Prominent publications by Jun Xiang

KOL Index score: 14028

PURPOSE: To evaluate corneal reinnervation, and the corresponding corneal sensitivity and keratocyte density after small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK).

METHODS: In this prospective, non-randomized observational study, 18 patients (32 eyes) received SMILE surgery, and 22 patients (42 eyes) received FS-LASIK surgery to correct myopia. The corneal subbasal nerve density and microscopic morphological changes in corneal ...

Also Ranks for: Situ Keratomileusis |  femtosecond laser |  corneal reinnervation |  fslasik smile |  subbasal nerve density
KOL Index score: 13335

In recent decades, the incidence rate of papillary thyroid carcinoma (PTC) has been rapidly increasing. However, the molecular mechanism of the physiological and pathological processes of PTC is still largely unknown. Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is a tumor suppressor and exerts anti-tumor effect in several human cancers, while the role and underlying mechanism of LHPP in PTC remain vague. In this study, we firstly evaluated the roles of LHPP ...

Also Ranks for: Thyroid Cancer |  cell growth |  signaling pathway |  inbred balb mice |  lhpp expression
KOL Index score: 12869

PURPOSE: The activation of ROS-NLRP3-IL-1β signaling axis induced by hyperosmotic stress (HS) has been recognized as a key priming stage of epithelial inflammation in dry eye pathogenesis. The current study aims to investigate whether calcitriol, the active metabolite of vitamin D3, could protect cells against HS-induced inflammation through modulating this critical step.

METHODS: Human corneal epithelial cells (iHCECs) were cultured in hyperosmotic medium (450 mOsM) with various ...

Also Ranks for: Hyperosmotic Stress |  epithelial cells |  nlrp3 activation |  human corneal |  calcitriol inhibits
KOL Index score: 11709

BACKGROUND: Programmed death-ligand 1 (PD-L1) expression has been reported in several malignancies, but the expression of PD-L1 in papillary thyroid cancer (PTC) has been characterized rarely. The aim of this study was to assess the significance of PD-L1 expression and its associations with clinicopathologic factors and disease outcome in PTC.

METHODS: Immunohistochemistry staining was conducted retrospectively to evaluate the expression of PD-L1 in a total of 260 PTC tumors and ...

Also Ranks for: Papillary Thyroid Cancer |  expression pdl1 |  ligand 1 |  programmed death |  extrathyroidal extension
KOL Index score: 11133

Long non-coding RNAs (lncRNAs) participate in cancer cell tumorigenesis, cell cycle control, migration, proliferation, apoptosis, metastasis and drug resistance. The BRAF-activated non-coding RNA (BANCR) functions as both an oncogene and a tumor suppressor. Here, we investigated BANCR's role in papillary thyroid carcinoma (PTC) by assessing BANCR levels in PTC and matched normal thyroid epithelial tissues from 92 patients using qRT-PCR. We also used lentiviral vectors to establish PTC ...

Also Ranks for: Tumor Suppressor |  papillary thyroid |  bancr levels |  ptc cell |  apoptosis migration
KOL Index score: 9264

INTRODUCTION: The status of central lymph node metastasis (CLNM) is crucial to determining the surgical strategies for papillary thyroid micro carcinoma (PTMC). The objective of the study was to establish a nomogram to predict the possibility of CLNM in PTMC patients.

METHODS: A total of 8668 PTMC patients who underwent total thyroidectomy or lobectomy with central lymph node dissection (CLND) from 2006 to 2016 were retrospectively retrieved. Univariate and multivariate analysis were ...

Also Ranks for: Clnm Nomogram |  lymph node |  papillary thyroid |  retrospective cohort study |  ptmc patients
KOL Index score: 9105

INTRODUCTION: To investigate whether the positive lymph node number (PLNN) and positive lymph node ratio (PLNR) could predict the prognosis of patients with major salivary gland cancer (MSGC) and to identify the optimal cutoff points for these variables that stratify patients according to their risk of survival.

METHODS: We used the Surveillance, Epidemiology, and End Results (SEER) database to identify all patients with MSGC between 1988 and 2014. A logistic regression analysis was ...

Also Ranks for: Salivary Gland |  lymph node |  seer database |  ductal carcinoma |  surveillance epidemiology
KOL Index score: 9009

KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. In the present study, we identified that KMT5A was elevated in 50 pairs of papillary thyroid cancer tissue samples and in cell lines K1 and TPC-1 by qRT-PCR and western blotting, as well as by immunohistochemical staining. CCK-8 assay and flow cytometric analysis revealed that ...

Also Ranks for: Thyroid Cancer |  lipid metabolism |  histone methyltransferase |  cell cycle |  kmt5a expression
KOL Index score: 8925

The mammalian peptide hormone stanniocalcin 2 (STC2) plays an oncogenic role in many human cancers. However, the exact function of STC2 in human head and neck squamous cell carcinoma (HNSCC) is unclear. We aimed to examine the function and clinical significance of STC2 in HNSCC. Using in vitro and in vivo assays, we show that overexpression of STC2 suppressed cell apoptosis, promoted cell proliferation, migration, invasion, and cell cycle arrest at the G1/S transition. By contrast, ...

Also Ranks for: Squamous Cell |  stc2 expression |  neck neoplasms humans |  carcinoma hnscc |  proteins akt
KOL Index score: 8355

OBJECTIVE: Analyze recent clinical features of thyroid cancer in eastern China.

METHODS: Investigation and comparison of clinical data of thyroid cancer patients from 1996 to 2006 from the Department of Head and Neck Surgery in the Cancer Hospital of Fudan University, Shanghai, China.

RESULTS: The number of patients with thyroid cancer rose from 148 in the year 1996 to 572 in the year 2006, a 3.9-fold increase. Routine ultrasound survey during physical examination revealed four cases ...

Also Ranks for: Thyroid Cancer |  eastern china |  carcinoma carcinoma |  lymph node |  early detection
KOL Index score: 7568

BACKGROUND: Uncovering the target gene of miR-584 to control thyroid carcinoma (TC) invasion and migration is of central importance in the diagnosis, treatment, and prognosis of TC. To validate whether miR-584 has a tumor-suppressive role in thyroid cancer cells by targeting ROCK1, a series of experiments were conducted to figure out the mechanism of action of miR-584.

MATERIAL AND METHODS: Migration analyses and cell proliferation assays were performed using miR-584-transfected cells. ...

Also Ranks for: Thyroid Carcinoma |  cell migration |  neoplastic humans |  rock1 expression |  target gene
KOL Index score: 6359

Conjunctivochalasis (Cch) is a very common ocular disorder, which can cause an unstable tear film and ocular discomfort. The study of vision-related quality of life (VR-QoL) in a community population with Cch can provide a better understanding of the impact of Cch on common people than objective clinical examinations alone. This cross-sectional comparative study enrolled 360 participants ≥ 40 years old living in Sanle Community, Shanghai. In the study, 198 subjects were diagnosed with ...

Also Ranks for: Conjunctivochalasis Cch |  life vrqol |  normal controls |  dry eye |  tear film
KOL Index score: 5709

PURPOSE: To investigate re-innervation in the implanted lenticule, as well as changes to the cornea, after correcting hyperopia with an autologous implantation of a lenticule obtained through small incision lenticule extraction (SMILE).

METHODS: This study retrospectively analysed re-innervation in the implanted lenticule, as well as microscopic morphological changes in the corneal architecture of the recipient cornea in five patients (with myopia in one eye and hyperopia in the ...

Also Ranks for: Implanted Lenticule |  vivo confocal |  situ lasers |  recipient cornea |  microscopic investigation
KOL Index score: 5344

Background: To explore the ability of the deep learning network Inception-v3 to differentiate between papillary thyroid carcinomas (PTCs) and benign nodules in ultrasound images.

Methods: A total of 2,836 thyroid ultrasound images from 2,235 patients were divided into a training dataset and a test dataset. Inception-v3 was trained and tested to crop the margin of the images of nodules and provide a differential diagnosis. The sizes and sonographic features of nodules were further ...

Also Ranks for: Ultrasound Images |  thyroid nodules |  deep learning |  training dataset |  diagnostic efficiency
KOL Index score: 5312

Objective: To evaluate the risk factors for predicting lymph nodes (LN) posterior to right recurrent laryngeal nerve metastasis in thyroid papillary carcinoma.

Methods: PubMed, PMC, EMBASE, and the Cochrane Library were systematically searched for articles published spanning 30/06/2009-30/8/2018 using multiple search terms. Thirteen articles involving 10,014 patients were reviewed in our meta-analysis. Stata 15.1 software was used for the meta-analysis.

Results: The rate of LN posterior ...

Also Ranks for: Lymph Nodes |  recurrent laryngeal |  capsule invasion |  nerve metastasis |  ptc patients

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Jun Xiang:Expert Impact

Concepts for whichJun Xianghas direct influence:Thyroid cancer,  Papillary thyroid cancer,  Eastern china,  Papillary thyroid,  Lymph node,  Vivo confocal microscopy,  Thyroid carcinoma,  Confocal microscopy.

Jun Xiang:KOL impact

Concepts related to the work of other authors for whichfor which Jun Xiang has influence:Thyroid cancer,  Dry eye,  Ocular surface,  Lymph node,  Deep learning,  Situ keratomileusis,  Migration invasion.



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Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai 200031, China; Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shang