• Disease
  • Alternative
  • Alternative Lengthening
  • Cynthia Elizabeth

    Prominent publications by Cynthia Elizabeth

    KOL Index score: 6754

    Although telomeres are maintained in most cancers by telomerase activation, a subset of tumors utilize alternative lengthening of telomeres (ALT) to sustain self-renewal capacity. In order to study the prevalence and significance of ALT in childhood brain tumors we screened 517 pediatric brain tumors using the novel C-circle assay. We examined the association of ALT

    with alterations in genes found to segregate with specific histological phenotypes and with clinical outcome. ALT was ...

    Also Ranks for: Alternative Lengthening |  brain tumors |  choroid plexus |  telomerase activation |  nuclear protein
    KOL Index score: 5214

    Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repopulate the tumor from which they are identified, and are drivers of recurrence in numerous cancers. In this study, telomerase enzymatic activity was directly measured and inhibited to assess ...

    Also Ranks for: Pediatric Ependymoma |  telomerase activity |  alternative lengthening |  maintenance mechanisms |  cell tumor


    Cynthia Elizabeth: Influence Statistics

    Sample of concepts for which Cynthia Elizabeth is among the top experts in the world.
    Concept World rank
    helicases glioma #75
    ccircle assay #91

    Key People For Alternative Lengthening

    Top KOLs in the world
    Roger R Reddel
    alternative lengthening cell lines telomerase activity
    Jeremy David Henson
    alternative lengthening cancer cells methionine restriction
    Titia De Lange
    human telomeres binding proteins telomeric dna
    Axel A Neumann
    alternative lengthening epithelial cells telomeric dna
    Thomas R Yeager
    telomerase activity raw milk alternative lengthening
    Jerry William Shay
    telomerase activity cellular senescence epithelial cells

    Cynthia Elizabeth:Expert Impact

    Concepts for whichCynthia Elizabethhas direct influence:Alternative lengthening,  Pediatric ependymoma,  Telomerase activity,  Alternative lengthening telomeres,  Pediatric ependymomas,  Telomerase inhibition,  Ccircle assay,  Telomerase activation.

    Cynthia Elizabeth:KOL impact

    Concepts related to the work of other authors for whichfor which Cynthia Elizabeth has influence:Alternative lengthening,  Telomere maintenance,  Tert promoter mutations,  Telomerase activation,  Molecular subgroups,  Posterior fossa,  Atrx loss.



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    The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON Canada | The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada