Klara Mareckova

Klara Mareckova

Campbell Family Mental Health Research Institute, Centre For Addiction And Mental Health, Toronto, Ontario, Canada; Brain And Mind Research, Central European Institute Of ...

Direct Impact

Concepts for which Klara Mareckova has direct influence:

young adulthood
dysphoric mood
prenatal stress
affective stimuli
depressive symptoms
sex differences
hippocampal volume

External impact

Concepts related to the work of other authors for which Klara Mareckova has influence:

major depressive disorder
brain aging
chronological age
stress-induced depression
r01 mh116147
lateral ventricles
dysphoric mood

Prominent publications by Klara Mareckova

KOL-Index: 148 Maternal depression during pregnancy is associated with elevated risk of anxiety and depression in offspring, but the mechanisms are incompletely understood. Here we conducted a neuroimaging follow-up of a prenatal birth cohort from the European Longitudinal Study of Pregnancy and Childhood (n = 131; 53% women, age 23-24) to test whether deviations from age-normative structural brain ...
Known for
54 Women | Neuroimaging Follow-Up | Elevated Brain Age Gap | Structural Brain Age
KOL-Index: 55 Convergent data from imaging and postmortem brain transcriptome studies implicate corticolimbic circuit (CLC) dysregulation in the pathophysiology of depression. To more directly bridge these lines of work, we generated a novel transcriptome-based polygenic risk score (T-PRS), capturing subtle shifts toward depression-like gene expression patterns in key CLC regions, and mapped this T-PRS ...
Known for
Prs Multivariate | Female-Specific Reductions | Clc Gene Expression | Transcriptome-Based Polygenic
KOL-Index: 42 Large-scale magnetic resonance (MR) studies of the human brain offer unique opportunities for identifying genetic and environmental factors shaping the human brain. Here, we describe a dataset collected in the context of a multi-centre study of the adolescent brain, namely the IMAGEN Study. We focus on one of the functional paradigms included in the project to probe the brain network ...
Known for
Cortical Regions | Brain Network Processing | Large-Scale Magnetic Resonance | Male Female Adolescents
KOL-Index: 30 Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring ...
Known for
2 Years | 23-24 Years | Stress Pregnancy | 85 Young Adults
KOL-Index: 25 Disruption of metabolic processes during human enamel mineralization may result in the appearance of accentuated lines in enamel. These accentuated lines in the enamel relate to stress events that were experienced and overcome in early ontogenetic phases. Accentuated lines are visible in transmitted light microscopy as dark areas. However, their appearance is variable even within single ...
KOL-Index: 21 BACKGROUND: Experience of early-life socioeconomic deprivation (ELSD) may increase the risk of mental disorders in young adulthood. This association may be mediated by structural and functional alterations of the hippocampus. METHODS: We conducted a prospective cohort study on 122 participants of the European Longitudinal Study of Pregnancy and Childhood. Information about ELSD was collected ...
Known for
Deprivation Elsd | Lower Volume | Mediated Structural | Connectivity Depressive
KOL-Index: 20 BACKGROUND: Exposure to maternal stress in utero has long-term implications for the developing brain and has been linked with a higher risk of depression. The amygdala, which develops during the early embryonic stage and is critical for emotion processing, might be particularly sensitive. METHODS: Using data from a neuroimaging follow-up of the European Longitudinal Study of Pregnancy and ...
Known for
Exposure Stress | Depression Amygdala | Offspring Depressive | Neuroimaging Follow-Up
KOL-Index: 16 Depression is the leading cause of years lost due to disability worldwide. Still, the mechanisms underlying its development are not well understood. This study aimed to evaluate white-matter properties associated with depressive symptomatology in young adulthood and their developmental origins. Diffusion tensor imaging and assessment of depressive symptomatology were conducted in 128 young ...
Known for
Symptoms Young | Stress Depressive | 47 Male | Superior Longitudinal Fasciculus
KOL-Index: 16 BACKGROUND: Maladaptive responses to negative affective stimuli are pervasive, including clinically ill and healthy people, and men and women respond differently at neural and hormonal levels. Inspired by the Research Domain Criteria initiative, we used a transdiagnostic approach to investigate the impact of sex and dysphoric mood on neural-hormonal responses to negative affective stimuli. ...
Known for
Orbitofrontal Cortex | Hypothalamus-Amygdala Connectivity | Women Dysphoric | Rois
KOL-Index: 15 Negative affective stimuli elicit behavioral and neural responses which vary on a continuum from adaptive to maladaptive, yet are typically investigated in a dichotomous manner (healthy controls vs. psychiatric diagnoses). This practice may limit our ability to fully capture variance from acute responses to negative affective stimuli to psychopathology at the extreme end. To address this, we ...
Known for
Neutral Valence | Cortex Mpfc | Function Dysphoric | Amyg Hipp

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic. Electronic address: klara

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