Prominent publications by Koko Murakami
Recruitment of osteoclast precursors by stromal cell derived factor‐1 (SDF‐1) in giant cell tumor of bone
[ PUBLICATION ]
Giant cell tumor (GCT) of bone is a unique bone lesion that is characterized by an excessive number of multinucleated osteoclasts. GCT consists of neoplastic stromal cells, multinucleated osteoclasts and their precursors, thus serving as a naturally occurring human disease model for the study of osteoclastogenesis. It still remains unclear how stromal cells of GCT recruit osteoclast precursors. In the present study, we characterized the cellular components of GCT and confirmed the ...
|Also Ranks for: Osteoclast Precursors | stromal cell | gct bone | chemokine cxcl12 | humans immunohistochemistry|
Little information exists on the molecular and biochemical pathophysiology of subacromial bursitis and rotator cuff disease. We investigated the pattern of expression of cytokines (interleukin [IL]-1beta, IL-1, IL-6, tumor necrosis factor [TNF] alpha, small inducible cytokines), metalloproteases, and cyclooxygenases in the subacromial bursa in patients with rotator cuff disease. Subacromial bursa specimens were prepared for molecular and biochemical analysis in patients undergoing ...
|Also Ranks for: Rotator Cuff Disease | subacromial bursitis | gene expression | shoulder surgery | microarray analysis|
Stromal cell‐derived factor 1 (SDF‐1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti‐inflammatory agents
[ PUBLICATION ]
Several studies have demonstrated that inflammation in the subacromial bursa is an important component in the pathogenesis of impingement syndrome. We have demonstrated in a previous study that many inflammatory cytokines, including stromal cell-derived factor 1 (SDF-1, CXCL12), are increased in the subacromial bursa [Blaine et al. 2005. J Shoulder Elbow Surg 14(Suppl 1):84S-89S]. SDF-1 is a potent chemotactic and angiogenic factor that stimulates recruitment of inflammatory cells. In ...
|Also Ranks for: Subacromial Bursa | sdf1 expression | stromal cell | factor 1 | cultured chemokine|
Key People For Rotator Cuff Disease
Koko Murakami:Expert Impact
Concepts for whichKoko Murakamihas direct influence:Rotator cuff disease, Subacromial bursitis, Osteoclast precursors, Stromal cell, Patients subacromial bursitis, Subacromial bursa patients, Sdf1 subacromial bursa, Subacromial bursa.
Koko Murakami:KOL impact
Concepts related to the work of other authors for whichfor which Koko Murakami has influence:Rotator cuff, Giant cell tumor, Subacromial bursa, Shoulder pain, Zoledronic acid, Stromal cells, Bone gctb.
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