Pei‐Hsin Huang: Influence Statistics

Pei‐Hsin Huang

Pei‐Hsin Huang

Department of Pathology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, 10051, Taiwan | College of Medicine, Graduate ...

Pei‐Hsin Huang: Expert Impact

Concepts for which Pei‐Hsin Huang has direct influence: Pompe disease , Newborn screening , Pulmonary emphysema , Sympathetic neurons , Early treatment , Cleft formation , Heterochromatin protein .

Pei‐Hsin Huang: KOL impact

Concepts related to the work of other authors for which for which Pei‐Hsin Huang has influence: Pompe disease , Newborn screening , Pancreatic cancer , Lysosomal storage disorders , Cell migration , Growth factor , Enzyme replacement therapy .

KOL Resume for Pei‐Hsin Huang

Year
2022

Department of Pathology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, 10051, Taiwan

2021

College of Medicine, Graduate Institute of Pathology, National Taiwan University, Taipei, 10617, Taiwan

2020

Department of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan

2019

Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan

2014

Department of Pathology, National Taiwan University Hospital, Taipei 100, Taiwan

2012

Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

2011

Department of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 7, Chung-Shan South Road, Taipei 100, Taiwan

2009

Pathology, National Taiwan University Hospital and National Taiwan University School of Medicine, Taipei, Taiwan

2008

Center for Neuroscience, University of California, Davis, CA 95618, USA

Genzyme Corporation, Cambridge, Massachusetts

2007

Department of Pathology, National Taiwan University Hospital, Taipei,Taiwan

2006

Pathology, and

2005

Center for Neuroscience, Section of Neurobiology, Physiology, and Behavior, Division of Biological Sciences and Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Davis, California 95616

2002

Department of Pathology, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taipei, Taiwan

2001

Department of Pathology, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan

2000

Department of Pathology, and

Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

1997

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115

Prominent publications by Pei‐Hsin Huang

KOL-Index: 12244 . OBJECTIVE: Pompe disease is an autosomal recessive lysosomal storage disorder that is caused by deficient acid alpha-glucosidase activity and results in progressive, debilitating, and often life-threatening symptoms involving the musculoskeletal, respiratory, and cardiac systems. Recently, enzyme replacement therapy with alglucosidase alpha has become possible, but the best outcomes in ...
Known for Pompe Disease | Newborn Screening | Early Detection | Earlier Diagnosis
KOL-Index: 11528 . The key gluconeogenic enzyme, fructose-1,6-bisphosphatase (FBPase), is induced when Saccharomyces cerevisiae are starved of glucose. FBPase is targeted from the cytosol to the yeast vacuole for degradation when glucose-starved cells are replenished with fresh glucose. Several vid mutants defective in the glucose-induced degradation of FBPase in the vacuole have been isolated. In some vid ...
Known for Fbpase Vesicles | Intracellular Structures | Wildtype Cells | Yeast Vacuole
KOL-Index: 11174 . Lymphangioma has long been thought of as congenital malformations resulting from the failure of lymphatic vessels communicating with the venous system in the fetal period. Alternatively, it is proposed to be true neoplasm originated from the transformation of lymphatic endothelia. To extend the molecular basis of the pathogenesis of lymphangioma, we have characterized the expression of ...
Known for Endothelial Cells | Vegfr3 Vegfr2 | Growth Factor | Expression Vegfc
KOL-Index: 10532 . Lymphomas involving the nasal and nasopharyngeal region mainly include CD56-positive natural killer (NK)/T-cell lymphomas, CD56-negative peripheral T-cell lymphomas (PTL), and B-cell lymphomas. Among these, the CD56-positive lymphoma, presumably of an NK/T-cell nature, is frequently seen in Asian, Mexican, and South American patients. NK cells are proposed to be closer developmentally to T ...
Known for Cell Lymphoma | Dependent Kinase | 6 Cdk6 | Gene Rearrangement
KOL-Index: 10229 . OBJECTIVE: Pompe disease causes progressive, debilitating, and often life-threatening musculoskeletal, respiratory, and cardiac symptoms. Favorable outcomes with early intravenous enzyme-replacement therapy and alglucosidase alfa have been reported, but early clinical diagnosis before the development of severe symptoms has rarely been possible in infants. METHODS: We recently conducted a ...
Known for Pompe Disease | Newborn Screening | Early Treatment | Muscle Pathology
KOL-Index: 8808 . To examine the role of placenta growth factor (PlGF) in the pathogenesis of pulmonary emphysema, we generated PlGF-transgenic (TG) mice using a phosphoglycerate kinase promoter. This resulted in constitutive overexpression of PlGF. In these TG mice, pulmonary emphysema, with enlarged air spaces and enhanced pulmonary compliance, first appeared at 6 months of age and became prominent at 12 ...
Known for Pulmonary Emphysema | Growth Factor | Plgf Pathogenesis | Endothelial Cell
KOL-Index: 8447 . BHLH-zip proteins usually play important regulatory roles in cell growth and differentiation. In this study, we show that Spz1, a bHLH-zip transcription factor, acts downstream of mitogen-activated protein kinase (MAPK, extracellular signal-regulated kinase 1/2) to up-regulate cell proliferation and tumorigenesis. In addition, through an interaction with proliferating cell nuclear antigen ...
Known for Cell Proliferation | Inbred Balb Mice | Protein Kinase | Spz1 Expression
KOL-Index: 7784 . The class 3 Semaphorins Sema3A and Sema3F are potent axonal repellents that cause repulsion by binding Neuropilin-1 and Neuropilin-2, respectively. Plexins are implicated as signaling coreceptors for the Neuropilins, but the identity of the Plexins that transduce Sema3A and Sema3F responses in vivo is uncertain. Here, we show that Plexin-A3 and -A4 are key determinants of these responses, ...
Known for 3 Semaphorins | Messenger Receptors | Sympathetic Neurons | Neuropilin1 Neuropilin2
KOL-Index: 7644 . BackgroundNew-onset diabetes mellitus (DM) is associated with pancreatic ductal cell adenocarcinoma (PDCA) and can resolve after pancreaticoduodenectomy (PD). Whether DM also resolves after PD in patients operated for disease other than PDCA remains to be determined.MethodsWe compared glycemic status before and after PD between patients with and without PDCA by review of a prospectively ...
Known for Patients Dm | Pancreatic Ductal | Cell Adenocarcinoma | Resolution Diabetes
KOL-Index: 7387 . Cancer cells often employ developmental cues for advantageous growth and metastasis. Here, we report that an axon guidance molecule, Sema3E, is highly expressed in human high-grade ovarian endometrioid carcinoma, but not low-grade or other ovarian epithelial tumors, and facilitates tumor progression. Unlike its known angiogenic activity, Sema3E acted through Plexin-D1 receptors to augment ...
Known for Mesenchymal Transition | Neoplastic Humans | Tumor Cells | Neuronal Cell
KOL-Index: 7373 . BACKGROUND & AIMS: Mcl-1-deficient hepatocytes are prone to undergo apoptosis. The tumor suppressor protein p53 plays an important role in apoptosis control as well as other cellular responses. This study was initially aimed to examine whether p53 was involved in Mcl-1 deficiency-induced apoptosis of hepatocytes. METHODS: Hepatocyte-specific Mcl-1 knockout (Alb-Mcl-1(-/-)) mice and ...
Known for Hepatic Injury | P53 Mcl1 | Liver Neoplasms | Apoptosis Hepatocytes
KOL-Index: 7337 . Caveolin-1 was up-regulated in different drug-resistant cancer cell lines and was suggested to confer drug resistance by different mechanisms. However, the relation of caveolin-1 expression and the clinical response to chemotherapy and prognosis in non-small cell lung cancer (NSCLC) remains unknown. Total 73 NSCLC (stages IIIB and IV) patients who received gemcitabine-based chemotherapy ...
Known for Cell Lung | Chemotherapy Patients | Caveolin1 Expression | Cancer Nsclc
KOL-Index: 7288 . Mucins play a key role in tumorigenesis. MUC15 is a membrane-bound mucin and the MUC15 messenger RNA (mRNA) has been detected in various organs. However, its role in tumor malignancy is still unclear. This study was to investigate the MUC15 expression in colorectal tumors and the role of MUC15 in colon cancer cells. We found that the mRNA expression of MUC15 was significantly higher in ...
Known for Cancer Cells | Muc15 Expression | Cell Proliferation | Inbred Balb Mice
KOL-Index: 7259 . Gastric cancer of youth is predominantly a disease of women, usually of the signet-ring cell subtype, with a predilection for metastasizing to the ovaries. The metastatic ovarian tumor is named a Krukenberg tumor. However, the characteristic genetic alterations between the primary gastric cancer and its metastatic ovarian tumor have not been studied. We used laser capture microdissection ...
Known for Gastric Cancer | Fhit Expression | Ring Cell | Krukenberg Tumor
KOL-Index: 7254 . During development, the semaphorin family of guidance molecules is required for proper formation of the sympathetic nervous system. Plexins are receptors that mediate semaphorin signaling, but how plexins function during sympathetic development is not fully understood. Using phenotypic analyses of mutant mice in vivo, expression pattern studies, and in vitro assays, we show that plexin-A3 ...
Known for Sympathetic Neurons | Neural Crest | Plexina3 Plexina4 | Cell Surface

Key People For Pompe Disease

Top KOLs in the world
#1
Ans Tjitske Van der Ploeg
pompe disease alglucosidase alfa enzyme replacement therapy
#2
Priya Sunil Kishnani
pompe disease alglucosidase alfa enzyme replacement therapy
#3
Arnold J J Reuser
pompe disease glycogen storage enzyme replacement therapy
#4
Wuh‐Liang Hwu
pompe disease newborn screening taiwanese patients
#5
Marian A Kroos
pompe disease glycogenosis type glycogen storage
#6
A J J Reuser
pompe disease glycogenosis type enzyme therapy

Department of Pathology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, 10051, Taiwan | College of Medicine, Graduate Institute of Pathology, National Taiwan University, Taipei, 10617, Taiwan | Depart