• Disease
  • Graves
  • Graves Ophthalmopathy
  • Wilmar Maarten Wiersinga

    Prominent publications by Wilmar Maarten Wiersinga

    KOL Index score: 14351

    OBJECTIVE: To determine how expert European thyroidologists assess and treat amiodarone-induced thyrotoxicosis (AIT).

    DESIGN: Members of the European Thyroid Association (ETA) with clinical interests were asked to answer a questionnaire on the diagnosis and management of AIT. A total of 124 responses were received: 116 from Europe, seven from USA and one from Brazil. After excluding responses coming from the same centre, 101 responses from 24 European countries were analysed, ...

    Also Ranks for: Type Ait |  thyroid gland |  induced thyrotoxicosis |  diagnosis management |  medical surveys
    KOL Index score: 13853

    OBJECTIVE: Increased levels of vascular endothelial growth factor (VEGF) in human plasma samples have suggested that circulating VEGF is a cause of endothelial dysfunction in diabetes mellitus. However, artificial release of VEGF from platelets as a source of VEGF in plasma samples, as also occurs in serum samples, has not been ruled out in these studies.

    RESEARCH DESIGN AND METHODS: We determined VEGF levels in plasma collected in both citrate and PECT, a medium that inactivates ...

    Also Ranks for: Vegf Levels |  platelet activation |  type 1 diabetes |  microvascular complications |  endothelial dysfunction
    KOL Index score: 12913

    PURPOSE: To evaluate the contribution of maximal removal of the deep lateral wall of the orbit to exophthalmos reduction in Graves' orbitopathy and its influence on the onset of consecutive diplopia.

    DESIGN: Case-control study.

    METHODS: The medical records of two cohorts of patients affected by Graves' orbitopathy with exophthalmos > or = 23 mm, without preoperative diplopia, were retrieved at random from the pool of patients decompressed for rehabilitative reasons at our institution ...

    Also Ranks for: Exophthalmos Reduction |  deep lateral wall |  orbital decompression |  patients graves orbitopathy |  23 mm
    KOL Index score: 12585

    Graves' disease (GD) is a common autoimmune disease (AID) that shares many of its susceptibility loci with other AIDs. The thyroid stimulating hormone receptor (TSHR) represents the primary autoantigen in GD, in which autoantibodies bind to the receptor and mimic its ligand, thyroid stimulating hormone, causing the characteristic clinical phenotype. Although early studies investigating the TSHR and GD proved inconclusive, more recently we provided convincing evidence for association of ...

    Also Ranks for: Hormone Receptor |  graves disease |  association gd |  thyroid stimulating |  tshr rs179247
    KOL Index score: 12525

    OBJECTIVE: Approximately 35% of patients with Graves' ophthalmopathy do not respond to immunosuppressive treatment. A possible explanation for this finding is that only patients with active ophthalmopathy respond to immunosuppressive treatment, whereas patients with fibrotic end stage disease do not. To distinguish between these two groups and to predict the outcome of immunosuppressive treatment, we developed a clinical activity score (CAS) based on four of the five classical signs of ...

    Also Ranks for: Clinical Activity Score |  patients graves ophthalmopathy |  immunosuppressive treatment |  therapeutic outcome |  retrobulbar irradiation
    KOL Index score: 12212

    BACKGROUND: Genetic and environmental factors are involved in the pathogenesis of autoimmune thyroid disease (AITD). Family members of patients with AITD are at increased risk for AITD, but not all will develop overt hypothyroidism or hyperthyroidism. Our goal was to develop a simple predictive score that has broad applicability and is easily calculated at presentation for progression to overt hypothyroidism or hyperthyroidism within 5 years in female relatives of patients with ...

    Also Ranks for: Overt Hypothyroidism |  autoimmune thyroid disease |  5 years |  tsh levels |  thyroid peroxidase
    KOL Index score: 12071

    OBJECTIVE: We evaluated pulsatile and circadian TSH secretion in primary hypothyroidism.

    DESIGN: In a prospective study, blood was sampled every 10 minutes during 24 hours for assay of TSH (IRMA). Thyroid hormones and TSH responsiveness to TRH were then measured.

    SUBJECTS: Nine patients with overt primary hypothyroidism, seven patients with subclinical hypothyroidism and 16 healthy controls.

    MEASUREMENTS: Computer-assisted analysis by the Desade and Cluster programs.

    RESULTS: Both ...

    Also Ranks for: Primary Hypothyroidism |  tsh pulse frequency |  usual nocturnal increase |  24 hours |  pulse amplitude
    KOL Index score: 11990

    INTRODUCTION: Some hypothyroid patients continue to have significant impairments in psychological well-being, despite adequate treatment with levothyroxine (LT4). T4 transport across the blood-brain barrier is one of the crucial processes for thyroid hormone action in the brain. OATP1C1, a thyroid hormone transporter expressed at the blood-brain barrier, is considered to play a key role in delivering serum T4 to the brain.

    OBJECTIVE: To examine whether polymorphisms in OATP1C1 are ...

    Also Ranks for: Hypothyroid Patients |  thyroid hormone |  transporter oatp1c1 |  replacement therapy |  bloodbrain barrier
    KOL Index score: 11942

    OBJECTIVE: From in vitro studies using cultures of orbital fibroblasts, it has become clear that cytokines play an important role in the orbital inflammation in Graves' ophthalmopathy (GO). Orbital fibroblasts seem to be the key target cells of the autoimmune attack, and they are able to express the TSH receptor (TSH-R). In vivo data on the presence of cytokines in orbital tissues are sparse, and mostly limited to samples obtained from patients with endstage, inactive GO; the same holds ...

    Also Ranks for: Orbital Tissue |  messenger receptors |  patients active |  graves ophthalmopathy |  cytokine profile
    KOL Index score: 11802

    BACKGROUND: Maternal thyroid function during early pregnancy is an important determinant of early fetal brain development because the fetal thyroid is unable to produce any T4 before 12-14 weeks' gestation. Overt maternal hypothyroidism as seen in severe iodine-deficient areas is associated with severely impaired neurological development of the offspring. At present, it is not known whether low free T4 (fT4) levels during pregnancy in healthy women from iodine sufficient areas may affect ...

    Also Ranks for: Early Pregnancy |  psychomotor development |  thyroxine concentrations |  low maternal |  children women
    KOL Index score: 11542

    BACKGROUND: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression.

    METHODS: We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was ...

    Also Ranks for: Major Depression |  hormone test |  dex crh |  antidepressant treatment |  corticotropin releasing
    KOL Index score: 11386

    Infections have been implicated in the pathogenesis of a number of autoimmune diseases, and Yersinia enterocolitica (YE) might play a role in the development of autoimmune thyroid disease (AITD). Clinical evidence in support of this hypothesis has been inconclusive. We reasoned that looking earlier in the natural course of AITD might enhance chances of finding evidence for YE infection. Consequently, we determined seroreactivity against YE in subjects at risk of developing AITD, i.e. in ...

    Also Ranks for: Yersinia Enterocolitica |  autoimmune thyroid disease |  ye infection |  aitd patients |  yop antibodies


    Wilmar Maarten Wiersinga: Influence Statistics

    Sample of concepts for which Wilmar Maarten Wiersinga is among the top experts in the world.
    Concept World rank
    noncompetitive inhibitor binding #1
    natural 4year followup #1
    incidence reactivation #1
    patients diffuse goiter #1
    decrease ldl receptor #1
    lps nti #1
    illness proinflammatory cytokine #1
    data overt hypothyroidism #1
    ldl receptor fasting #1
    sera euthyroid patients #1
    t4 serum ifnγ #1
    hyperthyroidism 37 #1
    tshr cultures #1
    ivmp cumulative doses #1
    mrna biological clock #1
    questionnaires thyroidectomy europe #1
    diurnal biological clock #1
    tpo negative #1
    thyroid hormones rodents #1
    oral adult body #1
    lower decrease #1
    binding receptor proteins #1
    goitre size dose #1
    hypothyroidism neurocognitive #1
    fatty acids inbactivity #1
    circadian rhythm hyperthyroidism #1
    1 year ov #1
    lps thyroid hormones #1
    nti decrease #1
    plasma tsh sng #1
    surgical outcome reduction #1
    dron #1
    subjects overt hypothyroidism #1
    knockout muscle lps #1
    assessment tsh #1
    topic graves #1
    orbital fibroblasts il1beta #1
    obvious logistic models #1
    rabbits radioimmunoassay reverse #1
    graves disease smoking #1
    death living patients #1
    europe clinical variants #1
    trbeta1 rat liver #1
    short antithyroid drugs #1
    16 lats #1
    decrease hyperthyroidism #1
    mild graves #1
    groups contribution #1
    mice muscle mrna #1
    tralpha1 tralpha2 ratio #1

    Key People For Graves Ophthalmopathy

    Top KOLs in the world
    Wilmar Maarten Wiersinga
    graves ophthalmopathy thyroid hormone fatty acids
    Rebecca S Bahn
    graves ophthalmopathy thyrotropin receptor thyroid association
    Luigi BARTALENA,
    graves disease orbital radiotherapy radioiodine therapy
    Maarten Ph Mourits
    graves orbitopathy intraocular lens strabismus surgery
    Claudio Marcocci
    primary hyperparathyroidism graves orbitopathy orbital radiotherapy
    Mark F Prummel
    graves ophthalmopathy orbital tissue tsh receptor

    Wilmar Maarten Wiersinga:Expert Impact

    Concepts for whichWilmar Maarten Wiersingahas direct influence:Graves ophthalmopathy,  Thyroid hormone,  Thyroid volume,  Graves disease,  Graves orbitopathy,  Thyroid function,  Dendritic cells,  Autoimmune thyroid disease.

    Wilmar Maarten Wiersinga:KOL impact

    Concepts related to the work of other authors for whichfor which Wilmar Maarten Wiersinga has influence:Graves disease,  Thyroid function,  Pregnant women,  Iodine deficiency,  Orbital decompression.



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    8Amsterdam University Medical Center, Amsterdam, the Netherlands | Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands | Department of Endocrinology and Metabolism, Academic Medical