Prominent publications by Byeong Keun Ha

KOL Index score: 9789

In the adult cerebellum, corticotropin releasing factor (CRF), that is localized in climbing fibers, mossy fibers, and a fine varicose plexus along the Purkinje cell layer, modulates the responsiveness of Purkinje cells to excitatory amino acids. During development, CRF has been detected in the primitive cerebellar anlage as early as embryonic day (E)10, and is continuously expressed throughout embryonic and postnatal cerebellar ontogeny. To investigate a possible trophic role for CRF ...

Known for Corticotropin Releasing |  Cerebellar Astrocytes |  Development Crf |  Induces Proliferation |  Purkinje Cells
KOL Index score: 7236

Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit development and experience-dependent plasticity. Although glia are affected by activity and ensheathe synapses, their influence on synaptic strength has largely been ignored. Here, we show that a protein produced by glia, tumor necrosis factor alpha (TNFalpha), enhances synaptic efficacy by increasing surface expression of AMPA receptors. Preventing the actions of endogenous TNFalpha has the ...

Known for Synaptic Strength |  Astrocytes Cells |  Spraguedawley Receptors |  Glial Tnfα |  Cultured Culture Media
KOL Index score: 4265

Microglia are key mediators of the immune response in the central nervous system (CNS). They are closely related to macrophages and undergo dramatic morphological and functional changes after CNS trauma or excitotoxic lesions. Microglia can be directly stimulated by excitatory neurotransmitters and are known to express many neurotransmitter receptors. The role of these receptors, however, is not clear. This study describes the microglial response to the glutamate receptor agonist kainate ...

Known for Neurotransmitter Receptors |  Central Nervous |  Actin Filaments |  Immune Response |  100 Microm
KOL Index score: 3899

In addition to well-known N-methyl-d-aspartate (NMDA) receptor-mediated excitotoxicity, recent studies suggest that non-NMDA type ionotropic glutamate receptors are also important mediators of excitotoxic neuronal death, and that their functional expression can be regulated by the cellular environment. In this study, we used cerebellar granule cells (CGCs) in culture to investigate kainate (KA)-induced excitotoxicity. Although previous reports indicated that KA induces apoptosis of CGCs ...

Known for Induced Excitotoxicity |  Glutamate Receptors |  Cerebellar Granule Cells |  Cell Death |  Response Relationship
KOL Index score: 3652

High concentrations of novel, haloperidol- and DTG-inaccessible (+)-[3H]-3-PPP binding sites were found in human peripheral blood leukocytes rat spleen and splenocytes, but not in rat brain. Splenic sites were localized in a course punctate pattern in the marginal zones and red pulp. The pharmacology of the splenic sites was: (-)-SKF 10,047 > or = naltrexone = (-)-pentazocine > (+)-pentazocine = (-)-3-PPP = (+)-SKF 10,047 > or = (+)-3-PPP > or = dextrorphan > dextromethorphan > PCP > ...

Known for Immune Tissues |  Spraguedawley Receptors |  Dopamine Antagonists |  Sigma Spleen Tritium |  Monoamine Oxidase
KOL Index score: 3510

In vitro receptor autoradiography was used to localize sigma 1 receptors, sigma 2 receptors, and novel haloperidol/DTG-inaccessible sites for sigma and opiate ligands in rat spleen. Sigma-1 receptors were present throughout the spleen, but were most concentrated in the T cell zones. Binding under "sigma 2 receptor-selective' conditions was 70% nonspecific, and sigma 2 receptors could not be detected. Haloperidol/DTG-inaccessible sites had a coarse, punctate distribution in the red pulp ...

Known for Sigma Receptor |  Ligands Male |  Analgesics Opioid |  Antipsychotic Agents |  Guanidines Haloperidol
KOL Index score: 3111

BACKGROUND: Smooth muscle tumors of the vulva are rare and sometimes create diagnostic difficulty because of unusual morphological features.

CASE: A 29-year-old African-American female presented with a vulval mass during her 5th week of pregnancy. The lesion was surgically removed under the clinical impression of a Bartholin cyst. Histopathological findings of the lesion and immunohistochemical stain results are characteristic of myxoid epithelioid leiomyoma.

CONCLUSION: Up to now, there ...

Known for Epithelioid Leiomyoma |  Bartholin Cyst |  Diagnostic Difficulty |  Vulva Case |  Smooth Muscle Tumors
KOL Index score: 2253

Interleukin-6 (IL-6) type cytokines show functional redundancy in the immune, hematopoietic, and nervous system, which is believed to result from sharing of the signal transducing receptor gp130. IL-6 type cytokines and their binding receptors have been localized in the adult cerebellum. However, the cellular localization and developmental regulation of gp130 in the cerebellum have not been determined. In the present study the expression pattern of gp130 in the developing and adult mouse ...

Known for Purkinje Cells |  Interleukin6 Il6 |  Receptor Gp130 |  Cerebellum Cytokine |  Membrane Glycoproteins


Byeong Keun Ha: Influence Statistics

Sample of concepts for which Byeong Keun Ha is among the top experts in the world.
Concept World rank
sigma1 receptors spleen #1
sigma opiate ligands #1
dtg inaccessible #1
coarse punctate distribution #1
sigma spleen tritium #1
leiomyoma epithelioid #1
modulation sigma receptors #1
2 receptors sigma #1
pulp marginal zones #2
crf cerebellar development #3
kastimulated microglia #3
condensed actin bundles #3
glia 40164174was #3
culture ka #3
nondesensitizing aspects #4
cgcs ka #4
cgcs shifted #4
longevans receptors ampa #4
low environment study #4
study kainduced excitotoxicity #4
culture cgcs #4
cgcs culture #4
cgcs low media #4
mature cgcs #4
ka type #5
leiomyoma vulva #5
excitotoxicity mature #6
bartholin cyst #7
crf cerebellar #7
kainate‐induced excitotoxicity #8
epithelioid leiomyoma #8
opioid animals anticonvulsants #8
spleen cell zones #8
haloperidol dtg #8

Key People For Synaptic Strength

Top KOLs in the world
Robert C Malenka
ampa receptors synaptic transmission nucleus accumbens
Roger A Nicoll
ampa receptors synaptic transmission term potentiation
Mark F Bear
visual cortex synaptic plasticity monocular deprivation
Roberto Malinow
ampa receptors synaptic plasticity lateral habenula
Richard L Huganir
ampa receptors synaptic plasticity tyrosine phosphorylation
Graham Leon Collingridge
synaptic plasticity ampa receptors ca1 region

Byeong Keun Ha:Expert Impact

Concepts for whichByeong Keun Hahas direct influence:Synaptic strength,  Spraguedawley receptors,  Rat spleen,  Corticotropin releasing factor,  Astrocytes cells,  Rapid redistribution,  Purkinje cells,  Corticotropin releasing.

Byeong Keun Ha:KOL impact

Concepts related to the work of other authors for whichfor which Byeong Keun Ha has influence:Synaptic plasticity,  Tumor necrosis factor,  Glial cells,  Spinal cord,  Ampa receptors,  Central nervous,  Neuropathic pain.



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Department of Pathology, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA | Department of Neuroscience, The Ohio State University, Columbus, Ohio | Department of Neuroscience, The Ohio State University Medical Center, Colu

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