Prominent publications by Todd J Schwedt

KOL Index score: 21753

BACKGROUND: Acute and persistent post-traumatic headache are often debilitating consequences of traumatic brain injury. Underlying physiological mechanisms of post-traumatic headache and its persistence remain unknown, and there are currently no approved therapies for these conditions. Post-traumatic headache often presents with a migraine-like phenotype. As calcitonin-gene related peptide promotes migraine headache, we explored the efficacy and timing of intervention with an anti- ...

Known for Traumatic Headache |  Brain Injury |  Persistent Post |  Cutaneous Allodynia |  Calcitonin Gene
KOL Index score: 16880

INTRODUCTION: Although migraine and persistent post-traumatic headache often share phenotypic characteristics, few studies have interrogated the pathophysiological differences underlying these headache types. While there is now some indication of differences in brain structure between migraine and persistent post-traumatic headache, differences in brain function have not been adequately investigated. The objective of this study was to compare static and dynamic functional connectivity ...

Known for Functional Connectivity |  Traumatic Headache |  Persistent Post |  Magnetic Resonance |  Static Dynamic
KOL Index score: 15538

OBJECTIVES: To summarize the baseline methods for the Migraine in America Symptoms and Treatment (MAST) Study and evaluate gender differences in sociodemographics and headache features; consultation and diagnosis patterns; and patterns of acute and preventive treatment use for migraine among study participants.

BACKGROUND: The MAST Study is a longitudinal, internet-based panel study of symptoms, approaches to management, and unmet treatment needs among US adults with migraine. This ...

Known for Gender Differences |  America Symptoms |  Women Migraine |  Treatment Patterns |  Mast Study
KOL Index score: 14426

BackgroundSubcutaneous erenumab reduced monthly migraine days and increased the likelihood of achieving a ≥ 50% reduction at all monthly assessment points tested in 2 pivotal trials in episodic migraine (EM) and chronic migraine (CM). Early efficacy of migraine preventive medications is an important treatment characteristic to patients. Delays in achievement of efficacy can result in failed adherence. The objective of these post-hoc analyses were to evaluate efficacy in the first 4 weeks ...

Known for Early Onset |  Erenumab Placebo |  Monoclonal Antibodies |  Chronic Migraine |  Week Treatment
KOL Index score: 14411

BACKGROUND: Most persistent posttraumatic headaches (PPTH) have a phenotype that meets diagnostic criteria for migraine or probable migraine. Although symptoms of autonomic dysfunction have been well described among those with migraine, the presence and relative severity of such symptoms among those with PPTH have yet to be reported.

OBJECTIVE: The objective of this study was to assess and compare symptoms of autonomic dysfunction among those with PPTH attributed to mild traumatic brain ...

Known for Autonomic Dysfunction |  Ppth Migraine |  Traumatic Brain |  Headache Attributed |  Higher Scores
KOL Index score: 12409

Initial studies indicate an increased prevalence of patent foramen ovale (PFO) in migraineurs with aura, and an increased prevalence of migraine and migraine with aura in persons with PFO. Retrospective analyses of PFO closure suggest clinically significant improvements in migraine patterns. The aim of this study was to examine the prevalence of migraine in patients with PFO, the prevalence of PFO in migraineurs, and the effect of PFO closure on migraine. We conducted a quantitative ...

Known for Pfo Migraine |  Patent Foramen |  Increased Prevalence |  Evidence Association |  Retrospective Analyses
KOL Index score: 12065

BackgroundThe majority of individuals with post-traumatic headache have symptoms that are indistinguishable from migraine. The overlap in symptoms amongst these individuals raises the question as to whether post-traumatic headache has a unique pathophysiology or if head trauma triggers migraine. The objective of this study was to compare brain structure in individuals with persistent post-traumatic headache (i.e. headache lasting at least 3 months following a traumatic brain injury) ...

Known for Traumatic Headache |  Brain Structure |  Persistent Post |  Migraine Differences |  Cortical Thickness
KOL Index score: 11658

OBJECTIVE: To identify factors associated with triptan discontinuation among migraine patients.

BACKGROUND: It is unclear why many migraine patients who are prescribed triptans discontinue this treatment. This study investigated correlates of triptan discontinuation with a focus on potentially modifiable factors to improve compliance.

METHODS: This multicenter cross-sectional survey (n = 276) was performed at US tertiary care headache clinics. Headache fellows who were members of the ...

Known for Triptan Discontinuation |  Migraine Patients |  Discontinued Users |  Outcome Tryptamines |  Withholding Treatment
KOL Index score: 11520

BACKGROUND AND OBJECTIVES: The association between migraine, depression, and anxiety has been established, but the impact of these psychiatric comorbidities on functional impairment in people with migraine has been under-investigated. The purpose of this cross-sectional observational study was to investigate the relationship between anxiety and depression symptoms on migraine-related disability, pain interference, work interference, and career success in a cohort of patients with ...

Known for Patients Migraine |  Pain Interference |  Anxiety Symptoms |  Functional Impairment |  Phq2 Scores
KOL Index score: 11018

BackgroundMigraine is associated with many debilitating symptoms that affect daily functioning. My Migraine Voice is a large global cross-sectional study aimed at understanding the full burden and impact of migraine directly from patients suffering from ≥4 monthly migraine days (MMDs) with a history of prophylactic treatment failure.MethodsThis study was conducted worldwide (31 countries across North and South Americas, Europe, the Middle East and Northern Africa, and the Asia-Pacific ...

Known for Migraine Voice |  Preventive Treatments |  Treatment Failure |  Online Survey |  31 Countries
KOL Index score: 10591

OBJECTIVE: To investigate differences in cortical thickness in patients with persistent post-traumatic headache (PPTH) relative to healthy controls and to interrogate whether cortical morphology relates to headache burden (headache frequency, years with post-traumatic headache, PTH) in patients with PPTH.

BACKGROUND: PTHs are one of the most common symptoms following concussion. In some patients, PTHs continue for longer than three months and are classified as PPTH. This study has two ...

Known for Patients Ppth |  Cortical Thickness |  Traumatic Headache |  Mri Study |  Persistent Post
KOL Index score: 10560

BACKGROUND/OBJECTIVE: Migraineurs have atypical pain processing, increased expectations for pain, and hypervigilance for pain. Recent studies identified correlations between brain structure and pain sensation in healthy adults. The objective of this study was to compare cortical thickness-to-pain threshold correlations in migraineurs to healthy controls. We hypothesized that migraineurs would have aberrant relationships between the anatomical neurocorrelates of pain processing and pain ...

Known for Cortical Thickness |  Pain Thresholds |  Healthy Controls Migraineurs |  Brain Structure |  Inferior Parietal
KOL Index score: 10390

BackgroundThe MAST Study is a longitudinal, cross-sectional survey study of US adults with migraine. These analyses were conducted to estimate rates of acute medication overuse (AMO) and determine associations of AMO with individual and headache characteristics.MethodsEligible respondents had ICHD-3-beta migraine, reported ≥3 monthly headache days (MHDs) in the past 3 months, ≥1 MHD in the past 30 days, and currently took acute headache medication. AMO was defined according to ...

Known for Medication Overuse |  Cutaneous Allodynia |  Migraine Amo |  America Symptoms |  Headache Disorders
KOL Index score: 10119

The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated ...

Known for Headache Society |  Acute Treatment |  Evidence Assessment |  Migraine Pharmacotherapies |  Nasal Spray
KOL Index score: 9866

OBJECTIVE: To evaluate the effect of migraine on women's pregnancy plans.

PATIENTS AND METHODS: Participants were enrolled in the American Registry for Migraine Research, an observational study that recruits patients from headache specialty clinics across the United States. Data for this analysis were collected via patient-completed questionnaires completed from February 1, 2016, through September 23, 2019. Participants were adult women with migraine who answered the American Registry ...

Known for Migraine Pregnancy |  Adult Women |  Studies Registries |  Patients Headache |  Enrolled Registry


Todd J Schwedt: Influence Statistics

Sample of concepts for which Todd J Schwedt is among the top experts in the world.
Concept World rank
migraineurs migraine attack #1
allodynia threshold adult #1
correlations pain thresholds #1
ppth mechanisms #1
migraineurs correlations #1
persistent post #1
migraine structure #1
specific thunderclap headache #1
differences fibertract profiles #1
guidelines imaging studies #1
galcanezumab early #1
article theorized mechanisms #1
pain migraineurs #1
objective migraineurs #1
insomnia severity ppth #1
preventive medication trial #1
compared migraine #1
total compass31 #1
traumatic headache #1
persistence pth #1
overused medication #1
regions migraineurs #1
participants pth #1
mm3 migraine #1
subclassification brain #1
functional connectivity differences #1
review posttraumatic headache #1
literature steroidal #1
correlations differentiate #1
thunderclap headache brain #1
cdh review #1
migraine hc #1
psychological symptoms disability #1
headache frequency differences #1
migraineurs greater #1
findingsepilepsy #1
controls negative correlations #1
hypothalamic region volume #1
pth brain #1
diagnostic criteria pth #1
migraine clinical symptoms #1
highquality treatment trial #1
cutaneous allodynia quartile #1
compared mwoa #1
primary humans #1
longer disease burden #1
data‐driven automated #1
structural co‐variance patterns #1
years migraine #1
migraine symptoms disease #1

Key People For Chronic Migraine

Top KOLs in the world
Richard B Lipton
chronic migraine united states acute treatment
Stephen David Silberstein
chronic migraine cluster headache acute treatment
David William Dodick
chronic migraine cluster headache acute treatment
Peter James Goadsby
cluster headache chronic migraine acute treatment
Hanschristoph C Diener
atrial fibrillation cluster headache chronic migraine
Marcelo Eduardo Bigal
chronic migraine preventive treatment temporomandibular disorders

Todd J Schwedt:Expert Impact

Concepts for whichTodd J Schwedthas direct influence:Chronic migraine,  Traumatic headache,  Thunderclap headache,  Cortical thickness,  Cluster headache,  Brain structure,  Pain thresholds,  Traumatic brain.

Todd J Schwedt:KOL impact

Concepts related to the work of other authors for whichfor which Todd J Schwedt has influence:Chronic migraine,  Cluster headache,  Acute treatment,  Cerebral vasoconstriction,  Central nervous,  Functional connectivity,  Patent foramen.



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Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA | Department of Neurology, Mayo Clinic Arizona, Scottsdale, Arizona, USA | From the Department of Neurology (T.J.S., J.G.H., M.L., D.W.D.), Mayo Clinic, Phoenix, AZ; Department of Neurolo

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