Prominent publications by Anthony J Bron

KOL Index score: 12424

PURPOSE: To evaluate the use of tear osmolarity in the diagnosis of dry eye disease.

DESIGN: A prospective, observational case series to determine the clinical usefulness of tear osmolarity and commonly used objective tests to diagnose dry eye disease.

METHODS: A multicenter, 10-site study consisting of 314 consecutive subjects between 18 and 82 years of age. Bilateral tear osmolarity, tear film break-up time (TBUT), corneal staining, conjunctival staining, Schirmer test, and meibomian ...

Known for Tear Osmolarity |  Dry Eye Disease |  Diagnostic Techniques |  Sensitivity Specificity |  Objective Tests
KOL Index score: 10831

PURPOSE: To determine the effects of visible light on normal or metabolically compromised cultured rat RGC-5 cells.

METHODS: Cultured RGC-5 cells were exposed to different durations as well as intensities of optical radiation, filtered to exclude wavelengths below 400 nm. Some cells were also subjected to metabolic compromise by depriving them of serum (serum deprivation; SD). Treated cells were assayed for cell viability using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium ...

Known for Visible Light |  Cell Viability |  Reactive Oxygen Species |  Nick Labeling |  Retinal Ganglion
KOL Index score: 10770

OBJECTIVE: To compare the postoperative rotation of plate and loop haptic implants of spherical power to ascertain the optimal design appropriate for toric intraocular lenses (IOLs).

DESIGN: Randomized, controlled trial.

PARTICIPANTS: Forty-eight patients attending for routine cataract surgery by phacoemulsification.

METHOD: Patients with cataract as the only ocular disease were randomly implanted with plate or loop haptic implants after uncomplicated phacoemulsification. The baseline ...

Known for Loop Haptic |  2 Weeks |  Lens Rotation |  6 Months |  Axial Length
KOL Index score: 10320

The lipid layer is an essential component of the tear film, providing a smooth optical surface for the cornea and retarding evaporation from the eye. The meibomian lipids which compose it are well adapted for this purpose. They form a thin, smooth film whose thickness, and probably composition, influences the rate of evaporation. Their melting range ensures sufficient fluidity for delivery to the tear film from the lid margin reservoirs, while the film itself may exhibit a higher ...

Known for Tear Film |  Lipid Layer |  Aqueous Phase |  Meibomian Glands |  Essential Component
KOL Index score: 9917

OBJECTIVE: To investigate the association of optic nerve sheath diameter (ONSD), as a correlate of intracranial pressure (ICP), with acute mountain sickness (AMS).

DESIGN: Longitudinal cohort study of mountaineers from sea level to 6400 m.

SETTING: Mount Everest (North side).

PARTICIPANTS: 13 mountaineers (10 men, 3 women; aged 23-52 years) on a British expedition to climb Mount Everest.

INTERVENTIONS: ONSD was measured ultrasonically, 3 mm behind the globe using B scans recorded with an ...

Known for Mount Everest |  Intracranial Pressure |  Optic Nerve |  Sheath Diameter |  Heart Rate
KOL Index score: 9488

PURPOSE: To evaluate in a general clinic-based cohort of patients with dry eye disease (DED) the distribution of patients with aqueous-deficient or evaporative subtype of DED.

METHODS: Schirmer tests and meibomian gland dysfunction (MGD) (Foulks-Bron scoring) were evaluated in both eyes of 299 normal subjects and DED patients (218 women and 81 men) across 10 sites in the European Union and the United States. Using the more severe measurement of the 2 eyes, subjects were considered to ...

Known for Dry Eye |  Mgd Subjects |  Patients Ded |  Aqueous Deficient |  Schirmer Tests
KOL Index score: 9300

BACKGROUND: There is a wide variation in the use of diagnostic tests for dry eye disease. The purpose of this study was to survey the attitudes of eye practitioners towards both tests and therapies available for dry eye disease.

METHOD: An anonymous, web-based questionnaire was used, containing both quantitative and qualitative sections.

RESULTS: Thirty-eight respondents, evenly distributed in experience, confirmed the wide variation of diagnostic tests in use. History and staining ...

Known for Diagnostic Tests |  Dry Eye Disease |  Eye Practitioners |  Wide Variation |  Physicians Surveys
KOL Index score: 9063

Publication of the DEWS report in 2007 established the state of the science of dry eye disease (DED). Since that time, new evidence suggests that a rethinking of traditional concepts of dry eye disease is in order. Specifically, new evidence on the epidemiology of the disease, as well as strategies for diagnosis, have changed the understanding of DED, which is a heterogeneous disease associated with considerable variability in presentation. These advances, along with implications for ...

Known for Eye Disease |  Patients Ded |  Tear Osmolarity |  Dews Report |  Meibomian Glands
KOL Index score: 9009

BACKGROUND/AIMS: To compare the safety and efficacy of hypotonic 0.18% sodium hyaluronate solution (0.18% SH) versus saline and versus 0.3% carbomer for the treatment of signs and symptoms of moderate dry eye syndrome.

METHODS: A total of 304 patients were randomized (1:1:1) in this parallel-group, multi-center, phase III trial. They were instructed to instill one drop of the allocated product in each eye two to four times per day over 84 days. The primary efficacy criterion was the ...

Known for Dry Eye |  Sodium Hyaluronate |  Signs Symptoms |  018 Sh |  Ophthalmic Solution
KOL Index score: 8873

OBJECTIVE: To investigate the relationship between tear volume and tear meniscus curvature by means of the video meniscometer.

METHODS: Eleven eyes of 11 patients with severe dry eye were studied (all female; mean +/- SD age, 66.2 +/- 7.7 years; 7 left eyes and 4 right eyes), each of whose puncta had been therapeutically occluded. Four instillations of balanced salt solution were given at intervals of 1 minute in each studied eye, with the concentration increasing in 5-microL steps from ...

Known for Tear Volume |  Diagnostic Techniques |  Meniscus Radius |  1 Minute |  Severe Dry Eye
KOL Index score: 8697

The distribution of sulphated proteoglycans within the stromas of three patients (A,B,C) suffering from macular corneal dystrophy was studied using the specific dye Cuprolinic Blue in a 'critical electrolyte concentration' method. The corneas were examined using transmission electron microscopy and A and C were further studied by low-angle synchroton X-ray diffraction. Sera from all three patients were analyzed for the presence of keratan sulphate using a monoclonal antibody in an ...

Known for Electron Microscopy |  Macular Corneal Dystrophy |  Ray Diffraction |  Cuprolinic Blue |  Collagen Fibrils
KOL Index score: 8666

PURPOSE: Collagen fibrils and proteoglycans are the main components of the corneal extracellular matrix and corneal transparency depends crucially on their proper arrangement. In the present study, we investigated the formation of collagen fibrils and proteoglycans in the developing cornea of the zebrafish, a model organism used to study vertebrate embryonic development and genetic disease.

METHODS: We employed thin-section electron microscopy to investigate the ultrastructure of the ...

Known for Collagen Fibrils |  Corneal Stroma |  Bowmans Layer |  Microscopy Electron |  Human Cornea
KOL Index score: 8611

It has long been assumed that unstimulated tears are more thoroughly equilibrated with epithelial secretions than stimulated tears, since they are in contact with tarsal, bulbar and corneal surfaces for longer. It was also believed from results with model solutions that soluble mucin is responsible for the observed surface tension and viscosity of tears. If longer contact means more mucin is dissolved in the aqueous tears, then the surface activity (surface tension lowered by mucin) and ...

Known for Stimulated Tears |  Surface Tension |  Physical Properties |  Tear Viscosity |  Proteins Mucins
KOL Index score: 8596

Tear hyperosmolarity is thought to play a key role in the mechanism of dry eye, a common symptomatic condition accompanied by visual disturbance, tear film instability, inflammation and damage to the ocular surface. We have constructed a model for the mass and solute balance of the tears, with parameter estimation based on extensive data from the literature which permits the influence of tear evaporation, lacrimal flux and blink rate on tear osmolarity to be explored. In particular the ...

Known for Dry Eye |  Tear Volume |  Ocular Surface |  Blink Rate |  Ede Adde


Anthony J Bron: Influence Statistics

Sample of concepts for which Anthony J Bron is among the top experts in the world.
Concept World rank
distribution keratoconus corneas #1
dyes fluorescein #1
tgtimolol timolol groups #1
leading publisher #1
capsular fusion #1
rheumatoid cornea #1
lens electron microscopy #1
eye mgd #1
agerelated nondiabetic cataracts #1
healthy orifice glands #1
transplant lens #1
pdm sessions #1
cataracts observers #1
computer monitorresults #1
repeated horizontal saccades #1
floral ropelike aggregations #1
dry eve disease #1
marxs paper #1
lacrimal apparatus humans #1
scheimpflug crystalline mathematics #1
anterior cortical layers #1
coronis foundation #1
mgd absence #1
osmolarity bto #1
ded tosm #1
initial observations chance #1
aqueousdeficient adde #1
sjögren tables 12 #1
tosm experiment #1
gradient tear #1
evaporation eye #1
increase lacrimal flux #1
foundation ophthalmic #1
fibre breaks waterclefts #1
micropooling #1
keratoconus microfibrils #1
lid margin meibometer #1
computerassisted lasers lens #1
reflection grid pattern #1
munsell grade 1 #1
cataract objective assessment #1
breaks tear film #1
cortical spoke #1
10 seconds nibut #1
1594 057 mm #1
cfs proteoglycans #1
waterclefts spoke #1
eosin mgs #1
1 bilateral saline #1
meniscus apex #1

Key People For Dry Eye

Top KOLs in the world
dry eye ocular surface lacrimal gland
Stephen Carl Pflugfelder
dry eye ocular surface sjögren syndrome
Debra Ann Schaumberg
dry eye macular degeneration tear osmolarity
David A Sullivan
gene expression meibomian gland secretory component
Murat Dogru
dry eye ocular surface tear function
Kelly Kinney Nichols
dry eye tear film meibomian gland dysfunction

Anthony J Bron:Expert Impact

Concepts for whichAnthony J Bronhas direct influence:Dry eye,  Tear film,  Dry eye disease,  Tear meniscus,  Diagnostic tests,  Ocular surface,  Tear osmolarity,  Meibomian glands.

Anthony J Bron:KOL impact

Concepts related to the work of other authors for whichfor which Anthony J Bron has influence:Dry eye,  Ocular surface,  Tear film,  Meibomian gland,  Cataract surgery,  Contact lens,  Diabetic retinopathy.



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University of Oxford, Nuffield Laboratory of Ophthalmology, Nuffield Dept of Clinical Neurosciences, OX1 2JD Oxford, UK. | Nuffield Department of Clinical Neurosciences and Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford OX2 6HZ, U

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