• Disease
  • Macular
  • Macular Hole
  • Makoto Inoue

    Prominent publications by Makoto Inoue

    KOL Index score: 19621

    PURPOSE: To determine whether the postoperative length of the photoreceptor cone outer segment tips (COST) line defect is significantly correlated with best-corrected visual acuity (BCVA) after macular hole closure.

    DESIGN: Retrospective, consecutive, observational case series.

    PARTICIPANTS: Fifty-one eyes of 51 patients with a surgically closed macular hole were studied.

    METHODS: Spectral-domain optical coherence tomography (SD-OCT) was used to obtain images of the foveal area, and the ...

    Also Ranks for: Cost Defect |  macular hole |  outer segment |  visual acuity |  postoperative bcva
    KOL Index score: 18755

    PURPOSE: To investigate the retinal neural damage that occurs during inflammation and the therapeutic effects of the angiotensin II type 1 receptor (AT1R) blocker, telmisartan, using a model of endotoxin-induced uveitis (EIU).

    METHODS: The localization of AT1R and AT2R was shown by immunohistochemistry. EIU was induced by intraperitoneal injection of lipopolysaccharide (LPS). Animals were treated with telmisartan for 2 days and were evaluated 24 hours later. Expression levels of ...

    Also Ranks for: Retinal Inflammation |  type 1 |  neuroprotective effects |  treatment telmisartan |  receptor angiotensin
    KOL Index score: 18524

    PURPOSE: To investigate the involvement of the renin-angiotensin system (RAS) and the nuclear factor (NF)-kappaB pathway with diabetes-induced retinal inflammation.

    METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week. Retinal mRNA and protein levels of the RAS components ...

    Also Ranks for: Type 1 |  nuclear factor |  induced retinal |  messenger receptor |  protein levels
    KOL Index score: 16057

    PURPOSE: To evaluate the clinical outcomes after vitrectomy, without gas tamponade or laser photocoagulation to the margin of the optic nerve, for the treatment of macular detachment associated with optic disc pits and to characterize retinal manifestations during treatment of optic pit maculopathy using optical coherence tomography (OCT).

    DESIGN: Noncomparative, retrospective, interventional case series.

    PARTICIPANTS: Eight consecutive patients (8 to 56 years of age) with unilateral ...

    Also Ranks for: Macular Detachment |  gas tamponade |  optic disc pit |  laser treatment |  vitrectomy induction
    KOL Index score: 15380

    PURPOSE: To examine whether the angiotensin II type 1 receptor (AT1-R) signaling plays a role in ocular inflammation in endotoxin-induced uveitis (EIU).

    METHODS: EIU was induced in C57BL/6 mice by a single intraperitoneal injection of 150 mug lipopolysaccharide (LPS). Tissue localization, mRNA expression, and protein levels of AT1-R in murine retinas were examined by immunohistochemistry, RT-PCR, and Western blot analyses, respectively. Telmisartan, an AT1-R antagonist widely used as an ...

    Also Ranks for: Ocular Inflammation |  type 1 |  induced uveitis |  leukocyte adhesion |  protein levels
    KOL Index score: 15024

    PURPOSE: A recent study revealed that angiotensin receptor signaling mediates ocular inflammation and neovascularization. It was also found that prorenin undergoes nonproteolytic activation leading to upregulation of the renin-angiotensin system (RAS) when prorenin receptor interacts specifically with the handle region of prorenin. The purpose of the present study was to elucidate the role of the receptor-dependent nonproteolytic activation of prorenin in ocular inflammation in ...

    Also Ranks for: Ocular Inflammation |  prorenin receptor |  nonproteolytic activation |  induced uveitis |  leukocyte adhesion
    KOL Index score: 14600

    PURPOSE: To determine whether a recovery of the microstructures of the foveal photoreceptors after macular hole closure is correlated with best-corrected visual acuity (BCVA).

    DESIGN: Retrospective, consecutive, observational case series.


    SETTING: Single-center academic practice.

    STUDY POPULATION: Forty-one eyes of 41 patients with surgically closed macular holes. OBSERVATIONAL PROCEDURES: The presence and intactness of the cone outer segment tips (COST) line were determined by ...

    Also Ranks for: Visual Acuity |  macular hole surgery |  foveal cone |  eyes bcva |  12 months
    KOL Index score: 14452

    PURPOSE: Angiotensin-converting enzyme (ACE), also known as kininase II, functions not only to convert angiotensin I to angiotensin II, but also to cleave bradykinin into inactive fragments. Thus, ACE inhibition causes the tissue accumulation of bradykinin, exerting either of two opposite effects: anti- or proangiogenic. The purpose of the present study was to investigate the role of bradykinin in the development of choroidal neovascularization (CNV), with or without ACE ...

    Also Ranks for: Choroidal Neovascularization |  converting enzyme |  cnv vegf |  receptor angiotensin |  inbred c57bl microscopy
    KOL Index score: 13919

    BACKGROUND: To determine whether the status of a macular hole can be determined by spectral-domain optical coherence tomography in gas-filled eyes.

    DESIGN: Prospective study, university hospital setting.

    PARTICIPANTS: Twenty-six eyes with a macular hole, seven eyes with a macular hole retinal detachment and four eyes with a macular hole and myopic traction maculopathy underwent vitreous surgery.

    METHODS: The macular area was examined by spectral-domain optical coherence tomography ...

    Also Ranks for: Macular Hole |  optical coherence |  eyes day |  postoperative status |  hexafluoride tomography
    KOL Index score: 13754

    PURPOSE: To investigate the structural abnormalities of optic disc pits and colobomas by swept-source optical coherence tomography (OCT).

    METHODS: Sixteen eyes with congenital optic disc pits, and seven eyes with optic disc colobomas were studied. Papillary and peripapillary areas were examined with swept-source OCT. The entire course of the pit or cavity and the spatial relationship between pits and retrobulbar subarachnoid space (SAS) were examined.

    RESULTS: Optical coherence ...

    Also Ranks for: Optic Disc |  coherence tomography |  source oct |  lamina cribrosa |  sixteen eyes
    KOL Index score: 13473

    PURPOSE: To determine whether there is a significant correlation between the integrity of the foveal microstructures and the best-corrected visual acuity (BCVA) after pars plana vitrectomy for epiretinal membrane (ERM) removal.

    METHODS: This was a retrospective, interventional case series. Forty-six eyes of 45 patients with an ERM underwent vitrectomy. The foveal area was examined by spectral-domain-optical coherence tomography (SD-OCT) preoperatively and postoperatively. The correlation ...

    Also Ranks for: Epiretinal Membrane |  outer segment |  bcva length |  cost defect |  visual recovery
    KOL Index score: 13162

    Interleukin (IL)-6, a potent proinflammatory cytokine, is suggested to be a risk factor for choroidal neovascularization (CNV) because of its increased levels in the serum of patients with age-related macular degeneration; however, the role of IL-6 in CNV has not been defined. The present study reveals the critical contribution of IL-6 signaling and its downstream STAT3 pathway to the murine model of laser-induced CNV. CNV induction by laser treatment stimulated IL-6 expression in the ...

    Also Ranks for: Choroidal Neovascularization |  il6 cnv |  signal transducer |  agerelated macular degeneration |  stat3 activation
    KOL Index score: 13041

    PURPOSE: To investigate the anti-inflammatory and anti-angiogenic effects of telmisartan, an angiotensin II type 1 receptor (AT1-R) antagonist, on ischemia-induced retinal neovascularization.

    METHODS: C57BL/6 neonatal mice were reared in an 80% concentration of oxygen from postnatal day (P)7 to P12, followed by room-air breathing until P17, to induce ischemia-initiated retinal neovascularization (i.e., a murine model of ischemic retinopathy). Tissue localization of AT1-R was examined by ...

    Also Ranks for: Type 1 |  retinal neovascularization |  messenger receptor |  physiologic rna |  vascular endothelial
    KOL Index score: 12691

    PURPOSE: To investigate the matrix metalloproteinase (MMP) species and their activation associated with the pathogenesis of proliferative diabetic retinopathy (PDR).

    METHODS: Sandwich enzyme immunoassays were used to measure concentrations of MMP-1, -2, -3, -7, -8, -9, and -13 in vitreous samples from patients with PDR and nondiabetic vitreoretinal diseases. To evaluate activation ratios of the zymogen of MMP-2 (proMMP-2) and -9 (proMMP-9) in the vitreous samples and fibrovascular ...

    Also Ranks for: Matrix Metalloproteinase |  fibrovascular tissues |  vitreous samples |  mmp2 mt1mmp |  diabetic retinopathy
    KOL Index score: 12295

    PURPOSE: To evaluate the effect of vitrectomy on the best-corrected visual acuity (BCVA) and postoperative complications in highly myopic eyes with myopic traction maculopathy.

    METHODS: The medical records of 71 eyes of 64 patients with myopic traction maculopathy and high myopia (≤-8.0 diopters and axial length, ≥26.0 mm) were reviewed. Twenty-six eyes had only macular retinoschisis, 30 eyes had foveal detachment, and 15 eyes had macular hole. The BCVA and complications were studied in ...

    Also Ranks for: Myopic Traction |  membrane peeling |  macular retinoschisis |  foveal detachment |  internal limiting


    Makoto Inoue: Influence Statistics

    Sample of concepts for which Makoto Inoue is among the top experts in the world.
    Concept World rank
    cost fovea #1
    iol case #1
    viewed wide #1
    grating images field #1
    oct monitor images #1
    nxg1 #1
    eyes intravitreal gas #1
    tilted intraocular #1
    26 mm clinicians #1
    blades wound leakage #1
    detachment iol #1
    wideangle viewing view #1
    eye dark ring #1
    failure macular reattachment #1
    16 eyes removed #1
    nasal foveal displacement #1
    hyperreflectivity retinal #1
    defect 0001 #1
    target vitreous #1
    periphery zm900 #1
    artifacts hyperreflectivity #1
    bcva length #1
    axial length mh #1
    pseudohole aged #1
    maximal angle iol #1
    isolated pig eyes #1
    resolving optic #1
    sa60d3 defocused images #1
    sfaz fellow #1
    va70 intraocular lenses #1
    surgery sizes #1
    temresultsthe retinas #1
    cost photoreceptor #1
    horizontal length aspheric #1
    sa60d3 defocused #1
    architecture incisions #1
    intraoperative retinal breaks #1
    fragmented cost lines #1
    blades differences #1
    patients macular pseudohole #1
    cost defect images #1
    iols sn6at5 #1
    eyes intact cost #1

    Key People For Macular Hole

    Top KOLs in the world
    William E Smiddy
    visual acuity macular hole retinal detachment
    Alain Gaudric
    macular edema optical coherence diabetic retinopathy
    Robert T Wendel
    pneumatic retinopexy macular hole cilioretinal artery
    J Donald M Gass
    visual acuity macular holes fluorescein angiography
    Neil E Kelly
    pneumatic retinopexy macular holes vitreous surgery
    Pascale Massin
    diabetic retinopathy macular edema visual acuity

    Makoto Inoue:Expert Impact

    Concepts for whichMakoto Inouehas direct influence:Macular hole,  Retinal detachment,  Model eye,  Intraocular lenses,  Blood flow,  Macular detachment,  Vitreous surgery,  Subtenon injection.

    Makoto Inoue:KOL impact

    Concepts related to the work of other authors for whichfor which Makoto Inoue has influence:Diabetic retinopathy,  Visual acuity,  Retinal detachment,  Macular hole,  Optical coherence,  Triamcinolone acetonide,  Plana vitrectomy.



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    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan | Department of Ophthalmology, Kyorin University, Tokyo, Japan | Kyorin Eye Center, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan