 | Yufan Yang |
Prominent publications by Yufan Yang
Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage
[ PUBLICATION ]
The activation of microglia and inflammatory responses is essential for the process of intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI). In this study, we investigated the effects of luteolin on ICH-induced SBI and the potential mechanisms. Autologous blood was injected to establish the ICH model in vivo, and oxyhemoglobin (OxyHb) was used to mimic the ICH model in vitro. We found that the administration of luteolin significantly improved motor and sensory impairments ...
| Also Ranks for: Intracerebral Hemorrhage | neuroprotective effects luteolin | tolllike receptor | alleviates neuroinflammation | nf κb |
Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage
[ PUBLICATION ]
Upregulation of neuronal oxidative stress is involved in the progression of secondary brain injury (SBI) following intracerebral hemorrhage (ICH). In this study, we investigated the potential effects and underlying mechanisms of luteolin on ICH-induced SBI. Autologous blood and oxyhemoglobin (OxyHb) were used to establish in vivo and in vitro models of ICH, respectively. Luteolin treatment effectively alleviated brain edema and ameliorated neurobehavioral dysfunction and memory loss in ...
| Also Ranks for: Intracerebral Hemorrhage | nrf2 pathway | ichinduced sbi | underlying mechanisms | autologous blood |
BACKGROUND: Inflammation plays an important role in the initiation and progression of cervicocranial arterial dissection (CCAD). New inflammatory indices derived from full cell blood count may be associated with increased risk of acute ischemic stroke (AIS) caused by CCAD. The goal of this study is to evaluate the diagnostic performances of neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR) in CCAD.
METHOD: We retrospectively analyzed 52 patients with AIS caused ...
| Also Ranks for: Acute Ischemic Stroke | lymphocyte ratio | nlr lmr | ais ccad | cervicocranial arterial |
Predictive Value of Serum Creatinine/Cystatin C in Acute Ischemic Stroke Patients under Nutritional Intervention
[ PUBLICATION ]
Background and PurposeAs a very common risk of adverse outcomes of the ischemic stroke patients, sarcopenia is associated with infectious complications and higher mortality. The goal of this retrospective study is to explore the predictive value of serum Cr/CysC ratio in acute ischemic stroke patients receiving nutritional intervention.MethodsWe reviewed adult patients with AIS from December 2019 to February 2020. Patients with acute kidney injury were excluded and all patients received ...
| Also Ranks for: Serum Creatinine |
MicroRNA-133b-3p Targets Purinergic P2X4 Receptor to Regulate Central Poststroke Pain in Rats
[ PUBLICATION ]
Central poststroke pain (CPSP) is a neuropathic pain syndrome that usually occurs after cerebrovascular accidents. Currently, the pathogenesis of CPSP is not fully understood. Purinergic P2X4 receptor (P2X4R) is implicated in neuropathic pain including CPSP. Herein, we demonstrated that the levels of microRNA-133b-3p (miR-133b-3p), which targets P2X4R transcripts, were significantly downregulated in the ventral posterolateral nucleus of the thalamus (VPL), cerebrospinal fluid (CSF), and ...
| Also Ranks for: P2x4 Receptor | neuropathic pain |
Neutrophil to Lymphocyte Ratio Predicts Outcome of Stroke by Cervicocranial Arterial Dissection
[ PUBLICATION ]
Background and Purpose: Neutrophil to lymphocyte ratio (NLR) is positively associated with poor prognosis in patients with cerebral infarction. The goal of this prospective study is to explore the predictive value of NLR in patients with acute ischemic stroke (AIS) caused by cervicocranial arterial dissection (CCAD). Methods: Ninety-nine patients with AIS caused by CCAD met criteria for inclusion and exclusion were selected for this study. We collected baseline data on the admission ...
| Also Ranks for: Arterial Dissection | 3 months | modified rankin | scale score |
Yufan Yang: Influence Statistics
| Concept | World rank |
|---|---|
| caused cervicocranial | #4 |
| ccad nlr | #4 |
| caused ccad | #4 |
| stroke cervicocranial | #5 |
| 3month poor outcomes | #5 |
| ais ccad | #8 |
| cervicocranial arterial | #10 |
| primary poor outcome | #14 |
| elevated nlr levels | #19 |
| ichinduced sbi | #20 |
| nlr poor outcome | #23 |
| 20 202 | #24 |
| nlr ais | #28 |
| 3 months ais | #32 |
| outcome divided | #39 |
| ais caused | #44 |
| mechanisms luteolin | #45 |
| induced sbi | #55 |
| neuroprotective effects luteolin | #59 |
| dissection ccad | #59 |
| luteolin alleviates | #73 |
| luteolin potential | #80 |
| nrf2 luteolin | #81 |
| luteolin nrf2 | #86 |
Key People For Intracerebral Hemorrhage
Yufan Yang:Expert Impact
Concepts for whichYufan Yanghas direct influence:Intracerebral hemorrhage, Nlr ais, Patients poor outcome, Poor outcome patients, Ais ccad, Nlr patients, Patients nlr, Ccad nlr.
Yufan Yang:KOL impact
Concepts related to the work of other authors for whichfor which Yufan Yang has influence:Intracerebral hemorrhage, Dezocine tolerance, Nrf2 activators, Brain volume, Nlrp3 inflammasomes, Large artery occlusion, Honeybush extracts.
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