• Disease
  • Stratum
  • Stratum Corneum
  • Hachiro Tagami

    Prominent publications by Hachiro TAGAMI

    KOL Index score: 17794

    CD80(B7-1) and CD86(B7-2) co-stimulatory molecules have been reported to activate Th1/Th2 development pathways differentially. It is well known that Langerhans cells (LC), potent antigen-presenting dendritic cells in the epidermis, express several co-stimulatory molecules and that this expression is modulated by several cytokines. Based on the recently reported effect of interferon (IFN)-gamma and interleukin (IL-)-10 on the expression of CD80 and CD86 by LC, we examined the effects of ...

    Also Ranks for: Antigen Presentation |  cd80 expression |  langerhans cells |  costimulatory molecules |  ifn gamma
    KOL Index score: 17711

    Previous studies have demonstrated that haptens induce several phenotypic and functional changes of dendritic cells in vivo as well as in vitro. Although recently, the crucial role of p38 mitogen-activated protein kinase has been reported in the activation of dendritic cells by haptens, the signal transduction elements involved in each phenotypic and functional changes that occur in the activation of dendritic cells by haptens remain unknown. Therefore, we examined the role of ...

    Also Ranks for: Dendritic Cells |  activated protein |  p38 mitogen |  extracellular signal |  monocyte derived
    KOL Index score: 17618

    BACKGROUND: Dermatologists and cosmetic scientists are becoming increasingly interested in stratum corneum (SC) hydration because the SC plays an important role in keeping the skin surface soft and smooth. However, conventional in vivo noninvasive methods do not provide direct information about the depth profiles of water content or SC components that hold water.

    OBJECTIVES: To study the depth profiles of water and SC components in vivo by Raman spectroscopy, and to analyse the changes ...

    Also Ranks for: Forearm Skin |  depth profiles |  water content |  raman spectroscopy |  stratum corneum
    KOL Index score: 16923

    Macrophage colony-stimulating factor has not been considered as a factor responsible for dendritic cell or Langerhans cell development from hematopoietic progenitor cells. In this study, we examined whether macrophage colony-stimulating factor could be used instead of granulocyte-macrophage colony-stimulating factor for the in vitro development of Langerhans cells from hematopoietic progenitor cells. We replaced granulocyte-macrophage colony-stimulating factor with macrophage ...

    Also Ranks for: Langerhans Cells |  stimulating factor |  macrophage colony |  transforming growth |  hematopoietic progenitor
    KOL Index score: 15583

    After application of haptens to the skin, Langerhans cells (LC), i.e. immature dendritic cells (DC) in the skin, move to secondary lymphoid organs to sensitize naive T cells. During this process, LC become mature DC with augmented expression of various co-stimulatory molecules and MHC class II antigens. In this scenario, however, critical questions remain as to what kind of chemicals can induce this maturation process through what kind of mechanisms. To clarify these questions, we used ...

    Also Ranks for: Stimulatory Molecules |  nicl2 dncb |  dendritic cells |  cd86 expression |  production cytokines
    KOL Index score: 15054

    Human monocyte-derived dendritic cells (MoDCs) obtained from peripheral blood monocytes (PBMC) cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) can be activated in vitro by a variety of simple chemicals such as haptens and several metals. Recently, it has been demonstrated that transforming growth factor-beta1 (TGF-beta1) can induce further differentiation of MoDCs to the cells that share some characteristics with epidermal Langerhans ...

    Also Ranks for: Allergic Contact |  epidermal langerhans cells |  growth factor |  tgf beta1 |  ccr7 receptors
    KOL Index score: 13689

    It has been reported that the in vivo maturation of Langerhans cells after hapten painting is mediated by IL-1 beta while Langerhans cell maturation after in vitro culture is mediated by granulocyte-macrophage colony-stimulating factor (GM-CSF). To clarify the reason for this discrepancy, we examine the expression of Ia antigen and several co-stimulatory molecules on Langerhans cells that were activated by in vitro culture, by hapten painting, or by an intradermal injection of several ...

    Also Ranks for: Langerhans Cells |  macrophage colony |  stimulating factor |  cell maturation |  il1 beta
    KOL Index score: 13202

    After hapten application, epidermal Langerhans cells migrate into the regional lymph nodes through dermal lymphatics. Recently, we have demonstrated that some of them take the phenotypic and functional characteristics similar to those of in vitro cultured Langerhans cells, before disappearing from the epidermis. To analyze the mechanisms underlying the migration of Langerhans cells, we studied the expression of several adhesion molecules on freshly isolated LC and cultured LC. Pgp-1 ...

    Also Ranks for: Langerhans Cells |  lymph nodes |  adhesion molecules |  α4 integrin |  inbred c3h
    KOL Index score: 11797

    Lipid peroxide levels, the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px), and the development of tanning in the skin of C57 BL/6 mice were assessed for long periods, from very early to late stages, after acute or chronic UVB irradiation. Acute UVB irradiation produced an increase in lipid peroxide levels that peaked 18 h after irradiation, after which the levels declined to a minimum 2–3 days after irradiation and then gradually rose to baseline. ...

    Also Ranks for: Superoxide Dismutase |  lipid peroxide levels |  glutathione peroxidase |  uv irradiation |  mouse skin
    KOL Index score: 11728

    The skin is a unique organ that contains two different subsets of dendritic cells, i.e., Langerhans cells and dermal dendritic cells. Our hypothesis is that cutaneous fibroblasts may affect the development of these dendritic cells. We cocultured cord blood CD34+ hematopoietic progenitor cells with several human cutaneous fibroblast cell lines without any exogenous cytokines for 3 wk. In this culture, hematopoietic progenitor cells increased in number from 20.1 +/- 2.4 times, and produced ...

    Also Ranks for: Dendritic Cells |  cord blood |  cd1 antigens |  stimulating factor |  macrophage colony
    KOL Index score: 11284

    Although ultraviolet B (UVB) induces apoptosis and functional perturbations in dendritic cells (DC), for example, Langerhans cells (LC), it also stimulates some LC into maturation after irradiation in vivo. To analyze its reciprocal effects on DC, we elucidated the direct effect of UVB on DC in vitro using human monocyte-derived DC (MoDC). UVB from 50 to 200 J per m2 stimulated the maturation of MoDC with (1) augmented expression of CD86 and HLA-DR, (2) enhanced production of IL-1beta, ...

    Also Ranks for: Activated Protein |  dendritic cells |  p38 mitogen |  apoptosis cell |  ultraviolet radiation
    KOL Index score: 10974

    This study revealed that the absence of histamine in histidine decarboxylase gene-knockout (HDC(-/-)) mice resulted in delayed cutaneous wound healing and that exogenously administered histamine compensated this process. With the overproduction of histamine in HDC gene-transgenic mice, the healing was accelerated compared to the HDC(+/+) mice. These results indicate that histamine positively accelerated the cutaneous wound healing. Macrophage recruitment and angiogenesis at the wound ...

    Also Ranks for: Fibroblast Growth Factor |  wound healing mice |  healing process |  physiologic pyrroles receptor |  histidine decarboxylase
    KOL Index score: 10950

    Skin disorders such as atopic dermatitis, psoriasis and senile xerosis show a tendency to exacerbate in winter. We investigated the seasonal influence on the functional parameters of the skin in healthy female volunteers of different age groups. Biophysical noninvasive measurements, including transepidermal water loss (TEWL) as a parameter for the barrier function of the stratum corneum (SC), high-frequency conductance as a parameter for the hydration state of the SC, temperature, color ...

    Also Ranks for: Forearm Skin |  barrier function |  summer winter |  hydration state |  japanese females
    KOL Index score: 10922

    Objective: To characterize the functional properties of the stratum corneum (SC) of various scars.Design: A prospective cohort study.Setting: University hospital medical center.Patients: Thirty-two consecutive patients surgically treated for various skin diseases and 26 consecutive patients with hypertrophic scars or keloids.Main Outcome Measures: Noninvasive bioengineering measurements of functional properties of the SC, such as transepidermal water loss (TEWL), high-frequency ...

    Also Ranks for: Hypertrophic Scars |  stratum corneum |  functional analyses |  highfrequency conductance |  skin surface
    KOL Index score: 10898

    BACKGROUND: Atopic dermatitis (AD) shows dry skin. Water-soluble, low molecular weight components, collectively known as natural moisturizing factor (NMF), play an important role in maintaining the stratum corneum (SC) hydration. Previous studies focused on reduced levels of free amino acids (FAAs) in NMF from AD skin. It remains unknown, however, whether other NMF components are also altered in AD.

    OBJECTIVE: To characterize the levels of various NMF components in the SC of healthy ...

    Also Ranks for: Stratum Corneum |  atopic dermatitis |  natural moisturizing factor |  nmf skin |  sodium potassium


    Hachiro TAGAMI: Influence Statistics

    Sample of concepts for which Hachiro TAGAMI is among the top experts in the world.
    Concept World rank
    osmolar concentration picibanil #1
    scars tewl #1
    stimulations il12p40 #1
    atopic 31 patients #1
    neutrophils lta #1
    stimulations contrast #1
    bacterial pustules #1
    il1 samples #1
    dfsp tumour cells #1
    body surface presence #1
    induced erythroderma #1
    diffuse eosinophilic infiltrate #1
    patients neoplasm candida #1
    petrolatumtreated #1
    lclike skin #1
    contrast modcs #1
    eosinophilia child #1
    skin robot finger #1
    pbms psoriatic patients #1
    normal individuals cpt #1
    mellitus experimental models #1
    moisturizers skin surface #1
    p001 autologous serum #1
    pnonly patients #1
    sensor haptic sensor #1
    124dihydroxycholecalciferol #1
    75 64 #1
    melasma thai females #1
    tewl data devices #1
    cheek seasonal difference #1
    complement psoriasis #1
    topical tretinoin retinoids #1
    schambergs disease #1
    irradiation uvbinduced ros #1
    sudden regression #1
    scarification patch tests #1
    postinflammatory pigmentation #1
    extremities normal cheek #1
    tyrosinemia report #1
    environmental effects functions #1
    tgfbeta1 dcs #1
    idl senile xerosis #1
    moisturizers areas #1
    cornified envelope complement #1
    atopic dermatitis ratio #1
    methoxsalen phototherapy puva #1
    cheek nasolabial fold #1
    chemicals nicl2 #1
    conductance application #1
    maintenance psoriatic lesions #1

    Key People For Stratum Corneum

    Top KOLs in the world
    Peter M Elias
    stratum corneum barrier function atopic dermatitis
    Joke A Bouwstra
    stratum corneum human skin lipid organization
    Howard Ira Maibach
    contact dermatitis percutaneous absorption human skin
    Richard H A Guy
    stratum corneum reverse iontophoresis drug delivery
    Philip W Wertz
    stratum corneum oral mucosa fatty acids
    Donald Talbot Downing
    fatty acids stratum corneum sebum secretion

    Hachiro TAGAMI:Expert Impact

    Concepts for whichHachiro TAGAMIhas direct influence:Stratum corneum,  Atopic dermatitis,  Dendritic cells,  Skin surface,  Contact sensitivity,  Langerhans cells,  Tyrosinase gene,  Hydration state.

    Hachiro TAGAMI:KOL impact

    Concepts related to the work of other authors for whichfor which Hachiro TAGAMI has influence:Atopic dermatitis,  Stratum corneum,  Dendritic cells,  Human skin,  Wound healing,  Transepidermal water loss,  Barrier function.



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    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, JPN | Tohoku University, Sendai, Japan | Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan | Department of Dermatology, Tohoku University S