Prominent publications by Maria Paola Canevini

KOL Index score: 15704

BACKGROUND: The potential effect of age-related factors on health-related quality of life (HRQOL) of patients with epilepsy has rarely been analyzed in the literature.

METHODS: We examined this association in a selected population of 815 adults with epilepsy recruited in the context of a multicentre study for the evaluation of Epi-QoL, one of the first Italian epilepsy-specific measures of HRQOL for adults with epilepsy. The Epi-QoL is a 46-item self-administered questionnaire focusing ...

Known for Age Onset |  Duration Epilepsy |  Life Hrqol |  Healthrelated Quality |  Qol Score
KOL Index score: 14802

Tuberous sclerosis complex (TSC) is a tumor suppressor gene disorder characterized by mutations in the TSC1 or TSC2 genes. These mutations lead to the development of benign tumors involving smooth muscle cells, causing life-threatening lymphangioleiomyomatosis. We isolated and characterized two types of cells bearing a mutation in TSC2 exon 18 from a renal angiomyolipoma of a TSC patient: one population of alpha-actin-positive smooth muscle-like cells with loss of heterozygosity for the ...

Known for Smooth Muscle |  Growth Factor |  Sclerosis Complex |  Renal Angiomyolipoma |  Loss Heterozygosity
KOL Index score: 14105

BACKGROUND: Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used. Therefore, we aimed to compare the occurrence of major congenital malformations following prenatal exposure to the eight most commonly used antiepileptic drugs in monotherapy.

METHODS: We did a longitudinal, prospective cohort study based on the EURAP international registry. We included data from pregnancies in women who were exposed to ...

Known for Major Congenital Malformations |  Antiepileptic Drugs |  Lamotrigine Levetiracetam |  Oxcarbazepine Phenobarbital |  Prospective Cohort
KOL Index score: 13209

PURPOSE: To evaluate the relative contribution of demographic and epilepsy-related variables, depressive symptoms, and adverse effects (AEs) of antiepileptic drugs (AEDs) to health-related quality of life (HRQOL) in adults with pharmacoresistant epilepsy.

METHODS: Individuals with epilepsy whose seizures failed to respond to at least one AED were enrolled consecutively at 11 tertiary referral centers. HRQOL was assessed by the Quality of Life in Epilepsy Inventory-31 (QOLIE-31), AEs by ...

Known for Pharmacoresistant Epilepsy |  Life Hrqol |  Depressive Symptoms |  Strongest Predictors |  Enrolled Patients
KOL Index score: 12321

PURPOSE: The aim of the present study was to investigate the possible frontal cognitive dysfunction in patients with juvenile myoclonic epilepsy (JME) and to compare the results with those of patients with frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE), as well as with controls.

METHODS: A total of 50 patients with JME, 40 patients with FLE, 40 patients with TLE, and 40 normal controls, all matched for age, education, and IQ, were administered tests to assess frontal ...

Known for Myoclonic Epilepsy |  Patients Jme |  Frontal Cognitive |  Fle Tle
KOL Index score: 11272

PURPOSE: The incidence of psychogenic non-epileptic seizures (PNES) is 4.9/100,000/year and it is estimated that about 20-30% of patients referred to tertiary care epilepsy centers for refractory seizures have both epilepsy and PNES. The purpose of our study is to evaluate psychiatric disorders and neuropsychological functions among patients with PNES, patients with epilepsy associated with PNES and patients with epilepsy.

METHODS: We evaluated 66 consecutive in-patients with video-EEG ...

Known for Patients Pnes |  Epileptic Seizures |  Epilepsy Female Humans |  Psychiatric Disorders |  Neuropsychological Profiles
KOL Index score: 10942

BACKGROUND: In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Studies performed in a naturalistic setting are a useful complement to characterize the drug profile.

OBJECTIVE: This multicentre study assessed the effectiveness and tolerability of adjunctive BRV in a large population of patients with focal epilepsy in the context of real-world clinical practice.

METHODS: The BRIVAFIRST (BRIVAracetam add-on ...

Known for Italian Network Study |  Brv Patients |  Focal Epilepsy |  Adjunctive Brivaracetam |  Rates Seizure
KOL Index score: 10921

Tuberous Sclerosis Complex (TSC) is a multisystemic condition caused by mutations in TSC1 or TSC2, but a pathogenic variant is not identified in up to 10% of the patients. The aim of this study was to delineate the phenotype of pediatric and adult patients with a definite clinical diagnosis of TSC and no mutation identified in TSC1 or TSC2. We collected molecular and clinical data of 240 patients with TSC, assessing over 50 variables. We compared the phenotype of the homogeneous group of ...

Known for Tuberous Sclerosis |  Patients Tsc |  Deep Phenotyping |  Nmi Individuals |  Mutation Identified
KOL Index score: 10711

PURPOSE: To evaluate the adverse effects (AEs) of antiepileptic drugs (AEDs) in adults with refractory epilepsy and their relationship with number of coprescribed AEDs and AED load.

METHODS: Patients with refractory epilepsy were enrolled consecutively at 11 tertiary referral centers. AEs were assessed through unstructured interview and the Adverse Event Profile (AEP) questionnaire. AED loads were calculated as the sum of prescribed daily dose (PDD)/defined daily dose (DDD) ratios for ...

Known for Refractory Epilepsy |  Drug Load |  Large Cohort |  Patients Monotherapy |  Adverse Effects Aes
KOL Index score: 10386

PURPOSE: Mutations of the protocadherin19 gene (PCDH19) cause a female-related epilepsy of variable severity, with or without mental retardation and autistic features. Despite the increasing number of patients and mutations reported, the epilepsy phenotype associated with PCDH19 mutations is still unclear. We analyzed seizure semiology through ictal video-electroencephalography (EEG) recordings in a large series of patients.

METHODS: We studied 35 patients with PCDH19 gene-related ...

Known for Focal Seizures |  Affective Symptoms |  Patients Pcdh19 Mutations |  Autistic Features |  Seizure Semiology
KOL Index score: 10251

BACKGROUND: Although anxiety and depression in populations with epilepsy have been studied, no research on fear of childbirth in women with epilepsy have been conducted. The purposes of this study were to examine whether a significant difference occurred in fear of childbirth between pregnant women with epilepsy and pregnant healthy controls and to evaluate the most common fears.

METHODS: Fifty pregnant women with epilepsy and 50 pregnant women without epilepsy were assessed at a ...

Known for Women Epilepsy |  Fear Childbirth |  Parturition Pregnancy |  Delivery Obstetric |  Anxiety Depression
KOL Index score: 10213

The goal of this study was to determine if there is a significant difference in the rate of postpartum depression among patients with epilepsy and healthy controls. All patients were recruited from the Epilepsy Center and the Department of Obstetrics and Gynecology, University of Milan, St. Paolo Hospital (Milan, Italy). Thirty-five pregnant women with epilepsy and an equal number of pregnant women without epilepsy were assessed with the Edinburgh Postnatal Depression Scale (EPDS), a ...

Known for Postpartum Depression |  Women Epilepsy |  Ppd Patients |  Clinical Interview |  Questionnaires Adult
KOL Index score: 9786

PURPOSE: The aim of the present study is to verify whether patients with partial epilepsy receiving levetiracetam (LEV) as an add-on treatment show an improvement in cognitive function.

METHODS: A neuropsychological battery of tests was administered to 35 patients with partial epilepsy before the assumption of LEV and after the achievement of the therapeutical dose of this drug, 7 weeks later. A control group of 35 patients with partial epilepsy was administered the same battery of tests ...

Known for Partial Epilepsy |  Patients Lev |  Combination Epilepsies |  Cognitive Function |  Verbal Fluency
KOL Index score: 9556

BACKGROUND: Neuropsychiatric disorders are present in up to 90% of patients with Tuberous Sclerosis Complex (TSC), and represent an important issue for families. Autism Spectrum Disorder (ASD) is the most common neurobehavioral disease, affecting up to 61% of patients. The aims of this study were: 1) to assess the prevalence of ASD in a TSC population; 2) to describe the severity of ASD; 3) to identify potential risk factors associated with the development of ASD in TSC ...

Known for Tuberous Sclerosis Complex |  Asd Tsc |  Autism Spectrum |  Neuropsychiatric Disorders |  Disorder Child
KOL Index score: 9509

This document provides guidance on the use of valproate in girls and women of childbearing age from a joint Task Force of the Commission on European Affairs of the International League Against Epilepsy (CEA-ILAE) and the European Academy of Neurology (EAN), following strengthened warnings from the Coordination Group for Mutual Recognition and Decentralised Procedures-Human (CMDh) of the European Medicines Agency (EMA), which highlight the risk of malformations and developmental problems ...

Known for Girls Women |  Childbearing Potential |  Treatment Epilepsy |  Task Force |  International League


Maria Paola Canevini: Influence Statistics

Sample of concepts for which Maria Paola Canevini is among the top experts in the world.
Concept World rank
specific stimuli context #1
433±106years #1
life 71 patients #1
women childbirth age #1
ring r20 #1
r20 chromosome #1
lvf adduction #1
pness suggestion #1
writing seizures #1
asd tsc nf1 #1
tsc deregulation #1
prevalent seizure types #1
day16 years #1
age valproic acid #1
r20 chromosome cells #1
tsc clinic tsc #1
adolescent brain chromosomes #1
underlying seizures disorders #1
ictal involvement #1
pnes cognitive deficits #1
total sdsc score #1
500 commonly #1
adult transition model #1
sdsc child #1
mutations cognitive level #1
everolimus withdrawal #1
tonic spastic activity #1
behavior seizures lgs #1
neuroimaging contribution #1
fortysix tsc patients #1
vpa dosage women #1
add italian #1

Key People For Tuberous Sclerosis Complex

Top KOLs in the world
Sergiusz Jóźwiak
tuberous sclerosis patients tsc giant cell
Elizabeth Petri Henske
tuberous sclerosis mammalian target tsc2deficient cells
David Neal Franz
tuberous sclerosis patients tsc mammalian target
David J Kwiatkowski
tuberous sclerosis lung cancer mammalian target
Ewell Steve Roach
tuberous sclerosis complex weber syndrome intracranial hypertension
Hope A Northrup
tuberous sclerosis complex spina bifida infantile spasms

Maria Paola Canevini:Expert Impact

Concepts for whichMaria Paola Canevinihas direct influence:Tuberous sclerosis complex,  Rett syndrome,  Postpartum depression,  Antiepileptic drugs,  Tuberous sclerosis,  Sleep disorders,  Patients epilepsy,  Vagus nerve stimulation.

Maria Paola Canevini:KOL impact

Concepts related to the work of other authors for whichfor which Maria Paola Canevini has influence:Antiepileptic drugs,  Tuberous sclerosis complex,  Patients epilepsy,  Rett syndrome,  Valproic acid,  Quality life,  Temporal lobe.



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Epilepsy Centre, Sleep Medicine Centre, Childhood and Adolescence Neuropsychiatry Unit, ASST Santi Paolo E Carlo, San Paolo Hospital, Via Antonio di Rudinì, 8, 20142 Milan, Italy | Department of Health Sciences, Università Degli Studi, Milan, Italy |

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