Cynthia Elizabeth

Cynthia Elizabeth

The Arthur And Sonia Labatt Brain Tumor Research Centre, The Hospital For Sick Children, Toronto, On, Canada

Direct Impact

Concepts for which Cynthia Elizabeth has direct influence:

telomerase inhibition
alternative lengthening
pediatric ependymoma
tumor-initiating cells
year survival
brain tumors
tp53 mutations

External impact

Concepts related to the work of other authors for which Cynthia Elizabeth has influence:

g–rich repeat
arrangement differs
mouse telomeres
gross organisation
distal region
restriction enzymes
mutation correction processes

Prominent publications by Cynthia Elizabeth

KOL-Index: 17 Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repopulate the tumor from which they are identified, and are drivers of recurrence in numerous ...
Known for
5-Year Progression-Free Survival | Ependymoma Pediatric | 64 ± | Telomerase Repeat Amplification Protocol
KOL-Index: 7 Although telomeres are maintained in most cancers by telomerase activation, a subset of tumors utilize alternative lengthening of telomeres (ALT) to sustain self-renewal capacity. In order to study the prevalence and significance of ALT in childhood brain tumors we screened 517 pediatric brain tumors using the novel C-circle assay. We examined the association of ALT with alterations in genes ...
Known for
Mutant Choroid | 67 ± | Pediatric Grade | Tumors Telomeres

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada

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