KOL | Peter John KirkpatrickDepartment of Neurosurgery, Cambridge University Hospital, United Kingdom (C.T., P.K.). | Department of Neurosurgery, Cambridge University Hospital, Hills Road, Box 166, ... |
KOL Resume for Peter John Kirkpatrick
| Year | |
|---|---|
| 2021 | Department of Neurosurgery, Cambridge University Hospital, United Kingdom (C.T., P.K.). |
| 2019 | Department of Neurosurgery, Cambridge University Hospital, Hills Road, Box 166, CB20QQ, Cambridge, UK |
| 2018 | From the Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, United Kingdom (N.N., M.C., K.B., X.L., J.D., P.K., C.H., P.S.). Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK. |
| 2017 | Academic Division of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK |
| 2016 | University of Cambridge, Cambridge, United Kingdom |
| 2015 | Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom |
| 2014 | Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke’s Hospital, University of Cambridge, Hills Road, CB2 0QQ, Cambridge, UK |
| 2013 | Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, UK |
| 2012 | Division of Neurosurgery, Addenbrooke’s Hospital & University of Cambridge, Cambridge, UK Department of Neurosurgery |
| 2011 | Academic Neurosurgery Unit, Addenbrooke’s Hospital, Box167, CB20QQ, Cambridge, UK Division of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom, . Neurosurgical Unit, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom |
| 2010 | From the Academic Neurosurgical Unit (C.Z., G.C., M.C., E.C., P.J.K., J.D.P., P.S.), University of Cambridge Clinical School, Cambridge, UK; and the Department of Anesthesiology and Critical Care Medicine (K.M.B.), Johns Hopkins Hospital, Baltimore, Md. Department of Clinical Neurosciences, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK |
| 2009 | Department of Clinical Neurosciences, Neurosurgery Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK Division of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom, . |
| 2008 | Departments of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK Academic Neurosurgery Unit Cambridge, England |
| 2007 | Academic Neurosurgery Unit, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK |
| 2006 | European Brain Injury Consortium, Cambridge, UK University Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, England (Al-Rawi, Turner, Kirkpatrick) Academic Department of Neurosurgery and Department of Clinical Pharmacology, Addenbrooke’s Hospital, Cambridge, United Kingdom |
| 2005 | From the Academic Department of Neurosurgery (C.L.T., P.J.K.), Addenbrooke’s Hospital, Cambridge, UK; Department of Neuroradiology (J.N.P.H.), Cambridge, UK; Departments of Neuroradiology (A.G.) and Neurosurgery (A.D.M.), Newcastle, UK; Departments of Neuroradiology (A.J.M.) and Neurosurgery (R.S.C.K.), Oxford, UK; and Department of Neuroradiology (S.C.), Oldchurch Hospital, Romford, UK. Department of Radiology, Addenbrooke's Hospital and the University of Cambridge, Cambridge, United Kingdom Academic Neurosurgery Unit, Addenbrooke's Hospital, Cambridge, UK |
| 2004 | Academic Department of Neurosurgery, Addenbrooke’s Hospital, CB2 2QQ, Cambridge, UK From the University Department of Radiology, Addenbrooke’s Hospital, Cambridge, United Kingdom. Neuroscience Critical Care Unit, and Department of Anaesthesia, University of Cambridge, Cambridge, England |
Peter John Kirkpatrick: Influence Statistics
| Concept | World rank |
|---|---|
| intracranial oxygenation | #1 |
| carotid angioplasty cap | #1 |
| stenosis svi | #1 |
| aneurysms control volunteers | #1 |
| snr pdw images | #1 |
| carotid frontal | #1 |
| srs machine | #1 |
| snr 15 3 | #1 |
| complete onp | #1 |
| intraoptode distances presence | #1 |
| 18f fluorodeoxyglucose positron | #1 |
| trigeminal neuralgia differences | #1 |
| niro 300 | #1 |
| moderate refilling sensitivity | #1 |
| 89 dsa | #1 |
| lesion endarterectomy | #1 |
| srs machine potential | #1 |
| backgroundthe surgical risk | #1 |
| grade sah outcome | #1 |
| deltasi uspioenhanced mri | #1 |
| outcome sahit model | #1 |
| reduction uspio | #1 |
| mortality surgical evacuation | #1 |
| dextrans atorvastatin therapy | #1 |
| decrease lactatepyruvate ratio | #1 |
| 6 months crystalloids | #1 |
| demonstrable relationship inflammation | #1 |
| focal pathology correlation | #1 |
| range 31 608 | #1 |
| cpb srs | #1 |
| brain focal pathology | #1 |
| spectroscopy adult | #1 |
| 6276 kpa | #1 |
| direct arteriotomy | #1 |
| drains recurrence | #1 |
| maximal predicted stresses | #1 |
| patch direct closure | #1 |
| dextrans carotid arteries | #1 |
| multiparameter sensor areas | #1 |
| sjvo2 areas | #1 |
| reduction uspiodefined inflammation | #1 |
| carotid atheroma vivo | #1 |
| territory compromise | #1 |
| response intracranial aneurysm | #1 |
| versus drains | #1 |
| illness hypertonic severity | #1 |
| uspiodefined inflammation | #1 |
| analysis contrastenhanced angiography | #1 |
| nonrandomized literature | #1 |
| fourmonth ultrasound assessment | #1 |
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Prominent publications by Peter John Kirkpatrick
Timing of surgery for supratentorial aneurysmal subarachnoid haemorrhage: report of a prospective study
[ PUBLICATION ]
OBJECTIVES: The debate on the timing of aneurysm surgery after subarachnoid haemorrhage (SAH) pivots on the balance of the temporal risk for fatal rebleeding versus the risk of surgical morbidity when operating early on an acutely injured brain. By following a strict management protocol for SAH, the hypothesis has been tested that in the modern arena of treatment for aneurysmal SAH the timing of surgery to secure supratentorial aneurysms does not affect surgical outcome.
METHODS: Over a ...
| Known for Timing Surgery | Subarachnoid Haemorrhage | Patients Sah | Surgical Outcome | 6 Months |
OBJECTIVE: Cerebrovascular vasomotor reactivity reflects changes in smooth muscle tone in the arterial wall in response to changes in transmural pressure or the concentration of carbon dioxide in blood. We investigated whether slow waves in arterial blood pressure (ABP) and intracranial pressure (ICP) may be used to derive an index that reflects the reactivity of vessels to changes in ABP.
METHODS: A method for the continuous monitoring of the association between slow spontaneous waves ...
| Known for Head Injury | Abp Icp | Continuous Assessment | Cerebral Vasomotor | Slow Waves |
OBJECTIVES: The aim of this study was to evaluate the effects of low-dose (10 mg) and high-dose (80 mg) atorvastatin on carotid plaque inflammation as determined by ultrasmall superparamagnetic iron oxide (USPIO)-enhanced carotid magnetic resonance imaging (MRI). The hypothesis was that treatment with 80 mg atorvastatin would demonstrate quantifiable changes in USPIO-enhanced MRI-defined inflammation within the first 3 months of therapy.
BACKGROUND: Preliminary studies indicate that ...
| Known for Atorvastatin Therapy | Magnetic Resonance | Iron Oxide | 12 Weeks | Plaque Inflammation |
OBJECTIVE: Cerebral critical closing pressure (CCP) has been defined as an arterial pressure threshold below which arterial vessels collapse. Hypothetically this is equal to intracranial pressure (ICP) plus the contribution from the active tone of cerebral arterial smooth muscle. The correlation of CCP with ICP, cerebral autoregulation, and other clinical and haemodynamic modalities in patients with head injury was evaluated.
METHOD: intracranial pressure, arterial blood pressure (ABP) ...
| Known for Critical Closing Pressure | Cerebrovascular Circulation | Ccp Icp | Cerebral Autoregulation | Head Injury |
Jugular bulb oximetry is the most widely used method of monitoring cerebral oxygenation. More recently, measurement of brain tissue oxygenation has been reported in head-injured patients. We compared the changes in brain tissue oxygen partial pressure (PbO2) with changes in jugular venous oxygen saturation (SjVO2) in response to hyperventilation in areas of brain with and without focal pathology. Thirteen patients with severe head injuries were studied. A multiparameter sensor was ...
| Known for Brain Tissue | Cerebral Oxygenation | Jugular Venous | Multiparameter Sensor | Monitoring Patients |
Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography.
[ PUBLICATION ]
OBJECT: The authors studied the reliability of a new method for noninvasive assessment of cerebral perfusion pressure (CPP) in head-injured patients in which mean arterial blood pressure (ABP) and transcranial Doppler middle cerebral artery mean and diastolic flow velocities are measured.
METHODS: Cerebral perfusion pressure was estimated (eCPP) over periods of continuous monitoring (20 minutes-2 hours, 421 daily examinations) in 96 head-injured patients (Glasgow Coma Scale score < 13) ...
| Known for Noninvasive Assessment | Cerebral Perfusion Pressure | Doppler Ultrasonography | Cpp Ecpp | Injured Patients |
Continuous monitoring of cerebrovascular pressure reactivity in patients with head injury.
[ PUBLICATION ]
OBJECT: Cerebrovascular pressure reactivity is the ability of cerebral vessels to respond to changes in transmural pressure. A cerebrovascular pressure reactivity index (PRx) can be determined as the moving correlation coefficient between mean intracranial pressure (ICP) and mean arterial blood pressure.
METHODS: The authors analyzed a database consisting of 398 patients with head injuries who underwent continuous monitoring of cerebrovascular pressure reactivity. In 298 patients, the ...
| Known for Pressure Reactivity | Continuous Monitoring | Head Injury | Optimal Cpp | Physiologic Ultrasonography |
Effect of Hypertonic Saline on Cerebral Blood Flow in Poor-Grade Patients With Subarachnoid Hemorrhage
[ PUBLICATION ]
BACKGROUND AND PURPOSE: The goal of this study was to examine the effects of hypertonic saline on cerebral blood flow (CBF) in poor-grade patients with subarachnoid hemorrhage.
METHODS: We administered 23.5% hypertonic saline (2 mL/kg IV) 1 time to 10 patients, 2 times to 7 patients, and 3 times to 1 patient. All patients had transcranial Doppler (TCD), intracranial pressure (ICP) monitoring, and analysis of serum sodium and osmolality; 6 had xenon CT (XeCT). Data were used to ...
| Known for Subarachnoid Hemorrhage | Hypertonic Saline | Cerebral Blood Flow | Cpp Icp | Grade Patients |
BACKGROUND AND PURPOSE: Statins may improve cerebral vasomotor reactivity through cholesterol-dependent and -independent mechanisms. A phase II randomized controlled trial was conducted to examine the hypothesis that acute pravastatin treatment could improve cerebrovascular autoregulation and reduce vasospasm-related complications after aneurysmal subarachnoid hemorrhage (SAH).
METHODS: A total of 80 aneurysmal SAH (aSAH) patients (18 to 84 years of age) within 72 hours from the ictus ...
| Known for Acute Treatment | Cerebral Vasospasm | Ischemic Deficits | Aneurysmal Subarachnoid | Impaired Autoregulation |
Detection and evaluation of intracranial aneurysms with 16-row multislice CT angiography
[ PUBLICATION ]
AIM: The aim of this study was to assess the usefulness of 16-row multislice CT angiography (CTA) in evaluating intracranial aneurysms, by comparison with conventional digital subtraction angiography (DSA) and intraoperative findings.
METHODS: A consecutive series of 57 patients, scheduled for DSA for suspected intracranial aneurysm, was prospectively recruited to have CTA. This was performed with a 16-detector row machine, detector interval 0.75 mm, 0.5 rotation/s, table speed ...
| Known for Intracranial Aneurysms | Dsa Cta | Sensitivity Specificity | Row Multislice | Intraoperative Findings |
Monitoring cerebral autoregulation after head injury. Which component of transcranial Doppler flow velocity is optimal?
[ PUBLICATION ]
BackgroundCerebral autoregulation assessed using transcranial Doppler (TCD) mean flow velocity (FV) in response to various physiological challenges is predictive of outcome after traumatic brain injury (TBI). Systolic and diastolic FV have been explored in other diseases. This study aims to evaluate the systolic, mean and diastolic FV for monitoring autoregulation and predicting outcome after TBI.Methods300 head-injured patients with blood pressure (ABP), intracranial pressure (ICP), ...
| Known for Transcranial Doppler | Cerebral Autoregulation | Flow Velocity | Cpp Abp | Head Injury |
Predictive value of initial clinical status, intracranial pressure and transcranial Doppler pulsatility after subarachnoid haemorrhage
[ PUBLICATION ]
Background. We examined the predictive value of initial clinical status, mean arterial blood pressure (MABP), intracranial pressure (ICP) and transcranial Doppler (TCD)-derived pulsatility and resistance indices for outcome and quality of life one year following aneurysmal subarachnoid haemorrhage (SAH).Method. Neuromonitoring was performed in 29 patients following clipping or coiling of an aneurysm. Mean arterial blood pressure was measured in the radial artery and intracranial pressure ...
| Known for Intracranial Pressure | Transcranial Doppler | Subarachnoid Haemorrhage | Gosling Pulsatility | Glasgow Outcome |
Increases in GABA concentrations during cerebral ischaemia: a microdialysis study of extracellular amino acids
[ PUBLICATION ]
OBJECTIVES: Increases in the extracellular concentration of the excitatory amino acids glutamate and aspartate during cerebral ischaemia in patients are well recognised. Less emphasis has been placed on the concentrations of the inhibitory amino acid neurotransmitters, notably gamma-amino-butyric acid (GABA), despite evidence from animal studies that GABA may act as a neuroprotectant in models of ischaemia. The objective of this study was to investigate the concentrations of various ...
| Known for Cerebral Ischaemia | Amino Acids | Head Injury | Microdialysis Study | Subarachnoid Haemorrhage |
Microdialysis continuously monitors the chemistry of a small focal volume of the cerebral extracellular space. Conversely, positron emission tomography (PET) establishes metabolism of the whole brain, but only for the duration of the scan. The objective of this study was to apply both techniques to head-injured patients simultaneously to assess the relation between microdialysis (glucose, lactate, lactate/pyruvate [L/P] ratio, and glutamate) and PET (cerebral blood flow [CBF], cerebral ...
| Known for Cerebral Blood Flow | Head Injury | Combined Microdialysis | Positron Emission | Tomography Study |
Key People For Subarachnoid Hemorrhage
Peter John Kirkpatrick:Expert Impact
Concepts for whichPeter John Kirkpatrickhas direct influence:Subarachnoid hemorrhage, Cerebral autoregulation, Decompressive craniectomy, Subarachnoid haemorrhage, Carotid endarterectomy, Intracranial pressure, Head injury, Traumatic brain injury.
Peter John Kirkpatrick:KOL impact
Concepts related to the work of other authors for whichfor which Peter John Kirkpatrick has influence:Subarachnoid hemorrhage, Traumatic brain injury, Decompressive craniectomy, Intracranial pressure, Cerebral autoregulation, Infrared spectroscopy, Blood flow.
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