• Disease
  • Long
  • Long Qt
  • Long Qt Syndrome
  • Peter John Schwartz

    Prominent publications by Peter John Schwartz

    KOL Index score: 17431

    BACKGROUND: The genes for the long QT syndrome (LQTS) linked to chromosomes 3 (LQT3) and 7 (LQT2) were identified as SCN5A, the cardiac Na+ channel gene, and as HERG, a K+ channel gene. These findings opened the possibility of attempting gene-specific control of ventricular repolarization. We tested the hypothesis that the QT interval would shorten more in LQT3 than in LQT2 patients in response to mexiletine and also in response to increases in heart rate.

    METHODS AND RESULTS: Fifteen ...

    Also Ranks for: Heart Rate |  lqt2 patients |  differential responses |  channel blockade |  human pair
    KOL Index score: 16476

    CONTEXT: Major depressive disorder (MDD) occurs in 15% to 23% of patients with acute coronary syndromes and constitutes an independent risk factor for morbidity and mortality. However, no published evidence exists that antidepressant drugs are safe or efficacious in patients with unstable ischemic heart disease.

    OBJECTIVE: To evaluate the safety and efficacy of sertraline treatment of MDD in patients hospitalized for acute myocardial infarction (MI) or unstable angina and free of other ...

    Also Ranks for: Sertraline Treatment |  mdd patients |  major depression |  unstable angina |  antidepressant drugs
    KOL Index score: 15945

    OBJECTIVES: This substudy tested a prospective hypothesis that European Myocardial Infarct Amiodarone Trial (EMIAT) patients with depressed heart rate variability (HRV) benefit from amiodarone treatment.

    BACKGROUND: The EMIAT randomized 1,486 survivors of acute myocardial infarction (MI) aged < or =75 years with left ventricular ejection fraction (LVEF) < or =40% to amiodarone or placebo. Despite a reduction of arrhythmic mortality on amiodarone, all-cause mortality was not ...

    Also Ranks for: Heart Rate |  patients hrv |  prophylactic treatment |  placebo amiodarone |  allcause mortality
    KOL Index score: 15541

    BACKGROUND: Experimental evidence suggests that autonomic markers such as heart-rate variability and baroreflex sensitivity (BRS) may contribute to postinfarction risk stratification. There are clinical data to support this concept for heart-rate variability. The main objective of the ATRAMI study was to provide prospective data on the additional and independent prognostic value for cardiac mortality of heart-rate variability and BRS in patients after myocardial infarction in whom ...

    Also Ranks for: Cardiac Mortality |  myocardial infarction |  mm hg |  heartrate variability |  baroreflex sensitivity
    KOL Index score: 15241

    OBJECTIVES: We aimed to determine whether long QT syndrome (LQTS) genotype has a differential effect on clinical course of disease in male and female children and adults after adjustment for QTc duration.

    BACKGROUND: Genotype influences clinical course of the LQTS; however, data on the effect of age and gender on this association are limited.

    METHODS: The LQTS genotype, QTc duration, and follow-up were determined in 243 cases of LQTS caused by the KCNQ1 potassium channel gene mutations ...

    Also Ranks for: Cardiac Events |  lqts genotype |  potassium channels |  long qt |  sudden death
    KOL Index score: 14832

    BACKGROUND: Ventricular arrhythmias are a major cause of death after myocardial infarction, especially in patients with poor left-ventricular function. Previous attempts to identify and suppress arrhythmias with various antiarrhythmic drugs failed to reduce or actually increase mortality. Amiodarone is a powerful antiarrhythmic drug with several potentially beneficial actions, and has shown benefit in several small-scale studies. We postulated that this drug might reduce mortality in ...

    Also Ranks for: Myocardial Infarction |  amiodarone patients |  randomised trial |  ventricular dysfunction |  cardiac death
    KOL Index score: 14758

    BACKGROUND: Heart rate (HR) variability is a marker of tonic cardiac autonomic activity and contributes in assessing risk for sudden death after myocardial infarction. Recent clinical observations have indicated that attenuation of HR variability, which occurs after myocardial infarction, may be transient. This study addresses the issue of whether autonomic control of heart rate recovers at different rates after myocardial infarction in subjects at high and low risk for ventricular ...

    Also Ranks for: Myocardial Infarction |  sudden death |  heart rate |  dogs vf |  adrenergic blockade
    KOL Index score: 14304

    BACKGROUND: J-wave syndromes have emerged conceptually to encompass the pleiotropic expression of J-point abnormalities including Brugada syndrome (BrS) and early repolarization syndrome (ERS). KCNJ8, which encodes the cardiac K(ATP) Kir6.1 channel, recently has been implicated in ERS following identification of the functionally uncharacterized missense mutation S422L.

    OBJECTIVE: The purpose of this study was to further explore KCNJ8 as a novel susceptibility gene for J-wave ...

    Also Ranks for: Wave Syndrome |  brs ers |  katp channel |  pathogenic substrate |  mutation s422l
    KOL Index score: 14041

    BACKGROUND: Changes in heart rate during exercise and recovery from exercise are mediated by the balance between sympathetic and vagal activity. Since alterations in the neural control of cardiac function contribute to the risk of sudden death, we tested the hypothesis that among apparently healthy persons, sudden death is more likely to occur in the presence of abnormal heart-rate profiles during exercise and recovery.

    METHODS: A total of 5713 asymptomatic working men (between the ages ...

    Also Ranks for: Sudden Death |  heart rate exercise |  myocardial infarction |  rate profile |  beats minute
    KOL Index score: 13858

    Mutations in the minK gene KCNE1 have been linked to the LQT5 variant of human long QT syndrome. MinK assembles with KvLQT1 to produce the slow delayed rectifier K+ current IKs and may assemble with HERG to modulate the rapid delayed rectifier IKr. We used electrophysiological and immunocytochemical methods to compare the cellular phenotypes of wild-type minK and four LQT5 mutants co-expressed with KvLQT1 in Xenopus oocytes and HERG in HEK293 cells. We found that three mutants, V47F, ...

    Also Ranks for: Long Qt |  mink mutants |  potassium channels |  current iks |  xenopus oocytes
    KOL Index score: 13848

    We have suggested that among conscious dogs with a healed anterior wall myocardial infarction (MI) a depressed baroreflex sensitivity (BRS) carries a higher risk of developing ventricular fibrillation during a brief ischemic episode associated with an exercise stress test. The clinical and pathophysiological implications of our previous findings prompted the present study, which addressed three major questions: 1) Is, indeed, analysis of BRS after MI a specific and sensitive marker for ...

    Also Ranks for: Sudden Death |  conscious dogs |  brs mm hg |  ventricular fibrillation |  baroreceptor reflexes
    KOL Index score: 13654

    BACKGROUND: The congenital long-QT syndrome (LQTS) is an important cause of sudden cardiac death in children without structural heart disease. However, specific risk factors for life-threatening cardiac events in children with this genetic disorder have not been identified.

    METHODS AND RESULTS: Cox proportional-hazards regression modeling was used to identify risk factors for aborted cardiac arrest or sudden cardiac death in 3015 LQTS children from the International LQTS Registry who ...

    Also Ranks for: Sudden Cardiac Death |  cardiac arrest |  prior syncope |  qt syndrome |  congenital long
    KOL Index score: 13216

    IMPORTANCE: Intrauterine fetal death or stillbirth occurs in approximately 1 out of every 160 pregnancies and accounts for 50% of all perinatal deaths. Postmortem evaluation fails to elucidate an underlying cause in many cases. Long QT syndrome (LQTS) may contribute to this problem.

    OBJECTIVE: To determine the spectrum and prevalence of mutations in the 3 most common LQTS susceptible genes (KCNQ1, KCNH2, and SCN5A) for a cohort of unexplained cases.


    Also Ranks for: Fetal Death |  long qt syndrome |  mutations kcnq1 |  cases stillbirth |  potassium channel
    KOL Index score: 13182

    The relationship between activity of the autonomic nervous system, myocardial ischemia, and malignant arrhythmias has been investigated in a new experimental preparation for sudden death. Fifty-seven dogs were chronically instrumented and studied under control conditions (n = 15) and 1 month after production of an anterior myocardial infarction (n = 42). The protocol consisted in occluding the left circumflex coronary artery for 2 min, commencing at the last minute of an exercise stress ...

    Also Ranks for: Ventricular Fibrillation |  autonomic mechanisms |  myocardial infarction |  exercise dogs |  experimental preparation
    KOL Index score: 13080

    The interest for the antifibrillatory effect of vagal stimulation has been largely limited by the fact that this concept seemed restricted to acute experiments in anesthetized animals. To explore the potentially protective role of vagal stimulation in conscious animals we developed a chronically implantable device to be placed around the cervical right vagus. An anterior myocardial infarction was produced in 161 dogs; 1 month later an exercise stress test was performed on the 105 ...

    Also Ranks for: Vagal Stimulation |  conscious dogs |  healed myocardial infarction |  sudden death |  ventricular fibrillation


    Peter John Schwartz: Influence Statistics

    Sample of concepts for which Peter John Schwartz is among the top experts in the world.
    Concept World rank
    qtc permanent pacemakers #1
    phenylephrine vagal activity #1
    15 cohb #1
    abnormal qtc qtc #1
    type1 marker #1
    interval standard deviation #1
    diagnosis compound mutation #1
    betablocker sudden death #1
    t1304m #1
    ischemia sympathetic #1
    qt qte #1
    predictors lta events #1
    veratridine6 #1
    multipolar distribution #1
    dogs resistant dogs #1
    ambasilide heart rate #1
    genespecific management #1
    ventricular fibrillation interaction #1
    variability myocardial infarction #1
    qt stellectomy #1
    responders trained patients #1
    2 genes calmodulin #1
    brs pathogenesis function #1
    lqt1 locus mutation #1
    lqts secondary analysis #1
    translational cardiology #1
    exstrt #1
    afterdepolarizations genesis #1
    deadly link #1
    analysis brs #1
    mcs qt interval #1
    d76n kvlqt1 current #1
    muscarinic stimulation apd #1
    lqts chromosomes #1
    lifethreatening arrhythmias #1
    complexity hp variability #1
    icd lqts therapy #1
    repolarization longqt syndrome #1
    evidence dad #1
    newborn ecg #1
    saline solution propranolol #1
    24 neural #1
    pa341neighbouring subgroup #1
    exercise predicts #1
    lqts cr24h #1
    brs computerassisted statistics #1
    kv43l450f #1
    sympathetic stimulation pvcs #1
    application placebo patch #1
    common kcnq1a341v mutation #1

    Key People For Long Qt Syndrome

    Top KOLs in the world
    Peter John Schwartz
    long qt syndrome myocardial infarction sudden death
    Arthur J Moss
    cardiac events long qt syndrome myocardial infarction
    G Michael Vincent
    long qt syndrome cardiac events heart rate
    Silvia Giuliana Priori
    brugada syndrome sudden cardiac death long qt
    Jeffrey Allen Towbin
    dilated cardiomyopathy brugada syndrome heart transplantation
    Katherine W Timothy
    long qt syndrome cardiac events qt interval

    Peter John Schwartz:Expert Impact

    Concepts for whichPeter John Schwartzhas direct influence:Long qt syndrome,  Myocardial infarction,  Qt syndrome,  Long qt,  Sudden death,  Heart rate,  Sudden cardiac death,  Qt interval.

    Peter John Schwartz:KOL impact

    Concepts related to the work of other authors for whichfor which Peter John Schwartz has influence:Heart rate,  Atrial fibrillation,  Brugada syndrome,  Sudden cardiac death,  Myocardial infarction,  Qt interval,  Blood pressure.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy. | Istituto Auxologico Italiano IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Ca