Hachiro TAGAMI: Influence Statistics

Hachiro TAGAMI

Hachiro TAGAMI

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, JPN | Tohoku University, Sendai, Japan | Department of Dermatology, Tohoku University School ...

Hachiro TAGAMI: Expert Impact

Concepts for which Hachiro TAGAMI has direct influence: Stratum corneum , Atopic dermatitis , Dendritic cells , Skin surface , Contact sensitivity , Langerhans cells , Tyrosinase gene .

Hachiro TAGAMI: KOL impact

Concepts related to the work of other authors for which for which Hachiro TAGAMI has influence: Atopic dermatitis , Stratum corneum , Dendritic cells , Human skin , Wound healing , Transepidermal water loss , Barrier function .

KOL Resume for Hachiro TAGAMI

Year
2021

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, JPN

2017

Tohoku University, Sendai, Japan

2016

Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan

2015

Department of Dermatology, Tohoku University School of Medicine

2014

Tohoku University School of Medicine Department of Dermatology Seiryomachi Aobaku Sendai Japan

2013

Tohoku University Graduate School of Medicine Sendai Japan

2011

Tohoku University School of Medicine, Japan

2010

Division of Dermatology, Department of Internal Medicine, Tohoku University Graduate School of Medicine

Tohoku University, 3-27-1 Kaigamori, Aobaku Sendai, 981-0942, Japan

2009

Department of Dermatology, Tohoku University school of Medicine, Sendai, Japan

2008

Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku Sendai 980, Japan

2007

Department of Dermatology, Tohoku University, Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Japan

2006

Department of Dermatology, Tohoku University Graduate School of Medicine.

Depertment of Dermatology, Tohoku University, Sendai, Japan

2005

Basic Research Laboratory, Kanebo Ltd, 5‐3‐28 Kotobuki‐cho, Odawara‐shi, Kanagawa 250‐0002, Japan
*Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
†Department of Internal Medicine, Division of Molecular Metabolism and Diabetes, Tohoku University School of Medicine, Sendai, Japan

2004

Department of Dermatology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai 980-8574, Japan

2003

Department of Dermatology, Graduate School of Medicine and School of Medicine, Tohoku University, Sendai, Japan

Dermatology and

2002

Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.

Sendai and Ishinomaki, Japan

2001

Department of Dermatology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan

2000

Department of Dermatology, Tohoku University School of Medicine, Sendai and

1999

TOHOKU UNIVERSITY, aLecturer, Department of Oral and Maxillofacial Surgery 1, School of Dentistry, bProfessor, Department of Oral and Maxillofacial Surgery 1, School of Dentistry, cProfessor, Department of Dermatology, School of Medicine, dInstructor, Department of Oral and Maxillofacial Surgery 1, School of Dentistry, eProfessor, Department of Oral and Maxillofacial Surgery 2, School of Dentistry, fProfessor, Department of Pathology, School of Medicine

Sendai Japan

1998

Department of Dermatology, Tohoku University School of Medicine, Aobaku Seiryo‐machi 1‐1, Sendai 980‐77, Japan,

Prominent publications by Hachiro TAGAMI

KOL-Index: 17794 . CD80(B7-1) and CD86(B7-2) co-stimulatory molecules have been reported to activate Th1/Th2 development pathways differentially. It is well known that Langerhans cells (LC), potent antigen-presenting dendritic cells in the epidermis, express several co-stimulatory molecules and that this expression is modulated by several cytokines. Based on the recently reported effect of interferon ...
Known for Antigen Presentation | Cd80 Expression | Langerhans Cells | Costimulatory Molecules
KOL-Index: 17711 . Previous studies have demonstrated that haptens induce several phenotypic and functional changes of dendritic cells in vivo as well as in vitro. Although recently, the crucial role of p38 mitogen-activated protein kinase has been reported in the activation of dendritic cells by haptens, the signal transduction elements involved in each phenotypic and functional changes that occur in the ...
Known for Dendritic Cells | Activated Protein | P38 Mitogen | Extracellular Signal
KOL-Index: 17618 . BACKGROUND: Dermatologists and cosmetic scientists are becoming increasingly interested in stratum corneum (SC) hydration because the SC plays an important role in keeping the skin surface soft and smooth. However, conventional in vivo noninvasive methods do not provide direct information about the depth profiles of water content or SC components that hold water. OBJECTIVES: To study the ...
Known for Forearm Skin | Depth Profiles | Water Content | Raman Spectroscopy
KOL-Index: 16923 . Macrophage colony-stimulating factor has not been considered as a factor responsible for dendritic cell or Langerhans cell development from hematopoietic progenitor cells. In this study, we examined whether macrophage colony-stimulating factor could be used instead of granulocyte-macrophage colony-stimulating factor for the in vitro development of Langerhans cells from hematopoietic ...
Known for Langerhans Cells | Stimulating Factor | Macrophage Colony | Transforming Growth
KOL-Index: 15583 . After application of haptens to the skin, Langerhans cells (LC), i.e. immature dendritic cells (DC) in the skin, move to secondary lymphoid organs to sensitize naive T cells. During this process, LC become mature DC with augmented expression of various co-stimulatory molecules and MHC class II antigens. In this scenario, however, critical questions remain as to what kind of chemicals can ...
Known for Stimulatory Molecules | Nicl2 Dncb | Dendritic Cells | Cd86 Expression
KOL-Index: 15054 . Human monocyte-derived dendritic cells (MoDCs) obtained from peripheral blood monocytes (PBMC) cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) can be activated in vitro by a variety of simple chemicals such as haptens and several metals. Recently, it has been demonstrated that transforming growth factor-beta1 (TGF-beta1) can induce further ...
Known for Allergic Contact | Epidermal Langerhans Cells | Growth Factor | Tgf Beta1
KOL-Index: 13689 . It has been reported that the in vivo maturation of Langerhans cells after hapten painting is mediated by IL-1 beta while Langerhans cell maturation after in vitro culture is mediated by granulocyte-macrophage colony-stimulating factor (GM-CSF). To clarify the reason for this discrepancy, we examine the expression of Ia antigen and several co-stimulatory molecules on Langerhans cells that ...
Known for Langerhans Cells | Macrophage Colony | Stimulating Factor | Cell Maturation
KOL-Index: 13202 . After hapten application, epidermal Langerhans cells migrate into the regional lymph nodes through dermal lymphatics. Recently, we have demonstrated that some of them take the phenotypic and functional characteristics similar to those of in vitro cultured Langerhans cells, before disappearing from the epidermis. To analyze the mechanisms underlying the migration of Langerhans cells, we ...
Known for Langerhans Cells | Lymph Nodes | Adhesion Molecules | Α4 Integrin
KOL-Index: 11797 . Lipid peroxide levels, the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px), and the development of tanning in the skin of C57 BL/6 mice were assessed for long periods, from very early to late stages, after acute or chronic UVB irradiation. Acute UVB irradiation produced an increase in lipid peroxide levels that peaked 18 h after irradiation, after ...
Known for Superoxide Dismutase | Lipid Peroxide Levels | Glutathione Peroxidase | Uv Irradiation
KOL-Index: 11728 . The skin is a unique organ that contains two different subsets of dendritic cells, i.e., Langerhans cells and dermal dendritic cells. Our hypothesis is that cutaneous fibroblasts may affect the development of these dendritic cells. We cocultured cord blood CD34+ hematopoietic progenitor cells with several human cutaneous fibroblast cell lines without any exogenous cytokines for 3 wk. In ...
Known for Dendritic Cells | Cord Blood | Cd1 Antigens | Stimulating Factor
KOL-Index: 11284 . Although ultraviolet B (UVB) induces apoptosis and functional perturbations in dendritic cells (DC), for example, Langerhans cells (LC), it also stimulates some LC into maturation after irradiation in vivo. To analyze its reciprocal effects on DC, we elucidated the direct effect of UVB on DC in vitro using human monocyte-derived DC (MoDC). UVB from 50 to 200 J per m2 stimulated the ...
Known for Activated Protein | Dendritic Cells | P38 Mitogen | Apoptosis Cell
KOL-Index: 10974 . This study revealed that the absence of histamine in histidine decarboxylase gene-knockout (HDC(-/-)) mice resulted in delayed cutaneous wound healing and that exogenously administered histamine compensated this process. With the overproduction of histamine in HDC gene-transgenic mice, the healing was accelerated compared to the HDC(+/+) mice. These results indicate that histamine ...
Known for Fibroblast Growth Factor | Wound Healing Mice | Healing Process | Physiologic Pyrroles Receptor
KOL-Index: 10950 . Skin disorders such as atopic dermatitis, psoriasis and senile xerosis show a tendency to exacerbate in winter. We investigated the seasonal influence on the functional parameters of the skin in healthy female volunteers of different age groups. Biophysical noninvasive measurements, including transepidermal water loss (TEWL) as a parameter for the barrier function of the stratum corneum ...
Known for Forearm Skin | Barrier Function | Summer Winter | Hydration State
KOL-Index: 10922 . Objective: To characterize the functional properties of the stratum corneum (SC) of various scars.Design: A prospective cohort study.Setting: University hospital medical center.Patients: Thirty-two consecutive patients surgically treated for various skin diseases and 26 consecutive patients with hypertrophic scars or keloids.Main Outcome Measures: Noninvasive bioengineering measurements of ...
Known for Hypertrophic Scars | Stratum Corneum | Functional Analyses | Highfrequency Conductance
KOL-Index: 10898 . BACKGROUND: Atopic dermatitis (AD) shows dry skin. Water-soluble, low molecular weight components, collectively known as natural moisturizing factor (NMF), play an important role in maintaining the stratum corneum (SC) hydration. Previous studies focused on reduced levels of free amino acids (FAAs) in NMF from AD skin. It remains unknown, however, whether other NMF components are also ...
Known for Stratum Corneum | Atopic Dermatitis | Natural Moisturizing Factor | Nmf Skin

Key People For Stratum Corneum

Top KOLs in the world
#1
Peter M Elias
stratum corneum barrier function atopic dermatitis
#2
Joke A Bouwstra
stratum corneum human skin lipid organization
#3
Howard Ira Maibach
contact dermatitis percutaneous absorption human skin
#4
Richard H A Guy
stratum corneum reverse iontophoresis drug delivery
#5
Philip W Wertz
stratum corneum oral mucosa fatty acids
#6
Donald Talbot Downing
fatty acids stratum corneum sebum secretion

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, JPN | Tohoku University, Sendai, Japan | Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan | Department of Dermatology, Tohoku University S