WALTER R NICKEL

As a graduate student it was a happy day when one first saw a case of urticaria pigmentosa. Classically it would be a child with scattered macular pigmentation which would urticate when the lesions were irritated (Darier's sign). This was satisfying and for the moment represented all there was to know of the clinical manifestations of this condition.However, with increasing clinical experience, it became increasingly clear that urticaria pigmentosa was not a single simple condition. The ...

Two brothers and a sister and brother with the de Sanctis-Cacchione syndrome (xeroderma pigmentosum, microcephaly, mental deficiency, dwarfism, and gonadal hypoplasia) are discussed. The syndrome is probably controlled by a single recessive autosomal gene. Porphyrins were not demonstrated in these patients.

It is an honor to address the Pacific Dermatologic Society as its President. This address is factual, rather than philosophical and presents material which we hope is unfamiliar to most of you.Most men worry about any unexplained lesion appearing in the region of their genitalia, particularly the penis. The sudden appearance therefore (Fig. 1) of a firm, curved, wormlike, translucent lesion, having the diameter of a normal vas deferens, almost encircling the penis, is apt to cause ...

The familia occurrence of systemic lupus erythematosus (S. L. E.) is reported in two sisters of Italian ancestry and a mother and daughter of Mexican ancestry. All four cases exhibited typical symptoms and signs of the disease. The first patient was studied before the L. E. test was in general use, but autopsy revealed the principal microscopic criteria for S. L. E. The other three patients had positive results of L. E. tests, and their conditions have been well controlled by the careful ...