• KOL
    • Trisomy 13
    • Long-Term Outcomes Of...
    • Long-Term Outcomes of Children With Trisomy 13 and 18 After Congenital Heart Disease Interventions: Influence Statistics

      Expert Impact

      Concepts for whichthey havehas direct influence:Trisomy 13,Patients trisomy,Congenital heart,Trisomy 18,13 trisomy,13 18,Human pair,Trisomy interventions.

      Key People For Trisomy 13

      Top KOLs in the world
      #1
      Kypros Nicolaides Nicolaides†
      cervical length gestational age maternal factors
      #2
      John C Carey
      neurofibromatosis type human pair birth defects
      #3
      Jan M Friedman
      neurofibromatosis 1 birth defects united states
      #4
      Sonja A Rasmussen
      birth defects pregnant women united states
      #5
      Quanhe Yang
      united states heart age cardiovascular disease
      #6
      Kristin M May
      parental origin subtelomeric regions sex chromosome

      Long-Term Outcomes of Children With Trisomy 13 and 18 After Congenital Heart Disease Interventions

      Abstract

      BACKGROUND: The purpose of this study is to report short- and long-term outcomes after congenital heart defect (CHD) interventions in patients with trisomy 13 or 18.

      METHODS: A retrospective review of the Pediatric Cardiac Care Consortium (PCCC) identified children with trisomy 13 or 18 with interventions for CHD between 1982 and 2008. Long-term survival and cause of death were obtained through linkage with the National Death Index.

      RESULTS: A total of 50 patients with trisomy 13 and 121 patients with trisomy 18 were enrolled in PCCC between 1982 and 2008; among them 29 patients with trisomy 13 and 69 patients with trisomy 18 underwent intervention for CHD. In-hospital mortality rates for patients with trisomy 13 or trisomy 18 were 27.6% and 13%, respectively. Causes of in-hospital death were primarily cardiac (64.7%) or multiple organ system failure (17.6%). National Death Index linkage confirmed 23 deaths after discharge. Median survival (conditioned to hospital discharge) was 14.8 years (95% confidence interval [CI]: 12.3 to 25.6 years) for patients with trisomy 13 and 16.2 years (95% CI: 12 to 20.4 years) for patients with trisomy 18. Causes of late death included cardiac (43.5%), respiratory (26.1%), and pulmonary hypertension (13%).

      CONCLUSIONS: In-hospital mortality rate for all surgical risk categories was higher in patients with trisomy 13 or 18 than that reported for the general population. However, patients with trisomy 13 or 18, who were selected as acceptable candidates for cardiac intervention and who survived CHD intervention, demonstrated longer survival than previously reported. These findings can be used to counsel families and make program-level decisions on offering intervention to carefully selected patients.

      Sign-in to see all concepts, it's free!

       

    Download on the App StoreGet it on Google Play

    Copyright © 2023 Key Opinion Leaders, LLC.