Yuan‐Li Huang

Yuan‐Li Huang

Department Of Cell Biology And Anatomy, College Of Medicine, National Cheng Kung University, #1 University Road, Tainan 701, Taiwan

Direct Impact

Concepts for which Yuan‐Li Huang has direct influence:

prostate cancer
chondrosarcoma cells
synovial fibroblasts
cordyceps sinensis
lysophosphatidic acid
tyrosine sulphation
vegf-c expression

External impact

Concepts related to the work of other authors for which Yuan‐Li Huang has influence:

prostate cancer
chondrosarcoma cells
rheumatoid arthritis
s1p3 receptor
lysophosphatidic acid
murine models
nacreous protein

Prominent publications by Yuan‐Li Huang

KOL-Index: 36 In recent years, osteosarcoma survival rates have failed to improve significantly with conventional treatment modalities because of the development of chemotherapeutic resistance. The human breast cancer resistance protein/ATP binding cassette subfamily G member 2 (BCRP/ABCG2), a member of the ATP-binding cassette family, uses ATP hydrolysis to expel xenobiotics and chemotherapeutics from ...
Known for
Secreted Protein | Member Ccn2 | Increased Osteosarcoma Viability | Chemotherapeutics
KOL-Index: 35 Osteoarthritis (OA) is a progressive degenerative joint disorder characterized by synovial inflammation. Interleukin-6 (IL-6) is a key proinflammatory cytokine in OA progression. Particulate matter 2.5 (PM2.5) exposure increases the risk of different diseases, including OA. Up until now, no studies have described any association between PM2.5 and IL-6 expression in human OA synovial ...
Known for
Osteoarthritis Synovial | Phosphorylation Signaling | Oasfs Ros | P38 Jnk
KOL-Index: 31 Rheumatoid arthritis (RA) is an autoimmune disorder that is characterized by increasing levels of proinflammatory cytokines. The ubiquitous enzyme dipeptidyl peptidase-4 (DPP4, also known as CD26) regulates different immune disorders, although the effects of DPP4 in RA are uncertain. Here, we found lower levels of DPP4 in RA synovial tissues compared with normal tissues. DPP4 levels were ...
Known for
Anti-Inflammatory Il-10 Synthesis | Rat Collagen-Induced Arthritis Model | Dpp4 Synovial | Ubiquitous Enzyme Dipeptidyl Peptidase-4
KOL-Index: 30 Prostate cancer (PCa) is the most common noncutaneous cancer in men worldwide. One of its major treatments is androgen deprivation therapy, but PCa frequently relapses as aggressive castration resistant local tumors and distal metastases. Hence, the development of novel agents or treatment modalities for advanced PCa is crucial. Many tumors, including PCa, first metastasize to regional lymph ...
Known for
Lymphangiogenesis Prostate | Acid Lpa | Therapy Pca | Lysophosphatidic
KOL-Index: 29 Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid with a variety of biological activities. It is generated from the conversion of ceramide to sphingosine by ceramidase and the subsequent conversion of sphingosine to S1P, which is catalyzed by sphingosine kinases. Through increasing its intracellular levels by sphingolipid metabolism and binding to its cell surface receptors, S1P ...
Known for
Distinct Functions | Physiological Pathological Processes | Ceramide Sphingosine | Potent Therapeutic Target
KOL-Index: 28 Prostate cancer is one of the most frequently diagnosed cancers in males, and PC-3 is a cell model popularly used for investigating the behavior of late stage prostate cancer. Lysophosphatidic acid (LPA) is a lysophospholipid that mediates multiple behaviors in cancer cells, such as proliferation, migration and adhesion. We have previously demonstrated that LPA enhances vascular endothelial ...
Known for
Lpa1 Lpa3 Sirna | Lpa-Induced Ros Generation | Late Stage Prostate Cancer | 10min
KOL-Index: 25 AIMS: Insulin-like growth factor (IGF) signaling has been documented in several human malignancies and is thought to contribute to cellular differentiation and migration, as well as malignant progression. A major binding molecule of IGF, IGF-binding protein 3 (IGFBP-3), regulates multiple IGF effects. Here, we focused on the effect of IGFBP-3 in the motility of osteosarcoma cells and ...
Known for
Cellular Differentiation | Ap-1 | Vcam-1-Dependent Migration | Expression Osteosarcoma
KOL-Index: 25 Chondrosarcomas are well known for their resistance to chemotherapeutic agents, including cisplatin, which is commonly used in chondrosarcomas. Amphiregulin (AR), a ligand of epidermal growth factor receptor (EGFR), plays an important role in drug resistance. We therefore sought to determine the role of AR in cisplatin chemoresistance. We found that AR inhibits cisplatin-induced cell ...
Known for
Mouse Xenograft Model | Cisplatin-Induced Apoptosis | Resistance Chondrosarcoma | Tumor Volume
KOL-Index: 24 In recent years, much research has focused on the role of angiogenesis in osteosarcoma, which occurs predominantly in adolescents and young adults. The vascular endothelial growth factor-A (VEGF-A) pathway is the key regulator of angiogenesis and in osteosarcoma. VEGF-A expression has been recognized as a prognostic marker in angiogenesis. Aberrant WNT1-inducible signaling pathway protein-1 ...
Known for
Fak | Mir-381 | Epc Migration | Microrna-381
KOL-Index: 24 The malignant bone tumors that are categorized as chondrosarcomas display a high potential for metastasis in late-stage disease. Higher-grade chondrosarcomas contain higher levels of expression of platelet-derived growth factor (PDGF) and its receptor. The phosphorylation of sphingosine by sphingosine kinase enzymes SphK1 and SphK2 generates sphingosine-1-phosphate (S1P), which inhibits ...
Known for
S1p Mediates | Chondrosarcoma Migration | Dependent Endothelial | Sphk1 Cdna

Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, #1 University Road, Tainan 701, Taiwan

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