• Disease
  • Trauma
  • Trauma Survivors
  • Roee Admon

    Prominent publications by Roee Admon

    KOL Index score: 9015

    Previous studies have shown that people who develop psychopathology such as posttraumatic stress disorder (PTSD) following stress exposure are characterized by reduced hippocampal (HC) volume and impaired HC functional connectivity with the ventromedial prefrontal cortex (vmPFC). Nevertheless, the exact interrelationship between reduced HC volume and HC-vmPFC connectivity deficits in the context of stress has yet to be established. Furthermore, it is still not clear whether such neural ...

    Also Ranks for: Hippocampal Volume |  prefrontal cortex |  stress exposure |  connectivity vmpfc |  functional mri
    KOL Index score: 8728

    OBJECTIVE: Major depressive disorder is characterized by reduced reward-related striatal activation and dysfunctional reward learning, putatively reflecting decreased dopaminergic signaling. The goal of this study was to test whether a pharmacological challenge designed to facilitate dopaminergic transmission can enhance striatal responses to reward and improve reward learning in depressed individuals.

    METHOD: In a double-blind placebo-controlled design, 46 unmedicated depressed ...

    Also Ranks for: Major Depression |  dopaminergic enhancement |  reward learning |  depressed participants |  nucleus accumbens
    KOL Index score: 8297

    Obsessive-compulsive disorder (OCD) patients suffer from risk aversion, which may be mediated by their exaggerated response to threat and diminished response to reward. In this study, 13 OCD patients and 13 healthy matched controls underwent functional magnetic resonance imaging (fMRI) while playing an interactive risky choice game encompassing distinct intervals of threat and reward; as well as anatomical diffusion tensor imaging (DTI). Compared to healthy controls OCD patients were ...

    Also Ranks for: Risk Aversion |  compulsive disorder |  ocd patients |  functional connectivity |  magnetic resonance
    KOL Index score: 8153

    Introduction: Post-Traumatic Stress Disorder (PTSD) is a prevalent, severe and tenacious psychopathological consequence of traumatic events. Neurobehavioral mechanisms underlying PTSD pathogenesis have been identified, and may serve as risk-resilience factors during the early aftermath of trauma exposure. Longitudinally documenting the neurobehavioral dimensions of early responses to trauma may help characterize survivors at risk and inform mechanism-based interventions. We present two ...

    Also Ranks for: Cognitive Flexibility |  ptsd symptoms |  trauma exposure |  14 months |  neurobehavioral mechanisms
    KOL Index score: 7981

    BACKGROUND: Increased sensitivity to stress and dysfunctional reward processing are two primary characteristics of major depressive disorder (MDD) that may persist after remission. Preclinical work has established the pivotal role of the striatum in mediating both stress and reward responses. Human neuroimaging studies have corroborated these preclinical findings and highlighted striatal dysfunction in MDD in response to reward but have yet to investigate striatal function during stress, ...

    Also Ranks for: Remitted Individuals |  amygdala hippocampus |  nucleus accumbens |  negative stimuli |  depressive disorder
    KOL Index score: 7471

    Negative affective stimuli elicit behavioral and neural responses which vary on a continuum from adaptive to maladaptive, yet are typically investigated in a dichotomous manner (healthy controls vs. psychiatric diagnoses). This practice may limit our ability to fully capture variance from acute responses to negative affective stimuli to psychopathology at the extreme end. To address this, we conducted a functional magnetic resonance imaging study to examine the neural responses to ...

    Also Ranks for: Negative Affective Stimuli |  dysphoric mood |  brain activity |  neural responses |  depressive disorder
    KOL Index score: 7334

    Trauma-related psychopathology has been associated with an intense emotional reaction to stressful event. Emotional responses have evolved to signal the presence of risks to be avoided or of rewards to be approached in the environment. Thus, individuals' sensitivity to signals of risk and reward may affect the level of stress vulnerability. Stress, however, can modify these sensitivities as well. In the current functional magnetic resonance imaging (fMRI) study, we prospectively probed ...

    Also Ranks for: Stress Vulnerability |  post exposure |  neural responsivity |  reward risk |  emotional responses

    Adolescent Depression

    KOL Index score: 7292

    LEARNING OBJECTIVES: After participating in this educational activity, the physician should be better able to 1. Evaluate the relationship between reward processes, stress, and depression. 2. Assess the characteristics of the three etiological models of stress and reward processes. 3. Identify the biological basis for stress and reward processes. Adolescence is a peak period for the onset of depression, and it is also a time marked by substantial stress as well as neural development ...

    Also Ranks for: Adolescent Depression |  reward stress |  depressive symptoms |  etiological models |  major humans
    KOL Index score: 6950

    Little is known about the acute effects of antidepressant treatments on brain glutamate and gamma-amino-butyric acid (GABA) levels, and their association with clinical response. Using proton magnetic resonance spectroscopy (1H-MRS) we examined longitudinally the effects of citalopram on glutamine/glutamate ratios and GABA levels in the pregenual anterior cingulate cortex (pgACC) of individuals with major depressive disorder (MDD). We acquired 1H-MRS scans at baseline and at days 3, 7, ...

    Also Ranks for: Antidepressant Response |  citalopram treatment |  gaba levels |  anterior cingulate |  longitudinal studies
    KOL Index score: 6789

    BACKGROUND: Individuals with major depressive disorder (MDD) are characterized by maladaptive responses to both positive and negative outcomes, which have been linked to localized abnormal activations in cortical and striatal brain regions. However, the exact neural circuitry implicated in such abnormalities remains largely unexplored.

    METHOD: In this study 26 unmedicated adults with MDD and 29 matched healthy controls (HCs) completed a monetary incentive delay task during functional ...

    Also Ranks for: Major Depression |  female gyrus |  striatal connectivity |  depressive disorder |  resonance imaging
    KOL Index score: 6414

    Contemporary symptom-based diagnosis of post-traumatic stress disorder (PTSD) largely overlooks related neurobehavioral mechanisms and relies entirely on subjective interpersonal reporting. Previous studies associating biomarkers with PTSD have mostly used symptom-based diagnosis as the main outcome measure, disregarding the wide variability and richness of PTSD phenotypical features. Here, we aimed to computationally derive potential biomarkers that could efficiently differentiate PTSD ...

    Also Ranks for: Trauma Survivors |  ptsd severity |  stress disorder |  cognitive functioning |  1 month
    KOL Index score: 6344

    Recent theoretical and empirical work has highlighted the role of domain-general, large-scale brain networks in generating emotional experiences. These networks are hypothesized to process aspects of emotional experiences that are not unique to a specific emotional category (e.g., “sadness,” “happiness”), but rather that generalize across categories. In this article, we examined the dynamic interactions (i.e., changing cohesiveness) between specific domain-general networks across time ...

    Also Ranks for: Emotional Experiences |  functional connectivity |  salience networks |  image processing |  emotion categories
    KOL Index score: 6100

    The development of robust laboratory procedures for acute stress induction over the last decades has greatly advanced our understanding of stress responses in humans and their underlying neurobiological mechanisms. Nevertheless, attempts to uncover linear relationships among endocrine, neural, and affective responses to stress have generally yielded inconsistent results. Here, 79 healthy females completed a well established laboratory procedure of acute stress induction that was modified ...

    Also Ranks for: Cortisol Response |  acute stress |  negative affect |  healthy females |  humans hydrocortisone
    KOL Index score: 5951

    Stressful experiences modulate neuro-circuitry function, and the temporal trajectory of these alterations, elapsing from early disturbances to late recovery, heavily influences resilience and vulnerability to stress. Such effects of stress may depend on processes that are engaged during resting-state, through active recollection of past experiences and anticipation of future events, all known to involve the default mode network (DMN). By inducing social stress and acquiring resting-state ...

    Also Ranks for: Functional Connectivity |  stress response |  default network |  temporal trajectory |  central hubs
    KOL Index score: 5876

    BACKGROUND: Stress is widely known to alter behavioral responses to rewards and punishments. It is believed that stress may precipitate these changes through modulation of corticostriatal circuitry involved in reinforcement learning and motivation, although the intervening mechanisms remain unclear. One candidate is inflammation, which can rapidly increase following stress and can disrupt dopamine-dependent reward pathways.

    METHODS: Here, in a sample of 88 healthy female participants, we ...

    Also Ranks for: Acute Stress |  reinforcement learning |  ventral striatum |  female participants |  interleukin6 il6


    Roee Admon: Influence Statistics

    Sample of concepts for which Roee Admon is among the top experts in the world.
    Concept World rank
    cortisol secretion mechanisms #1
    neural abnormalities #1
    pseudo pnes #1
    impact stress exposures #1
    stress exposure functionality #1
    participants stressinduced increase #1
    mechanisms stress responsivity #1
    impact stress exposure #1
    quadratic relations stress #1
    intraindividually variability #1
    nervoussystem mechanisms #1
    abnormal epileptic activity #1
    negative mood level #1
    interindividual variability mechanisms #1
    parsing inter #1
    key nervous mechanisms #1
    stress responsivity patterns #1
    acquired negativity #2
    enhanced remembrance #2
    brain systems rst #2
    analyses probed #2
    neuroticism temporary decrease #2
    discharge elevated neuroticism #2
    predisposing exposure #2
    neural abnormalities ptsd #2
    result extensive effort #2
    neutral cues #2
    reactivity prior #2
    connectivity neural abnormalities #2
    reallife combat stress #2
    depression improved understanding #2
    aversion obsessive #2
    brain biomarkers exposure #2
    hedonic capacity findings #2
    amygdala enhanced remembrance #2
    loudness reconstruction #2
    subject audiovisual #2
    nonetomild levels #2
    exaggerated fear generation #2
    audiovisual decoding #2
    personality stressrelated symptoms #2
    sexrelated structural #2
    aversion ocd #2

    Key People For Trauma Survivors

    Top KOLs in the world
    Ronald C Kessler
    mental disorders united states major depression
    posttraumatic stress disorder prolonged exposure ritual prevention
    Dennis S Charney
    panic disorder major depression depressed patients
    Terence M Keane
    posttraumatic stress disorder combat exposure ptsd symptoms
    Evelyn J Bromet
    mental health trade center bipolar disorder
    Arieh Y Shalev
    posttraumatic stress disorder trauma survivors ptsd symptoms

    Roee Admon:Expert Impact

    Concepts for whichRoee Admonhas direct influence:Trauma survivors,  Cortisol response,  Negative affective stimuli,  Major depression,  Posttraumatic stress disorder,  Enhanced remembrance,  Trauma exposure,  Neutral cues.

    Roee Admon:KOL impact

    Concepts related to the work of other authors for whichfor which Roee Admon has influence:Posttraumatic stress disorder,  Functional connectivity,  Reward processing,  Depressive symptoms,  Prefrontal cortex,  Acute stress,  Magnetic resonance.



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    The Integrated Brain and Behavior Research Center (IBBRC), University of Haifa, Haifa, Israel. | School of Psychological Sciences, University of Haifa, Haifa, Israel. | School of Psychological Sciences, University of Haifa, Haifa, Israel | University