 | Cynthia Elizabeth |
Prominent publications by Cynthia Elizabeth
Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors
[ PUBLICATION ]
Although telomeres are maintained in most cancers by telomerase activation, a subset of tumors utilize alternative lengthening of telomeres (ALT) to sustain self-renewal capacity. In order to study the prevalence and significance of ALT in childhood brain tumors we screened 517 pediatric brain tumors using the novel C-circle assay. We examined the association of ALT
with alterations in genes found to segregate with specific histological phenotypes and with clinical outcome. ALT was ...
| Also Ranks for: Alternative Lengthening | brain tumors | choroid plexus | telomerase activation | nuclear protein |
Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells
[ PUBLICATION ]
Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repopulate the tumor from which they are identified, and are drivers of recurrence in numerous cancers. In this study, telomerase enzymatic activity was directly measured and inhibited to assess ...
| Also Ranks for: Pediatric Ependymoma | telomerase activity | alternative lengthening | maintenance mechanisms | cell tumor |
Cynthia Elizabeth: Influence Statistics
| Concept | World rank |
|---|---|
| helicases glioma | #75 |
| ccircle assay | #91 |
Key People For Alternative Lengthening
Cynthia Elizabeth:Expert Impact
Concepts for whichCynthia Elizabethhas direct influence:Alternative lengthening, Pediatric ependymoma, Telomerase activity, Alternative lengthening telomeres, Pediatric ependymomas, Telomerase inhibition, Ccircle assay, Telomerase activation.
Cynthia Elizabeth:KOL impact
Concepts related to the work of other authors for whichfor which Cynthia Elizabeth has influence:Alternative lengthening, Telomere maintenance, Tert promoter mutations, Telomerase activation, Molecular subgroups, Posterior fossa, Atrx loss.
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