Prominent publications by Aaron J W HSUEH

KOL Index score: 19233

In addition to gonadotropins, steroidogenesis and proliferation of granulosa cells during follicular development are controlled by a number of intraovarian factors including growth differentiation factor-9 (GDF-9), bone morphogenetic protein-4 (BMP-4), and IGF-I. The objective of this study was to determine the effect of GDF-9 and BMP-4 and their interaction with IGF-I and FSH on ovarian granulosa cell function in cattle. Granulosa cells from small (1-5 mm) and large (8-22 mm) follicles ...

Also Ranks for: Granulosa Cells |  growth differentiation |  progesterone production |  small follicles |  fsh gdf9
KOL Index score: 19129

Urocortin (UCN), a member of the Corticotropin-Releasing Factor (CRF) family of peptides is a well described cardioprotective agent. UCN is able to bind to two types of G-protein coupled receptors: CRF receptor type 1 (CRFR1) and CRF receptor type 2 (CRFR2), whereas, two homologues of UCN, stresscopin (SCP) or also known as urocortin III (UCNIII) and stresscopin related peptide (SRP), or urocortin II (UCNII), bind exclusively and with high affinity to CRFR2, we hypothesised that they ...

Also Ranks for: Scp Srp |  urocortin ucn |  activated protein |  crf receptor type |  neonatal cardiomyocytes
KOL Index score: 18433

The second messenger cAMP has been implicated in the regulation of mammalian and amphibian oocyte maturation. Although a decrease in intraoocyte levels of cAMP precedes germinal vesicle breakdown (GVBD), the gonadotropin induction of ovulation and oocyte maturation is associated with major increases of cAMP in ovarian follicles. In the mammalian system, isolated oocytes undergo spontaneous maturation in vitro but this process is blocked by treatment with a phosphodiesterase (PDE) ...

Also Ranks for: Oocyte Maturation |  germ cells |  camp levels |  phosphodiesterase inhibitors |  4 pde
KOL Index score: 17662

The role of gonadotropin releasing hormone (GnRH) and its antagonist, [D-pGlu1, D-Phe2-DTrp3,6] GnRH, in the direct regulation of ovarian functions was studied in vivo and in vitro. Immature hypophysectomized rats were treated twice daily with FSH in the presence or absence of 30 μg GnRH or 500 μg antagonist or both. GnRH inhibited FSH stimulation of ovarian weight as well as LH receptor content and aromatase activity in the ovarian granulosa cells. In contrast, concomitant treatment ...

Also Ranks for: Hormone Gnrh |  gonadotropin releasing |  fsh lh |  concomitant treatment |  granulosa cells
KOL Index score: 16837

Prolactin (Prl), beta 2-adrenergic agents and human chorionic gonadotropin (hCG) are luteotropic in rats, whereas gonadotropin releasing hormone (GnRH) exerts direct inhibitory effects on ovarian steroidogenesis. The present study examined the modulation of the progestin biosynthetic pathway by the luteotropic agents, as well as the actions of GnRH. Rat granulosa cells were primed with follicle-stimulating hormone (FSH) to increase their responsiveness to the luteotropic agents. ...

Also Ranks for: Granulosa Cells |  human chorionic gonadotropin |  prolactin prl |  releasing hormone |  pregnenolone production
KOL Index score: 16791

Ovarian follicular development is controlled by numerous paracrine and endocrine regulators, including oocyte-derived growth differentiation factor 9 (GDF9), and a localized increase in bioavailable insulin-like growth factor 1 (IGF1). The effects of GDF9 on function of theca cells collected from small (3-6 mm) and large (8-22 mm) ovarian follicles were investigated. In small-follicle theca cells cultured in the presence of both LH and IGF1, GDF9 increased cell numbers and DNA synthesis, ...

Also Ranks for: Theca Cells |  growth differentiation |  factor 9 |  messenger receptor |  large follicles
KOL Index score: 16059

The direct effect of LH on estrogen secretion by rat granulosa cells was investigated. Ovarian granulosa cells from immature hypophysectomized diethylstilbestrol-treated rats were primed with FSH for 2 days in vitro to induce LH receptors. After the FSH priming, the granulosa cells were washed, and recultured for 4 additional days in media containing aromatase substrate (10(-7) M androstenedione) and purified FSH or LH. After the incubations, estrogen (E), progesterone (P) and 20 ...

Also Ranks for: Granulosa Cells |  fsh lh |  cultured rat |  20 alpha |  stimulating hormone

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Aaron J W HSUEH:Expert Impact

Concepts for whichAaron J W HSUEHhas direct influence:Granulosa cells,  Stimulating hormone,  Growth factors,  Lh receptor,  Growth factor,  Estrogen production,  Ovarian follicle,  Granulosa cell.

Aaron J W HSUEH:KOL impact

Concepts related to the work of other authors for whichfor which Aaron J W HSUEH has influence:Granulosa cells,  Growth factor,  Luteinizing hormone,  Gene expression,  Follicular development,  Ovarian follicle,  Cell death.



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Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA. | Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA | Center for Reproductive Medicine,