Prominent publications by Frank W Sharbrough

KOL Index score: 13249

PURPOSE: To investigate the relation among routine EEG, long-term EEG monitoring (LTM), quantitative magnetic resonance imaging (MRI), and surgical outcome in temporal lobe epilepsy (TLE).

METHODS: We evaluated 159 patients with intractable TLE who underwent an anterior temporal lobectomy between 1988 and 1993. The epileptogenic temporal lobe was determined by ictal LTM. A single awake-sleep outpatient EEG with standard activating procedures was performed before LTM. EEGs were analyzed ...

Also Ranks for: Temporal Lobe |  routine eeg |  operative outcome |  patients mri |  magnetic resonance
KOL Index score: 12688

The relationships between preoperatively acquired MRI-based hippocampal volumes (HV), seizure disorder onset and duration, and early childhood febrile convulsions were investigated retrospectively with data from 72 left and 56 right temporal lobectomy patients. Patients with lesional pathology and heterotopic abnormalities were excluded. Age at development of spontaneous seizures unprovoked by an acute illness defined age of seizure disorder onset. Age of onset was subtracted from age at ...

Also Ranks for: Age Onset |  febrile convulsions |  temporal lobectomy patients |  mri hippocampal |  recurrent seizures
KOL Index score: 12582

OBJECTIVE: To determine the surgical outcome and factors of predictive value in patients undergoing reoperation for intractable partial epilepsy.

METHODS: The authors retrospectively studied the operative outcome in 64 consecutive patients who underwent reoperation for intractable partial epilepsy. Demographic data, results of comprehensive preoperative evaluations, and the seizure and neurologic outcome after reoperation were determined. All patients were followed a minimum of 1 year ...

Also Ranks for: Failed Epilepsy Surgery |  resective reoperation |  intractable partial epilepsy |  operative outcome |  rare seizures
KOL Index score: 11818

We performed magnetic resonance imaging (MRI) using a high-field strength magnet (1.5 T) in two series of 53 patients with intractable partial epilepsy of frontal lobe or temporal lobe origin who subsequently received ablative surgery for their seizure disorder. In the first series of patients the pathologic correlation and prognostic importance of an MRI-identified lesion in the frontal lobe were assessed. Twenty-five percent of the patients with negative MRI studies and 67% of patients ...

Also Ranks for: Frontal Lobe |  presurgical evaluation |  epilepsy temporal |  sensitivity specificity |  1 year
KOL Index score: 9835

OBJECTIVE: To identify presurgical and postsurgical factors that are independently predictive of the outcome of anterior temporal lobectomy (ATL) for intractable epilepsy.

BACKGROUND: There have been reports of prognostic factors in epilepsy surgery, but little is known about factors that independently predict outcome of ATL.

METHODS: We studied 175 consecutive ATL patients who had at least 2 years of postsurgical follow-up. Significant factors on univariate analyses were subjected to ...

Also Ranks for: Intractable Epilepsy |  anterior temporal lobectomy |  excellent outcome |  ictal onset |  univariate analyses
KOL Index score: 9557

Phenol sulfotransferase (PST; EC catalyzes the sulfate conjugation of phenolic and catechol neurotransmitters and drugs. The human blood platelet has been the most thoroughly studied source of PST because of the possibility that the regulation of the enzyme in this easily accessible tissue might reflect the regulation of PST in the CNS. The human brain and platelet contain at least two forms of PST, forms designated as thermostable (TS) and thermolabile (TL) PST. TS PST ...

Also Ranks for: Phenol Sulfotransferase |  sulfate conjugation |  pst activities |  individual variations |  human platelet
KOL Index score: 9274

PURPOSE: To determine the extent to which periictal subtraction single-photon emission computed tomography (SPECT) may improve detection and definition of the epileptogenic zone in patients with focal malformations of cortical development (MCDs).

METHODS: Subtraction SPECT coregistered to magnetic resonance (MR) images (SISCOM) were constructed for 22 consecutive patients with focal MCDs who underwent periictal SPECT injection (18 ictal and four postictal). In the 17 patients who had ...

Also Ranks for: Epileptogenic Zone |  subtraction spect |  epilepsy surgery |  siscom localization |  cortical development
KOL Index score: 9082

BACKGROUND AND PURPOSE: Presurgical sensorimotor mapping with functional MR imaging is gaining acceptance in clinical practice; however, to our knowledge, its therapeutic efficacy has not been assessed in a sizable group of patients. Our goal was to identify how preoperative sensorimotor functional studies were used to guide the treatment of neuro-oncologic and epilepsy surgery patients.

METHODS: We retrospectively reviewed the medical records of 46 patients who had undergone ...

Also Ranks for: Surgical Planning |  functional imaging |  tumor patients |  motor evoked potentials |  brain mapping

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Frank W Sharbrough:Expert Impact

Concepts for whichFrank W Sharbroughhas direct influence:Temporal lobe,  Temporal lobectomy,  Carotid endarterectomy,  Magnetic resonance,  Partial epilepsy,  Intractable partial epilepsy,  Routine eeg,  Seizure control.

Frank W Sharbrough:KOL impact

Concepts related to the work of other authors for whichfor which Frank W Sharbrough has influence:Temporal lobe,  Carotid endarterectomy,  Epilepsy surgery,  Magnetic resonance,  Hippocampal sclerosis,  Evoked potentials,  Cardiac arrest.



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Division of Epilepsy, Mayo Clinic, Rochester, MN, USA | Department of Neurology | From the Division of Epilepsy (Drs. Siegel, Cascino, So, and Sharbrough) and Section of Electroencephalography (Drs. Cascino, So, and Sharbrough), Departments of Neurol