• Trigeminocervical Complex
    • The Trigeminocervical...
    • The trigeminocervical complex and migraine: Current concepts and synthesis: Influence Statistics

      Expert Impact

      Concepts for whichthey havehas direct influence:Trigeminocervical complex,Basic mechanisms,Migraine headaches,Trigeminocervical neurones,Primary headache,Head pain,Pain processing,Nociceptive afferents.

      Key People For Trigeminocervical Complex

      Top KOLs in the world
      Peter James Goadsby
      cluster headache chronic migraine acute treatment
      Simon Akerman
      trigeminocervical complex nitric oxide cluster headache
      Holger Kaube
      cluster headache blink reflex trigeminal nociception
      Michel Dominique Ferrari
      cluster headache migraine patients acute treatment
      Karen Lisa Hoskin
      superior sagittal sinus fos expression middle meningeal artery
      Robin James Storer
      trigeminocervical complex chronic migraine opioid receptors

      The trigeminocervical complex and migraine: Current concepts and synthesis


      Neurones in the trigeminocervical complex are the major relay neurones for nociceptive afferent input from the meninges and cervical structures; therefore, they are the neural substrates of head pain. This review highlights the importance of two basic mechanisms in headache physiology: convergence of nociceptive afferents and sensitization of trigeminocervical neurones. These physiologic findings have clinical correlates such as hypersensitivity and spread and referral of pain frequently seen in patients with primary headache, such as migraine. Special reference is made to the influence of structures from the upper cervical spine in generating and contributing to migraine headaches. The pathophysiology and functional relevance of these basic mechanisms to headaches is discussed in the context of recent experimental findings with regard to pain processing.

      Sign-in to see all concepts, it's free!


    Download on the App StoreGet it on Google Play

    Copyright © 2023 Key Opinion Leaders, LLC.