Prominent publications by Asbjørn Mohr Drewes

KOL Index score: 4975

BACKGROUND: Tapentadol is a combined opioid agonist and norepinephrine reuptake inhibitor with fewer gastrointestinal side effects at equianalgesic doses compared with classical strong opioids. Previous studies on tapentadol have included multi-morbid patients in whom confounders exclude detailed assessment of the mechanistic effects and strict comparison with other opioids or placebo. This study aimed at investigating the effects of tapentadol and oxycodone on gastrointestinal motility ...

Known for Tapentadol Oxycodone |  Opioid Therapy |  21 Healthy |  Males Participated
KOL Index score: 2747

OBJECTIVE: Postpancreatitis diabetes mellitus (PPDM) is a type of secondary diabetes that requires special considerations for management. The main objective was to examine prescription patterns of glucose-lowering therapy among adults with PPDM compared with type 1 and type 2 diabetes.

RESEARCH DESIGN AND METHODS: In a Danish nationwide population-based cohort study, we identified all individuals with adult-onset diabetes in the period 2000-2018 and categorized them as having type 1 ...

Known for Diabetes Mellitus |  Patients Ppdm |  Type 2 |  Glucose Humans |  New Onset
KOL Index score: 2105

BACKGROUND & AIMS: Pain is the foremost complication to chronic pancreatitis (CP), but no validated questionnaires for assessment exist. The COMPAT questionnaire includes all relevant pain dimensions in CP, but a short form is needed to make it usable in clinical practice.

METHODS: The full COMPAT questionnaire was completed by 91 patients and systematically reduced to 6 questions. Pain severity and analgesic use were merged, leaving 5 pain dimensions. The pain dimension ratings were ...

Known for Pain Assessment |  Chronic Pancreatitis |  Validated Questionnaires
KOL Index score: 1564

Moderate to severe pain is often treated with opioids, but central mechanisms underlying opioid analgesia are poorly understood. Findings thus far have been contradictory and none could infer opioid specific effects. This placebo-controlled, randomized, 2-way cross-over, double-blinded study aimed to explore opioid specific effects on central processing of external stimuli. Twenty healthy male volunteers were included and 3 sets of assessments were done at each of the 2 visits: 1) ...

Known for Morphine Placebo |  Cold Pressor |  Double Blinded
KOL Index score: 1482

BACKGROUND: Postpancreatitis diabetes mellitus (PPDM) is a common metabolic sequalae of acute and chronic pancreatitis. We conducted a cross-sectional study to examine the proportion of PPDM among patients clinically diagnosed with type 2 diabetes (T2D) in Denmark and their clinical and biochemical characteristics.

METHODS: We identified all past diagnoses of pancreatitis among patients in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort through linkage with ...

Known for Diabetes Mellitus |  Ppdm Common
KOL Index score: 1390

In this study we investigated brain morphology in adults with diabetic neuropathy. We aimed to characterize gray matter volume (GMV) and cortical thickness, and to explore associations between whole brain morphology and clinical characteristics. 46 adults with type 1 diabetes and distal symmetric peripheral neuropathy (DSPN) and 28 healthy controls underwent magnetic resonance imaging scans. GMV and cortical thickness were estimated using voxel-/surface-based morphometry. Associations ...

Known for Type 1 |  Clinical Characteristics |  Adult Brain |  28 Healthy |  Controls Underwent
KOL Index score: 1076

Magnetic resonance elastography (MRE) is a non-invasive technique suitable for assessing mechanical properties of tissues, i.e., stiffness. MRE of the pancreas is relatively new, but recently an increasing number of studies have successfully assessed pancreas diseases with MRE aiming to differentiate healthy from pathological pancreatic tissue with or without fibrosis. This review will systematically describe the practical and clinical applications of pancreatic MRE. We conducted a ...

Known for Magnetic Resonance |  Elastography Mre
KOL Index score: 907

Symptoms related to functional and sensory abnormalities are frequently encountered in patients with diabetes mellitus. Most symptoms are associated with impaired gastric and intestinal function. In this review, we discuss basic concepts of sensory-motor dysfunction and how they relate to clinical findings and gastrointestinal abnormalities that are commonly seen in diabetes. In addition, we review techniques that are available for investigating the autonomic nervous system, neuroimaging ...

Known for Gastrointestinal Tract
KOL Index score: 253

OBJECTIVES: Noninvasive vagus nerve stimulation (nVNS) has not only shown antinociceptive effects, but also demonstrated anti-inflammatory and antidepressant effects. These effects could be beneficial in chronic pancreatitis (CP) patients suffering from chronic abdominal pain, even though the underlying central mechanisms remain unclear. The aim was to investigate the effect of cervical nVNS in patients with painful CP on brain functional connectivity and cerebral metabolites.


Known for Chronic Pancreatitis |  Magnetic Resonance Spectroscopy


Asbjørn Mohr Drewes: Influence Statistics

Sample of concepts for which Asbjørn Mohr Drewes is among the top experts in the world.
Concept World rank
supraspinal level humans #6
source localization oxycodone #6
perception tapentadol #6
7 reduction analgesics #6
glutamate creatine levels #6
cortex tapentadol #6
tapentadol 135 ± #6
oxycodone central processing #6
oxycodone 126 #6
treatment 50 tapentadol #6
14 tonic pain #6
120 electroencephalography #6
oxycodone cingulate glutamate #6
tapentadol 126 #6
bands tapentadol #6
noradrenergic activity knowledge #6
reduce cingulate #6
tonic pain day #6
oxycodone central #6
temporal lobe placebo #6
tapentadol prefrontal cortex #6
ppdm common #7
baseline oxycodone #7
tapentadol pain perception #7
apmethodsa systematic search #8
2resultstwelve rcts #8
spectral alpha1 #8
modalities pooled scores #8
day identified rcts #8
crossovertrial #9
tapentadol decreased #9
efficacy analgesic modalities #9
24 nsaids #9
14 tonic #10
opiates 24 #11
relief opiates #11
nsaids 24 #11
lobe alpha2 #12
ppdm prevalence #12
24 opiates #12
day epidural analgesia #13
opiates placebo #13
placebo modalities #14
50 tapentadol #15
oxycodone reduce #15
ppdma #16
ppdm compared #18
2 °c water #19
decreased electroencephalography #20
14 spectral #23

Key People For Tapentadol Oxycodone

Top KOLs in the world
Akiko Okamoto
tapentadol oxycodone chronic pain gastrointestinal tolerability
Claudia Lange
tapentadol oxycodone multiple doses phase iii
Thomas Michael Tzschentke
spraguedawley receptors gyki 52466 neuropathic pain
Thomas Christoph
neuropathic pain opioid receptors rat model
Babette Y Kögel
aachen minipig trpv1 leu206stop mice opioid receptor
Christine Rauschkolb
chronic pain tapentadol extended release immpact recommendations

Asbjørn Mohr Drewes:Expert Impact

Concepts for whichAsbjørn Mohr Dreweshas direct influence:Tapentadol oxycodone,  Central processing,  Tonic pain,  Oxycodone tapentadol,  Patients acute pancreatitis,  Cingulate glutamate,  Initial management,  Tapentadol pain perception.

Asbjørn Mohr Drewes:KOL impact

Concepts related to the work of other authors for whichfor which Asbjørn Mohr Drewes has influence:Enteropathy symptoms,  Pain perception,  Cold pressor test,  Tapentadol oxycodone,  Anorectal function,  Hemorrhagic tolerance,  Dose morphine.



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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark | Department of Gastroenterology and Hepatology, Centre for Pancreatic Diseases, Aalborg University Hospital, Aalborg, Denmark | Mech-Sense, Department of Gastroenterology and Hepa

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