• Disease
  • Status
  • Status Epilepticus
  • Solomon L Moshe´

    Prominent publications by Solomon L Moshe´

    KOL Index score: 14239

    In adult rats, intraperitoneal administration of kainic acid, a glutamic acid analog and potent neurotoxin, induces persistent seizure activity that results in electrographic alterations and neuropathology that closely resemble human temporal lobe epilepsy. We used in situ hybridization to identify regions of altered glutamate and GABAA receptor gene expression following kainate-induced status epilepticus. In the CA3/CA4 area, the hippocampal region most vulnerable to neurodegeneration ...

    Also Ranks for: Situ Hybridization |  gabaa receptor |  status epilepticus |  dentate gyrus |  messenger rats
    KOL Index score: 14066

    The concept of epilepsy syndromes, introduced in 1989, was defined as "clusters of signs and symptoms customarily occurring together". Definition of epilepsy syndromes based on electro-clinical features facilitated clinical practice and, whenever possible, clinical research in homogeneous groups of patients with epilepsies. Progress in the fields of neuroimaging and genetics made it rapidly clear that, although crucial, the electro-clinical description of epilepsy syndromes was not ...

    Also Ranks for: Epilepsy Syndromes |  classification epilepsies |  task force |  ilae neurophysiology |  clinical practice concept
    KOL Index score: 14000

    Seizures cause a persistent enhancement in dentate synaptic inhibition concurrent with, and possibly compensatory for, seizure-induced hippocampal hyperexcitability. To study this phenomenon, we evoked status epilepticus in rats with systemic kainic acid (KA), and 2 weeks later assessed granule cell inhibition with paired-pulse stimulation of the perforant path (PP) in vitro. Controls demonstrated three components of paired-pulse inhibition: early inhibition (10-30 msec), intermediate ...

    Also Ranks for: Gabab Receptors |  dentate gyrus |  kainic acid |  induced seizures |  gaba release
    KOL Index score: 13973

    Several loci and candidate genes for epilepsies or epileptic syndromes map or have been suggested to map to chromosome 8. We investigated families with adolescent-onset idiopathic generalized epilepsy (IGE), for linkage to markers spanning chromosome 8. The IGEs that we studied included juvenile myoclonic epilepsy (JME), epilepsy with only generalized tonic-clonic seizures occurring either randomly during the day (random grand mal) or on awakening (awakening grand mal), and juvenile ...

    Also Ranks for: Genetic Heterogeneity |  generalized epilepsies |  myoclonic epilepsy |  lod score |  linkage chromosome
    KOL Index score: 13548

    Evidence for genetic influences in epilepsy is strong, but reports identifying specific chromosomal origins of those influences conflict. One early study reported that human leukocyte antigen (HLA) markers were genetically linked to juvenile myoclonic epilepsy (JME); this was confirmed in a later study. Other reports did not find linkage to HLA markers. One found evidence of linkage to markers on chromosome 15, another to markers on chromosome 6, centromeric to HLA. We identified ...

    Also Ranks for: Maternal Inheritance |  linkage evidence |  juvenile myoclonic |  chromosome 6 |  gene searches
    KOL Index score: 13461

    GABA(A) receptor activation by muscimol has sex and age specific effects on substantia nigra reticulata (SNR)-mediated control of generalized seizures. GABA(A) receptor agonists depolarize or hyperpolarize neurons depending upon the level of expression of the neuronal specific potassium chloride contransporter KCC2. We studied KCC2 mRNA expression in the SNR as a function of sex and age and correlated KCC2 expression with the in vivo and in vitro effects of muscimol. Methods included in ...

    Also Ranks for: Kcc2 Expression |  gabaa receptor |  muscimol snr neurons |  sex age |  messenger rats
    KOL Index score: 12680

    The purpose of this study was to investigate the effects of prenatal exposure to morphine (5-10 mg/kg on days 11-18 of gestation) on flurothyl seizure susceptibility in adult and developing male rats. In adult rats, prenatal morphine exposure increased the threshold to clonic seizures but not to tonic-clonic seizures. The effects of prenatal morphine exposure on clonic seizures were age dependent. At postnatal day (PND) 15, prenatal drug exposure did not alter the seizure threshold. At ...

    Also Ranks for: Male Rats |  prenatal morphine exposure |  clonic seizures |  seizure susceptibility |  induces age
    KOL Index score: 12394

    Gonadal hormones are important regulators of sexual differentiation of the CNS. Exposure to testosterone and estrogen during development causes permanent organizational differences between males and females. We previously described functional sex-related differences of the GABA(A)ergic circuits of the rat substantia nigra pars reticulata (SNR) involved in the control of flurothyl seizures. This sexual differentiation of the SNR is regulated by postnatal testosterone. To assess whether ...

    Also Ranks for: Estrogen Receptor |  rat substantia |  sexual differentiation |  snr postnatal testosterone |  eralpha erbeta
    KOL Index score: 12354

    The substantia nigra GABAergic system is considered important for the modification of seizures. Our previous studies have shown that, in rat pups, nigral infusions of baclofen suppressed flurothyl-induced seizures. In the present study, we determined, in rat pups, the effect of nigral infusions of gamma-vinyl-GABA (GVG) on clonic-tonic seizures induced by flurothyl, generated a dose-response curve of the GVG effect and investigated the possible role of the nigral GABAA receptor in ...

    Also Ranks for: Rat Pups |  substantia nigra |  gabaa receptor |  anticonvulsant gvg |  bicuculline muscimol
    KOL Index score: 12118

    The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy. Generalized and focal are redefined for seizures as occurring in and rapidly engaging bilaterally distributed networks (generalized) and within networks limited to one hemisphere and either discretely localized or more widely distributed (focal). Classification of generalized seizures is simplified. ...

    Also Ranks for: Ilae Commission |  classification terminology |  seizures epilepsies |  electroclinical syndromes |  forms epilepsy
    KOL Index score: 11964

    PURPOSE: Febrile status epilepticus (FSE) has been associated with hippocampal injury and subsequent hippocampal sclerosis (HS) and temporal lobe epilepsy. The FEBSTAT study was designed to prospectively examine the association between prolonged febrile seizures and development of HS and associated temporal lobe epilepsy, one of the most controversial issues in epilepsy. We report on the baseline phenomenology of the final cohorts as well as detailed aims and methodology.

    METHODS: The ...

    Also Ranks for: Febstat Study |  development epilepsy |  febrile seizure |  baseline 1 year |  emergency department
    KOL Index score: 11961

    Seizures in adult rats result in long-term deficits in learning and memory, as well as an enhanced susceptibility to further seizures. In contrast, fewer lasting changes have been found following seizures in rats younger than 20 days old. This age-dependency could be due to differing amounts of hippocampal neuronal damage produced by seizures at different ages. To determine if there is an early developmental resistance to seizure-induced hippocampal damage, we compared the effects of ...

    Also Ranks for: Status Epilepticus |  immature hippocampus |  adult rats |  kainic acid |  induced seizures
    KOL Index score: 11907

    GABAergic (gamma-aminobutyric acid) transmission in the substantia nigra pars reticulata (SNR) is critical for seizure control. The SNR effects on seizures are site-specific within the SNR and developmentally regulated. These age- and site-specific effects may be due to differential regional distribution and functionality of SNR GABA(A) receptor sites. We investigated the role of GABA/benzodiazepine (BZD) receptors in the SNR in the control of seizures as a function of age. In adult ...

    Also Ranks for: Seizures Snr |  spraguedawley receptors |  age specific |  substantia nigra |  seizure control
    KOL Index score: 11855

    The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure types, and to adopt more transparent names. Because current knowledge is insufficient to form a scientifically based classification, the 2017 Classification is operational ...

    Also Ranks for: Seizure Types |  international league |  operational classification |  position paper |  ilae commission
    KOL Index score: 11815

    PURPOSE: In a prospective study, Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT), we determined the frequency of human herpesvirus (HHV)-6 and HHV-7 infection as a cause of febrile status epilepticus (FSE).

    METHODS: Children ages 1 month to 5 years presenting with FSE were enrolled within 72 h and received a comprehensive assessment including specimens for HHV-6 and HHV-7. The presence of HHV-6A, HHV-6B, or HHV-7 DNA and RNA (amplified across a spliced junction) ...

    Also Ranks for: Human Herpesvirus |  febrile status epilepticus |  febstat study |  primary infection |  children fse


    Solomon L Moshe´: Influence Statistics

    Sample of concepts for which Solomon L Moshe´ is among the top experts in the world.
    Concept World rank
    proconvulsant effects muscimol #1
    snr spraguedawley receptors #1
    design spasms #1
    stimulation snr region #1
    seizures stn stimulation #1
    spc amygdala #1
    fse febrile seizure #1
    snr effects seizures #1
    groups aspartame administration #1
    epilepsy syndrome papers #1
    subthalamic nucleus seizures #1
    age 16 17 #1
    kindled pups #1
    postnatal day seizures #1
    consequences status epilepticus #1
    circuitry modification #1
    anticonvulsant effects doses #1
    febstat children #1
    8507 titles #1
    epilepsy autismepilepsy phenotype #1
    inhalation flurothyl ether #1
    γ2l subunit snr #1
    intensity postictal refractoriness #1
    febrile 11 #1
    neurodevelopmental decline #1
    behavioral manifestations seizures #1
    hippocampal slices 15 #1
    males consequences #1
    review animal data #1
    pathophysiology autisms #1
    pattern absence seizures #1
    seizures inhalation #1
    reticulata clonic seizures #1
    psychological surveys anticonvulsants #1
    biologic experiential factors #1
    agespecific seizure patterns #1
    snr p15 #1
    mri abnormality risk #1
    hybridization grains subunits #1
    infusions bicuculline #1
    restriction structures #1
    intranigral gabaergic #1
    limbic kindling rats #1
    nigra gabaa #1
    seizures effects #1
    fse cytokine levels #1
    spasms laboratory evidence #1
    snr microinfusions zolpidem #1
    seizures microinfusions #1
    rational neuroprotective agents #1

    Key People For Status Epilepticus

    Top KOLs in the world
    Daniel H Lowenstein
    status epilepticus dentate gyrus novo mutations
    David Michael Treiman
    status epilepticus antiepileptic drugs human hippocampus
    Simon D Shorvon
    status epilepticus patients epilepsy united kingdom
    Robert John DeLorenzo
    status epilepticus hippocampal neurons acquired epilepsy
    John M Pellock
    status epilepticus febrile seizures valproic acid
    Shlomo Shinnar
    status epilepticus febrile seizures unprovoked seizure

    Solomon L Moshe´:Expert Impact

    Concepts for whichSolomon L Moshe´has direct influence:Status epilepticus,  Substantia nigra,  Infantile spasms,  Febrile status epilepticus,  Epilepsy syndromes,  Task force,  Flurothyl seizures,  Febrile status.

    Solomon L Moshe´:KOL impact

    Concepts related to the work of other authors for whichfor which Solomon L Moshe´ has influence:Status epilepticus,  Temporal lobe epilepsy,  Febrile seizures,  Antiepileptic drugs,  Infantile spasms,  Ketogenic diet,  Hippocampal sclerosis.



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    Departments of Neuroscience and Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA | Isabelle Rapin Division of Child Neurology Saul R. Korey Department of Neurology, and Departments of Neuroscience and Pediatrics Albert Einstein C