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    • Kenji Sugibayashi: Influence Statistics

      Kenji Sugibayashi

      Kenji Sugibayashi

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      Faculty of Pharmaceutical Sciences, Josai International University. | Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado 350-0295, ...

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      Kenji Sugibayashi:Expert Impact

      Concepts for whichKenji Sugibayashihas direct influence:Skin permeation,Human skin,Skin concentration,Stratum corneum,Skin permeability,Eyelid skin,Hairless rat,Silicone membrane.

      Kenji Sugibayashi:KOL impact

      Concepts related to the work of other authors for whichfor which Kenji Sugibayashi has influence:Skin permeation,Drug delivery,Stratum corneum,Percutaneous absorption,Penetration enhancers,Molecular weight,Topical application.

      KOL Resume for Kenji Sugibayashi

      Year
      2022

      Faculty of Pharmaceutical Sciences, Josai International University.

      2021

      Graduate School of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, 350-0295, Saitama, Japan

      Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University.

      2020

      Graduate School of Pharmaceutical Sciences, Josai University, Saitama 350-0295, Japan;, (N.A.);, (S.I.);, (H.T.)

      Faculty of Pharmaceutical Sciences, Josai International University; 1 Gumyo, Togane, Chiba 283-8555, Japan;,

      2019

      Laboratory of Pharmaceutics and Cosmeceutics, School of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama 350-0295, Japan

      2018

      Graduate School of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. Electronic address:

      Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan.

      Working Group on Alternatives to Primary Skin Irritation Test, Japanese Society of Alternatives to Animal Experiments (JSAAE).

      2017

      Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan

      2016

      Josai University, Faculty of Pharmaceutical Sciences, Saitama, Japan

      Institute of Bioproduct Development, Universiti Teknologi Malaysia

      2015

      Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado-shi, Saitama 3500295, Japan

      2014

      Life Science Research Center, Josai University

      2013

      Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.

      2012

      Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-0295, Japan

      2011

      Life Science Research Center, Josai University, Saitama, Japan

      Department of Pharmaceutics, Faculty of Pharmaceutical Sciences

      2010

      Research Institute of TTS Technology, Josai University, Sakado, Saitama 350‐0295, Japan

      Faculty of Pharmaceutical Sciences, Josai University, 1‐1 Keyakidai, Sakado, Saitama 350‐0295

      2008

      Department of Pharmaceutics, Hoshi University

      2006

      Faculty of Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, 350-0295, Sakado, Saitama, Japan

      2004

      Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.

      2002

      Faculty of Pharmaceutial Sciences, Josai University

      Research Institute of TTS Technology

      2001

      Research Institute of TTS Technology, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan

      2000

      Faculty of Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, Sakado, Saitama 350-0290, Japan

      1998

      Faculty of Pharmaceutical Sciences, Josai University, 1‐1 Keyakidai, Sakado, Saitama 350‐0290, Japan

      1997

      Life Science Research Center, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-02, Japan

      1996

      Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-02, Japan

      1995

      Faculty of Pharmaceutical Sciences, Josai University, 1-I Keyakidai, Sakado, Saitama 350-02, Japan

      1994

      Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Josai University,SaitamaJapan

      Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyaki-dai, Sakado, 350-02, Saitama, Japan

      1993

      Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Saitama, Japan

      1992

      Faculty of Pharmaceutical Sciences, Josai University, 1–1 Keyakidai, Sakado, Saitama 350–02, Japan

      1991

      Faculty of Pharmaceutical Sciences, Josai University, 1‐1 Keyakidai, Sakado, Saitama 350‐02, Japan

      1989

      Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.

      1985

      Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-02 Japan

      University of Utah, Salt Lake City, UT 84112

      1983

      The First Department of Surgery, School of Medicine, Chiba University, 1-8-1, Inohana, 280, Chiba, (Japan)

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      Sample of concepts for which Kenji Sugibayashi is among the top experts in the world.
      Concept World rank
      stratm dose conditions #1
      lmenthol azone #1
      dermatopharmacokinetics systemic disposition #1
      skin ultrasonication #1
      ethanol enhancing #1
      mtt draize test #1
      dose conditions stratm #1
      stripped skin #1
      ability ivm concentration #1
      500 nmol fad #1
      chemicals artificial membranes #1
      polylarginine nasal absorption #1
      rats niacinamide nicorandil #1
      drug enhancing #1
      lmentholethanol #1
      pore pathway etoh #1
      calcein scll #1
      5ismn psa #1
      chloride electroporation #1
      increasing mge content #1
      solubility preapplied ointment #1
      eperizone hydrochloride #1
      topically applied medicines #1
      applied solutions water #1
      coadministration azone #1
      clearance isosorbide dinitrate #1
      skin 1menthol #1
      cpc mtt #1
      stratum comcum #1
      nitrosoureas methylccnu #1
      skin permeability compounds #1
      diosgenin βcd derivatives #1
      neat oil formulations #1
      halal cosmetics assessment #1
      antibiotics c0 #1
      nonelectrolyte drugs #1
      helium indomethacin #1
      formulation systemic circulation #1
      hairless silicones #1
      logko addition #1
      azidothymidine rats #1
      poly‐l‐lactic acid microspheres #1
      injectable mge formulations #1
      permeability nicorandil #1
      easily metabolizable drug #1
      size bombardment #1
      mtz solution pg #1
      etoh lm #1
      permeation mor #1
      3rs issues #1
      Sign-in to see all concepts, it's free!

      Prominent publications by Kenji Sugibayashi

      KOL-Index: 11546

      Purpose. Simultaneous skin transport and metabolism of ethyl nicotinate (EN), a model drug, were measured and theoretically analyzed.Methods. Several permeation studies of EN or its metabolite nicotinic acid (NA) were done on full-thickness skin or stripped skin with and without an esterase inhibitor. Permeation parameters such as partition coefficient of EN from the donor solution to the stratum corneum and diffusion coefficients of EN and NA in the stratum corneum and the viable ...

      Known for Simultaneous Transport | Ethyl Nicotinate | Hairless Rat Skin | Stratum Corneum | Viable Epidermis
      KOL-Index: 11424

      The effects of the concentration and molecular weight of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of fluorescein isothiocyanate-labeled dextran (MW, 4 kDa, FD-4) in rats were studied. When poly-L-Arg with a range of different molecular weights (MW, 8.9, 45.5 and 92.0 kDa) was applied intranasally at various concentrations, the bioavailability (F(0-9 h)) of FD-4 increased with the increasing concentration of poly-L-Arg. The enhanced absorption was also dependent on the ...

      Known for Molecular Weight | Nasal Absorption | Poly Arg | Fluorescein Isothiocyanate | Effects Concentration
      KOL-Index: 10958

      Bucolome, a nonsteroidal anti-inflammatory drug, has often been coadministered to patients who take warfarin as an anticoagulant. This combination increases the anticoagulant effect, which is most likely due to the interaction of bucolome with the pharmacokinetics (PK) or pharmacodynamics (PD) of warfarin. More than 30 years ago the mechanism of this interaction was reported to be inhibition of warfarin protein binding by bucolome, and the inhibition of warfarin metabolism by bucolome ...

      Known for Bucolome Warfarin | Drug Therapy | Combination Female | Pharmacokinetic Pharmacodynamic | Patient Variation
      KOL-Index: 10679

      PurposeTo calculate the skin concentration of active ingredients in cosmetics and topical pharmaceuticals using silicone membrane permeation.MethodsA series of parabens were used as model ingredients. Skin concentration of parabens was calculated using silicone membrane permeability. Their partition coefficient from formulations to the silicone membrane was determined by the membrane permeation profiles, and used to calculate their silicone membrane concentration, under an assumption ...

      Known for Skin Concentration | Silicone Membrane | Active Ingredients | Observed Values | Rats Hairless
      KOL-Index: 10198

      Several cationic compounds were screened as potential nasal absorption enhancers to increase intranasal absorption of a model drug, fluorescein isothiocyanate labeled dextran (MW 4.4 kDa, FD-4), without nasal membrane damage in rats. Their effects were compared with those of classical enhancers. Various cationic compounds (poly-L-arginines with different molecular weights (MW 8.9, 45.5 and 92.0 kDa, poly-L-Arg (10), (50) and (100), respectively), L-arginine (L-Arg), L-lysine (L-Lys), and ...

      Known for Absorption Enhancer | Nasal Drug | Cationic Compounds | Poly Arg | Mucosa Peptides
      KOL-Index: 9405

      A combination of microneedle pretreatment and iontophoresis was evaluated for the potential to increase skin permeation of drugs. Two model compounds with low and high molecular D(2)O and fluorescein isothiocyanate (FITC)-dextrans (FD-4, FD-10, FD-40, FD-70 and FD-2000; average molecular weight of 3.8, 10.1, 39.0, 71.2 and 200.0 kDa), respectively, were used and the effect of microneedle pretreatment and iontophoresis on their in vitro permeability was evaluated using excised hairless ...

      Known for Microneedle Pretreatment | Skin Permeation | Combination Iontophoresis | Molecular Compounds | Fluorescein Isothiocyanate
      KOL-Index: 9180

      An in vitro permeation study of ethyl nicotinate (EN) was carried out using excised hairless rat skin, and simultaneous skin transport and metabolism of the drug were kinetically followed. Fairly good steady-state fluxes of EN and its metabolite nicotinic acid (NA) through the skin were obtained after a short lag time for all the concentrations of EN applied. These steady-state fluxes were not proportional to the initial donor concentration of EN: EN and NA curves were concave and ...

      Known for Ethyl Nicotinate | Topical Application | Simultaneous Transport | Hairless Rat Skin | Enzyme Distribution
      KOL-Index: 9131

      The objectives of the present study are to clarify the relationship between the physicochemical properties and the nail permeability of drugs through human nail plates. Homologous p-hydroxybenzoic acid esters were used to investigate the relationship between the octanol/water partition coefficient and the permeability coefficient of several drugs. The nail permeability was found to be independent of the lipophilicity of a penetrating drug. However, the nail permeability of several model ...

      Known for Nail Permeability | Physicochemical Properties | Drug Permeation | Fungal Infections | Molecular Weight
      KOL-Index: 8932

      The stability of flavin adenin dinucleotide (FAD) in plasma was studied under a low-intensity light and FAD was found to be converted to flavin mononucleotide (FMN) and riboflavin (RF) in both human and rat plasma. The hydrolysis rates of FAD in plasma at 4 degrees C were lower than those at 37 degrees C. In addition, the hydrolysis rates were markedly inhibited when EDTA, known as an anticoagulant, was added to plasma. These results indicated that plasma samples in pharmacokinetic ...

      Known for Fad Fmn | Flavin Mononucleotide | Intravenous Administration | Adenine Dinucleotide | Plasma Samples
      KOL-Index: 8927

      A predictive method for skin permeability of drugs from polyethylene glycol 400 (PEG)-water and ethanol (EtOH)-water binary solvents is proposed. The method is based on a permeation model, in which the stratum corneum is assumed to be a membrane having two parallel permeation pathways: lipid and pore pathways. Skin permeability of several drugs with a variety of physicochemical properties from various PEG-water and EtOH-water solvents was tested. In PEG-water solvents, almost the same ...

      Known for Skin Permeability | Polyethylene Glycol | Lipophilic Drugs | Etoh Water | Pore Pathway
      KOL-Index: 8884

      The species difference in skin permeability, Kp, of nicorandil was determined by using excised skin samples from hairless mouse, hairless rat, guinea-pig, dog, pig, and human. The Kp value of nicorandil in hairless mice was the greatest among the six species, and those in pigs and humans were in good agreement. To clarify the reasons for the species difference, various skin characteristics in each species were measured. It was suggested that the difference of skin surface lipids in each ...

      Known for Species Difference | Percutaneous Absorption | Vitro Techniques | Hairless Mice | Skin Permeability
      KOL-Index: 8879

      The cytochrome P450 (CYP) isoforms that catalyze the oxidation metabolism of 6-methoxy-2-napthylacetic acid (6-MNA), an active metabolite of nabumetone, were studied in rats and humans. Using an extractive reversed-phase HPLC assay with fluorescence detection, monophasic Michaelis-Menten kinetics was obtained for the formation of 6-hydroxy-2-naphthylacetic acid (6-HNA) in liver microsomes of rats and humans, and kinetic analysis showed that the K(m) and V(max) values for the formation of ...

      Known for Active Metabolite | Cytochrome P450 | Prodrug Nabumetone | Liver Microsomes | Napthylacetic Acid
      KOL-Index: 8837

      Pressure sensitive adhesive (PSA) matrices containing amorphous ketotifen were prepared and evaluated for enhanced skin permeability of the drug. A solvent casting method using silicone-typed PSA was employed, and n-hexane, an original solvent for the PSA and one more solvent, dichloromethane, tetrahydrofuran, acetone, ethyl acetate or toluene, were used for complete dissolution of ketotifen and high dispersion in an amorphous state of the drug. Presence of the amorphous form was judged ...

      Known for Skin Permeation | Amorphous Form | Ketotifen Supersaturation | Drug Psa | Steady State

      Key People For Skin Permeation

      Top KOLs in the world
      #1
      Richard H A Guy
      stratum corneum reverse iontophoresis drug delivery
      #2
      Brian William Barry
      human skin stratum corneum penetration enhancers
      #3
      Jonathan Hadgraft
      percutaneous absorption stratum corneum human skin
      #4
      Kenji Sugibayashi
      skin permeation stratum corneum molecular weight
      #5
      Adrian C Williams
      human skin stratum corneum penetration enhancers
      #6
      Howard Ira Maibach
      contact dermatitis percutaneous absorption human skin

      Faculty of Pharmaceutical Sciences, Josai International University. | Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado 350-0295, Saitama, Japan;, gkd1902@josai.ac.jp, (A.O.);, gkm2118@josai.ac.jp, (R.N.);, yino

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