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    • Kazutoshi Takahashi
    • Kazutoshi Takahashi: Influence Statistics

      Kazutoshi Takahashi

      Kazutoshi Takahashi

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      Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America | Center for iPS Cell Research and Application (CiRA), Kyoto University, ...

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      Kazutoshi Takahashi:Expert Impact

      Concepts for whichKazutoshi Takahashihas direct influence:Stem cells,Pluripotent stem cells,Pluripotent stem,Induced pluripotent,Ips cells,Stem cell,Human fibroblasts,Transcription factors.

      Kazutoshi Takahashi:KOL impact

      Concepts related to the work of other authors for whichfor which Kazutoshi Takahashi has influence:Stem cells,Induced pluripotent,Regenerative medicine,Transcription factors,Cell differentiation,Gene expression,Tissue engineering.

      KOL Resume for Kazutoshi Takahashi

      Year
      2021

      Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America

      Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan

      2020

      Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA

      2018

      Center for iPS Cell Research and Application, Kyoto University , Kyoto , Japan.

      2016

      Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan;

      Kazutoshi Takahashi and Shinya Yamanaka are at the Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606–8507, Japan, and the Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.

      Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158;

      Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan

      2015

      Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan

      2014

      Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606-8507, Japan

      2013

      Department of Reprogramming Science, Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606-8507, Japan; and

      2012

      Center for iPS Cell Research and Application, Kyoto University 53, Kawahara-machi, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

      2011

      Center for iPS Cell Research and Application, Kyoto University, Kyoto

      2010

      Center for iPS Cell Research and Application, Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 600–8813, Japan

      Author to whom all correspondence should be addressed

      JST-CREST

      CiRA, iCeMS, Kyoto University

      2009

      From the Department of Medicine and Clinical Science (D.T., M.S., K.H., N.O., N.T., K.N.), Kyoto University Graduate School of Medicine; the Department of Stem Cell Biology (K.T., S.Y.), Institute for Frontier Medical Sciences, Kyoto University; and the Center for iPS Cell Research and Application (CiRA) (K.T., S.Y.), Institute for Integrated Cell-Material Sciences, Kyoto University, Japan.

      Center for iPS Cell Research and Application (CiRA), Institute for Integrated Cell-Material Sciences, Kyoto University, Japan

      2008

      Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan; CREST, Japan Science and Technology Agency, Kawaguchi, Japan; Gladstone Institute of Cardiovascular Disease, San Francisco, California; and Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan

      2007

      Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-machi, Shogoin, 606-8507, Sakyo-ku, Kyoto, Japan

      2006

      Laboratory of Animal Molecular Technology Research and Education, Center for Genetic Information, Nara Institute of Science and Technology, Nara, Japan

      2005

      Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.

      Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma 8916-5, Nara 630-0101, Japan

      2003

      Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Nara 630-0192

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      Sample of concepts for which Kazutoshi Takahashi is among the top experts in the world.
      Concept World rank
      sources transplantation therapy #1
      lowering gravity #1
      reprogramming 101 #1
      embryoid bodies teratomas #1
      embryolike fate pluripotency #1
      gravity direct reprogramming #1
      gift boxes studies #1
      transcription factors scientists #1
      newest types technology #1
      nuclear reprogramming technology #1
      discovery pluripotency #1
      nuclear reprogramming field #1
      gift boxes #1
      technology pathological studies #1
      differentiated skin fibroblasts #1
      clinic laboratories #1
      opportunities regenerative #1
      embryolike fate #1
      new pluripotent order #1
      multiple complex elements #1
      pharmaceutical industry clinic #1
      pathological studies addition #1
      cells rising star #1
      opened unprecedented #1
      body embryolike fate #1
      cellular reprogramming gravity #1
      differentiated somatic cell #1
      augmenting agents smallmolecules #1
      regenerative medicine sources #2
      prodifferentiation factors #2
      membrane rheb #2
      roles tumorlike properties #2
      –p21 pathwayinduced pluripotent #2
      mef isolation #2
      cells oncogenes mammalian #2
      cynomolgus mouse cells #2
      hipsc kyoto #2
      hypervariable region hras #2
      female hipsc #2
      pause retinoblastoma #2
      cells soxb1 #2
      renewal endogenous #2
      ltr7s long #2
      extraembryonic endoderm lineage #2
      ipscs klf4 #2
      endomembranes membrane localization #2
      forebrain marker #2
      Sign-in to see all concepts, it's free!

      Prominent publications by Kazutoshi Takahashi

      KOL-Index: 11944

      Acute kidney injury (AKI) is defined as a rapid loss of renal function resulting from various etiologies, with a mortality rate exceeding 60% among intensive care patients. Because conventional treatments have failed to alleviate this condition, the development of regenerative therapies using human induced pluripotent stem cells (hiPSCs) presents a promising new therapeutic option for AKI. We describe our methodology for generating renal progenitors from hiPSCs that show potential in ...

      Known for Acute Kidney Injury | Cell Therapy | Pluripotent Stem | Renal Progenitors | Kidney Diseases
      KOL-Index: 11137

      OBJECTIVE: Induced pluripotent stem (iPS) cells are a novel stem cell population derived from human adult somatic cells through reprogramming using a defined set of transcription factors. Our aim was to determine the features of the directed differentiation of human iPS cells into vascular endothelial cells (ECs) and mural cells (MCs), and to compare that process with human embryonic stem (hES) cells.

      METHODS AND RESULTS: We previously established a system for differentiating hES cells ...

      Known for Vascular Cells | Induced Pluripotent | Directed Differentiation | Stem Cell | Ecs Mcs
      KOL-Index: 11041

      Two Ras-related proteins, ERas and Rheb, which are involved in the phosphatidylinositol 3-kinase pathway, display high GTP affinity and have atypical CAAX motifs. The factors governing the intracellular localization of ERas and Rheb are incompletely understood. In the current study, we show by confocal microscopy that ERas is localized to the plasma membrane, whereas Rheb is confined to the endomembranes. Membrane localization of the two proteins was abolished by mutation of the cysteine ...

      Known for Membrane Localization | Phosphatidylinositol 3 | Ras Proteins | Confocal Microscopy | Amino Acid
      KOL-Index: 11004

      Human artificial chromosome (HAC) has several advantages as a gene therapy vector, including stable episomal maintenance that avoids insertional mutations and the ability to carry large gene inserts including the regulatory elements. Induced pluripotent stem (iPS) cells have great potential for gene therapy, as such cells can be generated from the individual's own tissues, and when reintroduced can contribute to the specialized function of any tissue. As a proof of concept, we show ...

      Known for Ips Cells | Muscular Dystrophy | Mdx Mice | Genetic Correction | Cultured Chromosomes
      KOL-Index: 10645

      Induced pluripotent stem cells (iPSCs) are novel stem cells derived from adult mouse and human tissues by reprogramming. Elucidation of mechanisms and exploration of efficient methods for their differentiation to functional cardiomyocytes are essential for developing cardiac cell models and future regenerative therapies. We previously established a novel mouse embryonic stem cell (ESC) and iPSC differentiation system in which cardiovascular cells can be systematically induced from ...

      Known for Cell Differentiation | Pluripotent Stem | Human Ipscs | Functional Cardiomyocytes | Induced Cardiomyocyte
      KOL-Index: 10604

      Methods have been established to generate dendritic cells (DCs) from mouse and human embryonic stem (ES) cells. We designated them as ES-DCs and mouse models have demonstrated the induction of anti-cancer immunity and prevention of autoimmune disease by in vivo administration of genetically engineered ES-DCs. For the future clinical application of ES-DCs, the histoincompatibility between patients to be treated and available human ES cells and the ethical concerns associated with human ES ...

      Known for Dendritic Cells | Pluripotent Stem | Ips Cell | Mouse Induced | Derived Macrophages
      KOL-Index: 10562

      Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS ...

      Known for Pluripotent Stem Cells | Nude Mice | Defined Factors | Mouse Embryonic | Adult Fibroblast
      KOL-Index: 10478

      Pluripotency of embryonic stem (ES) cells is maintained by a network consisting of multiple transcription factors, including Oct3/4, Sox2, Nanog, Klf4 and Sall4. Among these factors, the forced expressions of Oct3/4, Sox2 and Klf4 are sufficient to reprogram fibroblasts into induced pluripotent stem (iPS) cells. The current study analyzed the role of Sall4 during the generation of ES cells and iPS cells. The mouse Sall4 gene was deleted by homologous recombination. Sall4-null embryos ...

      Known for Stem Cells | Oct3 4 | Ips Cell Generation | Mouse Fibroblasts | Retroviral Transduction
      KOL-Index: 10202

      Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription factors. Here, we demonstrate the generation of iPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc. Human ...

      Known for Adult Human Fibroblasts | Pluripotent Stem | Cardiac Neurons | Generation Ips Cells | Inbred Icr Myocytes
      KOL-Index: 9761

      Pluripotency can be induced in somatic cells by overexpressing transcription factors, including POU class 5 homeobox 1 (OCT3/4), sex determining region Y-box 2 (SOX2), Krüppel-like factor 4 (KLF4), and myelocytomatosis oncogene (c-MYC). However, some induced pluripotent stem cells (iPSCs) exhibit defective differentiation and inappropriate maintenance of pluripotency features. Here we show that dynamic regulation of human endogenous retroviruses (HERVs) is important in the reprogramming ...

      Known for Dynamic Regulation | Endogenous Retroviruses | Long Noncoding Rna | Differentiation Potential | Stem Cells
      KOL-Index: 9649

      Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts grow infinitely while maintaining pluripotency. Leukemia inhibitory factor (LIF) can maintain self-renewal of mouse ES cells through activation of Stat3. However, LIF/Stat3 is dispensable for maintenance of ICM and human ES cells, suggesting that the pathway is not fundamental for pluripotency. In search of a critical factor(s) that underlies pluripotency in both ICM and ES cells, we performed in silico ...

      Known for Lif Stat3 | Icm Cells | Maintenance Pluripotency | Mouse Epiblast | Critical Factor
      KOL-Index: 9601

      Human (h) induced pluripotent stem cells (iPSCs) are a potentially abundant source of blood cells, but how best to select iPSC clones suitable for this purpose from among the many clones that can be simultaneously established from an identical source is not clear. Using an in vitro culture system yielding a hematopoietic niche that concentrates hematopoietic progenitors, we show that the pattern of c-MYC reactivation after reprogramming influences platelet generation from hiPSCs. During ...

      Known for Induced Pluripotent | Stem Cells | Transient Activation | Functional Platelets | Scid Microscopy
      KOL-Index: 9336

      BACKGROUND: For therapeutic usage of induced Pluripotent Stem (iPS) cells, to accomplish xeno-free culture is critical. Previous reports have shown that human embryonic stem (ES) cells can be maintained in feeder-free condition. However, absence of feeder cells can be a hostile environment for pluripotent cells and often results in karyotype abnormalities. Instead of animal feeders, human fibroblasts can be used as feeder cells of human ES cells. However, one still has to be concerned ...

      Known for Pluripotent Stem | Ips Cells | Autologous Feeders | Feeder Layers | Human Fibroblasts
      KOL-Index: 9317

      Novel APOBEC1 target 1 (Nat1) (also known as "p97," "Dap5," and "Eif4g2") is a ubiquitously expressed cytoplasmic protein that is homologous to the C-terminal two thirds of eukaryotic translation initiation factor 4G (Eif4g1). We previously showed that Nat1-null mouse embryonic stem cells (mES cells) are resistant to differentiation. In the current study, we found that NAT1 and eIF4G1 share many binding proteins, such as the eukaryotic translation initiation factors eIF3 and eIF4A and ...

      Known for Stem Cells | Mouse Embryonic | Binding Proteins | Translation Initiation | Cell Differentiation
      KOL-Index: 9292

      Mechanisms underlying human germ cell development are unclear, partly due to difficulties in studying human embryos and lack of suitable experimental systems. Here, we show that human induced pluripotent stem cells (hiPSCs) differentiate into incipient mesoderm-like cells (iMeLCs), which robustly generate human primordial germ cell-like cells (hPGCLCs) that can be purified using the surface markers EpCAM and INTEGRINα6. The transcriptomes of hPGCLCs and primordial germ cells (PGCs) ...

      Known for Human Germ | Stem Cells | Genetic Genes | Cell Fate | Naive Pluripotency

      Key People For Stem Cells

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      Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America | Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan | Center for iPS Cell Research and Application, Kyoto Un

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