Prominent publications by Koko Murakami

KOL Index score: 9625

Giant cell tumor (GCT) of bone is a unique bone lesion that is characterized by an excessive number of multinucleated osteoclasts. GCT consists of neoplastic stromal cells, multinucleated osteoclasts and their precursors, thus serving as a naturally occurring human disease model for the study of osteoclastogenesis. It still remains unclear how stromal cells of GCT recruit osteoclast precursors. In the present study, we characterized the cellular components of GCT and confirmed the ...

Also Ranks for: Osteoclast Precursors |  stromal cell |  gct bone |  chemokine cxcl12 |  humans immunohistochemistry
KOL Index score: 8607

Little information exists on the molecular and biochemical pathophysiology of subacromial bursitis and rotator cuff disease. We investigated the pattern of expression of cytokines (interleukin [IL]-1beta, IL-1, IL-6, tumor necrosis factor [TNF] alpha, small inducible cytokines), metalloproteases, and cyclooxygenases in the subacromial bursa in patients with rotator cuff disease. Subacromial bursa specimens were prepared for molecular and biochemical analysis in patients undergoing ...

Also Ranks for: Rotator Cuff Disease |  subacromial bursitis |  gene expression |  shoulder surgery |  microarray analysis
KOL Index score: 7498

Several studies have demonstrated that inflammation in the subacromial bursa is an important component in the pathogenesis of impingement syndrome. We have demonstrated in a previous study that many inflammatory cytokines, including stromal cell-derived factor 1 (SDF-1, CXCL12), are increased in the subacromial bursa [Blaine et al. 2005. J Shoulder Elbow Surg 14(Suppl 1):84S-89S]. SDF-1 is a potent chemotactic and angiogenic factor that stimulates recruitment of inflammatory cells. In ...

Also Ranks for: Subacromial Bursa |  sdf1 expression |  stromal cell |  factor 1 |  cultured chemokine

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Koko Murakami:Expert Impact

Concepts for whichKoko Murakamihas direct influence:Rotator cuff disease,  Subacromial bursitis,  Osteoclast precursors,  Stromal cell,  Patients subacromial bursitis,  Subacromial bursa patients,  Sdf1 subacromial bursa,  Subacromial bursa.

Koko Murakami:KOL impact

Concepts related to the work of other authors for whichfor which Koko Murakami has influence:Rotator cuff,  Giant cell tumor,  Subacromial bursa,  Shoulder pain,  Zoledronic acid,  Stromal cells,  Bone gctb.



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Center for Orthopaedic Research and Columbia University Center for Shoulder, Elbow, and Sports Medicine, Columbia University, New York, New York | Center for Orthopaedic Research, Department of Orthopaedic Surgery, Columbia University, 622 W. 168th S