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Prominent publications by Narsing A Rao
AIM: To report criteria for the diagnosis of intraocular sarcoidosis, taking into account suggestive clinical signs and appropriate laboratory investigations and biopsy results.
DESIGN: Concensus workshop of an international committee on nomenclature.
METHODS: An international group of uveitis specialists from Asia, Africa, Europe, and America met in a concensus conference in Shinagawa, Tokyo on October 28-29, 2006. Based on questionnaires that had been sent out prior to the conference, ...
| Also Ranks for: Ocular Sarcoidosis | international criteria | laboratory investigations | clinical signs | and or |
Upregulation of Chemokine Expression in the Retinal Vasculature in Ischemia–Reperfusion Injury
[ PUBLICATION ]
PURPOSE: To evaluate chemokine expression at various retinal sites after ischemia-reperfusion injury, using reverse transcription-polymerase chain reaction (RT-PCR) analysis of selected tissue obtained by laser capture microdissection.
METHODS: Retinal ischemia was produced in Lewis rats by increasing intraocular pressure for 75 minutes. At 3, 6, 12, and 24 hours after reperfusion, RT-PCR was used to measure the levels of monocyte chemoattractant protein (MCP)-1, macrophage inflammatory ...
| Also Ranks for: Reperfusion Injury | chemokine expression | retinal vessels | leukocyte infiltration | mcp1 mip1alpha |
Outcome of Treatment of Uveitic Macular Edema The Multicenter Uveitis Steroid Treatment Trial 2-Year Results
[ PUBLICATION ]
PURPOSE: To evaluate the 2-year outcomes of uveitic macular edema.
DESIGN: Longitudinal follow-up of a randomized cohort.
PARTICIPANTS: At baseline, 148 eyes of 117 patients enrolled in the Multicenter Uveitis Steroid Treatment (MUST) Trial had macular edema, and 134 eyes of 108 patients completed 2-year follow-up.
METHODS: Patients enrolled in the study were randomized to either systemic immunosuppression or intravitreal fluocinolone acetonide implant therapy. Macular edema was defined ...
| Also Ranks for: Macular Edema | oct resolution | systemic therapy | treatment trial | 2 years |
Differences in Clinical Findings between Caucasians and African Americans with Biopsy-Proven Sarcoidosis
[ PUBLICATION ]
OBJECTIVE: To study the prevalence of ocular manifestations in African American and Caucasian patients with biopsy-proven sarcoidosis at the initial ophthalmic examination and to determine the relationship between angiotensin-converting enzyme (ACE) levels, chest x-ray findings, and ocular signs of sarcoidosis.
DESIGN: Retrospective, cross-sectional, observational study.
PARTICIPANTS: Eighty-one consecutive patients with biopsy-proven sarcoidosis seen at the Doheny Eye Institute from ...
| Also Ranks for: African Americans | ocular manifestations | clinical findings | patients sarcoidosis | medical records |
PURPOSE: In experimental autoimmune uveitis (EAU), recent work has demonstrated that retinal damage involves oxidative stress early in uveitis, before macrophage cellular infiltration. The purpose of this study was to determine whether oxidative mitochondrial DNA damage occurs early in EAU, before leukocyte infiltration.
METHODS: Lewis rats were immunized with S-antigen mixed with complete Freund adjuvant (CFA) to induce EAU. Nonimmunized animals and animals injected with CFA served as ...
| Also Ranks for: Dna Damage | mitochondrial oxidative | experimental autoimmune uveitis | early phase | lewis rats |
PURPOSE: To devise methods for unequivocal identification of activated retinal microglia in experimental autoimmune uveoretinitis (EAU) and to investigate their role in the development of EAU.
METHODS: A group of Lewis rats underwent optic nerve axotomy with the application of N-4-(4-didecylaminostyryl)-N methylpyridinium iodide (4Di-10ASP) at the axotomy site. On days 3, 14, and 38 after axotomy, the rats were killed, the eyes were enucleated, and the retinas were stained for OX42. ...
| Also Ranks for: Retinal Microglia | eau tnfalpha | positive cells | optic nerve | photoreceptor cell |
An Animal Model for Cidofovir (HPMPC) Toxicity: Intraocular Pressure and Histopathologic Effects
[ PUBLICATION ]
Intravitreal cidofovir has been shown to be a long acting and highly efficacious treatment for CMV retinitis; however decrease in IOP is an adverse effect. We wanted to determine the effect of cidofovir on intraocular pressure (IOP) in the guinea pig, and rabbit eye to develop an animal model of cidofovir induced ocular hypotony and to study the histopathology of this toxicity. Twenty-eight guinea pig eyes were injected with cidofovir yielding final intravitreal concentrations of 25, ...
| Also Ranks for: Intraocular Pressure | animal model | guinea pig | ciliary body | intravitreal cidofovir |
Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis
[ PUBLICATION ]
AIMS: In early S-antigen induced experimental uveitis (EAU), photoreceptor mitochondrial proteins are nitrated prior to macrophage infiltration of the retina, suggesting that oxidative stress is an initial event in the development of EAU. We attempted to detect the oxidative stress and localise it in the EAU retina.
METHODS: Lewis rats were immunised with S-antigen in complete Freund's adjuvant (CFA). Animals were injected with CFA alone and non-immunised animals served as controls. ...
| Also Ranks for: Oxidative Stress | photoreceptor mitochondria | day eau | experimental autoimmune | lewis rats |
PURPOSE: During the early phase of experimental autoimmune uveitis (EAU), before macrophages infiltrate the retina and uvea, photoreceptor mitochondrial oxidative stress, nitration of photoreceptor mitochondrial proteins, and release of cytochrome c have been observed. However, no apoptosis has been detected during this phase. In this study, alphaA-crystallin upregulation in the retina and its antiapoptotic protective role were evaluated in early EAU.
METHODS: Gene microarrays were first ...
| Also Ranks for: Early Eau | heat shock | apoptosis retina | alphaa crystallin | oxidative stress |
We undertook a study to determine the incidence of hypopyon, as well as the most common anterior uveitis entities with which hypopyon is associated. A total of 216 patients with anterior uveitis were studied. The uveitis was acute in 155. Of the 155 patients, 11 (7.1%) had hypopyon. Nine of the 11 patients with hypopyon were positive for HLA B27. Of these nine, two had Reiter's syndrome and one had ankylosing spondylitis; the other six had no confirmed systemic disease. Of the two ...
| Also Ranks for: Anterior Uveitis | hla b27 | incidence hypopyon | ankylosing spondylitis | positive patients |
BACKGROUND: In previous natural history studies and clinical trials, AIDS-related cytomegalovirus (CMV) retinitis has occurred primarily in patients with absolute CD4 counts of 50 cells/microL or less (0.05 x 10(9)/L) at the time of diagnosis.
METHODS: We report five patients identified from our clinical practices who were diagnosed with CMV retinitis while their CD4 counts were above 195 cells/microL. We also analysed, based on CD4 counts, 76 AIDS patients with newly diagnosed CMV ...
| Also Ranks for: Cd4 Counts | cytomegalovirus retinitis | 100 cells | highly active | aids patients |
PURPOSE: To evaluate the associations between visual acuity and self-reported visual function; visual acuity and health-related quality of life (QoL) metrics; a summary measure of self-reported visual function and health-related QoL; and individual domains of self-reported visual function and health-related QoL in patients with uveitis.
METHODS: Best-corrected visual acuity, vision-related functioning as assessed by the NEI VFQ-25, and health-related QoL as assessed by the SF-36 and ...
| Also Ranks for: Visual Acuity | treatment trial | health qol | vision function | quality life |
PURPOSE: Photoreceptor mitochondrial oxidative stress is the initial pathologic event in experimental autoimmune uveitis. In this study, the authors determined alterations in retinal mitochondrial protein levels in response to oxidative stress during the early phase of experimental autoimmune uveitis (EAU).
METHODS: Retinal mitochondrial fractions during early EAU were prepared and subjected to two-dimensional difference in gel electrophoresis (2D-DIGE). Protein spots showing ...
| Also Ranks for: Oxidative Stress | experimental autoimmune uveitis | animal electrophoresis | crystallin proteins | atp synthase |
Distinguishing Features of Ocular Sarcoidosis in an International Cohort of Uveitis Patients
[ PUBLICATION ]
PURPOSE: To determine which clinical features distinguish ocular sarcoidosis from other forms of uveitis in an international population and to estimate the sensitivity and specificity of the International Workshop on Ocular Sarcoidosis (IWOS) clinical signs and laboratory tests.
DESIGN: Multicenter, retrospective medical record review.
PARTICIPANTS: Eight hundred eighty-four patients with uveitis from 19 centers in 12 countries.
METHODS: Data collected included suspected cause of ...
| Also Ranks for: Ocular Sarcoidosis | uveitis patients | iwos criteria | international workshop | clinical findings |
Narsing A Rao: Influence Statistics
| Concept | World rank |
|---|---|
| eyes convalescent stage | #1 |
| oral 15 patients | #1 |
| αa administration | #1 |
| tuberculosis tbslc | #1 |
| aids eye | #1 |
| ophthalmic manifestations iris | #1 |
| phase eau | #1 |
| anterior chamber nodules | #1 |
| uveal inflammation | #1 |
| swaf mcoct imaging | #1 |
| vzvr acyclovir | #1 |
| photoreceptors globes | #1 |
| unilateral ocular involvement | #1 |
| sunset glow fundi | #1 |
| drc 1 | #1 |
| dqb1 allele controls | #1 |
| eau photoreceptor | #1 |
| sympathetic ophthalmia trauma | #1 |
| death systemic dissemination | #1 |
| diagnosis ancillary investigations | #1 |
| transgenic mice inos | #1 |
| release marked apoptosis | #1 |
| pulmonary extrapulmonary ocular | #1 |
| management sympathetic ophthalmia | #1 |
| term aerosolized | #1 |
| vertebrate rna regulation | #1 |
| endophthalmitis endogenous candida | #1 |
| groups subretinal membranes | #1 |
| outcome uveomeningoencephalitic | #1 |
| rheumatoid scleritis scleritis | #1 |
| experimental uveitis eau | #1 |
| puncture diagnosis | #1 |
| uveitis hypopyon | #1 |
| apoptosis early eau | #1 |
| histopathology patient | #1 |
| proteins retinal mitochondria | #1 |
| pinealitis antigenpresenting cells | #1 |
| peroxidized retinal | #1 |
| corneal scrapings microorganisms | #1 |
| intraperitoneal neuritis autoimmune | #1 |
| vkh convalescent stage | #1 |
| sarcoidosis birdshot chorioretinopathy | #1 |
| oral corticosteroids cnv | #1 |
| “conjunctival nodules | #1 |
| iris ophthalmic manifestations | #1 |
| alphabcrystallin expression levels | #1 |
| antioxidant enzymes reduce | #1 |
| infectious choroiditis | #1 |
| sugiura vkh | #1 |
| vogt koyanagiharada syndrome | #1 |
Key People For Sympathetic Ophthalmia
Narsing A Rao:Expert Impact
Concepts for whichNarsing A Raohas direct influence:Sympathetic ophthalmia, Ocular sarcoidosis, Visual acuity, Ocular tuberculosis, Cytomegalovirus retinitis, Experimental autoimmune uveitis, Hispanic patients, Oxidative stress.
Narsing A Rao:KOL impact
Concepts related to the work of other authors for whichfor which Narsing A Rao has influence:Visual acuity, Cytomegalovirus retinitis, Sebaceous carcinoma, Sympathetic ophthalmia, Oxidative stress, Anterior uveitis, Ocular toxoplasmosis.
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