jolla, CA, United States


      Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, 92037, La Jolla, CA, USA

      Section Molecular Neurobiology, Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, the Netherlands.


      The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

      Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, and


      Salk Institute for Biological Studies, Laboratory of Genetics, 92037, La Jolla, California, USA


      Laboratory of Genetics, The Salk Institute, La Jolla, CA, USA

      Christopher and Dana Reeve Foundation International Consortium on Spinal Cord Injury Research, Short Hills, New Jersey 07078,


      Salk Institute for Biological Studies, Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037;

      Christopher and Dana Reeve Foundation International Consortium on Spinal Cord Injury Research

      Kavli Institute for Brain and Mind (KIBM), University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

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      Sample of concepts for which Fred H Gage is among the top experts in the world.
      Concept World rank
      septal hyperractivity #1
      lateral fornix damage #1
      ecl2 neurons fgfr1 #1
      aged rats degenerative #1
      denervated hf l1 #1
      cbincs #1
      raphe neurone implants #1
      creb aminobutyric acid #1
      exp atropine #1
      hippocampal function acquisition #1
      rodent1–4 #1
      c3h hej survival #1
      psa cholinergic axons #1
      intrastriatal nigral grafts #1
      hippocampus immunoreactive axons #1
      cht activity mice #1
      denervation cholinergic neurons #1
      plasma membrane axons #1
      npc rhythms lir #1
      proliferation cns #1
      mesencephalic glial cell #1
      collateral sprouting cd2ap #1
      transformed fetus genes #1
      modalityspecific behaviors #1
      adult eye ahpcs #1
      spg11npcs #1
      cells intracerebral implantation #1
      8 weeks grafts #1
      neurogenesis confocal microscopy #1
      ngf cholinergic #1
      hyponeophagia role #1
      eckenstcin #1
      f344 skin #1
      hipscs neurons #1
      pellucidum #1
      voluntary running neurogenesis #1
      neural genomes #1
      fgf2 adult nspcs #1
      fgf2 sodium #1
      psa l1 expression #1
      dg—without #1
      –derived neural precursors #1
      intact pirna pathway #1
      dentate circuitry consequences #1
      lewy bodies contributes #1
      phosphotauthr #1
      asdassociated #1
      neostriatum studies #1
      cns genetically #1
      innominata region striatum #1
      Sign-in to see all concepts, it's free!

      Prominent publications by Fred H Gage

      KOL-Index: 18749

      Acidic fibroblast growth factor (aFGF) enhances nerve growth factor (NGF) synthesis by astrocytes obtained from various brain regions. NGF secretion by fibrous-shaped astrocytes transformed by dibutyryl-cAMP (db-cAMP) pretreatment was less than that by untreated astrocytes. However, aFGF also enhanced NGF secretion by fibrous-shaped astrocytes. The effects of various kinds of intracellular signaling modulators on NGF synthesis were examined. None of the following second messenger ...

      Known for Ngf Synthesis | Growth Factor | Astrocytes Cytokines | Beta 1 | Cell Surface Receptors
      KOL-Index: 17205

      The ability of intrahippocampal grafts of fetal septal-diagonal band tissue, rich in developing cholinergic neurons, to ameliorate cognitive impairments induced by bilateral fimbria-fornix transections in rats was examined in three experiments using the Morris water-maze to test different aspects of spatial memory. Experiment 1. Rats with fimbria-fornix lesions received either septal cell suspension grafts or solid septal grafts; normal rats and rats with lesions alone were used as ...

      Known for Spatial Learning | Normal Rats | Fimbriafornix Lesions | Fetal Septal | Platform Site
      KOL-Index: 15896

      Complete unilateral fimbria-fornix transections, including the overlying cingulate cortex, were administered to female rats. At time points from 1 day to 6 weeks, the septal-diagonal band region was examined using acetylcholinesterase histochemistry, Cresyl Violet cell staining, and choline acetyltransferase biochemistry. As early as 1 day following the transection a decrease in acetylcholinesterase positive cell body staining was observed in the medial septum; however, no loss of ...

      Known for Medial Septum | Diagonal Band | 1 Day | Fornix Transection | Vertical Limb
      KOL-Index: 15195

      The objective of the present study was to evaluate the expression of polysialic acid (PSA) and the cell adhesion molecule L1 during axonal regeneration and sprouting after injury to the adult rat brain. All animals received a complete lesion of the fimbria-fornix (FF). Grafts of nerve growth factor (NGF)- or beta-galactosidase (betaGal)-producing fibroblasts were placed in the FF lesion cavity and induced septohippocampal cholinergic regeneration or sympathetic tyrosine hydroxylase ...

      Known for Expression L1 | Lesion Cavity | Reactive Gliosis | Confocal Microscopy | Axonal Regeneration
      KOL-Index: 14821

      BACKGROUND: Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization and prophylaxis using mood-stabilizing medications to reduce both manic and depressive symptoms. Lithium remains the gold standard of treatment with the strongest data for both efficacy and suicide prevention. However, many patients do not respond to this medication, and ...

      Known for Lithium Response | Bipolar Disorder | Genome Wide | Valproic Acid | Retrospective Studies
      KOL-Index: 14263

      Neuronal and axonal responses to neurotrophic factors in the developing spinal cord have been relatively well characterized, but little is known about adult spinal responses to neurotrophic factors. We genetically modified primary rat fibroblasts to produce either nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or basic fibroblast growth factor (bFGF), then grafted these neurotrophic factor-secreting cells into the central gray matter of the ...

      Known for Spinal Cord | Neurotrophic Factors | Genetically Modified | Fibroblasts Gene | Ngf Bdnf
      KOL-Index: 14068

      Rats received bilateral lesions of the nucleus basalis magnocellularis by infusion of ibotenic acid. Fourteen days later, osmotic minipumps releasing human recombinant nerve growth factor (0.3 micrograms/day) were implanted subcutaneously. Starting one month after the lesion, spatial learning of the animals was tested using the Morris water maze. Acquisition of the task was impaired by the lesion, but treatment with nerve growth factor reduced the average latency to find the platform by ...

      Known for Nerve Growth | Basalis Magnocellularis | Delayed Treatment | Rats Lesions | Spatial Learning
      KOL-Index: 13825

      Intracerebral grafts consisting of primary fibroblasts genetically engineered to express NGF were used to assess the regenerative capacity of cholinergic neurons of the adult rat septum. Our data reveal that NGF-producing grafts sustain a significantly higher proportion of NGF receptor-immunoreactive septal neurons following axotomy (approximately 65-75%) than do grafts of noninfected fibroblasts. In addition, NGF promotes the regeneration of septal axons. Following the ablation of ...

      Known for Nerve Growth | Septal Neurons | Adult Rats | Somatic Gene Transfer | Regeneration Axons
      KOL-Index: 13753

      BACKGROUND: Neural induction of human pluripotent stem cells often yields heterogeneous cell populations that can hamper quantitative and comparative analyses. There is a need for improved differentiation and enrichment procedures that generate highly pure populations of neural stem cells (NSC), glia and neurons. One way to address this problem is to identify cell-surface signatures that enable the isolation of these cell types from heterogeneous cell populations by fluorescence ...

      Known for Neural Stem | Human Pluripotent | Neurons Glia | Highly Pure Populations | Cell Surface
      KOL-Index: 13471

      Adult neural stem cells (NSC) proliferate and differentiate depending on the composition of the cellular and molecular niche in which they are immersed. Until recently, microglial cells have been ignored as part of the neurogenic niche. We studied the dynamics of NSC proliferation and differentiation in the dentate gyrus of the hippocampus (DG) and characterized the changes of the neurogenic niche in adrenalectomized animals (ADX). At the cellular level, we found increased NSC ...

      Known for Neurogenic Niche | Growth Factor | Dentate Gyrus | Activated Microglia | Wistar Receptors
      KOL-Index: 13463

      Suspensions of cells derived from the mesencephalic raphé or medullary raphé regions of the 13–14 day old embryonic rat brain were injected into the spinal cord of adult rats which had been previously denervated with 5,7-dihydroxytryptamine. At periods of up to 12 months after grafting, the spinal cords were taken for immunohistochemical analysis of 5-hydroxytryptamine (5HT), substance P (SP) and thyrotropin releasing hormone (TRH). In nearly all cases, surviving transplants were found. ...

      Known for Mesencephalic Raphé | Embryonic Medullary | Morphological Development | Transmitter Expression | Adult Rat
      KOL-Index: 13345

      The adult rat spinal cord contains cells that can proliferate and differentiate into astrocytes and oligodendroglia in situ. Using clonal and subclonal analyses we demonstrate that, in contrast to progenitors isolated from the adult mouse spinal cord with a combination of growth factors, progenitors isolated from the adult rat spinal cord using basic fibroblast growth factor alone display stem cell properties as defined by their multipotentiality and self-renewal. Clonal cultures derived ...

      Known for Adult Spinal | Cord Stem | Cells Transplantation | Dentate Gyrus | Generate Neurons
      KOL-Index: 13276

      We have previously shown that voluntary exercise produces enhanced neurogenesis and long-term potentiation (LTP) in the dentate gyrus (DG) of mice in vitro. In the present experiments we show that rats given access to a running wheel (Runners) exhibit significantly more short-term potentiation and LTP with theta-patterned conditioning stimulation in vivo than do age-matched litter mates (Controls). This increase in LTP appears to reflect an alteration in the induction threshold for ...

      Known for Voluntary Exercise | Gene Expression | Dentate Gyrus | Synaptic Plasticity | Animal Rna
      KOL-Index: 13231

      In Parkinson's disease, progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SN) leads to debilitating motor dysfunction. One current therapy aims at exogenous cellular replacement of dopaminergic function by transplanting fetal midbrain cells into the striatum, the main projection area of the SN. However, results using this approach have shown variable success. It has been proposed that cellular replacement by endogenous stem/progenitor cells may be useful for ...

      Known for Progenitor Cells | Adult Substantia | Neurogenic Potential | Bromodeoxyuridine Cell | Parkinsons Disease

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      Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA | Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA | Genetics Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, Un

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