Debra A Crumrine: Influence Statistics

Debra A Crumrine

Debra A Crumrine

Department of Dermatology, University of California San Francisco, San Francisco, California. | San Francisco Veterans Affairs Medical Center, Dermatology Service, San ...


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Debra A Crumrine: Expert Impact

Concepts for which Debra A Crumrine has direct influence: Stratum corneum , Permeability barrier , Barrier recovery , Calcium gradient , Barrier function , Barrier abnormality , Permeability barrier homeostasis .

Debra A Crumrine: KOL impact

Concepts related to the work of other authors for which for which Debra A Crumrine has influence: Atopic dermatitis , Stratum corneum , Skin barrier , Wound healing , Keratinocyte differentiation , Netherton syndrome , Hand eczema .

KOL Resume for Debra A Crumrine

Year
2022

Department of Dermatology, University of California San Francisco, San Francisco, California.

2021

San Francisco Veterans Affairs Medical Center, Dermatology Service, San Francisco, CA, USA; Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

2020

San Francisco Veterans Affairs Medical Center, Dermatology Service and University of California San Francisco; Department of Dermatology, San Francisco, California

2019

Dermatology Service, VA Medical Center and Department of Dermatology, University of California-San Francisco, 4150 Clement St., 94121, San Francisco, CA, United States

2018

Department of Dermatology, University of California, San Francisco, San Francisco, California

Derm, VAMC/UCSF, San Francisco, CA

2017

Dermatology Service, Veterans Affairs Medical Center, San Francisco and Department of Dermatology, University of California, San Francisco, California, USA

2016

Dermatology, UCSF, San Francisco, CA

Dermatology Service, Department of Veterans Affairs Medical Center, University of California, San Francisco, California, USA.

2015

Department of Dermatology, SF-VAMC and UCSF, San Francisco, CA, USA

2014

Dermatology Service (190), Department of Veterans Affairs Medical Center, UCSF, 4150 Clement Street, 94121, San Francisco, CA, USA

2013

Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA

2012

Dermatology Service, Veteran Affairs Medical Center and University of California, San Francisco, California, USA

2011

Dermatology Service, VAMC, and Department of Dermatology, University of California San Francisco, San Francisco, CA, USA

2010

Dermatology Research, Veterans Affairs Medical Center, University California San Francisco, San Francisco, USA

2009

Department of Dermatology, Veteran Affairs Medical Center, University of California San Francisco, San Francisco, California, USA

Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, Calif

2008

Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California, USA

2007

Department of Dermatology, University of California San Francisco and VA Medical Center San Francisco, San Francisco, California, USA

Dermatology, Veteran Affairs Medical Center, San Francisco, California

Veterans Affairs Medical Center, San Francisco

2006

1Dermatology and Medical Services (Metabolism), Veteran Affairs Medical Center San Francisco and Department of Dermatology and Medicine, University of California San Francisco, San Francisco, California; and 2Department of Dermatology, Yonsei University, Wonju College of Medicine, Wonju, Korea

Dermatology Research, UCSF, San Francisco, California, USA

2005

Department of Dermatology and Medicine, University of California San Francisco, San Francisco, California, USA

2004

From the Departments of Dermatology and Pediatrics, University of California San Francisco, and the Department of Veterans Affairs Medical Center, San Francisco, California USA

2003

Department of Environmental Toxicology, University of California, Davis, CA 95616‐8588, U.S.A.
*Dermatology Service, Veterans Affairs Medical Center, Department of Dermatology, University of California, San Francisco, CA 94121, U.S.A.
†Department of Dermatology, CHUV, CH‐1011 Lausanne, Switzerland
‡Southern General Hospital, Glasgow G51 4TF, U.K

VA Medical Center, Dermatology Section, San Francisco, California, USA

2002

Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, California 94121, the

Endocrine Unit, VA Medical Center, University of California, San Francisco, California, U.S.A.

2001

Dermatology Service, San Francisco, U.S.A.

2000

Department of Medicine and Dermatology, University of California San Francisco, Veterans Affairs Medical Center, San Francisco, California 94121

1999

Dermatology and Medical Services, Veterans Affairs Medical Center and Departments of Dermatology and Medicine, University of California, San Francisco, USA

1998

Dermatology and Medicine (Metabolism) Services, Veterans Administration Medical Center, Departments of Dermatology, Medicine, San Francisco, California,U.S.A.

1997

San Francisco, California

1994

Dermatology Services, Veterans Administration Medical Center and Department of Dermatology, University of California, San Francisco, California, USA

Prominent publications by Debra A Crumrine

KOL-Index: 14631 . Members of the superfamily of nuclear hormone receptors which are obligate heterodimeric partners of the retinoid X receptor may be important in epidermal development. Here, we examined the effects of activators of the receptors for vitamin D3 and retinoids, and of the peroxisome proliferator activated receptors (PPARs) and the farnesoid X-activated receptor (FXR), on the development of ...
Known for Nuclear Hormone | Barrier Development | Fetal Epidermal | Activators Pparalpha
KOL-Index: 12695 . Previously, we demonstrated that topical applications of peroxisome proliferator-activated receptors (PPARs) and liver X receptor (LXR) activators improve permeability barrier homeostasis. We showed further that stimulation of epidermal differentiation provides one mechanism that could account for such improvement. Here, we studied the effects of these agents on the lipid matrix of the ...
Known for Barrier Homeostasis | Lipid Synthesis | Lxr Activators | Lamellar Body
KOL-Index: 12243 . Prolonged exposure of human epidermis to excess endogenous or exogenous glucocorticoids can result in well-recognized cutaneous abnormalities. Here, we determined whether short-term glucocorticoid treatment would also display adverse effects, specifically on two key epidermal functions, permeability barrier homeostasis and stratum corneum integrity and cohesion, and the basis for such ...
Known for Stratum Corneum Integrity | Permeability Barrier | Epidermal Lipid | Topical Glucocorticoid
KOL-Index: 11880 . Ceramides in mammalian stratum corneum comprise a heterogeneous mixture of molecular species that subserve the epidermal permeability barrier, an essential function for survival in a terrestrial environment. In addition to a variation of sphingol species, hydroxylation of the amide-linked fatty acids contributes to the diversity of epidermal ceramides. Fatty acid 2-hydroxylase, encoded by ...
Known for Fatty Acid | Keratinocyte Differentiation | Fa2h Expression | Epidermal Ceramides
KOL-Index: 11647 . A barrier to water loss is vital to maintaining life on dry land. Formation of the mammalian skin barrier requires both the essential fatty acid linoleate and the two lipoxygenases 12R-lipoxygenase (12R-LOX) and epidermal lipoxygenase-3 (eLOX3), although their roles are poorly understood. Linoleate occurs in O-linoleoyl-ω-hydroxyceramide, which, after hydrolysis of the linoleate moiety, is ...
Known for Corneocyte Lipid Envelope | Essential Fatty | Skin Barrier | 12rlox Elox3
KOL-Index: 10152 . Nuclear receptors which interact with the retinoid X receptor are involved in the regulation of epidermal differentiation and development. We have recently shown that activators of the peroxisome proliferator-activated receptor and of the farnesoid X-activated receptor accelerate epidermal barrier maturation in fetal rat skin in vitro. In this study we asked whether cutaneous development ...
Known for Epidermal Differentiation | Barrier Development | Receptor Activators | Stratum Corneum
KOL-Index: 9520 . BACKGROUND: Chronologically aged skin exhibits delayed recovery rates after defined barrier insults, with decreased epidermal lipid synthesis, and particularly a reduction in cholesterol synthesis. Prior studies in young mice (< 10 weeks) and humans (20 to 30 years of age) have shown that application of a mixture of cholesterol, ceramides, and essential/nonessential free fatty acids (FFAs) ...
Known for Barrier Recovery | Aged Skin | Stratum Corneum | Young Mice
KOL-Index: 9239 . In this study we investigated whether hyaluronan (HA)-CD44 interaction influences epidermal structure and function. Our data show that CD44 deficiency is accompanied by reduction in HA staining in CD44 knockout (k/o) mouse skin leading to a marked thinning of epidermis versus wild-type mouse skin. A significant delay in the early barrier recovery (following acute barrier disruption) occurs ...
Known for Permeability Barrier | Cd44 Mouse Skin | Hyaluronan Receptors | Keratinocyte Differentiation
KOL-Index: 9177 . We have recently reported that human keratinocytes express both the full-length calcium sensing receptor (CaR) and an alternatively spliced form lacking exon 5, which were suggested to be involved in calcium induced keratinocyte differentiation. To understand further the role of these CaRs, we analyzed the structure of mouse CaRs, and investigated their role using a mouse model in which ...
Known for Epidermal Differentiation | Calcium Sensing Receptor | Alternatively Spliced | Fulllength Car
KOL-Index: 9053 . BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory dermatosis now increasingly linked to mutations that alter the structure and function of the stratum corneum. Activators of peroxisome proliferator-activated receptors (PPARs) alpha, beta/delta, and gamma and liver X receptor (LXR) regulate epidermal protein and lipid production, leading to superior barrier function. ...
Known for Atopic Dermatitis | Peroxisome Proliferator | Hairless Mice | Ppar Lxr
KOL-Index: 9022 . Mutations in the SPINK5 gene encoding the serine protease (SP) inhibitor, lymphoepithelial-Kazal-type 5 inhibitor (LEKTI), cause Netherton syndrome (NS), a life-threatening disease, owing to proteolysis of the stratum corneum (SC). We assessed here the basis for phenotypic variations in nine patients with "mild", "moderate", and "severe" NS. The magnitude of SP activation correlated with ...
Known for Serine Protease | Netherton Syndrome | Lekti Expression | Stratum Corneum
KOL-Index: 8864 . Epidermolytic hyperkeratosis is a dominantly inherited ichthyosis, frequently associated with mutations in keratin 1 or 10 that result in disruption of the keratin filament cytoskeleton leading to keratinocyte fragility. In addition to blistering and a severe disorder of cornification, patients typically display an abnormality in permeability barrier function. The nature and pathogenesis ...
Known for Barrier Abnormality | Epidermolytic Hyperkeratosis | Cornified Envelope | Electron Microscopy
KOL-Index: 8852 . Evidence is growing that protease-activated receptor-2 (PAR-2) plays a key role in epithelial inflammation. We hypothesized here that PAR-2 plays a central role in epidermal permeability barrier homeostasis by mediating signaling from serine proteases (SP) in the stratum corneum (SC). Since the SC contains tryptic- and chymotryptic-like activity, we assessed the influence of SP ...
Known for Permeability Barrier | Serine Protease | Hairless Mice | Par2 Activation
KOL-Index: 8847 . Keratinocytes express high levels of 25OHD 1alpha-hydroxylase (1OHase). The product of this enzyme, 1,25-dihydroxyvitamin D (1,25(OH)(2)D), promotes the differentiation of keratinocytes in vitro suggesting an important role for this enzyme in epidermal differentiation. To test whether 1OHase activity is essential for keratinocyte differentiation in vivo we examined the differentiation ...
Known for Permeability Barrier | 25 Hydroxyvitamin | Epidermal Differentiation | Hydroxylase Animals
KOL-Index: 8833 . The vitamin D receptor (VDR) is a nuclear hormone receptor that controls transcription of target genes. It exerts its biological effects through transcriptional coactivators. Previously, we identified two distinct classes of VDR coactivators, VDR-interacting protein (DRIP) and steroid receptor coactivator (SRC) at different stages of keratinocyte differentiation. Here, we determined the ...
Known for Barrier Formation | Vdr Coactivators | Vitamin Receptor | Mice Mice

Key People For Stratum Corneum

Top KOLs in the world
#1
Peter M Elias
stratum corneum barrier function atopic dermatitis
#2
Joke A Bouwstra
stratum corneum human skin lipid organization
#3
Howard Ira Maibach
contact dermatitis percutaneous absorption human skin
#4
Richard H A Guy
stratum corneum reverse iontophoresis drug delivery
#5
Philip W Wertz
stratum corneum oral mucosa fatty acids
#6
Donald Talbot Downing
fatty acids stratum corneum sebum secretion

Department of Dermatology, University of California San Francisco, San Francisco, California. | San Francisco Veterans Affairs Medical Center, Dermatology Service, San Francisco, CA, USA; Department of Dermatology, University of California San Franci