Prominent publications by Pietro Puddu

KOL Index score: 14052

IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes. In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic ...

Also Ranks for: Cxc Dermatitis |  ifn gamma |  keratinocyte expression |  intercellular signaling peptides |  chemokine skin
KOL Index score: 13110

BACKGROUND: Amelanotic malignant melanoma is a subtype of cutaneous melanoma with little or no pigment on visual inspection. It may mimic benign and malignant variants of both melanocytic and nonmelanocytic lesions.

OBJECTIVES: To evaluate whether dermoscopy is also a useful technique for the diagnosis of amelanotic/hypomelanotic melanoma (AHM).

METHODS: We conducted a retrospective clinical study of 151 amelanotic/hypomelanotic skin lesions from 151 patients with a mean age of 47 years ...

Also Ranks for: Hypomelanotic Melanoma |  dermoscopic features |  vascular patterns |  irregular pigmentation |  regression structures
KOL Index score: 11980

To investigate the mechanisms underlying the expression of allergic contact dermatitis, we compared the characteristics of nickel (Ni)-specific T cell responses in 10 patients with allergic contact dermatitis to Ni and in 10 healthy, nonallergic individuals. CD4+ T cells purified from peripheral blood of both allergic and nonallergic subjects proliferated similarly to NiSO4 in vitro, with the responses mostly restricted to CD4+ CD45RO+ memory T cells. In contrast, Ni-specific CD8+ T cell ...

Also Ranks for: Allergic Contact Dermatitis |  cell responses |  specific cd4 |  effector cd8 |  tlymphocyte antigens
KOL Index score: 11965

Allergic contact dermatitis (ACD) is the result of an exaggerated immune reaction to haptens mediated by skin-homing T cells, but the effector mechanisms responsible for the tissue damage are poorly understood. Here we studied the capacity of distinct subsets of hapten-specific T cells to induce apoptosis in autologous keratinocytes. Skin- and blood-derived nickel-specific CD8+ T cytotoxic 1 (Tc1) and Tc2 clones as well as CD4+ Th1 and Th2 expressed the cutaneous lymphocyte-associated Ag ...

Also Ranks for: Immunologic Dermatitis |  th1 cells |  cell subsets |  specific cd8 |  lymphocytes cytotoxic
KOL Index score: 11402

The most common complications in plastic surgery are tissue reactivity, infections, and wound dehiscence. In the literature, there are only a few studies with sample sizes large enough and methods of statistical analysis appropriate for evaluating the role of suture materials in inducing such complications. In the 1000 plastic surgery outpatients in this study, the association of different suture materials, individual patient characteristics, surgeon skill, and wound site and length with ...

Also Ranks for: Tissue Reactivity |  suture materials |  wound dehiscence |  plastic surgery |  surgical procedures
KOL Index score: 10986

The diagnosis of T-cell lymphoproliferative disorders, which frequently involve the skin and other extranodal sites, is often problematic because of the difficulty in establishing clonality in paraffin-embedded tissue. To this end, we developed a simple, nonradioactive method to detect T-cell receptor gamma (TCR-gamma) gene rearrangements by polymerase chain reaction single-strand conformational polymorphism (PCR-SSCP) in paraffin-embedded tissue. Jurkat and HSB-2 cell lines and ...

Also Ranks for: Gene Rearrangements |  chain reaction |  conformational polymorphism |  cell receptor |  paraffinembedded tissue
KOL Index score: 9901

BACKGROUND: Rituximab induces depletion of B cells and has shown efficacy in antibody-mediated autoimmune disorders. In studies on small series of patients with pemphigus, rituximab administration results in significant improvement. However, differences in inclusion criteria, treatment protocols, and follow-up make it difficult to derive uniform conclusions.

OBJECTIVES: We sought to test the efficacy and tolerability of rituximab as adjuvant therapy to corticosteroids in the treatment of ...

Also Ranks for: Patients Pemphigus |  complete response |  rituximab therapy |  6 months |  follow studies
KOL Index score: 9785

Mycosis fungoides and Sézary syndrome represent the most frequent forms of cutaneous T cell lymphoma. Both are characterized by skin infiltrating and/or circulating malignant cells displaying a CD4+CD7- phenotype in the majority of cases. Because an expansion of CD4+CD7- cells may also be found in inflammatory dermatoses or in the aging process, we evaluated, by flow cytometry, the relationship between CD7 expression and the distribution of differentiation/activation or homing antigens ...

Also Ranks for: Cell Lymphoma |  sézary syndrome |  cd7 expression |  dipeptidyl peptidase |  mycosis fungoides
KOL Index score: 9724

Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive collagen deposition in the skin and internal organs. Several cytokines and chemokines have been implicated in the induction of fibrosis, but a definitive relationship between specific cytokines and organ involvement has not been established yet. Serum samples, PBMC and T cell lines (TCL) obtained from 54 patients affected by SSc and 20 healthy donors (HD) were examined by ELISA for Interferon-gamma ...

Also Ranks for: Chemokine Levels |  systemic sclerosis |  organ involvement |  il6 il10 |  ssc serum
KOL Index score: 9684

Placenta growth factor (PlGF) is a dimeric glycoprotein, structurally and functionally related to the vascular endothelial growth factor, a potent angiogenic/permeability factor known to play a role in the neoangiogenesis during wound repair. In this study we evaluated the expression of PlGF in human keratinocytes and investigated its possible role in wound healing. Northern blot analysis on cultured keratinocytes revealed a 1.7 kb mRNA transcript and reverse transcriptase-polymerase ...

Also Ranks for: Wound Healing |  placenta growth factor |  human keratinocytes |  plgf mrna |  endothelial growth
KOL Index score: 9082

BACKGROUND: Psychological distress among healthcare professionals can have negative effects on the well-being of the professionals and also on the quality of care they provide to patients.

OBJECTIVES: To evaluate burnout and job satisfaction of dermatologists and nurses working with dermatological patients compared with physicians and nurses of other specialties.

METHODS: A self-completed anonymous questionnaire was distributed to the personnel of two hospitals in Rome, Italy: a ...

Also Ranks for: Physicians Nurses |  general hospital |  burnout dermatology |  healthcare professionals |  humans satisfaction
KOL Index score: 9063

Abstract. Chemokines are important mediators of immune-mediated skin diseases. Allergic contact dermatitis (ACD) is the most thoroughly investigated T cell-mediated disorder because of the ability to easily reproduce the lesions in humans and the availability of an excellent mouse model. Migration of dendritic cells from the skin to lymph nodes is absolutely required for induction of hapten sensitization, and depends upon expression of CCR7 by mature dendritic cells and SLC in the lymph ...

Also Ranks for: Allergic Contact Dermatitis |  dendritic cells |  chemokine receptors |  lymph nodes |  early stages
KOL Index score: 8898

Laminin-5 is the major adhesion ligand of epithelial cells. Mutations in the three genes (LAMA3, LAMB3, LAMC2) encoding the laminin-5 chains cause junctional epidermolysis bullosa, a clinically and genetically heterogeneous blistering skin disease. Here, we describe a non-Herlitz junctional epidermolysis bullosa patient, compound heterozygote for two novel mutations affecting the LAMC2 gene. The mutation in the paternal allele is a de novo splice site mutation (522-1G-->A) that results ...

Also Ranks for: Lamc2 Gene |  junctional epidermolysis |  epithelial cells |  compound heterozygote |  maternal mutation

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Pietro Puddu:Expert Impact

Concepts for whichPietro Pudduhas direct influence:Psychiatric morbidity,  Systemic sclerosis,  Tissue reactivity,  Suture materials,  Chemical peeling,  Fibroblastic rheumatism,  Cutaneous melanoma metastases,  Allergic contact dermatitis.

Pietro Puddu:KOL impact

Concepts related to the work of other authors for whichfor which Pietro Puddu has influence:Systemic sclerosis,  Skin cancer,  Atopic dermatitis,  Pemphigus vulgaris,  Basal cell carcinoma,  Quality life,  Bullous pemphigoid.



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Department of Immunology and Allergology, Istituto Dermopatico dell’Immacolata, IRCCS; | Department of Immunodermatology, Istituto Dermopatico dell’Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy | Department of I