 | Jennifer Adamski |
Prominent publications by Jennifer Adamski
Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells
[ PUBLICATION ]
Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repopulate the tumor from which they are identified, and are drivers of recurrence in numerous cancers. In this study, telomerase enzymatic activity was directly measured and inhibited to assess ...
| Also Ranks for: Pediatric Ependymoma | telomerase activity | alternative lengthening | maintenance mechanisms | cell tumor |
Medulloblastoma subgroup-specific outcomes in irradiated children: who are the true high-risk patients?
[ PUBLICATION ]
BACKGROUND: The advent of integrated genomics has fundamentally changed our understanding of medulloblastoma. Although survival differences exist among the 4 principal subgroups, this has yet to be elucidated in a North American cohort of irradiated patients.
METHODS: Ninety-two consecutive patients between the ages of 3 and 17 treated with surgery, craniospinal irradiation, and chemotherapy were identified at the Hospital for Sick Children. Molecular subgrouping was performed using ...
| Also Ranks for: 4 Patients | medulloblastoma subgroup | craniospinal irradiation | sick children | treatment protocols |
Key People For Pediatric Ependymoma
Jennifer Adamski:Expert Impact
Concepts for whichJennifer Adamskihas direct influence:Pediatric ependymoma, Pediatric ependymomas, Telomerase inhibition, Medulloblastoma subgroup, Alternative lengthening, Craniospinal irradiation, Maintenance mechanisms, Sick children.
Jennifer Adamski:KOL impact
Concepts related to the work of other authors for whichfor which Jennifer Adamski has influence:Patients medulloblastoma, Molecular subgroups, Brain tumors, Posterior fossa, Daoy cells, Metastatic dissemination, Tert promoter mutations.
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