• Disease
  • Tissue
  • Tissue Sodium
  • Rachelle L Crescenzi

    Prominent publications by Rachelle L Crescenzi

    KOL Index score: 8689

    OBJECTIVE: To test the hypothesis that tissue sodium and adipose content are elevated in patients with lipedema; if confirmed, this could establish precedence for tissue sodium and adipose content representing a discriminatory biomarker for lipedema.

    METHODS: Participants with lipedema (n = 10) and control (n = 11) volunteers matched for biological sex, age, BMI, and calf circumference were scanned with 3.0-T sodium and conventional proton magnetic resonance imaging (MRI). Standardized ...

    Also Ranks for: Tissue Sodium |  subcutaneous adipose |  patients lipedema |  control participants |  calf skin
    KOL Index score: 8321

    Glutamate is the primary excitatory neurotransmitter in the brain, and is implicated in neurodegenerative diseases such as Alzheimer's disease (AD) and several other tauopathies. The current method for measuring glutamate in vivo is proton magnetic resonance spectroscopy ((1)H MRS), although it has poor spatial resolution and weak sensitivity to glutamate changes. In this study, we sought to measure the effect of tau pathology on glutamate levels throughout the brain of a mouse model of ...

    Also Ranks for: Mouse Model |  synapse loss |  glutamate levels |  magnetic resonance |  tau pathology
    KOL Index score: 8016

    Glutamate chemical exchange saturation transfer (GluCEST) MRI was used to measure metabolic changes in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by mapping regional cerebral glutamate. The GluCEST contrast following MPTP treatment was correlated with 1 H-MR spectroscopy, motor function, and immunohistochemical measures. The GluCEST contrast was found to be significantly higher in the striatum and motor cortex of mice treated with MPTP than in controls ...

    Also Ranks for: Glucest Mri |  mouse model |  dopamine deficiency |  mptp treatment |  fibrillary acidic
    KOL Index score: 7115

    Glutamate Chemical Exchange Saturation Transfer (GluCEST) MRI is a recently developed technique to image glutamate. In the present study, we evaluated the reproducibility and background contamination to the GluCEST and source of the GluCEST changes in a mouse model of Parkinson’s disease. Repeated measurements in five mice demonstrated an intra-animal coefficient of variation (CV) of GluCEST signal to be 2.3 ± 1.3% and inter-animal CV of GluCEST to be 3.3 ± 0.3%. Mice were treated with ...

    Also Ranks for: Glucest Mri |  mouse model |  parkinson disease |  glutamate concentration |  imaging mice
    KOL Index score: 7046

    BACKGROUND: Breast cancer treatment-related lymphedema (BCRL) arises from a mechanical insufficiency following cancer therapies. Early BCRL detection and personalized intervention require an improved understanding of the physiological processes that initiate lymphatic impairment. Here, internal magnetic resonance imaging (MRI) measures of the tissue microenvironment were paired with clinical measures of tissue structure to test fundamental hypotheses regarding structural tissue and ...

    Also Ranks for: Manual Lymphatic Drainage |  breast cancer |  patients bcrl |  deep tissue |  treatment lymphedema
    KOL Index score: 6539

    OBJECTIVE: The aim of this study is to compare tissue sodium and fat content in the upper and lower extremities of participants with lipedema versus controls using magnetic resonance imaging (MRI).

    METHODS: MRI was performed at 3.0 T in females with lipedema (n = 15, age = 43.2 ± 10.0 years, BMI = 30.3 ± 4.4 kg/m2 ) and controls without lipedema (n = 14, age = 42.8 ± 13.2 years, BMI = 28.8 ± 4.4 kg/m2 ). Participants were assessed for pain and disease stage. Sodium MRI was performed in ...

    Also Ranks for: Tissue Sodium |  participants lipedema |  lower extremity |  magnetic resonance imaging |  versus control
    KOL Index score: 5858

    Tauopathies are neurodegenerative disorders characterized by abnormal intracellular aggregates of tau protein, and include Alzheimer's disease, corticobasal degeneration, frontotemporal dementia, and traumatic brain injury. Glutamate metabolism is altered in neurodegenerative disorders manifesting in higher or lower concentrations of glutamate, its transporters or receptors. Previously, glutamate chemical exchange saturation transfer (GluCEST) magnetic resonance imaging (MRI) ...

    Also Ranks for: Mouse Model |  neurodegenerative disorders |  glutamate levels |  synapse density |  glucest imaging
    KOL Index score: 4302

    Glutamate (Glu) is a major excitatory neurotransmitter in the brain and has been shown to decrease in the early stages of Alzheimer's disease (AD). Using a glutamate chemical (amine) exchange saturation transfer (GluCEST) method, we imaged the change in [Glu] in the APP-PS1 transgenic mouse model of AD at high spatial resolution. Compared with wild-type controls, AD mice exhibited a notable reduction in GluCEST contrast (~30%) in all areas of the brain. The change in [Glu] was further ...

    Also Ranks for: Glucest Contrast |  alzheimers disease |  glutamate glu |  spatial resolution |  early stages
    KOL Index score: 3815

    BACKGROUND: Tissue sodium content in patients on maintenance hemodialysis (MHD) and peritoneal dialysis (PD) were previously explored using 23Sodium magnetic resonance imaging (23NaMRI). Larger studies would provide a better understanding of sodium stores in patients on dialysis as well as the factors influencing this sodium accumulation.

    METHODS: In this cross-sectional study, we quantified the calf muscle and skin sodium content in 162 subjects (10 PD, 33 MHD patients, and 119 ...

    Also Ranks for: Peritoneal Dialysis |  tissue sodium |  muscle skin |  resonance imaging |  mhd patients
    KOL Index score: 3686

    Background: Lipedema and Dercum's disease (DD) are incompletely characterized adipose tissue diseases, and objective measures of disease profiles are needed to aid in differential diagnosis. We hypothesized that fluid properties, quantified as tissue water bioimpedance in the upper and lower extremities, differ regionally between these conditions. Methods and Results: Women (cumulative n = 156) with lipedema (n = 110), DD (n = 25), or without an adipose disease matched for age and body ...

    Also Ranks for: Patients Lipedema |  dercums disease |  differential diagnosis |  upper lower extremities |  adipose tissue
    KOL Index score: 3619

    PURPOSE: To exploit the long 3.0T relaxation times and low flow velocity of lymphatic fluid to develop a noninvasive 3.0T lymphangiography sequence and evaluate its relevance in patients with lymphedema.

    MATERIALS AND METHODS: A 3.0T turbo-spin-echo (TSE) pulse train with long echo time (TEeffective  = 600 msec; shot-duration = 13.2 msec) and TSE-factor (TSE-factor = 90) was developed and signal evolution simulated. The method was evaluated in healthy adults (n = 11) and patients with ...

    Also Ranks for: Noninvasive 3 |  bcrl participants |  94 ± |  lymphatic drainage |  lymphography magnetic
    KOL Index score: 3527

    PURPOSE: To quantify chemical exchange saturation transfer contrast in upper extremities of participants with lymphedema before and after standardized lymphatic mobilization therapy using correction procedures for B0 and B1 heterogeneity, and T1 relaxation.

    METHODS: Females with (n = 12) and without (n = 17) breast cancer treatment-related lymphedema (BCRL) matched for age and body mass index were scanned at 3.0T MRI. B1 efficiency and T1 were calculated in series with chemical exchange ...

    Also Ranks for: Breast Cancer |  bcrl participants |  cest mri |  saturation transfer |  therapy evaluation
    KOL Index score: 3466

    The purpose of this work was to quantify 3.0 T (i) T1 and T2 relaxation times of in vivo human lymph nodes (LNs) and (ii) LN relaxometry differences between healthy LNs and LNs from patients with lymphatic insufficiency secondary to breast cancer treatment-related lymphedema (BCRL). MR relaxometry was performed over bilateral axillary regions at 3.0 T in healthy female controls (105 LNs from 20 participants) and patients with BCRL (108 LNs from 20 participants). Quantitative T1 maps were ...

    Also Ranks for: Magnetic Resonance |  lymph nodes |  adult breast |  cancer treatment |  clinical indicators
    KOL Index score: 3190

    OBJECTIVE: Lipedema is characterized by pain, fatigue, and excessive adipose tissue and sodium accumulation of the lower extremities. This case-control study aims to determine whether sodium or vascular dysfunction is present in the central nervous system.

    METHODS: Brain magnetic resonance imaging was performed at 3 T in patients with lipedema (n = 15) and control (n = 18) participants matched for sex, age, race, and BMI. Standard anatomical imaging and intracranial angiography were ...

    Also Ranks for: Patients Lipedema |  brain sodium |  adipose tissue
    KOL Index score: 2405

    PurposeBreast cancer treatment-related lymphedema (BCRL) evaluation is frequently performed using portable measures of limb volume and bioimpedance asymmetry. Here quantitative magnetic resonance imaging (MRI) is applied to evaluate deep and superficial tissue impairment, in both surgical and contralateral quadrants, to test the hypothesis that BCRL impairment is frequently bilateral and extends beyond regions commonly evaluated with portable external devices.Methods3-T MRI was applied ...

    Also Ranks for: Magnetic Resonance |  healthy participants |  cancer treatment |  lymphedema bcrl |  imaging mri


    Rachelle L Crescenzi: Influence Statistics

    Sample of concepts for which Rachelle L Crescenzi is among the top experts in the world.
    Concept World rank
    metrics bcrl #3
    mld therapy ptrapt #3
    surgical contralateral limbs #3
    ptrapt #3
    mld ptr #3
    portable external devices #3
    female bcrl #3
    lymphedema electric #3
    lymphedema purposebreast #3
    mrimeasured water relaxation #3
    efficiency upper extremities #3
    bcrl topographical impairment #3
    lymphatic mobilization #3
    bcrl young adult #3
    arm volume asymmetry #3
    unpreserved lymphatic reserve #3
    upper extremities ptr #3
    bcrl healthy participants #3
    ptr ptrapt #3
    bcrl participants mld #3
    bioimpedance asymmetry #3
    resultsbioimpedance asymmetry #3
    lipedema 15 #3
    procedures ptrapt #3
    30t mri efficiency #3
    metrics bcrl participants #3
    extremities ptr #3
    unpreserved lymphatic #3
    quadrants bcrl #3
    bcrl 33 #3
    therapy ptrapt #3
    bcrl impairment #3
    lymphedema therapy evaluation #3
    ptrapt spearmans rho #3
    lipedema fat content #4
    control participants forearm #4
    20 participants patients #4
    quantified cortex #4
    relaxation axillary lns #4
    distinguish lipedema #4
    resonance lymphatic #4
    bcrl evaluation #4
    bmi human 30 #4
    lns quantified #4
    lipedema early #4
    cohens fat water #4
    sodium mri forearm #4
    12 hilum #4
    forearm skin tsc #4
    lipedema control participants #4

    Key People For Tissue Sodium

    Top KOLs in the world
    Friedrich Cameron Luft
    blood pressure sodium intake heart rate
    Jens M Titze
    blood pressure tissue sodium salt intake
    Dominik N Müller
    blood pressure human renin nitric oxide
    Anke Dahlmann
    hemodialysis patients tissue sodium liddle syndrome
    Kai‐Uwe Eckardt
    kidney disease global outcomes cardiovascular events
    Michael Michael
    image quality computed tomography magnetic resonance

    Rachelle L Crescenzi:Expert Impact

    Concepts for whichRachelle L Crescenzihas direct influence:Tissue sodium,  Glutamate levels,  Salt sensitivity,  Resonance imaging,  Fat content,  Glucest mri,  Patients lipedema,  Synapse loss.

    Rachelle L Crescenzi:KOL impact

    Concepts related to the work of other authors for whichfor which Rachelle L Crescenzi has influence:Cest mri,  Chemical exchange,  Saturation transfer,  Resonance imaging,  Disc degeneration,  Tissue sodium,  Rat brain.



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    Department of Radiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA;, rachelle.crescenzi@vumc.org, (R.C.);, daniel.colvin@vumc.org, (D.C.C.) | Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville,